Home About us Contact
|
Home About us Contact | ||
|
|
||
Right Place (right + place)
Selected AbstractsThe Right Stuff in the Right Place: The Institution of Contemporary ArtCURATOR THE MUSEUM JOURNAL, Issue 1 2007Ian Wedde What does our ramble reveal about the institution of contemporary art? "Diversity" hardly seems an adequate word. [source] ,Fishing in the Right Place': Analytical Examples from the Tonalities ProjectMUSIC ANALYSIS, Issue 2-3 2004Michael Russ First page of article [source] Client satisfaction and risk behaviours of the users of syringe dispensing machines: a pilot studyDRUG AND ALCOHOL REVIEW, Issue 1 2008MD MOFIZUL ISLAM MSc Abstract Introduction and Aims. The study examines risk behaviours of the users of syringe dispensing machines (SDMs) and evaluates the usefulness of these machines in providing injecting drug users (IDUs) with sterile injecting equipment. Design and Methods. Self-administered questionnaires were used among users of SDMs in an Area Health Service of Sydney. Results. The majority of the 167 participants reported being happy with the quality of the SDM services. Problems identified with machines were that they were often broken or jammed (32.8% respondents), not in the right place (21.9%) or require money (16.7%). Just over half (50.9%) of the IDUs use SDMs only from 5 p.m. to 9 a.m., the time when almost all other outlets for accessing sterile injecting equipment remain closed. Relatively young IDUs (age , 30 years) were more likely to prefer SDMs over staffed needle syringe programmes (NSPs) compared with older users (age > 30) and to identify stigma (a desire to hide their identity or not liking the way people treat them at staffed NSPs or chemists) as a main reason for using these machines. Primary users of SDMs do not differ from primary users of NSP/chemists in terms of sharing of needles. Those users who had shared in the last month were nearly four times as likely to have never used condoms in sexual encounters over that period (95% confidence interval: 1.2,14.5). Discussion and Conclusion. SDMs appear to complement other outlets of NSPs. Providing free-of-cost equipment from SDMs should be considered carefully, as needing money to buy equipment was a reason given for sharing of needles by 35% of those who shared. [source] Type III secretion: The bacteria-eukaryotic cell expressFEMS MICROBIOLOGY LETTERS, Issue 1 2005Luís Jaime Mota Abstract Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future. [source] Microsoft implements readiness as a strategic forceGLOBAL BUSINESS AND ORGANIZATIONAL EXCELLENCE, Issue 5 2008Dustin Grosse The success of Microsoft's global product launches and solutions for a huge, diverse customer base hinges upon readiness in the field. To make workforce readiness a strategic lever, field training is aligned with business objectives, the role, and the task, and delivered to highly mobile communities at the right time, in the right place, and on the right device. The Sales, Marketing, and Services Group Readiness group builds its training offerings on three pillars of content development: an operating model that aligns priorities across businesses, regions, and customer segments; strong partnerships with business groups and subject matter experts; and metrics for assessing results. © 2008 Wiley Periodicals, Inc. [source] Communicating throughout Katrina: Competing and Complementary Conceptual Lenses on Crisis CommunicationPUBLIC ADMINISTRATION REVIEW, Issue 2007James L. Garnett Hurricane Katrina was as much a communication disaster as it was a natural and bureaucratic disaster. Communication gaps, missed signals, information technology failures, administrative buffering, turf battles, and deliberate and unintentional misinterpretations delayed and handicapped both the recognition of the crisis that Katrina posed and the response to its devastation. This essay views crisis communication through four conceptual lenses: (1) crisis communication as interpersonal influence, (2) crisis communication as media relations, (3) crisis communication as technology showcase, and (4) crisis communication as interorganizational networking. A conceptual framework is presented that compares these lenses with regard to agency, transparency, technology, and chronology. The planning, response, and recovery stages of the Hurricane Katrina disaster are viewed through these communication conceptual lenses, illustrating key facets of each perspective and adding to our deepening understanding of the events. Many of the problems we have identified can be categorized as "information gaps",or at least problems with information-related implications, or failures to act decisively because information was sketchy at best. Better information would have been an optimal weapon against Katrina. Information sent to the right people at the right place at the right time. Information moved within agencies, across departments, and between jurisdictions of government as well. Seamlessly. Securely. Efficiently , One would think we could share information by now. But Katrina again proved we cannot. ,U.S. House Select Bipartisan Committee With the floodwalls gashed and hemorrhaging billions of gallons of water into the city, it was only a matter of a few hours on Monday before the communications citywide began to fail , Communication was about to become the biggest problem of the catastrophe. ,Christopher Cooper and Robert Block, Disaster: Hurricane Katrina and the Failure of Homeland Security Truth became a casualty, news organizations that were patting their own backs in early September were publishing protracted mea culpas by the end of the month. ,Matt Welch, "They Shoot Helicopters, Don't They?" [source] Development, repair and fibrosis: What is common and why it mattersRESPIROLOGY, Issue 5 2009Wei SHI ABSTRACT The complex structure of the lung is developed sequentially, initially by epithelial tube branching and later by septation of terminal air sacs with accompanying coordinated growth of a variety of lung epithelial and mesenchymal cells. Groups of transcriptional factors, peptide growth factors and their intracellular signaling regulators, as well as extracellular matrix proteins are programmed to be expressed at appropriate levels in the right place at the right time to control normal lung formation. Studies of lung development and lung repair/fibrosis to date have discovered that many of the same factors that control normal development are also key players in lung injury repair and fibrosis. Transforming growth factor-, (TGF-,) family peptide signaling is a prime example. Lack of TGF-, signaling results in abnormal lung branching morphogenesis and alveolarization during development, whereas excessive amounts of TGF-, signaling cause severe hypoplasia in the immature lung and fibrosis in mature lung. This leads us to propose the ,Goldilocks' hypothesis of regulatory signaling in lung development and injury repair that everything must be done just right! [source] Signaling by Neuronal Tyrosine Kinase Receptors: Relevance for Development and RegenerationTHE ANATOMICAL RECORD : ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, Issue 12 2009Barbara Hausott Abstract Receptor tyrosine kinase activation by binding of neurotrophic factors determines neuronal morphology and identity, migration of neurons to appropriate destinations, and integration into functional neural circuits as well as synapse formation with appropriate targets at the right time and at the right place. This review summarizes the most important aspects of intraneuronal signaling mechanisms and induced gene expression changes that underlie morphological and neurochemical consequences of receptor tyrosine kinase activation in central and peripheral neurons. Anat Rec, 292:1976,1985, 2009. © 2009 Wiley-Liss, Inc. [source] Canadian economic geography at the millenniumTHE CANADIAN GEOGRAPHER/LE GEOGRAPHE CANADIEN, Issue 1 2000TREVOR J. BARNES Over the last quarter of a century the Canadian economy experienced a series of profound changes which have affected every level of society. They include new forms of flexible production, fundamental changes in regulation at all spatial scales, structural shifts away from manufacturing towards service sector activities, the rise of information technology (IT) and computerization at the workplace, the feminization of the labour market, and, what has become the leitmotif of the age, globalization. Such changes are intimately connected with geography. By that we mean not merely that they take on a geographical form, but that geography is pan of their very constitution. In this sense Canadian economic geographers are exactly in the right time and the right place to make use of their skills. Indeed, over the last five years there has been an explosion of literature by Canadian economic geographers on precisely these kinds of changes that are simultaneously both economic and geographical. In reviewing that literature the paper begins by situating Canada within its wider global setting, which we then follow by surveying the diverse writing around the three broad sectors that make-up the Canadian economy: the resource sector, the manufacturing sector, and the service sector. We conclude by highlighting two particular research themes within Canadian economic geography that have become especially germane over the late 1990s. The first is on new labour markets and forms of work both of which have been transformed during the last decade; and the second is on new forms of industrial innovation, which are clearly pivotal to the future well-being of the country for the next millennium. Au cours des vingt-cinq dernières années, l'économie canadienne a connu une série, de changements profonds qui ont affecté toutes les couches de la société. Ces changements comprennent les nouvelles formes de production flexible, les changements fondamentaux dans la réglementation à toutes les échelles spatiales, la mutation structurelle du secteur industriel au secteur tertiaire, la montée de la technologie de l'information (Tl) et l'informatisation sur le lieu de travail, la présence plus importante des femmes sur le marché du travail, et, ce qui est devenu le leitmotiv de notre époque, la mondialisation. De tels changements sont intimement liés à la geographie. Par la, nous ne disons pas simplement qu'ils prennent une forme géographique, mais que la géographie fait partie intégrante de leur constitution. Dans ce sens, les géographes-économistes canadiens arrivent, si l'on peut dire, au bon endroit au bon moment pour mettre leurs connaissances à profit. En effet, on assiste depuis les cinq dernières années à une recrudescence impressionnante des travaux de géographes-économistes canadiens portant, précisément, sur ces types de changements qui sont à la fois économiques et géographiques. En faisant le compte-rendu de cette littérature scientifique, cet article situe d'abord le Canada dans son contexte mondial plus large, passe ensuite en revue ce qui a étéécrit au sujet des trois grands secteurs qui forment l'économie canadienne: les secteurs primaire, secondaire et tertiaire. Nous concluons en mettant en relief deux thèmes de recherches de la géographie économique canadienne qui sont devenus particulièrement pertinents depuis la fin des années 1990. Le premier traite des nouveaux marchés du travail et des nouvelles formes de travail, qui ont tous deux subi des transformations au cours de la dernière décennie. Le second traite des nouvelles formes d'innovation industrielle, qui sont cruciales pour le bien-être futur du pays à l'aube du nouveau millénaire. [source] Suspension Culture Process of MethA Tumor Cell for the Production of Heat-Shock Protein Glycoprotein 96: Process Optimization in Spinner FlasksBIOTECHNOLOGY PROGRESS, Issue 6 2007Ya-Jie Tang Heat-shock proteins (HSPs) act like "chaperones", making sure that the cellapos;s proteins are in the right shape and in the right place at the right time. Heat-shock protein glycoprotein 96 (gp96) is a member of the HSP90 protein family, which chaperones a number of molecules in protein folding and transportation. Heat-shock protein gp96 serves as a natural adjuvant for chaperoning antigenic peptides into the immune surveillance pathways. Currently, heat-shock protein gp96 was only isolated from murine and human tissues and cell lines. An animal cell suspension culture process for the production of heat-shock protein gp96 by MethA tumor cell was developed for the first time in spinner flasks. Effects of culture medium and condition were studied to enhance the MethA tumor cell density and the production and productivity of heat-shock protein gp96. Initial glucose concentration had a significant effect on the heat-shock protein gp96 accumulation, and an initial glucose level of 7.0 g/L was desirable for MethA tumor cell growth and heat-shock protein gp96 production and productivity. Cultures at an initial glutamine concentration of 3 and 6 mM were nutritionally limited by glutamine. At an initial glutamine concentration of 6 mM, the maximal viable cell density of 19.90 × 105 cells/mL and the maximal heat-shock protein gp96 production of 4.95 mg/L was obtained. The initial concentration of RPMI 1640 and serum greatly affected the MethA tumor cell culture process. Specifically cultures with lower initial concentration of RPMI 1640 resulted in lower viable cell density and lower heat-shock protein gp96 production. At an initial serum concentration of 8%, the maximal viable cell density of 19.18 × 105 cells/mL and the maximal heat-shock protein gp96 production of 5.67 mg/L was obtained. The spin rate significantly affected the cell culture process in spinner flasks, and a spin rate of 150 rpm was desirable for MethA tumor cell growth and heat-shock protein gp96 production and productivity. Not only the cell density but also the production and productivity of heat-shock protein gp96 attained in this work are the highest reported in the culture of MethA tumor cell. This work offers an effective approach for producing heat-shock protein glycoprotein 96 from the cell culture process. The fundamental information obtained in this study may be useful for the efficient production of heat-shock protein by animal cell suspension culture on a large scale. [source] Unverzichtbar gegen Bakterien: Antibiotika.CHEMIE IN UNSERER ZEIT (CHIUZ), Issue 5 200980 Jahre Verwendung von Antibiotika in der Medizin Abstract Auch 80 Jahre nach der Entdeckung von Penicillin ist die Forschung nach neuen Antibiotika noch nicht abgeschlossen. Zunehmendes Auftreten von Resistenzen gegenüber den verwendeten Antibiotika erfordern einen verantwortungsvollen Einsatz bekannter Anibiotika und die Entwicklung verbesserter Medikamente. Mittlerweile existieren 8000 antibiotisch wirksame Substanzen, von denen ca. 100 in der Medizin angewandt werden. Trotzdem gibt es zahlreiche Infektionen, die nicht ausreichend behandelt werden können. Antibiotika werden in der Human- und Veterinärmedizin eingesetzt. Der bedenkliche Einsatz als Ergotropika, um die Infektionsraten von Masttieren zu vermindern und die Futterverwertung der Tiere zu steigern, konnte in den letzten Jahren zurückgedrängt werden. Die teils unsachgemäße Anwendung erzeugt einen selektiven Druck, der Resistenzen bei den Erregern hervorruft. Ihr bedrohlicher Einfluss auf die Therapie vor allem gramnegativer Bakterien könnten manche Teile der Welt in eine präantibiotische Ära zurückversetzen, da sich adäquate Therapiemöglichkeiten zunehmend verringern. Dies unterstreicht wiederum die Wichtigkeit neue Antibiotika bzw. neue Therapieansätze zu entwickeln. Ideen dazu gibt es genug. Eighty years after the recovery of Penicillin the search for new antibiotics is still ongoing. By now there exist 8000 effective antibiotics, from which 100 have medical applications. Nevertheless there exist a lot of infections, which cannot be sufficiently treated. New antibiotics should have a specific mode of function that differs from known antibiotics. Additionally they should avoid secondary effects on humans, have a good resorption and act at the right place in the body, without being immediately released. [source] Children's nurses' experiences of child protection: what helps?CHILD ABUSE REVIEW, Issue 3 2009Vicki Rowse Abstract This paper reports on one area of findings of a study undertaken in the spring of 2008 at a district general hospital in the south of England. Individual semi-structured interviews using an interpretive phenomenological approach were undertaken with 15 nurses and midwives working in paediatrics who had been involved in child protection cases. The aim was to explore their views and feelings of the experience. Very little research was found to inform this subject and none specifically with nurses working with sick children. Interviews were taped, transcribed and analysed thematically. It was discovered that involvement in child protection has a lasting impact on individuals; nurses need procedural information from a knowledgeable supporter during a case; and they need support from the right person in the right place at the right time for them. The Named Nurse was identified as being crucial in giving effective support to individuals during child protection cases and trusted advice and support helps staff follow through on niggling concerns, potentially preventing abuse. Copyright © 2009 John Wiley & Sons, Ltd. [source] Growth and specification: fly Pax6 homologs eyegone and eyeless have distinct functionsBIOESSAYS, Issue 6 2004Aloma B. Rodrigues Development requires not only the correct specification of organs and cell types in the right places (pattern), but also the control of their size and shape (growth). Many signaling pathways control both pattern and growth and how these two are distinguished has been something of a mystery. In the fly eye, a Pax6 homolog (eyeless) controls eye specification together with several other genes. Now Dominguez et al.1 show that Notch signaling controls eye growth through a second Pax6 protein (Eyegone). In mice and humans the single Pax6 gene appears to encode both specification and growth controlling proteins through alternative mRNA splicing. BioEssays 26:600,603, 2004. © 2004 Wiley Periodicals, Inc. [source] | ||||||||||||||||