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Related Aspects (relate + aspect)
Selected AbstractsPatenting Pharmaceutical Inventions on Second Medical Uses in BrazilTHE JOURNAL OF WORLD INTELLECTUAL PROPERTY, Issue 4 2009Viviane Yumy Mitsuuchi Kunisawa The current Brazilian industrial property law (Law 9279 of 14 May 1996) allows patents for pharmaceuticals, along with the Agreement on Trade Related Aspects of Intellectual Property Rights provisions. Since 1999, after an amendment in the legislation, two governmental authorities,the Instituto Nacional da Propriedade Industrial (INPI) and the Agência Nacional de Vigilância Sanitária (ANVISA),have been concomitantly acting in the patent-granting procedures for pharmaceuticals. The INPI is the office usually responsible for the examination and granting of patents, and the ANVISA is the agency primarily responsible for the granting of marketing approval of drugs. In a peculiar situation, the two institutions have been responsible for the granting or denial of applications and have very often been divergent in their positions. The patentability of pharmaceutical inventions claiming second medical use is an example. The purpose of this work is to analyze the current situation of the Brazilian patent-granting system in the pharmaceutical field, with a special focus on the patentability of inventions claiming second medical use. It debates the two governmental positions and questions whether the existing conflicts are harmful to the system. [source] Feminist Research Management in Higher Education in Britain: Possibilities and PracticesGENDER, WORK & ORGANISATION, Issue 5 2010Natasha S. Mauthner This article aims to explore the possibilities and ambivalent practices of feminist management in the context of research management in higher education in Britain. Drawing on a reflexive and critical analysis of our experiences of contract research and research management over the past 15 years, we discuss the challenges of putting feminist management principles into practice in team-based and collaborative research projects. By rendering academic cultures increasingly competitive, individualist and managerial, we argue, new managerialist reforms in higher education over the past two decades have intensified those very aspects of academic life that feminists have long struggled with. In particular, in creating the new subject position of research manager, with concomitant institutional expectations and obligations, new managerialism has exacerbated tensions between our identities as feminists, scholars and managers and between collective, individual and institutional needs and aspirations. We illustrate these tensions through a discussion of four related aspects of team research which, we suggest, undermine attempts at implementing the feminist ideals of intellectual equity and political equality: divisions of labour in research teams; divisions of intellectual status and the differential valuation of researchers and research labour; divisions of formal power and the management structure of research teams; and exertions of informal power and the micropolitics of research teams. We suggest that feminist research management and feminist management, more generally, need to recognize and accept differences and inequalities among feminists and work with these issues in reflexive, ethical and caring ways. [source] Managerial ability , a review of its basis and potential improvement using psychological conceptsAGRICULTURAL ECONOMICS, Issue 3 2001P.L. Nuthall Abstract Achieving an appropriate resource allocation structure usually revolves around the farm manager. His or her ability is crucial to success. Yet, most farmers learn by experience and/or through various courses that concentrate on technical, production economic and related aspects. Putting more effort into understanding the components of managerial ability and how a managers' ability to perform well in each component might be improved is well overdue. As psychology is the study of people and their actions it is the obvious discipline to turn to for assistance. This paper contains a review of the psychology of decision making from a farm management perspective, outlines what psychology offers for changing a person's attributes, and considers the structure of a research programme aimed at developing methods for improving individual's managerial ability. [source] Operationalizing quality of life for people with profound multiple disabilities: a Delphi studyJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 5 2007K. Petry Abstract Background In a recent study, we constructed an item pool that contains items on the quality of life (QOL) and related aspects of support of people with profound multiple disabilities (PMD). In the present study, a panel of experts assessed the content and the structure of this item pool in order to enhance its validity and usefulness. Method A two-round Delphi study was set up. The panel consisted of 45 experts, of whom 12 were theory-experts, 12 practice-experts and 12 experience-experts from Belgium (n = 12), Germany (n = 12), the Netherlands (n = 11) and the UK/Ireland (n = 10). Both quantitative and qualitative methods of analysis were applied to the data. Results The majority of the items were considered relevant for the QOL of people with PMD. In the first round, 91% of the items reached the 80% criterion of consensus. In the second round, 78.7% of the items reached the 85% criterion of consensus. There were no significant differences in opinion neither between types of experts nor between countries. Several items were reported as missing in the item pool and were added. Conclusions The results provide some evidence that the item pool is a valid operationalization of QOL of people with PMD and can be used in an instrument to measure the QOL of this target group. [source] Equivalence of Three Allocation Currencies as Estimates of Reproductive Allocation and Somatic Cost of Reproduction in Pinguicula vulgarisPLANT BIOLOGY, Issue 4 2007M. Méndez Abstract: Which is the most appropriate currency (biomass, energy, water, or some mineral nutrient) for expressing resource allocation in plants has been repeatedly discussed. Researchers need to assess to which extent interindividual, interpopulational, or interspecific comparisons of resource allocation could be affected by the allocation currency chosen. The "currency issue" is relevant to at least three related aspects of resource allocation to reproduction: (a) reproductive allocation (RA), (b) size-dependence of reproductive allocation, and (c) somatic cost of reproduction (SCR). Empirical tests have mostly dealt with the first aspect only. We examined the equivalence of estimates for the three aspects above across three different allocation currencies (dry mass, N, P) in 11 populations of Pinguicula vulgaris. For RA we studied the equivalence of allocation currencies at three scales: among individuals of the same population, between populations of the same species, and among species. Equivalence of currencies in the ranking of RA for individuals within populations was high (Rs 0.43) and did not strongly decrease when comparing populations or species. Excepting for size-dependence of RA, ranking of RA, or SCR between populations was equivalent for biomass and N, but not for P. Our study gives two positive guidelines for empirical plant reproductive ecologists facing the "currency issue": (1) become increasingly concerned about the "currency issue" as you increase the scale of your comparison from individuals to populations to species, and (2) avoid estimating allocation in redundant currencies (biomass and N in our case) and choose preferentially "complementary" currencies that provide a broader view of allocation patterns (biomass and P in our case). [source] Challenging the developmental state: Nature conservation in SingaporeASIA PACIFIC VIEWPOINT, Issue 2 2007Harvey Neo Abstract: Nature conservation efforts are often reactive to encroaching development plans and systematic conservation planning that is integral with development is not only uncommon, but is often fraught with difficulties even where it is actually attempted. Such obstacles to conservation are especially apparent in developmental states where state legitimacy is largely derived from the state's ability to develop the country. Among other things, developmental states place a premium on physical and economic development. This paper critiques, through the standpoint of nature conservation, the inadequate conceptualisation of ,development' in the developmental state thesis. Specifically, this paper argues that the seemingly value-free (but ultimately economically based) underpinnings of development goals pushed by the developmental state needs to be tempered with a broader concern for the ethics of development. To that end, I draw on two case studies of nature conservation tussles in Singapore to show how alternative extra-economic visions of development have been articulated, notwithstanding the developmental state's monopoly on the discourse (and practice) of progress and development. The case studies, set in the heady economic growth of the early 1990s, will critique two related aspects of the developmental state: its ,amoral' economistic conception of development and its use of growth and materialism as legitimacy. [source] The role of solvent transport in cryo-annealing of macromolecular crystalsACTA CRYSTALLOGRAPHICA SECTION D, Issue 3 2004Douglas H. Juers Macromolecular crystals are usually cooled to ,100,K for X-ray diffraction experiments in order to diminish lattice damage arising from the ionizing radiation. Such cooling often produces lattice disorder, but this disorder can sometimes be substantially reduced by cycling the crystal between low and higher temperatures (called annealing). Here, two related aspects of cryocooling and annealing are investigated using crystals of ,-galactosidase and thermolysin. Firstly, as has been reported with other systems, there is an optimal cryoprotectant concentration above and below which diffraction is poor, with high mosaicity, diffuse scatter and low signal to noise. Measurements of the bulk density of the respective cryosolvents are consistent with the idea that at the optimal cryoprotectant concentration the contraction of the bulk solvent on cooling largely compensates for the contraction of the macromolecular lattice. Secondly, by controlling the relative humidity of the gas that contacts the crystal during the high (room) temperature phase, it is found that water is either imported into or exported out of the crystals during the melting phase of annealing. This water transport appears to change the concentration of the cryoprotectant solution and in so doing alters its thermal contraction. Thus, annealing appears to be involved, at least in part, in the tuning of the thermal contraction of the bulk solvent to best compensate for lattice contraction. Furthermore, it is found that if the cryoprotectant concentration is initially too high then annealing is more successful than if the concentration is initially too low. This result suggests that the search for optimal cryoprotectant conditions may be facilitated by equilibration of the crystal to relatively high cryoprotectant concentration followed by annealing. [source] THE USE OF AGGREGATE DATA TO ESTIMATE GOMPERTZ-TYPE OLD-AGE MORTALITY IN HETEROGENEOUS POPULATIONSAUSTRALIAN & NEW ZEALAND JOURNAL OF STATISTICS, Issue 4 2009Christopher R. Heathcote Summary We consider two related aspects of the study of old-age mortality. One is the estimation of a parameterized hazard function from grouped data, and the other is its possible deceleration at extreme old age owing to heterogeneity described by a mixture of distinct sub-populations. The first is treated by half of a logistic transform, which is known to be free of discretization bias at older ages, and also preserves the increasing slope of the log hazard in the Gompertz case. It is assumed that data are available in the form published by official statistical agencies, that is, as aggregated frequencies in discrete time. Local polynomial modelling and weighted least squares are applied to cause-of-death mortality counts. The second, related, problem is to discover what conditions are necessary for population mortality to exhibit deceleration for a mixture of Gompertz sub-populations. The general problem remains open but, in the case of three groups, we demonstrate that heterogeneity may be such that it is possible for a population to show decelerating mortality and then return to a Gompertz-like increase at a later age. This implies that there are situations, depending on the extent of heterogeneity, in which there is at least one age interval in which the hazard function decreases before increasing again. [source] Animal models in urological disease and sexual dysfunctionBRITISH JOURNAL OF PHARMACOLOGY, Issue S2 2006Gordon McMurray There are several conditions associated with dysfunction of the lower urinary tract or which result in a reduction in the ability to engage in satisfactory sexual function and result in significant bother to sufferers, partners and/or carers. This review describes some of the animal models that may be used to discover safe and effective medicines with which to treat them. While alpha adrenoceptor antagonists and 5-alpha-reductase inhibitors deliver improvement in symptom relief in benign prostatic hyperplasia sufferers, the availability of efficacious and well-tolerated medicines to treat incontinence is less well served. Stress urinary incontinence (SUI) has no approved medical therapy in the United States and overactive bladder (OAB) therapy is limited to treatment with muscarinic antagonists (anti-muscarinics). SUI and OAB are characterised by high prevalence, a growing ageing population and a strong desire from sufferers and physicians for more effective treatment options. High patient numbers with low presentation rates characterizes sexual dysfunction in men and women. The introduction of ViagraÔ in 1998 for treating male erectile dysfunction and the success of the phosphodiesterase type 5 inhibitor class (PDE5 inhibitor) have indicated the willingness of sufferers to seek treatment when an effective alternative to injections and devices is available. The main value of preclinical models in discovering new medicines is to predict clinical outcomes. This translation can be established relatively easily in areas of medicine where there are a large number of drugs with different underlying pharmacological mechanisms in clinical usage. However, apart from, for example, the use of PDE5 inhibitors to treat male erectile dysfunction and the use of anti-muscarinics to treat OAB, this clinical information is limited. Therefore, current confidence in existing preclinical models is based on our understanding of the biochemical, physiological, pathophysiological and psychological mechanisms underlying the conditions in humans and how they are reflected in preclinical models. Confidence in both the models used and the pharmacological data generated is reinforced if different models of related aspects of the same disorder generate confirmatory data. However, these models will only be fully validated in retrospect once the pharmacological agents they have helped identify are tested in humans. British Journal of Pharmacology (2006) 147, S62,S79. doi:10.1038/sj.bjp.0706630 [source] Green supply chains and the missing link between environmental information and practiceBUSINESS STRATEGY AND THE ENVIRONMENT, Issue 1 2010Cecilia Solér Abstract Within the field of green supply chain management (GSCM), an interest in supply chain cooperation to create sustainable competitive advantage, i.e. the collaborative paradigm, has made researchers turn their attention to information related aspects of the supply chain. This study contributes to an understanding of a suboptimal use of environmental information, which is critical for all collaborative efforts aiming at sustainable competitive advantage. The aim of this article is to describe the use of environmental information at different stages of the Swedish food supply chain. The results from this case study of the Swedish food supply chain indicate that environmental information is perceived and used differently by purchasers in the supply chain depending on where (in the supply chain) they are situated in relation to other chain actors. The main contribution of this study is the suggestion of a stage-dependent connection between perceived environmental cost and perceived environmentally informed consumer demand, which are barriers to GSCM practice discussed in recent GSCM literature. The missing link between information sharing and (environmental) performance of supply chains is explained as distance to end-consumer in terms of supply chain stages. Implications for GSCM practice and theory are discussed. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment. [source] Insect chemistry and chiralityCHIRALITY, Issue S1 2003Patricia Y. Hayes Abstract Examination of the chemistry of a number of Australian insect species provided examples of unusual structures and encouraged determinations of their absolute stereochemistry by stereocontrolled syntheses and chromatographic comparisons. Inter alia, studies with the fruit-spotting bug (Amblypelta nitida), certain parasitic wasps (Biosteres sp.), the aposematic shield bug (Cantao parentum), and various species of scarab grubs are summarized. The determination of enantiomeric excesses (ee's) for component epoxides, lactones, spiroacetals, and allenes are described. Stereochemical and related aspects of the biosynthesis of spiroacetals in certain fruit-fly species (Bactrocerae sp.) are also presented. Chirality 15:S116,S127, 2003. © 2003 Wiley-Liss, Inc. [source] | ||||||||||||||||