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Refractory Anaemia (refractory + anaemia)

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Medical Sciences100%

Selected Abstracts

Quantitative, phenotypic, and functional evaluation of basophils in myelodysplastic syndromes

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 10 2001
W. Füreder
Background The myelodysplastic syndromes (MDS) are a group of clonal haematological disorders characterized by cytopenia(s), reduced differentiation-capacity of myeloid cells, and impaired leukocyte function. However, little is known so far about basophil granulocytes in MDS. Design We have compared the numbers, phenotype and function of basophils in MDS patients with those in healthy subjects. A total numer of 23 patients with MDS (refractory anaemia, n = 8; refractory anaemia with ringsideroblasts, n = 7; refractory anaemia with excess of blasts/refractory anaemia with excess of blasts in transformation, n = 8) and 20 healthy donors were included. Results The numbers of blood basophils in MDS patients (34·6 ± 62·9 ,L,1) was lower compared to healthy controls (58·6 ± 64·9 ,L,1). Correspondingly, whole blood histamine levels were lower in MDS patients (MDS 34·1 ± 29·1 ng mL,1 vs. normal donors 72·0 ± 36·9 ng mL,1). Like ,normal' basophils, basophils in MDS expressed interleukin-3 receptor , (CD123), E-NPP3 (CD203c), CR1 (CD35), CR3 (CD11b), CR4 (CD11c), membrane co-factor protein (CD46), decay-accelerating factor (CD55) and membrane attack complex inhibitory factor (CD59), as well as receptors for C3a, C5a (CD88), and IgE. Recombinant human (rh) C5a and anti-IgE induced significant release of histamine from basophils in both groups of donors without significant differences between MDS and healthy controls. Conclusions The absolute numbers of basophils in MDS patients are lower than in normal donors. However, basophils in MDS do not differ from their ,normal counterparts' in terms of complement receptor expression, IgE-receptor expression, or functional responses to respective ligands. [source]

Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome

NEPHROLOGY, Issue 2 2005
Case Report
SUMMARY: A diabetic predialysis patient who had significantly reduced sensitivity to erythropoietin therapy was admitted to Tsukuba University Hospital. Many factors that might have been the cause of the erythropoietin resistance were examined, and a diagnosis of refractory anaemia was made based on a bone marrow aspiration biopsy. A cytogenetic abnormality (47, XXY) was also detected in the bone marrow biopsy specimen, and hence the patient was also diagnosed with Klinefelter syndrome. It was suspected that the sex chromosome abnormality influenced glucose intolerance, renal insufficiency, and erythropoietin resistance due to myelodysplastic changes in the bone marrow. [source]

Schizophrenia and refractory anaemia with ring sideroblasts

BRITISH JOURNAL OF HAEMATOLOGY, Issue 5 2004
Alicia Domingo-Claros
No abstract is available for this article. [source]

Pure red cell aplasia in patients with refractory anaemia treated with two different recombinant erythropoietins

BRITISH JOURNAL OF HAEMATOLOGY, Issue 6 2004
Laurent Quint
No abstract is available for this article. [source]

Chromosome 11 rearrangements and specific MLL amplification revealed by spectral karyotyping in a patient with refractory anaemia with excess of blasts (RAEB)

BRITISH JOURNAL OF HAEMATOLOGY, Issue 5 2003
Giuseppe Calabrese
Summary. A patient with refractory anaemia with excess of blasts (RAEB) had a complex karyotype with multiple markers. Spectral karyotyping (SKY) showed rearrangements including three different der(11), containing a very high number of MLL gene copies, shown by fluorescence in situ hybridization (FISH) analysis. Fibre-FISH experiments disclosed the presence of chromatin fibres with multiple MLL copies with a head-to-tail pattern. Apparently, no other region flanking the MLL site was present in the three der(11). MLL amplification was confirmed by the reverse transcription polymerase chain reaction (RT-PCR). The patient died 6 months after diagnosis, supporting the severe prognosis of sole MLL amplification. [source]

Aleukaemic leukaemia cutis presenting as a benign-appearing eruption

CLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 2 2003
T. P. Millard
Summary A 68-year-old Caucasian male presented with a 5-week history of a widespread pruritic papular eruption. Histology from a papule on the left shoulder showed a dense dermal infiltrate of large mononuclear cells which were positive for leucocyte common antigen, KP1 and PGM1, with an MIB-1 proliferating fraction of 40%, diagnostic of acute monocytic (M5) leukaemia cutis. Full blood count revealed pancytopaenia but no blasts. Bone marrow aspirate showed reduced red cell precursors and 10% blasts, consistent with myelodysplastic syndrome (refractory anaemia with excess blasts). The patient was managed with a 3 unit transfusion of packed red cells, after which his skin eruption resolved within 6 weeks and his peripheral blood counts returned to normal. No chemotherapy was administered. In conclusion, leukaemia can present in the skin, the eruption may be nonspecific and it may precede systemic involvement by either myelodysplastic syndrome or acute leukaemia. [source]