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Remodeling Rates (remodeling + rate)

Distribution by Scientific Domains

Medical Sciences	40%

Selected Abstracts

The Use of Buccal Mucosa Graft at Posterior Cricoid Splitting for Subglottic Stenosis Repair,

THE LARYNGOSCOPE, Issue 12 2001
Robert Thomé PhD
Abstract Background Since 1955, when Réthi established the posterior cricoid split augmentation (PCSA) method, several authors have published supporting reports of the validity and proven efficacy of its basic principles. A 27-year prospective, retrospective study. Objectives To report on experience in performing the PCSA method for subglottic and/or posterior,glottic stenosis repair using buccal mucosa interposition grafting at posterior cricoid split and stenting for 8 weeks, and to assess the impact on vocal function. Methods From 1972 on, 60 patients (45 adults, 15 children, aged 8 mo to 72 y) with subglottic and/or posterior,glottic stenosis were operated on using a modified PCSA method. The surgical technique consisted of posterior cricoid splitting, including or not the interarytenoid muscle; wide lateral retraction of the posterior cricoid halves; buccal mucosa interposition grafting and stenting for 8 weeks. The factors evaluated included the subglottic remodeling rate, donor and recipient sites morbidity, time to decannulation, rate of graft take, and phonatory function tests. Results The modified PCSA procedure resulted in a decannulation rate of 90%, 18 (30%) of which had further procedure to achieve decannulation, and 6 adult patients (10%) were considered failures because of restenosis. The rate of take of the mucosa graft was 100% in both children and adults, with complete epithelialization of the grafted area, the mucosa not becoming dry and crusty. No interarytenoid muscle division resulted in near-normal to normal glottic voicing. Interarytenoid muscle division determined supraglottic voicing with inspiratory noise and pneumophonic incoordination, breathy and hoarse voice, low fundamental frequency, limited dynamic range, and shortened phonation time. Conclusion The PCSA procedure with buccal mucosa graft is reliable, safe, and highly successful with respect to the graft incorporation and subglottic remodeling. The division or not of the interarytenoid muscle is the most important factor influencing the postoperative vocal function. [source]

Therapy of Osteoporosis With Calcium and Vitamin D,

JOURNAL OF BONE AND MINERAL RESEARCH, Issue S2 2007
Bess Dawson-Hughes MD
Abstract Inadequate intakes of vitamin D and calcium lead to reduced calcium absorption, higher bone remodeling rates, and increased bone loss. Vitamin D insufficiency has also been linked to reduced muscle function and increased risk of falling. The mechanisms for the performance and muscle effects are not well understood. Administering vitamin D to those with inadequate vitamin D status has been shown to lower fracture rates in some trials but not in others. The purpose of this presentation is (1) to examine how calcium and vitamin D work in concert, (2) to consider key evidence that increasing vitamin D intake will affect risk of falls and fractures, and (3) to estimate the 25-hydroxyvitamin D [25(OH)D] level needed to achieve maximum fracture protection. [source]

Brief communication: Bone remodeling rates in Pleistocene humans are not slower than the rates observed in modern populations: A reexamination of Abbott et al. (1996)

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 2 2010
Margaret Streeter
Abstract Bone histomorphometry has been applied to the lower limb cortical bone of Pleistocene humans to establish age at death and to determine bone remodeling rates (Abbott et al.: Am J Phys Anthropol 226 (1996) 307,313). Both of these procedures require the determination of osteon density and mean osteon size. Previous analyses of Middle and Late Pleistocene human lower limb bones have produced bone remodeling rates that are slower than those determined in a more recent archeological sample. Recalculation of the data reported in Abbott et al.: Am J Phys Anthropol 226 (1996) 307,313) has revealed mathematical errors in the remodeling rates reported for the Pleistocene humans. The corrected remodeling rates for the Pleistocene group are similar to the values obtained in the more recent comparative sample. Am J Phys Anthropol, 2010. © 2009 Wiley-Liss, Inc. [source]