Radiographic Analysis (radiographic + analysis)

Distribution by Scientific Domains


Selected Abstracts


Noggin Inhibits Postoperative Resynostosis in Craniosynostotic Rabbits,

JOURNAL OF BONE AND MINERAL RESEARCH, Issue 7 2007
Gregory M Cooper PhD
Abstract Inhibition of bone formation after surgery to correct craniosynostosis would alleviate the need for secondary surgeries and decrease morbidity and mortality. This study used a single dose of Noggin protein to prevent resynostosis and improve postoperative outcomes in a rabbit model of craniosynostosis. Introduction: Craniosynostosis is defined as the premature fusion of one or more of the cranial sutures, which causes secondary deformations of the cranial vault, cranial base, and brain. Current surgical intervention involves extirpation of the fused suture to allow unrestricted brain growth. However, resynostosis of the extirpated regions often occurs. Several bone morphogenetic proteins (BMPs), well-described inducers of ossification, are involved in bone healing. This study tested the hypothesis that a postoperative treatment with Noggin, an extracellular BMP inhibitor, can inhibit resynostosis in a rabbit model of human familial nonsyndromic craniosynostosis. Materials and Methods: Thirty-one New Zealand white rabbits with bilateral coronal suture synostosis were divided into three groups: (1) suturectomy controls (n = 13); (2) suturectomy with BSA in a slow-resorbing collagen vehicle, (n = 8); and (3) suturectomy with Noggin in a slow-resorbing collagen vehicle (n = 10). At 10 days of age, a 3 × 15-mm coronal suturectomy was performed. The sites in groups 2 and 3 were immediately filled with BSA-loaded gel or Noggin-loaded gel, respectively. Serial 3D-CT scan reconstructions of the defects and standard radiographs were obtained at 10, 25, 42, and 84 days of age, and the sutures were harvested for histological analysis. Results: Radiographic analysis revealed that Noggin-treated animals had significantly greater coronal suture marker separation by 25 days and significantly greater craniofacial length at 84 days of age compared with controls. 3D-CT analysis revealed that Noggin treatment led to significantly greater defect areas through 84 days and to increased intracranial volumes at 84 days of age compared with other groups. Histological analysis supported CT data, showing that the untreated and BSA-treated groups had significant healing of the suturectomy site, whereas the Noggin-treated group had incomplete wound healing. Conclusions: These data support our hypothesis that inhibition of BMP activity using Noggin may prevent postoperative resynostosis in this rabbit model. These findings also suggest that Noggin therapy may have potential clinical use to prevent postoperative resynostosis in infants with craniosynostosis. [source]


Platelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine bone

JOURNAL OF CLINICAL PERIODONTOLOGY, Issue 10 2010
Jesús Torres
Torres J, Tamimi F, Alkhraisat MH, Manchón Á, Linares R, Prados-Frutos JC, Hernández G, López Cabarcos E. Platelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine bone. J Clin Periodontol 2010; 37: 943,951. doi: 10.1111/j.1600-051X.2010.01615.x. Abstract Objective: Bone augmentation with the titanium-mesh (Ti-mesh) technique is susceptible to a large rate of complications such as morbidity of bone graft donor site, and mesh exposure to the oral cavity. The purpose of this study was to evaluate the effectiveness of anorganic bovine bone (ABB) in alveolar bone augmentation with the Ti-mesh technique. In addition, we investigated the effect of platelet-rich plasma (PRP) in preventing mesh exposure by using it to cover the Ti-mesh. Patients and Methods: Patients included in the clinical trial were randomly allocated by a blinded assistant into two groups. The 30 patients recruited for this study underwent 43 alveolar bone augmentation with the Ti-mesh technique using ABB as graft material in all of them. In 15 patients, the Ti-meshes were covered with PRP (PRP group) whereas in the other 15 the Ti-meshes were not (control group). After 6 months, patients were called for clinical, radiographic, and histological evaluation, and implant placement surgery. A total of 97 implants were placed in the augmented bone and their evolution was followed up for a period of 24 months. Results: Significant differences were found between the two study groups in terms of complications and bone formation. In the control group, 28.5% of the cases suffered from mesh exposure, while in the PRP group, no exposures were registered. Radiographic analysis revealed that bone augmentation was higher in the PRP group than in the control group. Overall, 97.3% of implants placed in the control group and 100% of those placed in the PRP group were successful during the monitoring period. We suggest that the positive effect of PRP on the Ti-mesh technique is due to its capacity to improve soft tissue healing, thereby protecting the mesh and graft material secured beneath the gingival tissues. Conclusions: Alveolar bone augmentation using ABB alone in the Ti-mesh technique is sufficient for implant rehabilitation. Besides, covering the Ti-meshes with PRP was a determining factor in avoiding mesh exposure. Ti-mesh exposure provoked significant bone loss, but in most cases it did not affect the subsequent placement of implants. [source]


Effect of pulsed electromagnetic fields on maturation of regenerate bone in a rabbit limb lengthening model,

JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 1 2006
Kenneth F. Taylor
Abstract To study the effect of applying pulsed electromagnetic fields (PEMF) during the consolidation phase of limb lengthening, a mid-tibial osteotomy was performed in 18 adult New Zealand White rabbits and an external fixator was applied anteromedially. Animals were randomly assigned to treatment and control groups. After a 7-day latency period, the tibiae were distracted 0.5 mm every 12 h for 10 days. The treatment group received a 20-day course of PEMF for 60 min daily, coinciding with initiation of the consolidation phase. The control group received sham PEMF. Radiographs were performed weekly after distraction. Animals were euthanized 3 weeks after the end of distraction. Radiographic analysis revealed no significant difference in regenerate callus area between treatment and control tibiae immediately after distraction, at 1 week, 2 weeks, or 3 weeks after distraction (,p,=,0.71, 0.22, 0.44, and 0.50, respectively). There was also no significant difference in percent callus mineralization (,p,=,0.96, 0.69, 0.99, and 0.99, respectively). There was no significant difference between groups with respect to structural stiffness (,p,=,0.80) or maximal torque to failure (,p,=,0.62). However, there was a significant positive difference in mineral apposition rate between groups during the interval 1,2 weeks post-distraction (,p,<,0.05). This difference was no longer evident by the interval 2,3 weeks post-distraction. While PEMF applied during the consolidation phase of limb lengthening did not appear to have a positive effect on bone regenerate, it increased osteoblastic activity in the cortical bone adjacent to the distraction site. Since the same PEMF signal was reported to be beneficial in the rabbit distraction osteogenesis when applied during distraction phase and consolidation phase, application of PEMF in the early phase may be more effective. Further work is necessary to determine optimal timing of the PEMF stimulation during distraction osteogenesis. © 2005 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res [source]


Total knee replacement in the morbidly obese: a literature review

ANZ JOURNAL OF SURGERY, Issue 9 2010
Anthony J. Samson
Abstract Background:, The ,obesity epidemic' is expected to result in an increased incidence of knee osteoarthritis and hence total knee replacements (TKRs). Reviews have demonstrated the conflicting results of TKR for all obese (body mass index (BMI) >30). The aim of this literature review was to specifically evaluate outcomes of TKR in patients with morbid obesity (MO; BMI >40). Methods:, A systematic review of medical databases (PubMed, Medline, Cochrane Library, ScienceDirect) by use of keywords from January 1990 to September 2009 was undertaken. Results:, Clinical and functional Knee Society Scores (KSS) improve after TKR for patients with MO. The post-operative functional KSS was, in general, less than in controls. Radiographic analysis was inconclusive because of small study populations and short duration of follow-up. All studies reporting complications noted a greater prevalence in MO patients (10,30%). Of concern was the significantly higher prevalence of deep prosthetic infection (3,9-times that of controls). The morbidly obese also had a significantly higher incidence of wound complications. TKR did not result in weight loss for MO patients, and therefore has no benefit on weight-related medical conditions. Bariatric surgery in MO under 65 years of age has been shown to be a cost-effective and clinically effective method of weight reduction. This surgery also results in significant improvement in weight-related medical conditions, the KSS and knee pain. Conclusions:, Given the increase in complications for MO patients after TKR, these patients should be advised to lose weight before surgery and, if suitable, would probably benefit from bariatric surgery. [source]


Early Loading of Four or Five Astra Tech Fixtures with a Fixed Cross-Arch Restoration in the Mandible

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Issue 3 2002
Bruno Collaert DDS
ABSTRACT Background: A change in implant placement has emerged recently from two-stage to one-stage surgery and to earlier and even immediate loading of the fixtures. Purpose: The aim of this study was to verify whether four or five fixtures installed in the edentulous mandible were suitable for early loading with a cross-arch fixed restoration. Materials and Methods: In 25 consecutively treated patients (28,88 yr), four or five Astra Tech fixtures (Mölndal, Sweden) were installed in edentulous mandibles. During the same surgical procedure, the abutments were connected. An impression was taken immediately after surgery. All patients received a fixed prosthetic rehabilitation of 10 to 12 teeth made of a cast metal framework and acrylic teeth/gingiva within a month. The fixtures were followed up clinically and radiographically for 7 to 24 months. Bone level was measured from the most coronal point of the vertical part of the fixture to the most apical bone level mesially or distally. Results: No fixtures were lost during follow-up. No postoperative complications occurred. Radiographic analysis showed a mean bone level of 0.6 mm after 7 to 12 months. Fixtures followed up from 13 to 18 and 19 to 24 months showed a mean bone level of 0.7 mm. Around two fixtures, the bone level was found at the first implant thread. All other fixtures showed the bone level somewhere along the vertical unthreaded part of the fixture. Conclusions: Early loading within 1 month of four or five Astra Tech fixtures in the edentulous mandible is a predictable procedure for a follow-up period of 6 to 24 months. [source]


Healing of 208 intraalveolar root fractures in patients aged 7,17 years

DENTAL TRAUMATOLOGY, Issue 2 2001
Miomir Cvek
Abstract , This retrospective study consisted of 208 root-fractured, 168 splinted and 40 not splinted incisors in young individuals (aged 7,17 years) treated in the period 1959,1973 at the Pedodontic Department, Eastman Institute, Stockholm. Clinical and radiographic analyses showed that 69 teeth (33%) had developed hard tissue (fusion) healing of fragments. Interposition of periodontal ligament (PDL) and bone between the fragments was found in 17 teeth (8%). Interposition of PDL alone was found in 74 teeth (36%). Finally, non-healing with pulp necrosis and inflammatory changes between fragments was seen in 48 teeth (23%). Various clinical factors were analyzed for their relationship to the healing outcome with respect to healing/no healing and type of healing (hard tissue versus interposition of bone and/or PDL). Immature root and positive pulp sensitivity at time of injury was found to be significantly related to both pulp healing and hard tissue repair of the fracture. The same applied to concussion or subluxation of the coronal fragment compared to luxation with displacement (extrusive or lateral luxation). This relation was also represented by the variable millimeter diastasis between fragments before and after repositioning. Repositioning appeared to enhance the likelihood of both pulp healing and hard tissue repair. A positive effect of splinting, splinting methods (cap splints or orthodontic bands with an arch wire) or splinting periods could not be demonstrated on either pulp healing or type of healing (hard tissue versus interposition of bone and/or PDL). In conclusion, the findings from this retrospective study have cast doubts on the efficacy of long-term splinting and the types of splint used for root fracture healing. It is suggested that the role of splinting and splinting methods be examined in further studies. [source]


Hydroxyapatite fiber material with BMP-2 gene induces ectopic bone formation

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 1 2009
Mitsumasa Oda
Abstract Collagen containing bone morphogenetic protein-2 (BMP-2) expression vector, which is called "gene-activated matrix," promotes bone regeneration when transplanted to the bone defect. We speculated that hydroxyapatite fiber (HF) would be an ideal matrix for "gene-activated matrix" especially for bone regeneration, because it is oseteoconductive and has high affinity to DNA. The purpose of this study is to clarify whether HF containing BMP-2 expression vector induces ectopic bone formation. We prepared HF containing 0, 10, 50, and 100 ,g BMP-2 expression vector. Wistar male rats (8 weeks) were used and each rat received two HF implants in the left and right dorsal muscle. The rats were sacrificed 4, 8, and 12 weeks after the operation, and implants were analyzed radiographically by softex, dual-energy X-ray absorptiometry, and they were histologically examined. At 4 weeks, HF containing 50 or 100 ,g BMP-2 expression vector showed high bone mineral contents and large radiopaque volume compared to the other implants. At 8 and 12 weeks, HF containing 50 ,g BMP-2 expression vector exerted the highest values in the radiographic analyses. Bonelike tissue was histologically observed in HF containing 50 and 100 ,g BMP-2 expression vector groups but not detected in the other implants. The present results suggest that HF is potential as a matrix for "gene-activated matrix" for bone tissue engineering. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009 [source]


Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment

ARTHRITIS & RHEUMATISM, Issue 10 2009
S. Bar-Yehuda
Objective Studies have suggested that rheumatoid arthritis (RA) and osteoarthritis (OA) share common characteristics. The highly selective A3 adenosine receptor agonist CF101 was recently defined as a potent antiinflammatory agent for the treatment of RA. The purpose of this study was to examine the effects of CF101 on the clinical and pathologic manifestations of OA in an experimental animal model. Methods OA was induced in rats by monosodium iodoacetate, and upon disease onset, oral treatment with CF101 (100 ,g/kg given twice daily) was initiated. The A3 adenosine receptor antagonist MRS1220 (100 ,g/kg given twice daily) was administered orally, 30 minutes before CF101 treatment. The OA clinical score was monitored by knee diameter measurements and by radiographic analyses. Histologic analyses were performed following staining with hematoxylin and eosin, Safranin O,fast green, or toluidine blue, and histologic changes were scored according to a modified Mankin system. Signaling proteins were assayed by Western blotting; apoptosis was detected via immunohistochemistry and TUNEL analyses. Results CF101 induced a marked decrease in knee diameter and improved the changes noted on radiographs. Administration of MRS1220 counteracted the effects of CF101. CF101 prevented cartilage damage, osteoclast/osteophyte formation, and bone destruction. In addition, CF101 markedly reduced pannus formation and lymphocyte infiltration. Mechanistically, CF101 induced deregulation of the NF-,B signaling pathway, resulting in down-regulation of tumor necrosis factor ,. Consequently, CF101 induced apoptosis of inflammatory cells that had infiltrated the knee joints; however, it prevented apoptosis of chondrocytes. Conclusion CF101 deregulated the NF-,B signaling pathway involved in the pathogenesis of OA. CF101 induced apoptosis of inflammatory cells and acted as a cartilage protective agent, which suggests that it would be a suitable candidate drug for the treatment of OA. [source]


Ossification of Laryngeal Structures as Indicators of Age,

JOURNAL OF FORENSIC SCIENCES, Issue 5 2008
Heather M. Garvin M.S.
Abstract:, As the role of forensic anthropologists expands to the medical examiner setting, their expertise is being applied beyond the traditional dry skeletal material. In such scenarios radiographic techniques can be applied when maceration is not appropriate. This study explores the use of radiographic analysis of laryngeal structures for age-at-death determination. Isolated human laryngeal structures (n = 104) from individuals between the ages of 15 and 89 were removed at autopsy and radiographically examined. The cricoid and individual regions of the thyroid cartilage were scored according to degree of ossification, and the relationship between age and degree of ossification statistically examined. A previously published study on age-determination from thyroid ossification by ,erný was assessed for accuracy. The results of the study indicate that although a consistent sequence in the ossification of laryngeal structures exists, variations in timing does not permit narrow age range estimates. Consequently the method presented by ,erný is inaccurate and should not be used in the forensic setting. [source]


Joint degeneration following closed intraarticular fracture in the mouse knee: A model of posttraumatic arthritis

JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 5 2007
Bridgette D. Furman
Abstract Posttraumatic arthritis is one of the most frequent causes of disability following joint trauma. The objective of this study was to develop a model of a closed articular fracture in the mouse knee joint to quantify the temporal sequence of joint degeneration in a model of posttraumatic arthritis. Closed intraarticular fractures were created in the tibial plateau of adult mice (C57BL/6) using a computer-controlled materials testing system and a custom-built indenter tip. Tibial plateau fractures were classified and imaged over time using high-resolution digital radiography. Animals were sacrificed at 2, 4, 8, and 50 weeks following fracture, and the experimental and contralateral control limbs were harvested for histology and micro-computed tomography (microCT) analysis. By radiographic analysis, tibial plateau fractures closely resembled clinical fractures. More complex and comminuted fractures correlated to significantly higher fracture energies. Histologic analysis demonstrated progressive joint degeneration as measured by a modified Mankin scale, with fibrillation and loss of proteoglycan in the articular cartilage. Subchondral bone thickening was also observed in experimental joints. The induction of a closed intraarticular fracture of the mouse tibial plateau generated a reproducible and clinically relevant joint injury that progressed to osteoarthritis-like changes by histologic and microCT evaluations. The ability to induce joint degeneration without an osteotomy or open arthrotomy provides a valuable new model for studying the natural sequelae of posttraumatic arthritis. Notably, the use of a murine model will facilitate the use of genetically modified animals for the investigation of specific genes implicated in the pathology of posttraumatic arthritis. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:578,592, 2007 [source]


Augmentation of osseous phenotypes in vivo with a synthetic peptide

JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 4 2007
Xinhua Lin
Abstract The synthetic peptide B2A2-K-NS augmented the in vitro expression of osseous phenotypes when cells were stimulated with BMP-2, an osteoinductive growth factor. B2A2-K-NS significantly enhanced the effects of BMP-2-induced alkaline phosphatase activity and mineralization. In the absence of BMP-2, B2A2-K-NS did not have an effect on these endpoints. Based on these observations, in vivo studies were conducted to evaluate if B2A2-K-NS could augment osseous phenotypes in an osteoinductive environment in which BMP-2 should be present. In one study, human demineralized bone matrix (DBM) was used to generate an osteoinductive environment and the effects of B2A2-K-NS on ectopic mineralization of subcutaneous implants evaluated. In the second study, a noncritical sized defect in rabbit ulnas with inherent reparative capacity was used as the osteoinductive environment and was treated with or without B2A2-K-NS. In the DBM studies, B2A2-K-NS augmented mineralization as determined using a combination of radiographic analysis and von Kossa staining at 4 weeks postimplant. In the rabbit ulna model, B2A2-K-NS significantly increased the radiographic bone density in the defects compared to carrier-only or no-treatment controls after 6 weeks. Histological staining confirmed that B2A2-K-NS generated a pronounced bone repair response. The results are consistent with the hypothesis that B2A2-K-NS augments osseous phenotypes in an osteoinductive environment, and suggests that B2A2-K-NS may have clinical utility. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:531,539, 2007 [source]


Mapping the intake of different elements in vegetal tissues by dual-energy X-ray imaging at Da,ne synchrotron light source

MICROSCOPY RESEARCH AND TECHNIQUE, Issue 3 2008
L. Reale
Abstract This article reports on the first utilization of the soft X-ray beamline at the Da,ne synchrotron light source for mapping the intake of different elements in plant tissues. As a test, the method of dual-energy X-ray microradiography was applied to the investigation of the natural sulfur content in dried leaf and root samples. Our ultimate goal was to monitor the pollutant lead and its intake, which was added in controlled doses to the hydroponic medium of laboratory-controlled samples of vegetal species. The results obtained by the nondestructive X-ray radiographic analysis are compared to the values of concentrations determined by a standard chemical analysis utilizing atomic absorption spectroscopy. From this comparison the validity of the X-ray detection of heavy metals in biological samples has been confirmed. The superposition of the dual energy results on the simple planar radiography shows the representation of the pollutant intake directly on the sample structures. It should be pointed out that this method, developed here for plant root and leaves could be applied to any biological sample of interest, but the preparation and observation conditions necessitate different strategies according to the type of sample under analysis. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc. [source]


Radiographic assessment of alignment following TKA: outline of a standardized protocol and assessment of a newly devised trigonometric method of analysis

ANZ JOURNAL OF SURGERY, Issue 5 2010
Vikram Balakrishnan
Abstract Background:, An important determinant of long-term outcomes following total knee arthrolplasty (TKA) is post-operative alignment as measured on radiographs. Thus far, radiographs have been measured using the goniometer method (GM) and no standard protocol has been followed. The aim of this prospective study was to: (i) outline a protocol for radiographic measurement following TKA; and (ii) compare the accuracy of the traditional GM with a new trigonometric method (TM) of radiographic analysis. Methods:, A protocol for the measurement of alignment on radiographs following TKA was outlined in detail with step-by-step instructions. A new TM of angle measurement was also delineated. Alignment was measured on 51 post-operative TKA radiographs. A single angle was chosen and measured by two observers using both the GM and TM. Results:, The TM had a precision of 1.06° compared with 1.5° using the GM. The standard deviation of the TM was significantly smaller than the GM (P= 0.033). The intra-class correlation coefficient of the TM was 0.94 versus 0.90 for the GM. Conclusion:, The study detailed a protocol for the measurement of axial alignment of the limbs and components following TKA, and provided evidence that a newer TM of angle measurement was superior in terms of precision and intra-rater reliability in comparison with the traditional method. [source]


Effect of implant design on survival and success rates of titanium oral implants: a 10-year prospective cohort study of the ITI® Dental Implant System

CLINICAL ORAL IMPLANTS RESEARCH, Issue 1 2004
Ioannis K. Karoussis
Abstract Aim: The aim of this 10-year study (observation time 8,12 years, mean: 10 years) was to compare the survival rates, success rates and incidences of biological complications using three different implant designs of the ITI® Dental Implant System. Material and methods: In 89 dental patients treated comprehensively, a total of 112 hollow screw (HS), 49 hollow cylinder (HC) and 18 angulated hollow cylinder (AHC) implants were installed depending on the available bone volume and according to prosthetic needs. One and 10 years after surgical placement, clinical and radiographic parameters were assessed. The incidences of peri-implantitis according to various thresholds were registered over 10 years of maintenance. Results: Success criteria at 10 years were set at: pocket probing depth (PPD)5 mm, bleeding on probing (BoP),, bone loss < 0.2 mm annually. The survival rate for HS was 95.4%, for HC 85.7% and for AHC 91.7%. Ninety percent of all the HS, 71% of the HC and 88% of the AHC did not present with an incidence of peri-implantitis over the 10 years, HC having significantly higher incidence of peri-implantitis than HS (P< 0.004). With the success criteria set above, a success rate for HS of 74%, for HC of 63% and for AHC of 61% was identified at 10 years. However, including a definition of PPD6 mm, BoP , and bone loss < 0.2 mm annually for success, the rates for HS were 78%, for HC 65% and for AHC 67%, respectively. Basing success criteria purely on clinical parameters (without radiographic analysis), such as: PPD5 mm and BoP,, the success rates increased to 90%, 76% and 89%, respectively. With PPD6 mm and BoP , as success criteria chosen, the respective rates were 94%, 82% and 94% for HS, HC and AHC implants, respectively. Conclusions: A significantly higher survival rate as well as a significantly lower incidence of peri-implantitis was identified for hollow screw design ITI® Dental Implants after 10 years of service when compared to hollow cylinder design ITI® Dental Implants (95.4% vs. 85.7%; 10% vs. 29%). Depending on the setting of the threshold criteria for success, success rates are highly variable and hence, reporting of success rates with elaboration on the criteria set appears crucial for comparison of different studies. Résumé Le but de ce suivi d'une décennie a été de comparer les taux de survie, les taux de succès et les incidences des complications biologiques de l'utilisation de trois modèles implantaires différents du système ITI® Dental Implant. Chez 89 patients, 112 vis creuses (HS), 49 cylindres creux (HC) et 18 cylindres creux angulés (AHC) ont été placés suivant le volume osseux disponible et les nécessités prothétiques. Une et dix années après leur placement, des paramètres cliniques et radiographiques ont été définis. Les incidences de paroïmplantite relatives aux différents seuils ont été enregistrées durant ces dix années de maintenance. Les succès des critères à dix ans étaient placés à : PPD5 mm, BoP-, perte osseuse <0,2 mm/an. Le taux de survie pour HS était de 95,4%, pour HC de 86% et pour AHC de 92%. Nonante pour cent de tous les HS, 71% des HC et 88% des AHC ne présentaient pas d'incidences de paroïmplantite durant ces dix années, HC ayant une plus importante incidence de paroïmplantite que HS (p<0,004). Grace aux critères de succès indiqués, un taux de succès de 74% pour HS, de 63% pour HC et de 61% pour AHC a été identifié après dix ans. Cependant, en définissant le succès avec PPD6mm, BoP- et perte osseuse <0,2mm/an, les taux étaient de 78% pour HS, de 65% pour HC et de 67% pour AHC. En basant les taux de succès uniquement sur les paramètres cliniques (sans l'analyse radiographique) tels que PPD5 mm et BoP-, les taux de succès augmentaient respectivement à 90, 76 et 89%. Avec PPD6mm et BoP- comme critères de succès, les taux s'élevaient respectivement à 94, 82 et 94%. Un taux de survie significativement plus important ainsi qu'une incidence significativement plus faible de paroïmplantite étaient constatés au niveau des implants vis creuses après dix ans de mise en fonction comparés aux cylindres creux. Suivant l'établissement du seuil pour les critères du succès, les taux de ce succès sont extrêmement variables et rapporter les taux de succès suivant l'élaboration des critères est donc crucial pour comparer différentes études. Zusammenfassung Ziel: Das Ziel dieser 10-Jahresstudie (Beobachtungszeit 8,12 Jahre, Mittelwert: 10 Jahre) war es, bei ITI® -Implantaten mit drei verschiedenen Designs, die Erfolgs- und Überlebensrate zu vergleichen, und das Auftreten von biologischen Zwischenfällen zu untersuchen. Material und Methode: Bei 89 synoptisch behandelten Patienten implantierte man in Abhängigkeit des vorhandenen Knochenvolumens und der prothetischen Anforderungen insgesamt 112 Hohlschraubenimplantate (HS), 49 Hohlzylinderimplantate (HC) und 18 abgewinkelte Hohlzylinderimplantate (AHC). Ein und zehn Jahre nach der Implantation nahm man die klinischen und radiologischen Parameter auf. Eine Periimplantitis registrierte während der 10-jährigen Erhaltungsphase anhand verschiedener Grenzwerte. Resultate: Die Kriterien für einen Erfolg nach 10 Jahren legte man bei den folgenden Werten fest: PPD <5mm, BOP-, jährlicher Knochenverlust <0.2mm. Die Überlebensrate für ein HS lag bei 95.4%, für ein HC bei 85.7% und für ein AHC bei 91.7%. 90% aller HS, 71% aller HC und 88% aller AHC zeigte während den 10 Jahren nie Anzeichen einer Periimplantitis, wobei die HC signifikant häufiger Periimplantitis hatten, als die HS (p<0.004). Mit den oben festgelegten Erfolgskriterien ergab sich nach 10 Jahren für die HS eine Erfolgsrate von 74%, für die HC eine von 63% und für die AHC eine von 61%. Veränderte man die Definition auf "PPD<6mm, BOP -, jährlicher Kochenverlust <0.2mm", so betrugen die Erfolgsraten für die HS 78%, für die HC 65% und für die AHC 67%. Basierten die Erfolgskriterien rein auf klinischen Parametern (PPD <5mm, BOP-, keine röntgenologische Anlyse), so stiegen die Erfolgsraten auf 90%, 76% und 89% an. Wählte man die Erfolgskriterien "PPD <6mm und BOP -", so betrugen die Erfolgsraten für die HS 94%, für die HC 82% und für die AHC 94%. Zusammenfassung: Verglich man nach 10-jähriger Funktion die Hohlschrauben des ITI® -Implantat-Systems mit den Hohlzylindern desselben Systems, so ergab sich für die HS sowohl eine signifikant höher Überlebensrate, wie auch ein selteneres Auftreten von Periimplantitis (95.4% vs. 85.7%; 10% vs. 29%). Die Erfolgsraten variieren in Abhängigkeit der in der Definition eines Erfolges festgelegten Grenzwerten enorm stark. Dies erweist sich im Vergleich von verschiedenen Studien als hinderlich, weil die Definition der Erfolgsraten meist auf verschiedenen Kriterien beruhen. Resumen Intención: La intención de este estudio de 10 años (tiempo de observación 8,12, media: 10 años) fue comparar los índices de supervivencia, índices de éxito e índices de complicaciones biológicas usando tres diferentes diseños de implantes del Sistema de Implantes Dentales ITI®. Material y Métodos: Se instalaron en 89 pacientes dentales tratados completamente un total de 112 tornillos huecos (HS), 49 cilindros huecos (HC) y 18 cilindros huecos angulados (AHC) dependiendo de la disponibilidad de volumen óseo y de acuerdo con las necesidades protésicas. Se valoraron parámetros clínicos y radiográficos uno y diez años tras la colocación quirúrgica. Se registraron las incidencias de periimplantitis de acuerdo con varios umbrales a lo largo de 10 años de mantenimiento. Resultados: Los criterios de éxito a los 10 años se situaron en PPD5mm, BoP-, pérdida ósea < 0.2mm por año. El índice de supervivencia para los HS fue del 95.4%, para los HC del 85.7% y para los AHC del 91.7%. El 90% de los HS, el 71% de los HC y el 88% de los AHC no presentaron ninguna incidencia de periimplantitis a lo largo de los 10 años, HC tuvo una significativamente mayor incidencia de periimplantitis que HS (p< 0.004). Con los criterios de éxito antes mencionados, se identificó un índice de éxito para HS del 74%, para HC del 63% y para AHC del 61% a los 10 años. De todos modos, incluyendo una definición de PPD6mm, BoP, y pérdida ósea <0.2mm al año para tener éxito, los índices para HS fueron del 78%, para HC 65% y para AHC 67%, respectivamente. Basando los criterios de éxito puramente en parámetros clínicos (sin análisis radiográficos), tales como: PPD5mm y BoP-, los índices de éxito subieron hasta el 90%, 76% y 89%, respectivamente. Con el PPD6mm y BoP , como criterios de éxito elegidos, los índices respectivos fueron del 94%,82% y 94% para implantes HS, HC y AHC, respectivamente. Conclusiones: Se identificó un significativamente mayor índice de supervivencia al igual que una menor incidencia de periimplantitis para el diseño de tornillo hueco Implante Dental ITI®. (95.4% vs. 85.7; 10% vs. 29%). Dependiendo de la definición del criterio del umbral de éxito, los índices de éxito son altamente variables y por tanto, los informes de los índices de éxito con elaboración de la definición de criterios parece ser crucial para la comparación de los diferentes estudios. [source]