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Remote
Kinds of Remote Terms modified by Remote Selected AbstractsReducing complexity in Qualitative Comparative Analysis (QCA): Remote and proximate factors and the consolidation of democracyEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2006CARSTEN Q. SCHNEIDER However, real-world research situations might make the application of fs/QCA difficult in two respects , namely, the complexity of the results and the phenomenon of limited diversity. We suggest a two-step approach as one possibility to mitigate these problems. After introducing the difference between remote and proximate factors, the application of a two-step fs/QCA approach is demonstrated analyzing the causes of the consolidation of democracy. We find that different paths lead to consolidation, but all are characterized by a fit of the institutional mix chosen to the societal context in terms of power dispersion. Hence, we demonstrate that the application of fs/QCA in a two-step manner helps to formulate and test equifinal and conjunctural hypotheses in medium-size N comparative analyses, and thus to contribute to an enhanced understanding of social phenomena. [source] Financial Exclusion in Rural and Remote New South Wales, Australia: a Geography of Bank Branch Rationalisation, 1981,98GEOGRAPHICAL RESEARCH, Issue 2 2000N.M. Argent The provision of financial services in rural Australia is a significant public policy issue, reflected in the high level of media and political interest in the recent spate of branch closures. There are, however, many aspects of the current debate regarding the delivery of financial services to rural communities that are, at best, less than ideal and, at worst, erroneous. Using telephone directories for New South Wales, non-metropolitan bank branch listings for the period 1981 to 1998 were collated. A recategorisation of these data according to the Rural, Remote and Metropolitan Areas classification reveals, amidst a spatial realignment of financial service provision, that rural and remote New South Wales have been disproportionately affected by a relatively recent and concerted withdrawal of services. The research demonstrates that corporate-level responses to increased competition within the financial system are significantly more important in deciding rural access to banking services than local and regional population trends. Indeed, two-thirds of rural localities that have lost branches had experienced healthy population growth during the study period. In the wake of the post-deregulation reconfiguration of the bank branch network, the socio-economic marginalisation of rural communities is being compounded, a process of ,financial exclusion' recognised in other parts of the developed world. [source] Device Monitoring: Remote and Not So Remote Responsibilities: A Call to the Professional SocietiesPACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 12 2009F.A.C.C., F.A.H.A., F.E.S.C., F.H.R.S., JOHN D. FISHER M.D. No abstract is available for this article. [source] Remote, Wireless, Ambulatory Monitoring of Implantable Pacemakers, Cardioverter Defibrillators, and Cardiac Resynchronization Therapy Systems: Analysis of a Worldwide DatabasePACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 2007ARNAUD LAZARUS M.D. Study Objective: To describe the daily routine application of a new telemonitoring system in a large population of cardiac device recipients. Methods: Data transmitted daily and automatically by a remote, wireless Home MonitoringÔ system (HM) were analyzed. The average time gained in the detection of events using HM versus standard practice and the impact of HM on physician workload were examined. The mean interval between device interrogations was used to compare the rates of follow-up visits versus that recommended in guidelines. Results: 3,004,763 transmissions were made by 11,624 recipients of pacemakers (n = 4,631), defibrillators (ICD; n = 6,548), and combined ICD + cardiac resynchronization therapy (CRT-D) systems (n = 445) worldwide. The duration of monitoring/patient ranged from 1 to 49 months, representing 10,057 years. The vast majority (86%) of events were disease-related. The mean interval between last follow-up and occurrence of events notified by HM was 26 days, representing a putative temporal gain of 154 and 64 days in patients usually followed at 6- and 3-month intervals, respectively. The mean numbers of events per patient per month reported to the caregivers for the overall population was 0.6. On average, 47.6% of the patients were event-free. The mean interval between follow-up visits in patients with pacemakers, single-chamber ICDs, dual chamber ICDs, and CRT-D systems were 5.9 ± 2.1, 3.6 ± 3.3, 3.3 ± 3.5, and 1.9 ± 2.9 months, respectively. Conclusions: This broad clinical application of a new monitoring system strongly supports its capability to improve the care of cardiac device recipients, enhance their safety, and optimize the allocation of health resources. [source] WORK OF FEMALE RURAL DOCTORSAUSTRALIAN JOURNAL OF RURAL HEALTH, Issue 2 2004Jo Wainer Objectives: To identify the impact of family life on the ways women practice rural medicine and the changes needed to attract women to rural practice. Design: Census of women rural doctors in Victoria in 2000, using a self-completed postal survey. Setting: General and specialist practice. Subjects: Two hundred and seventy-one female general practitioners and 31 female specialists practising in Rural, Remote and Metropolitan Area Classifications 3,7. General practitioners are those doctors with a primary medical degree and without additional specialist qualifications. Main outcome measure: Interaction of hours and type of work with family responsibilities. Results: Generalist and specialist women rural doctors carry the main responsibility for family care. This is reflected in the number of hours they work in clinical and non-clinical professional practice, availability for oncall and hospital work, and preference for the responsibilities of practice partnership or the flexibility of salaried positions. Most of the doctors had established a satisfactory balance between work and family responsibilities, although a substantial number were overworked in order to provide an income for their families or meet the needs of their communities. Thirty-six percent of female rural general practitioners and 56% of female rural specialists preferred to work fewer hours. Female general practitioners with responsibility for children were more than twice as likely as female general practitioners without children to be in a salaried position and less likely to be a practice partner. The changes needed to attract and retain women in rural practice include a place for everyone in the doctor's family, flexible practice structures, mentoring by women doctors and financial and personal recognition. [source] Mechanism of Remote Conjugate Addition of Lithium Organocuprates to Polyconjugated Carbonyl CompoundsCHEMISTRY - AN ASIAN JOURNAL, Issue 3 2006Naohiko Yoshikai Abstract Regioselective reaction of a lithium organocuprate (R2CuLi) and a polyconjugated carbonyl compound affords a remote-conjugate-addition product. This reaction proceeds particularly cleanly when the conjugation is terminated by a CC triple bond. The reaction pathways and the origin of the regioselectivity of this class of transformations are explored with the aid of density functional calculations. The outline of the reaction pathway is as follows. An initially formed ,-cuprio(III) enolate intermediate undergoes smooth copper migration along the conjugated system. This process takes place faster than reductive elimination of intermediary ,/,-allylcopper(III) species, since the latter reaction disrupts the conjugation in the substrate and hence is not preferred. The copper migration to the acetylenic terminal affords a ,/,-allenylcopper(III) intermediate, which undergoes facile and selective CC bond forming reductive elimination at the terminal carbon atom. The present mechanistic framework shows good agreement with some pertinent experimental data, including 13C,NMR chemical shifts and kinetic isotope effects. [source] An Exploratory Technique for Coherent Visualization of Time-varying Volume DataCOMPUTER GRAPHICS FORUM, Issue 3 2010A. Tikhonova Abstract The selection of an appropriate global transfer function is essential for visualizing time-varying simulation data. This is especially challenging when the global data range is not known in advance, as is often the case in remote and in-situ visualization settings. Since the data range may vary dramatically as the simulation progresses, volume rendering using local transfer functions may not be coherent for all time steps. We present an exploratory technique that enables coherent classification of time-varying volume data. Unlike previous approaches, which require pre-processing of all time steps, our approach lets the user explore the transfer function space without accessing the original 3D data. This is useful for interactive visualization, and absolutely essential for in-situ visualization, where the entire simulation data range is not known in advance. Our approach generates a compact representation of each time step at rendering time in the form of ray attenuation functions, which are used for subsequent operations on the opacity and color mappings. The presented approach offers interactive exploration of time-varying simulation data that alleviates the cost associated with reloading and caching large data sets. [source] Object-oriented distributed computing based on remote class referenceCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 1 2003Yan Huang Abstract Java RMI, Jini and CORBA provide effective mechanisms for implementing a distributed computing system. Recently many numeral libraries have been developed that take advantage of Java as an object-oriented and portable language. The widely-used client-server method limits the extent to which the benefits of the object-oriented approach can be exploited because of the difficulties arising when a remote object is the argument or return value of a remote or local method. In this paper this problem is solved by introducing a data object that stores the data structure of the remote object and related access methods. By using this data object, the client can easily instantiate a remote object, and use it as the argument or return value of either a local or remote method. Copyright © 2003 John Wiley & Sons, Ltd. [source] Extent of Nontimber Resource Extraction in Tropical Forests: Accessibility to Game Vertebrates by Hunters in the Amazon BasinCONSERVATION BIOLOGY, Issue 2 2003Carlos A. Peres We conducted a basin-wide geographic information system analysis of the nonmotorized accessibility of Amazonian NTFP extraction and estimated the proportion of the Amazon drainage basin within Brazil ( 3.74 million km 2 ) that can be accessed on foot from the nearest navigable river or functional road. We use a long-term series of standardized line-transect vertebrate censuses conducted throughout the region to illustrate the effects of physical accessibility on wildlife densities in terms of hunting pressure as a function of distance from the nearest point of access. Population abundance in large-bodied, prime-target species preferred by game hunters tended to increase at greater distances from the access matrix, whereas small-bodied species ignored by hunters usually showed the reverse trend. In addition, we estimated the proportion of presumably inviolate core areas within nature, extractive, and indigenous reserves of Brazilian Amazonia that are prohibitively remote and unlikely to be overhunted; for instance, only 1.16% of the basin-wide area is strictly protected on paper and is reasonably safe from extractive activities targeted to game vertebrates and other valuable NTFPs. Finally, we discuss the concept of truly undisturbed wildlands in the last major tropical forest regions by distinguishing potentially overharvested areas from those that remain largely or entirely pristine and that maintain viable populations of a full complement of harvest-sensitive species. Resumen: Las actividades de extracción enfocadas en un amplio rango de productos forestales no maderables ( NTFPs ) son omnipresentes en los bosques tropicales. Sin embargo, la extensión de bosques estructuralmente intactos en una determinada región afectada por esta forma de perturbación críptica ha sido escasamente documentada. Realizamos un análisis GIS del acceso no motorizado para la extracción NTFP en el Amazonas y estimamos la proporción de la desembocadura de la cuenca amazónica ( ,3.74 millones de km2 ) a la cual se puede acceder a pie a partir del río navegable o la carretera funcional más cercana. Utilizamos series de censos de vertebrados a largo plazo empleando transectos en línea estandarizados a lo largo de la región para ejemplificar los efectos del acceso físico sobre las densidades de vida silvestre en términos de presión de caza como función de la distancia al punto de acceso más cercano. La abundancia poblacional de especies de cuerpo grande que son blancos preferidos por los cazadores tendió a crecer a mayores distancias de la matriz de acceso, mientras que las especies de cuerpo pequeño ignoradas por los cazadores generalmente muestran la tendencia inversa. Además, estimamos la proporción de áreas medulares presuntamente inviolables dentro de las reservas naturales, extractivas e indígenas del Amazonas brasileño que son prohibitivamente remotas y poco probables de ser sobreexplotadas: por ejemplo, solo el 1.16% del área de la cuenca estrictamente proyectada en papel está razonablemente a salvo de las actividades extractivas de los vertebrados de caza y otras NTFPs valiosas. Finalmente, discutimos el concepto de tierras silvestres verdaderamente no perturbadas en las grandes regiones de bosque tropical restantes diferenciando las áreas potencialmente sobreexplotadas de aquellas que son en su mayor parte o totalmente prístinas y que mantienen poblaciones viables de un complemento total de especies sensibles a la cosecha. [source] Review of the Liposuction, Abdominoplasty, and Face-Lift Mortality and Morbidity Risk LiteratureDERMATOLOGIC SURGERY, Issue 7 2005Robert A. Yoho MD Background The statistical discrepancies that exist in the mortality and morbidity risk literature are such that surgeons and patients cannot accurately assess the true risk rates associated with plastic surgery procedures. Objectives and Methods To review any relevant literature published to date in which the risk rates from liposuction, abdominoplasty, and rhytidectomy are cited and to reassess these figures alongside those published for both elective and emergency general surgeries. Results and Conclusion Despite the lack of reliable, comprehensive reporting of deaths and complications resulting from cosmetic surgeries, published data demonstrate that the risks associated with liposuction and rhytidectomy compare favorably with those from most general surgical procedures. In contrast, the morbidity and mortality rates from abdominoplasty remain unacceptably high. A significant lack of literature documenting cosmetic breast implant surgery and blepharoplasty risks is observed, which should be of concern to both patients and physicians. Liposuction and face-lift surgery data generally show that surgical centers are statistically safer than hospital operating rooms, although the data have not been standardized for the patients' American Society of Anesthesiologists (ASA) risk class, the health of the patient prior to surgery. General anesthesia may carry a risk roughly equivalent to or perhaps greater than cosmetic surgery, although, again, ASA class variables confound clear comparison between studies. Recent anesthesia literature refutes the many claims that general anesthesia risks are now remote: a landmark study that surveyed the entire scholarly literature showed a mortality rate of 1 in 13,000, roughly similar to overall cosmetic surgery mortality risks. Moreover, a prolonged operating time has been repeatedly implicated in other surgical literature to be related to morbidity and mortality. The latter certainly has relevance to cosmetic surgery. [source] Stroke in the developing brain and intractable epilepsy: effect of timing on hippocampal sclerosisDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 9 2003Waney Squier FRCP FRC Path A detailed study was made of the pathology of specimens removed by hemispherectomy for the treatment of intractable epilepsy in children with unilateral middle cerebral artery stroke. Neuropathological criteria were used to differentiate strokes that occurred in early intrauterine development (before 28 weeks gestational age) from those occurring in the last trimester, at birth, or after birth: 19 children had early strokes and 21 late. There was no difference in seizure history or occurrence of febrile convulsions in these two groups. Hippocampal tissue was available in 20 patients; pathology in the hippocampus, remote from the infarcted area, showed a marked difference between early-onset and late-onset groups. Hippocampal sclerosis was uncommon in children with early-onset strokes but developed in most of the children whose strokes were of later origin. However, hippocampal sclerosis was more closely related to a clinical history of a late initial precipitating insult irrespective of infarct timing. These findings demonstrate the changing vulnerability of the developing brain and show that hippocampal pathology is more closely related to the timing of an insult than seizure history or the occurrence of febrile convulsions. [source] Curiosity and cure: Translational research strategies for neural repair-mediated rehabilitationDEVELOPMENTAL NEUROBIOLOGY, Issue 9 2007Bruce H. Dobkin Abstract Clinicians who seek interventions for neural repair in patients with paralysis and other impairments may extrapolate the results of cell culture and rodent experiments into the framework of a preclinical study. These experiments, however, must be interpreted within the context of the model and the highly constrained hypothesis and manipulation being tested. Rodent models of repair for stroke and spinal cord injury offer examples of potential pitfalls in the interpretation of results from developmental gene activation, transgenic mice, endogeneous neurogenesis, cellular transplantation, axon regeneration and remyelination, dendritic proliferation, activity-dependent adaptations, skills learning, and behavioral testing. Preclinical experiments that inform the design of human trials ideally include a lesion of etiology, volume and location that reflects the human disease; examine changes induced by injury and by repair procedures both near and remote from the lesion; distinguish between reactive molecular and histologic changes versus changes critical to repair cascades; employ explicit training paradigms for the reacquisition of testable skills; correlate morphologic and physiologic measures of repair with behavioral measures of task reacquisition; reproduce key results in more than one laboratory, in different strains or species of rodent, and in a larger mammal; and generalize the results across several disease models, such as axonal regeneration in a stroke and spinal cord injury platform. Collaborations between basic and clinical scientists in the development of translational animal models of injury and repair can propel experiments for ethical bench-to-bedside therapies to augment the rehabilitation of disabled patients. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] Diabetic retinopathy screening: a systematic review of the economic evidenceDIABETIC MEDICINE, Issue 3 2010S. Jones Diabet. Med. 27, 249,256 (2010) Abstract This paper systematically reviews the published literature on the economic evidence of diabetic retinopathy screening. Twenty-nine electronic databases were searched for studies published between 1998 and 2008. Internet searches were carried out and reference lists of key studies were hand searched for relevant articles. The key search terms used were ,diabetic retinopathy', ,screening', ,economic' and ,cost'. The search identified 416 papers of which 21 fulfilled the inclusion criteria, comprising nine cost-effectiveness studies, one cost analysis, one cost-minimization analysis, four cost,utility analyses and six reviews. Eleven of the included studies used economic modelling techniques and/or computer simulation to assess screening strategies. To date, the economic evaluation literature on diabetic retinopathy screening has focused on four key questions: the overall cost-effectiveness of ophthalmic care; the cost-effectiveness of systematic vs. opportunistic screening; how screening should be organized and delivered; and how often people should be screened. Systematic screening for diabetic retinopathy is cost-effective in terms of sight years preserved compared with no screening. Digital photography with telemedicine links has the potential to deliver cost-effective, accessible screening to rural, remote and hard-to-reach populations. Variation in compliance rates, age of onset of diabetes, glycaemic control and screening sensitivities influence the cost-effectiveness of screening programmes and are important sources of uncertainty in relation to the issue of optimal screening intervals. There is controversy in relation to the economic evidence on optimal screening intervals. Further research is needed to address the issue of optimal screening interval, the opportunities for targeted screening to reflect relative risk and the effect of different screening intervals on attendance or compliance by patients. [source] ARGUING OVER [THE] REMOTE CONTROL: WHY INDIGENOUS POLICY NEEDS TO BE BASED ON EVIDENCE AND NOT HYPERBOLEECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 1 2007BOYD H. HUNTER Recent public debate on Indigenous issues has been provoked, inter alia, by a 2005 Centre for Independent Studies paper by Helen Hughes and Jenness Warin, who focused on the extent to which policies have been effective in improving the living conditions of Indigenous Australians since the era of self-determination commenced. Unfortunately, the quality of historical data is questionable, and hence we need an appreciation of the reliability of estimates. The 2002 National Aboriginal and Torres Strait Islander Social Survey allows a detailed interrogation of the reliability of estimates. This paper critically analyses socioeconomic changes between 1994 and 2002 for remote and other areas by comparing the recent data with analogous data collected in 1994. Changes in health status and a range of socio-economic indicators are documented to provide a more balanced assessment of the level of economic and social development in the respective areas. [source] Amalgam Electrodes for ElectroanalysisELECTROANALYSIS, Issue 8 2003Øyvind Mikkelsen Abstract Liquid mercury is a unique material for the indicator electrode in voltammetry. One reason for this is the high overvoltage for hydrogen formation, thus extending the actual potential window. Diluted amalgams are important reaction products in voltammetric (polarographic) processes, however liquid amalgams are rarely used directly as electrode material for analytical purposes. Because of the fact that voltammetry is very suitable for field and remote monitoring, issues concerning the use of mercury electrodes in environmental analyses have led to considerable research effort aimed at finding alternative tools with acceptable performance. Solid electrodes are such alternatives. Different types of electrodes are reviewed. In particular, solid amalgam electrodes are very promising, with acceptable low toxicity to be used for field measurements. Solid amalgam electrodes are easy and cheap to construct and are stable over a reasonable time up to several weeks. Assessment of the toxicity risk and the long time stability for remote and unattended monitoring is discussed. The differences between solid dental amalgam electrodes, made by using techniques known from dental clinical practice, and mercury film or mercury layer electrodes on solid substrates are reviewed. In particular the dental technique for constructing solid amalgam electrodes gives advantage because it's fast and inexpensive. Also the technique for making dental amalgam has been explored and optimized over years by dentists, giving advantage when the same technique is used for constructing electrodes. Dental amalgam electrodes has been found to act similar to a silver electrodes, but with high overvoltage towards hydrogen. This make it possible to use the dental amalgam electrode for detection of zinc, cobalt and nickel in additions to other metals like lead, copper, thallium, cadmium, bismuth, iron etc. Also the use for reducible organic compounds is expected to be promising. [source] Comparative Ant Faunas between Seonyudo and Seven Other Islands of West Sea in KoreaENTOMOLOGICAL RESEARCH, Issue 2 2002So-Jin HA ABSTRACT This paper is intended as an investigation of the biogeographic characteristics of ant faunas of the eight islands in West Sea of South Korea, using quantitative genetic analyses. The faunal similarity is examined using the Nomura-Simpson's Coefficient (NSC). The obtained NSC value matrix was examined by a cluster analysis using UPGMA method. The MSC-values between the seven areas investigated range from 0.500 (Deokjeokdo Hongdo) to 0.909 (Wonsando-Hongdo). In these islands including Seonyudo, the NSC -values range from 0.571 (Deokjeokdo) to 0.778 (Bigeumdo). The cluster analysis using the similarity index (NSC) showed that eight islands were divided into two groups at the level of 41%. It was shown that Wonsando and Bigeumdo were closer (Similarity = 83%) than those between others. Deokjeokdo and Bigeumdo were remote (Similarity = 41%) from each conspecific population. That is, the species composition of Bigeumdo (Similarity = 70%) was similar to that of the Seonyudo, while that of Deokjeokdo (Similarity = 41%) was different from that. [source] Near real-time, autonomous detection of marine bacterioplankton on a coastal mooring in Monterey Bay, California, using rRNA-targeted DNA probesENVIRONMENTAL MICROBIOLOGY, Issue 5 2009Christina M. Preston Summary A sandwich hybridization assay (SHA) was developed to detect 16S rRNAs indicative of phylogenetically distinct groups of marine bacterioplankton in a 96-well plate format as well as low-density arrays printed on a membrane support. The arrays were used in a field-deployable instrument, the Environmental Sample Processor (ESP). The SHA employs a chaotropic buffer for both cell homogenization and hybridization, thus target sequences are captured directly from crude homogenates. Capture probes for seven of nine different bacterioplankton clades examined reacted specifically when challenged with target and non-target 16S rRNAs derived from in vitro transcribed 16S rRNA genes cloned from natural samples. Detection limits were between 0.10,1.98 and 4.43, 12.54 fmole ml,1 homogenate for the 96-well plate and array SHA respectively. Arrays printed with five of the bacterioplankton-specific capture probes were deployed on the ESP in Monterey Bay, CA, twice in 2006 for a total of 25 days and also utilized in a laboratory time series study. Groups detected included marine alphaproteobacteria, SAR11, marine cyanobacteria, marine group I crenarchaea, and marine group II euryarchaea. To our knowledge this represents the first report of remote in situ DNA probe-based detection of marine bacterioplankton. [source] Harbor seals (Phoca vitulina) in British Columbia, Canada, and Washington State, USA, reveal a combination of local and global polychlorinated biphenyl, dioxin, and furan signalsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 1 2004Peter S. Ross Abstract The harbor seal (Phoca vitulina) can serve as a useful indicator of food web contamination by persistent organic pollutants (POPs) because of its high trophic level, wide distribution in temperate coastal waters of the Northern Hemisphere, and relative ease of capture. In 1996 through 1997, we live-captured 60 harbor seal pups from three regions, spanning remote (Queen Charlotte Strait, BC, Canada), moderately industrialized (Strait of Georgia, BC, Canada), and heavily industrialized (Puget Sound, WA, USA) marine basins straddling the Canada-United States border. Biopsy samples of blubber were taken and analyzed for congener-specific polychlorinated biphenyls (PCBs), polychlorinated dibenzo- p -dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) by using high-resolution gas chromatography-high-resolution mass spectrometry. Harbor seals in Puget Sound were heavily contaminated with PCBs, whereas seals from the Strait of Georgia had relatively high concentrations of PCDDs and PCDFs. Pattern evaluation and principal components analysis suggested that proximity to sources influenced the mixture to which seals were exposed, with those inhabiting more remote areas being exposed to lighter PCB congeners (those with lower Henry's law constant and KOW) that disperse more readily through atmospheric and other processes. Total toxic equivalents to 2,3,7,8-tetrachlorodibenzo- p -dioxin for the PCBs, PCDDs, and PCDFs suggest that Puget Sound seals are at greatest risk for adverse health effects, and that PCBs represent the class of dioxinlike contaminants of greatest concern at all sites. [source] Using regional exposure criteria and upstream reference data to characterize spatial and temporal exposures to chemical contaminants,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 4 2000Susan M. Cormier Abstract Analyses of biomarkers in fish were used to evaluate exposures among locations and across time. Two types of references were used for comparison, an upstream reference sample remote from known point sources and regional exposure criteria derived from a baseline of fish from reference sites throughout Ohio, USA. Liver, bile, and blood were sampled from white suckers (Catostomus commersoni) and common carp (Cyprinus carpio) collected during 1993 and 1996 in the Ottawa River near Lima, Ohio. Levels of exposure were measured for petroleum by naphthalene-type metabolites, combustion by-products by benzo[a]pyrene-type metabolites, coplanar organic compounds by ethoxyresorufin- O -deethylase (EROD) activity, and urea by blood urea nitrogen (BUN) levels. The four biomarkers analyzed proved effective in determining differences between reference and polluted sampling sites, between geographically close (<0.5 km) sites, and between sampling years at sites common in both years. Calculated exposure criteria levels of the polycyclic aromatic hydrocarbon bile metabolites were found to be a conservative approximation of levels from a designated reference site and could thereby permit comparison of biomarker levels of fish from the Ottawa River to a regional reference level. Polycyclic aromatic hydrocarbon bile metabolite and EROD activity levels were more reflective of spatial patterns of contamination than BUN, although all biomarkers indicated differences overtime. Biomarkers from white suckers seemed to be more responsive in detecting changes in contaminant levels than the same biomarkers from common carp. Lower levels in 1996 of all biomarkers at many sites suggested lower exposures than in 1993 and could be indicative of some improvement over the period. [source] Potato wart disease survey in TurkeyEPPO BULLETIN, Issue 3 2005E. Çak Synchytrium endobioticum was first detected in Turkey in 2003, in two areas remote from each other: two potato fields at Ordu and Giresun in the Black Sea region and adjacent potato fields at Nev,ehir and Ni,de in Central Anatolia. After an extensive survey carried out in the whole potato-growing areas of Turkey, the disease was found only in these places. The disease was present in areas of 1999.7, 54.2, 9.2 and 1.5 ha in Nev,ehir, Ni,de, Ordu and Giresun provinces respectively in 2004. This comprises 1.8% of the total potato-growing area. [source] Infrastructure and Rural Development: US and EU Perspectives Infrastruktur und Entwicklung des ländlichen Raums: Perspektiven aus den USA und der EU Infrastructures et développement rural : Perspectives aux États-Unis et dans l'Union européenneEUROCHOICES, Issue 1 2008David Blandford Infrastructure and Rural Development: US and EU Perspectives Infrastructural development remains a cornerstone of rural development policy in both the United States and Europe. It is evident that rural development objectives differ, but similar policy measures are used. The economic rationale for infrastructure development centres on efficiency and creation of competitive advantage. Policy intervention is justified because of the added costs of infrastructure provision in remote, sparsely populated areas. Although this policy focus does not guarantee success, regions leading in economic development typically have better physical infrastructure. In the United States, policy must adapt to challenges posed by an ageing rural infrastructure and demographic change that will increase demands on social infrastructure such as housing and health facilities. There will be greater local responsibility for funding, and expanded use of public/private partnerships. In the European Union, the major challenge is in redirecting resources to new member states, where there is urgent need for both large new investments in transport networks and small investments to improve local access. Although two current options for funding these diverse needs focus on European policies only, investments in non-farm physical capital and public infrastructure cannot be sustained without active national policies to complement the European efforts, perhaps through co-financing requirements. Infrastructures et développement rural : Perspectives aux États-Unis et dans l'Union européenne Le développement des infrastructures demeure un pilier de la politique de développement rural aux États-Unis comme dans l'Union européenne. Les objectifs de développement rural diffèrent bien évidemment mais des mesures semblables sont employées. La justification économique du développement des infrastructures repose sur l'efficience et la création d'avantages concurrentiels. L'intervention publique est justifiée par les coûts supplémentaires des infrastructures dans les zones éloignées à population clairsemée. Bien que ce type de politique ne garantisse pas le succès, les régions en avance de développement économique ont en général de meilleures infrastructures physiques. Aux États-Unis, la politique soit s'adapter aux défis que posent le vieillissement des infrastructures rurales et l'évolution démographique qui va augmenter la demande d'infrastructures sociales telles que les services de santé et de logement. La responsabilité du financement local va augmenter et les partenariats public/privé vont se développer. Dans l'Union européenne, le principal défi est de réorienter les ressources vers les nouveaux pays membres qui ont un besoin urgent de nouveaux investissement d'ampleur dans les réseaux de transport et d'investissement de plus faible ampleur dans l'amélioration des accès locaux. Deux options actuelles de financement de ces divers besoins se concentrent sur les seules politiques européennes, mais les investissements dans le capital physique non agricole et dans les infrastructures publiques ne peuvent pas se poursuivre sans des politiques nationales actives complémentant les efforts fournis au niveau européen, peut-être à travers des mécanismes de co-financement. Infrastruktur und Entwicklung des ländlichen Raums: Perspektiven aus den USA und der EU Bei der Entwicklung der Infrastruktur handelt es sich nach wie vor sowohl in den USA als auch in Europa um einen Eckpfeiler in der Politik zur Entwicklung des ländlichen Raums. Es ist offensichtlich, dass sich die Ziele bei der Entwicklung des ländlichen Raums unterscheiden, die Politikmaßnahmen ähneln sich jedoch. Die wirtschaftliche Begründung für die Entwicklung der Infrastruktur zielt auf die Effizienz und das Schaffen von Wettbewerbsvorteilen ab. Politikeingriffe sind gerechtfertigt, da die Bereitstellung von Infrastruktur in entlegenen, dünn besiedelten Gebieten höhere Kosten verursacht. Obgleich dieser Schwerpunkt der Politik den Erfolg noch nicht garantiert, verfügen die wirtschaftlich am weitesten entwickelten Regionen typischerweise über eine bessere physische Infrastruktur. In den USA muss sich die Politik an die Herausforderungen anpassen, welche eine in die Jahre gekommene Infrastruktur im ländlichen Raum und der demografische Wandel mit sich bringen, und wodurch neue Anforderungen an die soziale Infrastruktur, wie z.B. Wohnungsbau und Gesundheitseinrichtungen, gestellt werden. Bei der Finanzierung werden die Kommunen stärker in die Verantwortung genommen, und öffentlich-private Partnerschaften werden an Bedeutung gewinnen. In der EU besteht die größte Herausforderung darin, Ressourcen zu den neuen Mitgliedstaaten umzuverteilen, wo sowohl neue Großinvestitionen in die Transportnetzwerke als auch kleinere Investitionen zur Verbesserung des lokalen Zugangs dringend benötigt werden. Obwohl sich die beiden im Moment vorhandenen Optionen zur Finanzierung dieser vielfältigen Bedürfnisse ausschließlich auf europäische Politikmaßnahmen konzentrieren, können die Investitionen in außerlandwirtschaftliches physisches Kapital und in die öffentliche Infrastruktur nicht ohne wirksame Politikmaßnahmen auf nationaler Ebene (z.B. die Pflicht zur Kofinanzierung) als Ergänzung zu den Bemühungen auf europäischer Ebene aufrecht erhalten werden. [source] Provision of oncology services in remote rural areas: a Scottish perspectiveEUROPEAN JOURNAL OF CANCER CARE, Issue 2 2004S.M. SMITH research assistant There is a paucity of research into rural health care services. In particular little is known about the provision of specialist cancer services for patients who live in remote rural areas of the UK. This study set out to investigate current models of medical and clinical oncology care in Scotland. A national survey with key health professionals was conducted to identify rural oncology schemes currently in operation. Detailed quantitative data about the schemes together with qualitative data on how health professionals view current models of care were collected by a computer-assisted telephone survey. Schemes that currently provide outpatient and chemotherapy oncology services for remote rural patients fell into three categories: central clinics (5); shared care outreach clinics with chemotherapy provision (11); and shared care outreach clinics without chemotherapy provision (7). All radiotherapy was conducted at central clinics (5). Widely varying practices in delivery of cancer care were found across the country. The main issues for professionals about current models of care involved expertise, travelling and accessibility (for patients), communication and expansion of the rural service. Nation-wide consistency in cancer care has still to be achieved. Travelling for treatment was seen to take its toll on all patients but particularly for the very remote, elderly and poor. Most professionals believe that an expansion of rural services would be of benefit to these patients. It is clear, however, that the proper infrastructure needs to be in place in terms of local expertise, ensured quality of care, and good communication links with cancer centres before this could happen. [source] Paediatric dentistry in outreach settings: an essential part of undergraduate curricula?EUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 4 2009M. L. Hunter Abstract Introduction:, Although placements in primary care settings remote from dental schools are becoming a common feature of undergraduate dental curricula, little evidence is available regarding the experience of paediatric dentistry gained in this way. Materials and methods:, Treatment logs relating to salaried primary care placements undertaken by the Class of 2007 at Cardiff University School of Dentistry were examined, particular attention being paid to paediatric-specific procedures. Results:, Forty-nine logs relating to placements undertaken in South East Wales and 51 relating to those in North Wales were retrieved. In South East Wales, 90% of students gained experience of primary tooth restoration, 61% carrying out primary endodontics. Sixty-three percent of students undertaking placements in South East Wales and 69% of those placed in North Wales gained experience of primary tooth extraction under local anaesthesia. All but three students gained experience of administering inhalation sedation. Discussion:, The findings of this study should go some way towards reassuring those who have expressed concern that recruitment difficulties within dental schools inevitably lead to increasing numbers of students qualifying without clinical experience of paediatric dental procedures considered to be within the remit of a newly qualified dental practitioner. However, there remains wide variation in the breadth and depth of experience of individual students and it is still possible for some students to graduate without what might be considered core experience in paediatric dentistry. Conclusion:, Salaried primary care settings are ideally placed to provide students with experience of paediatric-specific procedures. Clinical education in paediatric dentistry should, therefore, incorporate the strengths of dental school and placement education. [source] Immunoregulatory effects of adenosine 5,-triphosphate on cytokine release from stimulated whole bloodEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 3 2005Els L. R. Swennen Abstract In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5,-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of the present study was to determine the effects of ATP on TNF-,, IL-6 and IL-10 release in stimulated whole blood. Blood samples were drawn from healthy volunteers and incubated with ATP and lipopolysaccharide (LPS) + phytohemagglutinin (PHA) for 24,h. Contrary to expectations, ATP at 100,,M and 300,,M induced a reduction in TNF-, secretion by 32±8% (mean ± SEM) and 65±4%, respectively. Furthermore, these ATP concentrations induced an increase in IL-10 secretion by 48±5% and 62±7% in whole blood. The ATP analogue adenosine 5,-O-(3-thiotriphosphate) (ATP-,-S) and adenosine 5,-diphosphate (ADP) also inhibited TNF-, release, but only ADP showed a stimulatory effect on IL-10. Co-treatment with adenosine deaminase did not reverse the ATP effect on TNF-, and IL-10. These results show, for the first time, that ATP inhibits the inflammatory response in stimulated whole blood as indicated by inhibition of TNF-, and stimulation of IL-10 release and that this effect is predominantly mediated by ATP and not by adenosine. [source] Demonstration of long-range GABAergic connections distributed throughout the mouse neocortexEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 6 2005Ryohei Tomioka Abstract ,-Aminobutyric acid (GABA)ergic neurons in the neocortex have been mainly regarded as interneurons and thought to provide local interactions. Recently, however, glutamate decarboxylase (GAD) immunocytochemistry combined with retrograde labeling experiments revealed the existence of GABAergic projection neurons in the neocortex. We further studied the network of GABAergic projection neurons in the neocortex by using GAD67-green fluorescent protein (GFP) knock-in mice for retrograde labeling and a novel neocortical GABAergic neuron labeling method for axon tracing. Many GFP-positive neurons were retrogradely labeled after Fast Blue injection into the primary somatosensory, motor and visual cortices. These neurons were labeled not only around the injection site, but also at a long distance from the injection site. Of the retrogradely labeled GABAergic neurons remote from the injection sites, the vast majority (91%) exhibited somatostatin immunoreactivity, and were preferentially distributed in layer II, layer VI and in the white matter. In addition, most of GABAergic projection neurons were positive for neuropeptide Y (82%) and neuronal nitric oxide synthase (71%). We confirmed the long-range projections by tracing GFP-labeled GABAergic neurons with axon branches traveled rostro-caudally and medio-laterally. Axon branches could be traced up to 2 mm. Some (n = 2 of 4) were shown to cross the areal boundaries. The GABAergic projection neurons preferentially received neocortical inputs. From these results, we conclude that GABAergic projection neurons are distributed throughout the neocortex and are part of a corticocortical network. [source] Reducing complexity in Qualitative Comparative Analysis (QCA): Remote and proximate factors and the consolidation of democracyEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2006CARSTEN Q. SCHNEIDER However, real-world research situations might make the application of fs/QCA difficult in two respects , namely, the complexity of the results and the phenomenon of limited diversity. We suggest a two-step approach as one possibility to mitigate these problems. After introducing the difference between remote and proximate factors, the application of a two-step fs/QCA approach is demonstrated analyzing the causes of the consolidation of democracy. We find that different paths lead to consolidation, but all are characterized by a fit of the institutional mix chosen to the societal context in terms of power dispersion. Hence, we demonstrate that the application of fs/QCA in a two-step manner helps to formulate and test equifinal and conjunctural hypotheses in medium-size N comparative analyses, and thus to contribute to an enhanced understanding of social phenomena. [source] Directed evolution of formate dehydrogenase from Candida boidinii for improved stability during entrapment in polyacrylamideFEBS JOURNAL, Issue 17 2006Marion B. Ansorge-Schumacher In two cycles of an error-prone PCR process, variants of formate dehydrogenase from Candida boidinii were created which revealed an up to 4.4-fold (440%) higher residual activity after entrapment in polyacrylamide gels than the wild-type enzyme. These were identified in an assay using single precursor molecules of polyacrylamide instead of the complete gel for selection. The stabilization resulted from an exchange of distinct lysine, glutamic acid, and cysteine residues remote from the active site, which did not affect the kinetics of the catalyzed reaction. Thermal stability increased at the exchange of lysine and glutamic acid, but decreased due the exchange of cysteine. Overall, the variants reveal very suitable properties for application in a technical synthetic process, enabling use of entrapment in polyacrylamide as an economic and versatile immobilization method. [source] Analysis of the thyrotropin-releasing hormone-degrading ectoenzyme by site-directed mutagenesis of cysteine residuesFEBS JOURNAL, Issue 9 2000Cys68 is involved in disulfide-linked dimerization Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2). Cloning of the cDNA of this enzyme and biochemical studies revealed that the large extracellular domain of the enzyme with the catalytically active site contains nine cysteine residues that are highly conserved among species. To investigate the functional role of these cysteines in TRH-DE we used a site-directed mutagenesis approach and replaced individually each cysteine by a serine residue. The results revealed that the proteolytically truncated and enzymatically fully active enzyme consists of two identical subunits that are associated noncovalently by protein,protein interactions but not via interchain S-S bridges. The eight cysteines contained within this region are all important for the structure of the individual subunit and the enzymatic activity, which is dramatically reduced in all mutant enzymes. This is even true for the four cysteines that are clustered within the C-terminal domain remote from the Zn-binding consensus sequence HEICH. In contrast, Cys68, which resides within the stalk region seven residues from the end of the hydrophobic membrane-spanning domain, can be replaced by serine without a significant change in the enzymatic activity. Interestingly, this residue is involved in the formation of an interchain disulfide bridge. Covalent dimerization of the subunits, however, does not seem to be essential for efficient biosynthesis, enzymatic activity and trafficking to the cell surface. [source] Tuvalu and Climate Change: Constructions of Environmental Displacement in The Sydney Morning HeraldGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 4 2005Carol Farbotko Abstract Tuvalu, a place whose image in the ,West' is as a small island state, insignificant and remote on the world stage, is becoming remarkably prominent in connection with the contemporary issue of climate change-related sea-level rise. My aim in this paper is to advance understanding of the linkages between climate change and island places, by exploring the discursive negotiation of the identity of geographically distant islands and island peoples in the Australian news media. Specifically, I use discourse analytic methods to critically explore how, and to what effects, various representations of the Tuvaluan islands and people in an Australian broadsheet, the Sydney Morning Herald, emphasize difference between Australia and Tuvalu. My hypothesis is that implicating climate change in the identity of people and place can constitute Tuvaluans as .tragic victims. of environmental displacement, marginalizing discourses of adaptation for Tuvaluans and other inhabitants of low-lying islands, and silencing alternative constructions of Tuvaluan identity that could emphasize resilience and resourcefulness. By drawing attention to the problematic ways that island identities are constituted in climate change discourse in the news media, I advocate a more critical approach to the production and consumption of representations of climate change. [source] Aggregate sources and supplies in JamaicaGEOLOGICAL JOURNAL, Issue 5 2008Peter W. Scott Abstract Aggregate resources in Jamaica are sand and gravel found in active river systems, and limestone. Other rocks in Cretaceous inliers and elsewhere are generally too weathered at the surface or too remote from centres of population to be considered suitable as significant sources of aggregates. Sand and gravel generally supplies the south of the country with limestone production and markets being concentrated along the northern coastal areas. Limestone aggregates are produced by ripping and crushing, blasting being uncommon. Sand and gravel are often simply processed using a single screen, although fixed crushing and screening plant are used in some operations. The aggregate industry operates inefficiently, generally utilizing old plant, although an economic assessment shows it to be very profitable. Substitution of sand and gravel by limestone would help mitigate the negative environmental impact of extraction of aggregates from active river systems, but would considerably distort the supply of aggregates throughout the country. Copyright © 2008 John Wiley & Sons, Ltd. [source] | |||||||||||||||||||||||||||||||||||||||||||