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Retriever Dogs (retriever + dog)

Distribution by Scientific Domains
Medical Sciences75%

Kinds of Retriever Dogs

  • golden retriever dog
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    Selected Abstracts

    Multisystem Axonopathy and Neuronopathy in Golden Retriever Dogs

    JOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 4 2009
    R.C. Da Costa
    First page of article [source]

    Cosegregation of a Factor VIII Microsatellite Marker with Mild Hemophilia A in Golden Retriever Dogs

    JOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 2 2005
    Marjory B. Brooks
    Mild hemophilia A (factor VIII deficiency) was diagnosed in Golden Retrievers and pedigree studies were undertaken to test the cosegregation of an intragenic factor VIII marker with the disease phenotype. The study population consisted of 30 client-owned dogs (22 males and 8 females). Hemophilic males (n = 12) typically demonstrated prolonged bleeding after trauma or surgery rather than spontaneous hemorrhagic events. The affected males had a proportionate reduction in factor VIII coagulant activity (mean FVIII:C = 4%) and factor VIII protein concentration (mean FVIII:Ag = 3%). Twenty-five dogs (10 affected males, 8 clear males, 2 obligate carrier dams, and 5 suspect carrier daughters) were genotyped for a factor VIII microsatellite marker, with allele size assigned by an automated capillary electrophoresis system. Five distinct marker alleles were present in the study pedigree and a 300-base pair allele was found to segregate with the hemophilia A phenotype. The inheritance of the hemophilia-associated allele defined carrier status for 5 suspect daughters of obligate carrier dams. The limitations inherent to linkage analyses (ie, lack of access to key family members and homozygosity at the marker locus) did not preclude carrier detection in this pedigree. We conclude that genotype analysis for the intragenic factor VIII marker can aid in control of canine hemophilia A through enhanced carrier detection. [source]

    Duchenne's muscular dystrophy: animal models used to investigate pathogenesis and develop therapeutic strategies

    INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 4 2003
    C.A. Collins
    Summary., Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining muscle structure and function. Homologues of DMD have been identified in several animals including dogs, cats, mice, fish and invertebrates. The most notable of these are the extensively studied mdx mouse, a genetic and biochemical model of the human disease, and the muscular dystrophic Golden Retriever dog, which is the nearest pathological counterpart of DMD. These models have been used to explore potential therapeutic approaches along a number of avenues including gene replacement and cell transplantation strategies. High-throughput screening of pharmacological and genetic therapies could potentially be carried out in recently available smaller models such as zebrafish and Caenorhabditis elegans. It is possible that a successful treatment will eventually be identified through the integration of studies in multiple species differentially suited to addressing particular questions. [source]

    Analysis of variation in the melanocortin-4 receptor gene (mc4r) in golden retriever dogs

    ANIMAL GENETICS, Issue 5 2010
    L. Van Den Berg
    No abstract is available for this article. [source]