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Resorption Cavities (resorption + cavity)

Distribution by Scientific Domains

Medical Sciences	80%

Selected Abstracts

A Three-Dimensional Simulation of Age-Related Remodeling in Trabecular Bone,

JOURNAL OF BONE AND MINERAL RESEARCH, Issue 4 2001
J. C. Van Der Linden
Abstract After peak bone mass has been reached, the bone remodeling process results in a decrease in bone mass and strength. The formation deficit, the deficit of bone formation compared with previous resorption, results in bone loss. Moreover, trabeculae disconnected by resorption cavities probably are not repaired. The contributions of these mechanisms to the total bone loss are unclear. To investigate these contributions and the concomitant changes in trabecular architecture and mechanical properties, we made a computer simulation model of bone remodeling using microcomputed tomography (micro-CT) scans of human vertebral trabecular bone specimens. Up to 50 years of physiological remodeling were simulated. Resorption cavities were created and refilled 3 months later. These cavities were not refilled completely, to simulate the formation deficit. Disconnected trabeculae were not repaired; loose fragments generated during the simulation were removed. Resorption depth, formation deficit, and remodeling space were based on biological data. The rate of bone loss varied between 0.3% and 1.1% per year. Stiffness anisotropy increased, and morphological anisotropy (mean intercept length [MIL]) was almost unaffected. Connectivity density increased or decreased, depending on the remodeling parameters. The formation deficit accounted for 69,95%, disconnected trabeculae for 1,21%, and loose fragments for 1,17% of the bone loss. Increasing formation deficit from 1.8% to 5.4% tripled bone loss but only doubled the decrease in stiffness. Increasing resorption depth from 28 to 56 ,m slightly increased bone loss but drastically decreased stiffness. Decreasing the formation deficit helps to prevent bone loss, but reducing resorption depth is more effective in preventing loss of mechanical stiffness. [source]

Effectiveness of different gutta-percha techniques when filling experimental internal resorptive cavities

INTERNATIONAL ENDODONTIC JOURNAL, Issue 10 2008
N. Gencoglu
Abstract Aim, To determine the quality of root fillings in teeth with artificial internal resorptive cavities filled with Thermafil, JS Quick-Fill, Soft Core, System B and Microseal, and by cold lateral compaction (LC) technique. Methodology, Sixty maxillary incisor teeth were selected. After access cavity preparation and root canal instrumentation, the roots were sectioned horizontally and artificial internal resorption cavities were prepared on the canal walls. The tooth sections were cemented together and the root canals were filled using one of six different techniques: Thermafil, JS Quick-Fill, Soft Core, System B and Microseal, and by LC. The roots were then divided at the level of the previous section and each root surface was photographed. Image analysis program was used to calculate the percentage of sealer, gutta-percha and void in the internal resorptive cavities. All measurements were analysed statistically using One-way anova and Newman,Keuls tests. Results, The Microseal technique filled 99% of the artificial resorptive area followed by LC (92%), SystemB (89%), Quick-Fill (88%), Thermafil (74%) and Soft-Core (73%). Warm gutta-percha compaction techniques filled the resorption areas with more gutta-percha than sealer (Microseal 68%, System B 62%) compared to the other techniques (LC 48%, Quick Fill 41%, Soft Core 34%, Thermafil 35%). In addition, core techniques left a considerable volume of voids in the resorptive areas (Quick-Fill 12%, Thermafil 26%, Soft Core 27%). Conclusions, Warm gutta techniques filled artificial resorption cavities significantly better than the other gutta-percha techniques. [source]

Bone adaptation to load: microdamage as a stimulus for bone remodelling

JOURNAL OF ANATOMY, Issue 6 2002
T. C. Lee
Abstract Mechanical loading in the proximal radius was increased by ulnar osteotomy (Group O), altered by Steinmann pinning (Group P) or unaltered in sham operated controls (Group C) in skeletally mature female sheep, aged 2,4 years. A series of intravenous fluorochromes were given to label bone formation and fuchsin-stained microdamage assessed at intervals of up to 24 weeks. Microcracks were present in all groups and were found in the original cortex near the periosteal surface. No microcracks were found in the new, fibrolamellar bone laid down at periosteal or endosteal surfaces. Mean microcrack length (49 µm, SD 10 µm) did not differ between groups or over time. Microcrack numerical and surface densities and resorption cavity density peaked in all groups at 6 weeks, consistent with a regional acceleratory phenomenon (RAP), but the peaks were significantly greater in Group O. The density of refilling or secondary osteons peaked at 10 weeks and the mean time required for the formation of an osteon was 7.51 ± 0.59 weeks. Fatigue-induced microdamage is normally present in bone and is increased due to repetitive loading of the mechanically overloaded radius. The location and timing of microcracks, resorption cavities and secondary osteons are consistent with the activation-resorption-formation remodelling cycle and suggest that microdamage is a stimulus for bone remodelling. [source]

A Novel Tetracycline Labeling Schedule for Longitudinal Evaluation of the Short-Term Effects of Anabolic Therapy With a Single Iliac Crest Bone Biopsy: Early Actions of Teriparatide,

JOURNAL OF BONE AND MINERAL RESEARCH, Issue 3 2006
Robert Lindsay MD
Abstract We describe a quadruple tetracycline labeling method that allows longitudinal assessment of short-term changes in bone formation in a single biopsy. We show that 1 month of hPTH(1-34) treatment extends the bone-forming surface, increases mineral apposition rate, and initiates modeling-based formation. Introduction: Iliac crest biopsy, with histomorphometric evaluation, provides important information about cellular activity in bone. However, to obtain longitudinal information, repeat biopsies must be performed. In this study, we show the capability to obtain short-term longitudinal information on bone formation in a single biopsy using a novel, quadruple labeling technique. Materials and Methods: Two tetracycline labels were administered using a standard 3 days on, 12 days off, 3 days on format. Four weeks later, the tetracycline labeling was repeated using the same schedule but with a different tetracycline that can be distinguished from the first by its color under fluorescent light. Iliac crest biopsies were performed 1 week later and prepared undecalcified for histomorphometry. Indices of bone formation 1 month apart were measured and calculated using the two sets of labels. We used this method to investigate the early effects of teriparatide [hPTH(1-34)] treatment on bone formation. The results were compared with those from a group of control subjects who were quadruple-labeled, but did not receive hPTH(1-34). Results: Treatment with hPTH(1-34) dramatically stimulated bone formation on cancellous and endocortical surfaces. This was achieved by both an increase in the linear rate of matrix apposition and extension of the bone-forming surface. New bone was deposited on previously quiescent surfaces (i.e., modeling-based formation), but a proportion of this could occur by encroachment from adjacent resorption cavities. Conclusions: A single transiliac crest bone biopsy, after sequential administration of two sets of tetracycline labels is a useful approach to study the short-term effects of anabolic agents on human bone. One month of hPTH(1-34) treatment extends the bone-forming surface, increases mineral apposition rate, and initiates modeling-based formation. [source]