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Relative Terms (relative + term)
Selected AbstractsTreatment of Vitiligo on Difficult-to-Treat Sites Using Autologous Noncultured Cellular GraftingDERMATOLOGIC SURGERY, Issue 1 2009SANJEEV V. MULEKAR MD BACKGROUND Because of the limitations of medical treatment, various surgical therapies have been developed and are being accepted to treat vitiligo. However, certain areas such as the fingers and toes, palms and soles, lips, eyelids, nipples and areolas, elbows and knees, and genitals are considered difficult-to-treat areas. OBJECTIVE To evaluate data pertaining to individual sites considered to be difficult to treat and highlight that noncultured melanocyte,keratinocyte transplantation (MKT) does not require any special precautions to treat these anatomical sites. METHODS AND MATERIALS Forty patients (13 male and 27 female) with bilateral vitiligo and nine (4 male and 5 female) with unilateral vitiligo were treated using noncultured MKT, for "difficult-to-treat" sites at the National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia, and were analyzed for response according to region. Repigmentation was graded as excellent with 95% to 100% pigmentation, good with 65% to 94%, fair with 25% to 64%, and poor with 0% to 24% of the treated area. RESULTS For bilateral vitiligo, more than 50% of patients treated for difficult sites showed more than 65% repigmentation of the treated areas. For unilateral vitiligo, all of the patients except for two treated for the eyelids showed more than 65% repigmentation of the treated area. CONCLUSIONS The concept of a "difficult-to-treat site" is a relative term and depends upon the technique used. The noncultured MKT does not require any special precautions to treat these anatomical sites. This review may help physicians to change the concept of "difficult-to-treat site." [source] AN ASSESSMENT OF RECENT TRENDS IN GIRLS' VIOLENCE USING DIVERSE LONGITUDINAL SOURCES: IS THE GENDER GAP CLOSING?CRIMINOLOGY, Issue 2 2005DARRELL STEFFENSMEIER Applying Dickey-Fuller time series techniques in tandem with intuitive plot-displays, we examine recent trends in girls' violence and the gender gap as reported in four major sources of longitudinal data on youth violence. These sources are arrest statistics of the Uniform Crime Reports, victimization data of the National Crime Victimization Survey (where the victim identifies sex of offender) and self-reported violent behavior of Monitoring the Future and National Youth Risk Behavior Survey. We find that the rise in girls' violence over the past one to two decades as counted in police arrest data from the Uniform Crime Reports is not borne out in unofficial longitudinal sources. Several net-widening policy shifts have apparently escalated girls' arrest-proneness: first, stretching definitions of violence to include more minor incidents that girls in relative terms are more likely to commit; second, increased policing of violence between intimates and in private settings (for example, home, school) where girls' violence is more widespread; and, third, less tolerant family and societal attitudes toward juvenile females. These developments reflect both a growing intolerance of violence in the law and among the citizenry and an expanded application of preventive punishment and risk management strategies that emphasize early identification and enhanced formal control of problem individuals or groups, particularly problem youth. [source] Policy Reform and Foreign Direct Investment in Africa: Absolute Progress but Relative DeclineDEVELOPMENT POLICY REVIEW, Issue 1 2004Elizabeth Asiedu Despite improvements in the policy environment, sub-Saharan Africa's share of foreign direct investment (FDI) in developing countries continues to decline. This article provides an explanation for the deterioration in SSA's FDI global position. It argues that, although SSA has reformed its institutions, improved its infrastructure and liberalised its FDI regulatory framework, the degree of reform has been mediocre compared with the reform implemented in other developing countries. As a consequence, relative to other regions, SSA has become less attractive for FDI. An important implication of these results is that in a competitive global economy, it is not enough just to improve one's policy environment: improvements need to be made both in absolute and relative terms. [source] Regulation, productivity and growth: OECD evidenceECONOMIC POLICY, Issue 36 2003Giuseppe Nicoletti SUMMARY Liberalization and privatization have made the regulatory environment more market-friendly throughout the OECD. However using a large new dataset on product market regulation, we show that regulatory policies in OECD nations have become more dissimilar in relative terms, even as all nations have liberalized. This seemingly contradictory finding is explained by different starting points and different reform speeds. Our data also show that this divergence in the regulatory settings lines up with the divergent growth performance of OECD nations, in particular the poor performance of large Continental economies relative to that of the US. The data, which tracks various types of product market regulation in manufacturing and service industries for 18 OECD economies over the past two decades, allows us to explore this link in detail. We find that productivity growth is boosted by reforms that promote private corporate governance and competition (where these are viable). Moreover, our detailed findings suggest how product market regulation and productivity growth are linked. In manufacturing, the productivity gains from liberalization are greater the further a given country is from the technology leader. This indicates that entry-limiting regulation may hinder the adoption of existing technologies, possibly by reducing competitive pressures, technology spillovers, or the entry of new high-tech firms. These results offer an interpretation of poor Continental performance. Strict product market regulations , and lack of regulatory reforms , appear to underlie the meagre productivity performance of some European countries, especially in those industries where Europe has accumulated a technology gap (e.g. industries producing or using information and communication technologies). , Giuseppe Nicoletti and Stefano Scarpetta [source] Ecological research in the office of research and development at the U.S. Environmental Protection Agency: An overview of new directions,,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 4 2000Rick A. Linthurst Abstract In virtually every major environmental act, Congress has required that the U.S. Environmental Protection Agency (U.S. EPA) ensure not only that the air be safe to breathe, the water safe to drink, and the food supply free of contamination, but also that the environment be protected. In response, the U.S. EPA's Office of Research and Development (ORD) has established research to improve ecosystem risk assessment and management, identifying it as one of the highest priority research areas for investment over the next 10 years. The research is intended to provide environmental managers with new tools and flexible guidance that reflect a holistic environmental management perspective of science and that can be applied both to common and unique problems. In keeping with its responsibility to provide the U.S. EPA with science that supports a dynamic changing regulatory agenda, the ORD has set the goal of its Ecological Research Program to "provide the scientific understanding required to measure, model, maintain and/or restore, at multiple scales, the integrity and sustainability of ecosystems now, and in the future." In the context of this program, ecological integrity is defined in relative terms as the maintenance of ecosystem structure and function characteristic of a reference condition deemed appropriate for its use by society, and sustainability is defined as the ability of an ecosystem to maintain relative ecological integrity into the future. Therefore, the research program will emphasize relative risk and consider the impact of multiple stressors, at multiple scales and at multiple levels of biological organization. The program will also shift from chemical to biological and physical stressors to a far greater extent than in the past. The purpose of this paper is to provide an introduction to the U.S. EPA's changing ecological research program. [source] Regional socio-economic importance of fisheries in FinlandFISHERIES MANAGEMENT & ECOLOGY, Issue 4-5 2001J. Virtanen The total value of Finnish fisheries production in 1997 was almost FIM 2 billion. The bulk of this sum was from processing and wholesaling, but in terms of value added, somewhat more than half was contributed by the primary sector, i.e. fishing and fish farming. In economic terms, fisheries accounted for 0.1% of gross domestic product (GDP) in 1997 and the relative job creation capacity was 0.15%. This paper examines the structure of Finnish fisheries in terms of production value and employment. It also considers the level of dependency on fisheries and of value added along the production chain. The focus is on concentration of the industry and on input to the economy at the regional level. The concentration of fisheries and regional dependence on fisheries are assessed in absolute and relative terms. Examining employment and value added in these two ways enables the regional nature of fisheries to be shown in greater detail. The input of fisheries to the regional economy is examined by the share of value added and by location quotients. The location quotient compares an area's share of a particular activity with that area's share of some basic or aggregated phenomenon. The location quotient showed that fisheries have importance not only in the coastal area but also inland. [source] Role of land cover changes for atmospheric CO2 increase and climate change during the last 150 yearsGLOBAL CHANGE BIOLOGY, Issue 8 2004Victor Brovkin Abstract We assess the role of changing natural (volcanic, aerosol, insolation) and anthropogenic (CO2 emissions, land cover) forcings on the global climate system over the last 150 years using an earth system model of intermediate complexity, CLIMBER-2. We apply several datasets of historical land-use reconstructions: the cropland dataset by Ramankutty & Foley (1999) (R&F), the HYDE land cover dataset of Klein Goldewijk (2001), and the land-use emissions data from Houghton & Hackler (2002). Comparison between the simulated and observed temporal evolution of atmospheric CO2 and ,13CO2 are used to evaluate these datasets. To check model uncertainty, CLIMBER-2 was coupled to the more complex Lund,Potsdam,Jena (LPJ) dynamic global vegetation model. In simulation with R&F dataset, biogeophysical mechanisms due to land cover changes tend to decrease global air temperature by 0.26°C, while biogeochemical mechanisms act to warm the climate by 0.18°C. The net effect on climate is negligible on a global scale, but pronounced over the land in the temperate and high northern latitudes where a cooling due to an increase in land surface albedo offsets the warming due to land-use CO2 emissions. Land cover changes led to estimated increases in atmospheric CO2 of between 22 and 43 ppmv. Over the entire period 1800,2000, simulated ,13CO2 with HYDE compares most favourably with ice core during 1850,1950 and Cape Grim data, indicating preference of earlier land clearance in HYDE over R&F. In relative terms, land cover forcing corresponds to 25,49% of the observed growth in atmospheric CO2. This contribution declined from 36,60% during 1850,1960 to 4,35% during 1960,2000. CLIMBER-2-LPJ simulates the land cover contribution to atmospheric CO2 growth to decrease from 68% during 1900,1960 to 12% in the 1980s. Overall, our simulations show a decline in the relative role of land cover changes for atmospheric CO2 increase during the last 150 years. [source] Towards the Spatial Patterns of Sectoral Adjustments to Trade Liberalisation: The Case of NAFTA in MexicoGROWTH AND CHANGE, Issue 4 2007BENJAMIN FABER ABSTRACT A recent string of "new economic geography" (NEG) models has set focus on the impacts of trade liberalisation on the intra-national distribution of economic activity. What the existing contributions have in common is a basic two-sector assumption (agriculture/manufacturing) and a resulting focus on the question of whether liberalisation leads to a greater concentration of aggregate manufacturing activity. Reconsidering these models from a multi-sectoral perspective, the aim is to allow for sectoral differences in the spatial adjustments to liberalisation. This introduces a conceptual nexus between comparative advantage (CA)-type sectoral recomposition effects of trade and NEG-type spatial adjustments. In the analysis of Mexican manufacturing location 1993,2003, incipient empirical evidence is found in favour of the hypothesis that sectors characterised by a revealed comparative advantage and/or cross-border intermediate supplies grow faster in regions with good foreign market access, whereas import competing ones gain in relative terms in regions with higher "natural protection" from poor market access. The relevancy of the proposed NEG/CA framework concerns both efficiency and equity objectives of trade adjustment policies, and opens a new perspective on the long-run effects of trade on spatial inequality. [source] The Joint Democracy,Dyadic Conflict Nexus: A Simultaneous Equations ModelINTERNATIONAL STUDIES QUARTERLY, Issue 3 2003Rafael Reuveny Many statistical studies in international relations investigate the claim that democracies do not fight one another. Virtually all of these studies employ a single-equation design, where the dependent variable measures the presence or absence of a dyadic militarized interstate dispute (MID). A separate group of studies argues that conflict affects democracy and that its effect could be positive or negative. By and large, these two bodies of literature have not incorporated one another's insights. We argue that democracy and dyadic conflict affect each other significantly and that statistical models that ignore the reciprocal nature of these effects may make incorrect inferences. To test this argument, we develop a simultaneous equations model of democracy and dyadic conflict. Our sample includes all the politically relevant dyads from 1950 to 1992. We find that dyadic military disputes reduce joint democracy and joint democracy reduces the probability of MIDs. Compared with the single-equation estimates in the literature, the absolute effect of joint democracy in our paper is smaller while in relative terms, the effect is similar in size. The effect of joint democracy on MID involvement is considerably smaller for noncontiguous countries than for contiguous ones. The effects of a number of control variables in the MID equation are also found to differ from those reported previously in single- equation,based studies. [source] Effects of Conjugated Equine Estrogen on Risk of Fractures and BMD in Postmenopausal Women With Hysterectomy: Results From the Women's Health Initiative Randomized TrialJOURNAL OF BONE AND MINERAL RESEARCH, Issue 6 2006Rebecca D Jackson MD Abstract Further analyses from the Women's Health Initiative estrogen trial shows that CEE reduced fracture risk. The fracture reduction at the hip did not differ appreciably among risk strata. These data do not support overall benefit over risk, even in women at highest risk for fracture. Introduction: The Women's Health Initiative provided evidence that conjugated equine estrogen (CEE) can significantly reduce fracture risk in postmenopausal women. Additional analysis of the effects of CEE on BMD and fracture are presented. Materials and Methods: Postmenopausal women 50,79 years of age with hysterectomy were randomized to CEE 0.625 mg daily (n = 5310) or placebo (n = 5429) and followed for an average 7.1 years. Fracture incidence was assessed by semiannual questionnaire and verified by adjudication of radiology reports. BMD was measured in a subset of women (N = 938) at baseline and years 1, 3, and 6. A global index was used to examine whether the balance of risks and benefits differed by baseline fracture risk. Results: CEE reduced the risk of hip (hazard ratio [HR], 0.65; 95% CI, 0.45,0.94), clinical vertebral (HR, 0.64; 95% CI, 0.44,0.93), wrist/lower arm (HR, 0.58; 95% CI, 0.47,0.72), and total fracture (HR, 0.71; 95% CI, 0.64,0.80). This effect did not differ among strata according to age, oophorectomy status, past hormone use, race/ethnicity, fall frequency, physical activity, or fracture history. Total fracture reduction was less in women at the lowest predicted fracture risk in both absolute and relative terms (HR, 0.86; 95% CI, 0.68,1.08). CEE also provided modest but consistent positive effects on BMD. The HRs of the global index for CEE were relatively balanced across tertiles of summary fracture risk (lowest risk: HR, 0.81; 95% CI, 0.62,1.05; mid risk: HR, 1.09; 95% CI, 0.92,1.30; highest risk: HR, 1.04; 95% CI, 0.88,1.23; interaction, p = 0.42). Conclusions: CEE reduces the risk of fracture and increases BMD in hysterectomized postmenopausal women. Even among the women with the highest risk for fractures, when considering the effects of estrogen on other important health outcomes, a summary of the burden of monitored effects does not indicate a significant net benefit. [source] Competitor identification and competitor analysis: a broad-based managerial approachMANAGERIAL AND DECISION ECONOMICS, Issue 4-5 2002Mark Bergen Managerial myopia in identifying competitive threats is a well-recognized phenomenon (Levitt, 1960; Zajac and Bazerman, 1991). Identifying such threats is particularly problematic, since they may arise from substitutability on the supply side as well as on the demand side. Managers who focus only on the product market arena in scanning their competitive environment may fail to notice threats that are developing due to the resources and latent capabilities of indirect or potential competitors. This paper brings together insights from the fields of strategic management and marketing to develop a simple but powerful set of tools for helping managers overcome this common problem. We present a two-stage framework for competitor identification and analysis that brings into consideration a broad range of competitors, including potential competitors, substitutors, and indirect competitors. Specifically we draw from Peteraf and Bergen's (2001) framework for competitor identification to develop a hierarchy of competitor awareness. That is used, in combination with resource equivalence, to generate hypotheses on competitive analysis. This framework not only extends the ken of managers, but also facilitates an assessment of the strategic opportunities and threats that various competitors represent and allows managers to assess their significance in relative terms. Copyright © 2002 John Wiley & Sons, Ltd. [source] Water balance modelling of (Sub-)Arctic rivers and freshwater supply to the Barents Sea BasinPERMAFROST AND PERIGLACIAL PROCESSES, Issue 3 2005Eduard Koster Abstract Recently, changes in the freshwater supply by rivers to the Arctic Ocean have attracted a great deal of attention. However, quantitative assessments of changes in the annual and seasonal discharge regime of (Sub-)Arctic rivers resulting from climate change are still far from accurate. The sensitivity of discharge to potential changes in climate in two river catchments of intermediate size (104,105,km2), the Tana River in northern Fennoscandia and the Usa River in northern Russia, both draining into the Barents Sea Basin, was evaluated using a spatially distributed water balance model. The tentative results show that discharge amounts during peak flow might remain more or less the same or show a slight increase. However, peakflow events are expected to occur about 20 days or more earlier in spring. Concerning annual discharge amounts a strong increase of 25% for the Usa River and even 39% for the Tana River is simulated in conformity with projected increases in precipitation. Obviously, the resulting increases of the annual freshwater influx from the Tana River (from 5.3 to 7.3,km3) and that of the Usa River (from 42 to 52,km3) into the Barents Sea are insignificant in absolute terms. But in relative terms they agree remarkably well with earlier estimates of changes in freshwater inflow by the very large (Sub-)Arctic rivers. Copyright © 2005 John Wiley & Sons, Ltd. [source] Accuracy of reproducing hand position when using active compared with passive movementPHYSIOTHERAPY RESEARCH INTERNATIONAL, Issue 2 2001Yocheved Laufer PT PhD Head of Physical Therapy Department Abstract Background and Purpose Evaluating proprioception is relevant to physical rehabilitation because of its significance in motor control. One method of proprioceptive testing involves having subjects either imitate or point at a joint position or movement which was presented via a passive movement. However, as the muscle spindles are subject to central fusimotor control, the proprioceptive system may be better-tuned to movements created by active muscular contraction than to passive movements. The objective of the present study was to determine whether accuracy of reproducing hand position is dependent on whether proprioceptive input is obtained via an active or a passive movement. Method Thirty-nine healthy volunteers (mean age (±SD) 24.6 (±3.6) years) participated in the study. Subjects' right hands, which were obscured from view, were acoustically guided to five targets on a digitizer tablet with either an active or passive upper extremity movement. Subjects were then asked to reproduce the targets' location by either reaching to them with the unseen hand or by use of a laser beam. Distance from target and angular deviations were calculated in both absolute and relative terms. Repeated measures analysis of variance (ANOVA) was performed for each variable followed by predetermined contrasts. Results Comparison between the active and passive conditions when reconstruction of target location was guided kinaesthetically indicates significant differences in absolute distance, range and angular deviation. The comparison when reconstruction of target location was guided visually indicates significant differences in absolute distance, absolute angle and angular deviation. Conclusions The ability to reproduce hand position accurately is enhanced when position is encoded by active upper extremity movement compared with passive movement. The results have implications for the design of strategies for evaluating as well as treating patients with impaired proprioception and limited movement. Copyright © 2001 Whurr Publishers Ltd. [source] Brief communication: Dental development and enamel thickness in the Lakonis Neanderthal molarAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 1 2009T.M. Smith Abstract Developmental and structural affinities between modern human and Neanderthal dental remains continue to be a subject of debate as well as their utility for informing assessments of life history and taxonomy. Excavation of the Middle Paleolithic cave site Lakonis in southern Greece has yielded a lower third molar (LKH 1). Here, we detail the crown development and enamel thickness of the distal cusps of the LKH 1 specimen, which has been classified as a Neanderthal based on the presence of an anterior fovea and mid-trigonid crest. Crown formation was determined using standard histological techniques, and enamel thickness was measured from a virtual plane of section. Developmental differences include thinner cuspal enamel and a lower periodicity than modern humans. Crown formation in the LKH 1 hypoconid is estimated to be 2.6,2.7 years, which is shorter than modern human times. The LKH 1 hypoconid also shows a more rapid overall crown extension rate than modern humans. Relative enamel thickness was approximately half that of a modern human sample mean; enamel on the distal cusps of modern human third molars is extremely thick in absolute and relative terms. These findings are consistent with recent studies that demonstrate differences in crown development, tissue proportions, and enamel thickness between Neanderthals and modern humans. Although overlap in some developmental variables may be found, the results of this and other studies suggest that Neanderthal molars formed in shorter periods of time than modern humans, due in part to thinner enamel and faster crown extension rates. Am J Phys Anthropol, 2009. © 2008 Wiley-Liss, Inc. [source] EMPLOYEE TRAINING AND WAGE COMPRESSION IN BRITAIN*THE MANCHESTER SCHOOL, Issue 3 2005FILIPE ALMEIDA-SANTOS We use linked data for 1460 workplaces and 19,853 employees from the Workplace Employee Relations Survey 1998 to analyse the incidence and duration of employee training in Britain. We find training to be positively associated with having a recognized vocational qualification and current union membership. However, being non-white, having shorter current-job tenure and part-time or fixed-term employment statuses are all associated with less training. Furthermore, in line with recent non-competitive training models, higher levels of wage compression (measured in absolute or relative terms) are positively related to training. [source] The potential of variational retrieval of temperature and humidity profiles from Meteosat Second Generation observationsTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 638 2009F. Di Giuseppe Abstract The quality of temperature and humidity retrievals from the infrared Spinning Enhanced Visible and Infrared Imager (SEVIRI) sensors on the geostationary Meteosat Second Generation (MSG) satellites is assessed by means of a one-dimensional variational algorithm. The study is performed with the aim of improving the spatial and temporal resolution of available observations to feed analysis systems designed for high-resolution regional-scale numerical weather prediction (NWP) models. The non-hydrostatic forecast model COSMO in the ARPA-SIMC operational configuration is used to provide background fields. Only clear-sky observations over sea are processed. An optimized one-dimensional variational set-up comprised of two water-vapour and three window channels is selected. It maximizes the reduction of errors in the model backgrounds while ensuring ease of operational implementation through accurate bias correction procedures and correct radiative transfer simulations. The 1Dvar retrieval quality is first quantified in relative terms, employing statistics to estimate the reduction in the background model errors. Additionally the absolute retrieval accuracy is assessed by comparing the analysis with independent radiosonde observations. The inclusion of satellite data brings a substantial reduction in the warm and dry biases present in the forecast model. Moreover it is shown that the use of the retrieved profiles generated by the 1Dvar in the COSMO nudging scheme can locally reduce forecast errors. Copyright © 2009 Royal Meteorological Society [source] The international logistics of wood pellets for heating and power production in Europe: Costs, energy-input and greenhouse gas balances of pellet consumption in Italy, Sweden and the NetherlandsBIOFUELS, BIOPRODUCTS AND BIOREFINING, Issue 2 2010Richard Sikkema Abstract The European wood pellet market is booming: concerns about climate change and renewable energy targets are predominant drivers. The aim of this analysis is to compare typical wood pellet chains from the purchase of the feedstock from sawmills to the conversion into heat or electricity. Cost structures, primary energy inputs and avoided greenhouse gas (GHG) emissions are reviewed. Three cases are defined: pellets for district heating (DH) in Sweden (replacing heavy fuel oil); bagged pellets for residential heating in Italy (natural gas); and Canadian pellets for electricity production in the Netherlands (coal). Supply may cost ,110,,170 per tonne of delivered pellets, with the main cost factors being feedstock collection, drying and long-distance ocean transportation (for Canadian pellets only). Largest avoided emissions are for power production (1937 kg CO2eq/tonne of pellets), followed by district heating (1483 kg). In relative terms, the GHG reduction varies from 81% for residential heating (with pre-dried feedstock) to 97% for DH. Based on a wood-pellet consumption of 8.2 million tonnes, the EU27 plus Norway and Switzerland avoided about 12.6 million tonnes of CO2 emissions in 2008. Concluding, wood pellets can achieve substantial GHG savings, especially when substituting coal for power production. However, wood pellets are relatively expensive, especially compared to coal. Only in the case of high oil prices, can the substitution of heating oil for DH be commercially viable. In most other cases, substitution is only possible with financial support from national governments, for example, feed-in tariffs or carbon taxes. The commercial markets for CO2 emission rights may cover some costs, but their impact is still limited. Copyright © 2010 Society of Chemical Industry and John Wiley & Sons, Ltd [source] Non-invasive assessment of endothelial function , relation between vasodilatory responses in skin microcirculation and brachial arteryCLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, Issue 6 2004Jimmy Hansell Summary Objective:, To compare different non-invasive methods for determination of human endothelial function in peripheral circulation. Design:, Observational, cross-sectional study in 39 healthy subjects (21 females, age 17,56 years). Setting:, Vascular research laboratory at university hospital. Methods:, Laser Doppler (LD) flowmetry was used to compare skin microvascular perfusion changes during postocclusive reactive hyperaemia with those induced by iontophoretic administration of acetylcholine (ACh), an endothelial-dependent vasodilator. LD measurements were compared with ultrasonographic measurements of postocclusive flow-mediated dilatation (FMD) in the brachial artery (n = 21). Results:, Local ACh induced a larger and more sustained skin perfusion increase than reactive hyperaemia after 4 min of regional arterial occlusion (P<0·001). A significant correlation was found between the magnitude of ACh-induced vasodilatation and peak reactive hyperaemia, both in absolute (r = 0·62, P<0·001) and relative terms (r = 0·58, P<0·001). A correlation was also found between brachial artery FMD and the magnitude of ACh-induced skin perfusion increase (r = 0·43, P<0·05) but not between FMD and reactive hyperaemia. Conclusion:, Endothelial function, an early marker of cardiovascular risk, can be non-invasively assessed and graded by LD and FMD-measurements and despite inherent differences, both methods do correlate. [source] | ||||||||||||||||||||||