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Reported Series (reported + series)

Distribution by Scientific Domains

Medical Sciences	66%

Selected Abstracts

BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML)

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 3 2002
R.M. Arana-Trejo
There are two major forms of the BCR/ABL fusion gene, involving ABL exon 2, but including different exons of BCR gene. The transcripts b2a2 or b3a2 code for a p210 protein. Another fusion gene leads to the expression of an e1a2 transcript, which codes for a p190 protein. Another, less common fusion gene is c3a2[e19a2], which encodes a p230 protein. The incidence of one or the other rearrangement in chronic myeloid leukaemia (CML) patients varies in different reported series. This study was designed to determine the frequency of coexpresion of the p210, p190 and p230 transcripts in 250 Mexican patients with CML. We performed nested and multiplex reverse transcriptase polymerase chain reaction (RT-PCR) on bone marrow samples from adult patients and found that all cases were positive for some type of BCR/ABL rearrangement. In 226 (90.4%) patients it was p210, while the remaining 9.6% showed coexpression or one of the transcripts of p190/p210/p230. In 7% of patients with p210 expression there are both isoforms (b3a2/b2a2), presumably the result of alternative splicing. The rate of coexpression of the p190/p210 transcripts was 5%, which is much lower than in other reports. This may be due to the technical factors. These patients had high platelet counts, marked splenomegaly and chromosomal abnormalities in addition to Ph,. Other types of coexpression seen were p210/p230 and p190/p210/p230, in patients with high-risk clinical factors. Our study confirms the occurrence of coexpression of different BCR/ABL transcripts, although the rate (9.6%) was much lower than has been reported in other populations. This may reflect either the sensitivity of the detection techniques used or the possibility of genetic differences between the populations studied. Coexpression may be due to alternative splicing or to phenotypic variation, with clinical courses different from classical CML. [source]

Oral Abuse of Fentanyl Patches (Duragesic®): Seven Case Reports

JOURNAL OF FORENSIC SCIENCES, Issue 1 2008
Karen L. Woodall Ph.D.
Abstract:, In order to increase the understanding regarding the oral abuse and potential toxicity of fentanyl patches seven cases were identified over a 3-year period where fentanyl, either alone or in combination with other factors, contributed to death following the oral abuse of Duragesic® patches. The decedents comprised three females and four males with ages ranging from 20 to 51 years. Postmortem blood fentanyl concentrations were determined in all cases and ranged from 7 to 97 ng/mL. Two deaths were classified as a fentanyl overdose, three deaths were classified as a fentanyl and ethanol overdose, one death was considered a mixed drug intoxication and the remaining death was determined to be a combination of fentanyl and medical causes. These cases represent the largest reported series of deaths following the oral administration of transdermal fentanyl patches and provide detailed information on the potential for the abuse of transdermal Duragesic® patches via this route. The postmortem blood fentanyl concentrations detected for each of the decedents demonstrate the potentially fatal blood concentrations that can arise after this relatively rare route of administration. [source]

Synthesis and Structure,Efficiency Relations of 1,3,5-Benzenetrisamides as Nucleating Agents and Clarifiers for Isotactic Poly(propylene),

MACROMOLECULAR CHEMISTRY AND PHYSICS, Issue 2 2010
Frank Abraham
Abstract This paper presents the synthesis and properties of 1,3,5-benzenetrisamides with a particular focus on structure-efficiency relationships of nucleation and optical property enhancement of isotactic poly(propylene) (i -PP). A family of twenty 1,3,5-benzenetrisamide derivatives was synthesized, in which the direction of the amide linkage between the core and the peripheral substituents, as well as their length (C-3 to C-6) and flexibility were systematically varied. Dissolution- and recrystallization temperatures of the additives in the polymer melt, the crystallization temperature of i -PP, and the optical properties clarity and haze were determined in the additive concentration range from 200 to 2,500,ppm. Within the reported series of compounds, few exhibited very good nucleating and clarification abilities, only one with outstanding characteristics, whereas other, very closely related derivatives were found to be incapable to nucleate or clarify i -PP, although, intriguingly, most are structural isomers. We conclude that it is the particular chemical structure of the additive that determines its crystallization/self-assembly process, and, therewith, the structure of the heterogeneous nuclei, and at a higher hierarchical level the morphology of the poly(propylene) solid state and its final properties; and, hence, that a predictive understanding is still elusive. [source]

Laryngeal Angiosarcoma: A Clinicopathologic Study of Five Cases With a Review of the Literature,

THE LARYNGOSCOPE, Issue 7 2001
Benjamin M. Loos MD
Abstract Objective Primary laryngeal angiosarcoma (LA) is rare without a reported series evaluating these tumors. Study Design/Methods Five patients with LA were retrospectively retrieved from the Otorhinolaryngic Registry of the Armed Forces Institute of Pathology. Results Three men and 2 women, aged 29 to 71 years, presented with hoarseness (n = 4) and hemoptysis (n = 1). Two patients had previous neck radiation. The tumors involved the supraglottis (n = 4) with a mean size of 3.1 cm. Histologically, all tumors had anastomosing vascular channels lined by remarkably atypical endothelial cells protruding into the lumen, frequent atypical mitotic figures, and hemorrhage. All cases tested (n = 4) demonstrated immunoreactivity with antibodies to Factor VIII-RA and CD34. All patients had surgery followed by postoperative radiation (n = 3 patients). Three patients died with disease (mean, 17 mo), whereas one patient is alive with no evidence of disease at 18 years. Conclusions LA is a rare tumor, frequently associated with previous radiation, usually involving the supraglottis with characteristic histomorphologic and immunophenotypic features. LA has a poor prognosis, making appropriate separation from other conditions important. [source]

HN09P ASSESSMENT OF FREE FIBULAR BONE IN THE RECONSTRUCTED MANDIBLE USING THREE-DIMENSIONAL COMPUTER GENERATED IMAGES

ANZ JOURNAL OF SURGERY, Issue 2007
H. Nabi
We report the preliminary results of the Royal Adelaide Hospital experience with multidimensional simulated views of the fibula-flap reconstructed mandible. The free fibular flap is a well recognised option for mandibular reconstruction. What is not well understood however is how the fibula behaves in comparison to the dentate mandible. To date, skeletal remodelling and bone atrophy has only been assessed using standard orthopantogram films. For many years three-dimensional (3D) computer generated models using data from CT scans have been utilised for craniofacial reconstruction. We proposed that these images will enable us to more accurately visualise the integration of the transplanted graft within the mandible. We recalled and CT scanned patients from 2004 to 2006 that underwent free fibular flaps for reconstruction of mandibular malignancy and performed 3D reconstruction of these images. This is the first reported series of multidimensional computer generated images to assess bone in the reconstructed mandible. [source]

Prevention and management of infections in patients without a spleen

CLINICAL MICROBIOLOGY AND INFECTION, Issue 12 2001
R. N. Davidson
Patients who lack a functioning spleen become vulnerable to sepsis caused by bacteria and, occasionally, protozoa. The risk is higher in children and in those who have had immunosuppressive treatment, and the risk remains lifelong. Overwhelming post-splenectomy infection (OPSI) occurs at an estimated incidence of 0.23,0.42% per year, with a lifetime risk of 5%. Episodes of OPSI are emergencies, requiring immediate parental antibiotics and intensive care; intravenous immunoglobulins may be useful. OPSI carries a mortality of 38,69%. Streptococcus pneumoniae is the commonest infecting organism, accounting for 50,90% of isolates from blood cultures in reported series; it is particularly common in children with sickle cell disease. Less commonly, the infecting organisms are other bacteria, Babesia or Ehrlichia. OPSI may be, to some extent, preventable by several interventions. These are surgical conservation of the spleen; immunization against S. pneumoniae, Haemophilus influenzae type b, and Neisseria meningitidis; prophylactic antibiotics; stand-by antibiotics; patient information sheets; and a medical alert bracelet. Asplenic patients living in malaria-endemic areas require optimal prophylaxis. The initial step in prevention of OPSI is the creation of an asplenia register, as many patients are not covered by these simple measures. [source]