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Proposal
Kinds of Proposal Terms modified by Proposal Selected AbstractsTOWARD THE GLOBAL STANDARDIZATION OF ENDOSCOPIC SUBMUCOSAL DISSECTION PROPOSAL FOR 10 YEARS FROM NOW , PRESENT AND FUTURE VIEW OF KOREADIGESTIVE ENDOSCOPY, Issue 2009Joo Young Cho Endoscopic submucosal dissection (ESD) is the main treatment of early gastric cancer in Korea. The Korean Society of Gastrointestinal Endoscopy (KSGE) has organized an ESD research group and made several plans to standardize pathologic and therapeutic points of view. This article is to introduce the present and future view of ESD in Korea. [source] ENDING WELFARE AS WE KNOW IT: A MODEST PROPOSALECONOMIC AFFAIRS, Issue 1 2002Robert W. McGee Government welfare schemes are based on a false premise, the belief that forcible redistribution can be moral if the cause is just. People forget that whatever resources government has, it first had to take from someone. Government welfare schemes violate property rights and destroy incentives. There is no way to reform such a system simply. The only just system is one of voluntary charity. The government system, which relies on force, must be abolished and replaced by private charity. [source] COMMERCIAL DEVELOPMENT AND NATURAL RESOURCE MANAGEMENT ON THE INDIGENOUS ESTATE: A PROFIT-RELATED INVESTMENT PROPOSALECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 3 2005Jon Altman This article assesses the state of commercial development and resource management on Indigenous land in remote Australia. Indigenous landowners control significant assets,over one million square kilometres of land,often with substantial resource rights and income earning potential. The inactivity and missed opportunities on the Indigenous estate are of such magnitude as to represent a major risk both for Indigenous landowning communities, in terms of their future economic and social well-being, and for national and international interests in terms of ecological vulnerability. The article explores the role of government as risk manager in such circumstances and outlines the principles that might underpin any intervention program targeted to the commercial development of Indigenous land. Using the analytical framework for profit-related loans and elements of an existing venture capital support programme, the Innovation Investment Fund Program, we outline the hypothetical skeleton of a new investment scheme to assist development and natural resource management on the Indigenous estate. Our proposal can be conceptualised as a profit-related loan scheme or as a form of capped public investment. It seeks to address key elements of the market failure that exists in relation to financing development on remote Indigenous land, provides incentives for greater private sector investment, and ensures that commercial and social risks are shared equitably between government, private sector investors and Indigenous-owned corporations to avoid problems of adverse selection and moral hazard. [source] PROPOSAL FOR A NEW MEASURE OF CORRUPTION, ILLUSTRATED WITH ITALIAN DATAECONOMICS & POLITICS, Issue 1 2005Miriam A. Golden Standard cross-national measures of corruption are assembled through surveys. We propose a novel alternative objective measure that consists of the difference between a measure of the physical quantities of public infrastructure and the cumulative price government pays for public capital stocks. Where the difference is larger between the monies spent and the existing physical infrastructure, more money is being siphoned off to mismanagement, fraud, bribes, kickbacks, and embezzlement; that is, corruption is greater. We create this measure for Italy's 95 provinces and 20 regions as of the mid-1990s, controlling at the regional level for possible differences in the costs of public construction. [source] LEVIATHANS, CRITICAL THINKING, AND LEGAL PHILOSOPHY: A PROPOSAL FOR A GENERAL EDUCATION LEGAL STUDIES COURSEJOURNAL OF LEGAL STUDIES EDUCATION, Issue 1 2003Nim Razook [source] PROPOSAL OF ECTOCARPUS SILICULOSUS (ECTOCARPALES, PHAEOPHYCEAE) AS A MODEL ORGANISM FOR BROWN ALGAL GENETICS AND GENOMICS,JOURNAL OF PHYCOLOGY, Issue 6 2004Akira F. Peters The emergence of model organisms that permit the application of a powerful combination of genomic and genetic approaches has been a major factor underlying the advances that have been made in the past decade in dissecting the molecular basis of a wide range of biological processes. However, the phylogenetic distance separating marine macroalgae from these model organisms, which are mostly from the animal, fungi, and higher plant lineages, limits the latters' applicability to problems specific to macroalgal biology. There is therefore a pressing need to develop similar models for the macroalgae. Here we describe a survey of potential model brown algae in which particular attention was paid to characteristics associated with a strong potential for genomic and genetic analysis, such as a small nuclear genome size, sexuality, and a short life cycle. Flow cytometry of nuclei isolated from zoids showed that species from the Ectocarpales possess smaller haploid genomes (127,290 Mbp) than current models among the Laminariales (580,720 Mbp) and Fucales (1095,1271 Mbp). Species of the Ectocarpales may complete their life histories in as little as 6 weeks in laboratory culture and are amenable to genetic analyses. Based on this study, we propose Ectocarpus siliculosus (Dillwyn) Lyngbye as an optimal choice for a general model organism for the molecular genetics of the brown algae. [source] NEW NATURAL LAW THEORY AND FOUNDATIONAL SEXUAL ETHICAL PRINCIPLES: A CRITIQUE AND A PROPOSALTHE HEYTHROP JOURNAL, Issue 2 2006TODD A. SALZMAN The New Natural Law Theory (NNLT) argues against the morality (and legality) of same sex-unions on the basis that homosexual (and non-reproductive heterosexual) acts are unnatural, unreasonable, and therefore immoral. In this paper, we explore and critique the foundational principles , biological and personal complementarity, their subcategories, and the interrelationship between them , that the NNLT uses to justify its claim. We propose alternative principles , orientation, personal, and genital-biological complementarity, with a distinct interrelationship , to argue that homosexual couples can engage in sexual acts that are natural, reasonable, and therefore moral. Our study clearly demonstrates that for the NNLT genital complementarity, a subcategory of biological complementarity, is the sine qua non for personal complementarity. In other words, personal complementarity within a sexual act is only possible if there is genital complementarity between male and female. We believe that the NNLT's foundational principles reflect too narrow an understanding of the human person and human sexuality. Instead, we propose "holistic complementarity" as the fully human integration of orientation, personal, and genital-biological complementarity. What defines a natural, reasonable, and moral sexual act is not genital complementarity as the foundational principle, but a dialectic between these three principles of complementarity. [source] ASSESSING LARGE MERGER PROPOSALSECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 3 2002PENNY NEAL First page of article [source] The Constitutional Reform Proposal of the Turkish Government: The Return of Majority ImpositionCONSTELLATIONS: AN INTERNATIONAL JOURNAL OF CRITICAL AND DEMOCRATIC THEORY, Issue 2 2010Andrew Arato First page of article [source] O-11 Proposal for extending the role Of ABMSPS in reporting cervical loopsCYTOPATHOLOGY, Issue 2007K. Ellis Introduction:, The advanced biomedical scientist practitioner (ABMSP) in Cervical Cytology was established in the NHS cervical screening programme (NHSCCSP) in 2001 and there are approximately 60 ABMSPs in post. The aim of this study was to explore the potential for further expansion of their role in the NHSCSP by reporting the histology of loop excision biopsies of the cervical transformation zone (LLETZ). Methods:, The initial study included LLETZ specimens from 55 sequential patients, which, according to standard local practice had the diagnosis of CIN confirmed by cervical punch biopsy prior to the procedure. All the cases were independently examined by an ABMSP and a consultant histopathologist and reports complying with the Royal College of pathologists (RCPath) minimum data sets were assembled. The cases were reviewed at the discussion microscope and ABMSP reports were compared to the final reports issued by the histopathologist. Results:, In the preliminary findings, total agreement between ABMSP and consultant histopathologist was reached on just under 90% of cases. Of those cases that did not reach total agreement, none varied by more than one grade. There was agreement on other parameters from the RCPath minimum data sets. Discussion:, Based on our preliminary findings, it appears there may be scope for extending the role of ABMSPs to report LLETZ samples under the supervision of a histopathologist. We plan to increase the number of cases both in our department and through collaboration with other UK centres and to present evidence to the RCPath, with a view to adoption of this role by ABMSPs and development of an appropriate training scheme. [source] A "Modest Proposal" for Making the Standardized Normal Distribution Tables in Business Statistics Texts to an Upper-Tail Format,DECISION SCIENCES JOURNAL OF INNOVATIVE EDUCATION, Issue 1 2007Ram B. Misra First page of article [source] Evaluation of the American Joint Committee on Cancer Staging System for Cutaneous Squamous Cell Carcinoma and Proposal of a New Staging SystemDERMATOLOGIC SURGERY, Issue 11 2005Scott M. Dinehart MD Purpose. To identify and propose corrections for deficiencies in the American Joint Committee on Cancer (AJCC) system for staging cutaneous squamous cell carcinoma (CSCC). Materials and Methods. Prognostic factors for CSCC were identified by retrospective analysis of the published literature. Limitations and deficiencies in the current AJCC staging system for CSCC were then determined using these prognostic factors. Results. Size, histologic differentiation, location, previous treatment, depth of invasion, tumor thickness, histologic subtype, perineural spread, and scar etiology are the most powerful tumor prognostic indicators in patients with localized disease. The most important prognostic factors for patients with nodal metastases are the location, number, and size of the positive lymph nodes. Proposed changes for the T classification include increased stratification of tumor size, identification of patients with perineural invasion, and the addition of tumor thickness or depth of invasion. The N classification has been expanded to include the number and size of nodal metastases. Conclusion. The current AJCC staging system for carcinoma of the skin has deficiencies that limit its use for CSCC. The proposed TMN staging system for CSCC more accurately reflects the prognosis and natural history of CSCC. SCOTT M. DINEHART, MD, AND STEVEN PETERSON, MD, HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS. [source] Famine Intensity and Magnitude Scales: A Proposal for an Instrumental Definition of FamineDISASTERS, Issue 4 2004Paul Howe Ambiguities in current usage of the term ,famine' have had tragic implications for response and accountability in a number of recent food crises. This paper proposes a new approach to defining famine based on the use of intensity and magnitude scales, where ,intensity' refers to the severity of the crisis at a given location and point in time, while ,magnitude' describes the aggregate impact of a crisis. The scales perform three operations on ,famine': first, moving from a binary conception of ,famine/no famine' to a graduated, multi-level definition; second, disaggregating the dimensions of intensity and magnitude; and third, assigning harmonised ,objective' criteria in place of subjective, case-by-case judgements. If adopted, the famine scales should contribute to more effective and proportionate responses, as well as greater accountability in future food crises. [source] Proposal and development of radial air-gap coreless generator suitable for small wind turbine used in urban areaELECTRICAL ENGINEERING IN JAPAN, Issue 1 2009Toshiyuki Takahashi Abstract Independent distributed power generation using small wind turbines is becoming more widespread as wind power generation increases. Installation of small wind turbines in densely populated urban areas is not only useful from the viewpoint of extracting wind power sources in weak-wind areas but also for making renewable energy easier to access when power supplies are closer to consumers. It is from this point of view that the authors proposed "urban wind power generation" using a collective system with a number of small vertical wind turbines, and have developed a suitable generator for low-speed vertical wind turbines such as a Savonius windmill. Based on a standard coreless generator, the proposed generator is designed to make the direction of the magnetic flux radial in order to install the magnets and coils on the outer end of the generator. The change of magnet composition and flux direction maximizes the speed of the flux change and output voltage within a limited space. With the above configuration, the power of the proposed generator is independent of the diameter. In this report, the authors describe and evaluate the fundamental performance of a prototype of the proposed generator. Based on the experiments, a maximum output power of 283 W was obtained. The obtained starting torque is small enough to begin rotation under weak wind conditions of no more than 1 m/s. Therefore, it is clear that the proposed "radial" coreless generator is suitable for self-starting and producing high power at low wind speed. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 167(1): 26, 34, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20695 [source] Proposal and evaluation of a gas engine and gas turbine hybrid cogeneration system in which cascaded heat is highly utilizedELECTRICAL ENGINEERING IN JAPAN, Issue 3 2009Pyong Sik Pak Abstract A high-efficiency cogeneration system (CGS) is proposed for utilizing high-temperature exhaust gas (HTEG) from a gas engine (GE). In the proposed system, for making use of heat energy of HTEG, H2O turbine (HTb) is incorporated and steam produced by utilizing HTEG is used as working fluid of HTb. HTb exhaust gas is also utilized for increasing power output and for satisfying heat demand in the proposed system. Both of the thermodynamic characteristics of the proposed system and a gas engine CGS (GE-CGS) constructed by using the original GE are estimated. Energy saving characteristics and CO2 reduction effects of the proposed CGS and the GE-CGS are also investigated. It was estimated that the net generated power of the proposed CGS has been increased 25.5% and net power generation efficiency 6.7%, compared with the original GE-CGS. It was also shown that the proposed CGS could save 27.0% of energy consumption and reduce 1137 t-CO2/y, 1.41 times larger than those of GE-CGS, when a case study was set and investigated. Improvements of performance by increasing turbine inlet temperature were also investigated. © 2008 Wiley Periodicals, Inc. Electr Eng Jpn, 166(3): 37, 45, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20708 [source] Electroanalytical Approach to Evaluate Antioxidant Capacity in Honeys: Proposal of an Antioxidant IndexELECTROANALYSIS, Issue 18 2006Mónica Ávila Abstract A novel electrochemical route to estimate the antioxidant capacity in honey samples is proposed just using flow injection analysis. The analytical strategy involved the selective oxidation of polyphenolic compounds using two different target potentials, +0.8 and +0.5,V, at two different pHs. An oxidation current obtained at the fixed potential was used as an analytical guide of the antioxidant activity of the target honeys. Chemometrics (correlation and principal component analysis, PCA) demonstrated the significance of the electrochemical protocol versus the traditional spectrophotometric ones in the evaluation of antioxidant capacity and revealed the role of detection potential as a screening variable. The proposed protocol is very simple and fast. However, the most relevant merit of the electrochemical procedure is its inherent versatility which allows the evaluation of the antioxidant activity under predesigned controlled oxidation conditions. In addition, since intercept was statistically zero, its corresponding antioxidant content using just a calibration factor is proposed thus simplifying the calibration-analysis process. As a result, an electrochemical antioxidant index (EAI) is proposed. [source] Kozhevnikov,Rasmussen Syndrome and the New Proposal on ClassificationEPILEPSIA, Issue 8 2002C. P. Panayiotopoulos No abstract is available for this article. [source] Diisobutylaluminium Hydride (DIBAL-H) Promoted Secondary Rim Regioselective Demethylations of Permethylated ,-Cyclodextrin: A Mechanistic ProposalEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 8 2010Sulong Xiao Abstract Diisobutylaluminium hydride (DIBAL-H) promotes secondary rim regioselective bis-de- O -methylation at the 2A - and 3B -positions of permethylated ,-cyclodextrin. This result contrasts with the selective bis-de- O -benzylation of perbenzylated cyclodextrins in which regioselective deprotection occurs at the primary rim. To gain an insight into the mechanism of this remarkable contrasting behavior, the two corresponding permethylated cyclodextrins with an alcohol function at either the 2- or 3-position were synthesized. The cyclodextrin with the alcohol at the 3-position reacts withDIBAL-H to afford the 2A,3B -diol whereas the cyclodextrin with the alcohol at the 2-position is unreactive. This observation allows us to propose a mechanism for the demethylation reaction that involves for each demethylation step two molecules of aluminium reagent, in accord with the previous hypothesis on the debenzylation reaction. The second demethylation step appears to be faster than the first, the coordination of aluminium now being an intramolecular process. [source] Proposal of a standard approach to dental extraction in haemophilia patients.HAEMOPHILIA, Issue 5 2000A case-control study with good results We found no case,control studies on dental extraction in haemophilia patients in the literature even though the use of antifibrinolytic agents following a single infusion of factor VIII or IX has been accompanied by a lower number of bleeding complications in dental extractions. In this study we verified the incidence of bleeding complications after dental extraction in a group of 77 haemophilia patients. One hundred and eighty-four male patients requiring dental extraction represented the control group. All haemophilia patients received 20 mg kg,1 of tranexamic acid and a single infusion of factor VIII or IX to achieve a peak level about 30% of factor VIII or IX in vivo prior to dental extraction. Forty-five of 98 (45.9%) dental extractions in haemophilia patients and 110 of 239 (46%) dental extractions in the control group were surgical ones. We registered two bleeding complications in the group of haemophilia patients (one late bleeding and one haematoma in the site of the anaesthetic injection) and one (a late bleeding) in the control group. The difference of bleeding complications in the two groups of patients were not statistically significant (P=0.2; OR 0.2; CI 0.01,2.22). The protocol proposed in this study, characterized by the feasibility and the number of haemorrhagic complications not different from normal population, make dental extractions in haemophilia patients possible on an out-patient basis with a cost reduction for the community and minor discomfort for the patients. [source] A Proposal for Teaching Introductory and Intermediate Accounting in an Environment of International Financial Reporting Standards and Generally Accepted Accounting Principles for Private Enterprises,ACCOUNTING PERSPECTIVES, Issue 1 2010FRED PRIES comptabilité générale; enseignement; IFRS Abstract Teaching introductory and intermediate financial accounting in an environment of international financial reporting standards (IFRS) and generally accepted accounting principles for private enterprises (GAAP for PEs) is an issue facing faculty at Canadian universities and colleges. We present a number of options and then propose an approach that we believe provides a balanced treatment of accounting standards for both publicly accountable and private enterprises. This approach focuses on the concepts and principles that are common to both IFRS and GAAP for PEs. We argue that this approach encourages deep learning resulting in students' better understanding of accounting standards and their application. Proposition d'enseignement de la comptabilitéélémentaire et intermédiaire dans un contexte de normes internationales d'information financière et de principes comptables généralement reconnus pour les entreprises à capital fermé Résumé L'enseignement de la comptabilité générale élémentaire et intermédiaire dans le contexte des IFRS et des PCGR pour les entreprises à capital fermé est problématique pour les professeurs des universités et des collèges canadiens. Les auteurs exposent différentes options et proposent ensuite une approche qui offre, selon eux, un traitement équilibré des normes comptables pour les entreprises ayant une obligation d'information du public ainsi que les entreprises à capital fermé. Cette approche est axée sur les notions et les principes que partagent les IFRS et les PCGR pour les entreprises à capital fermé. Selon les auteurs, elle favorise un apprentissage en profondeur permettant aux étudiants de mieux comprendre les normes comptables et leur application. [source] Victims of Domestic Violence: A Proposal for a Community Diagnosis Based on One of Two Domains of NANDA Taxonomy IIINTERNATIONAL JOURNAL OF NURSING TERMINOLOGIES AND CLASSIFICATION, Issue 2003Patricia Serpa de Souza Batista PURPOSE To explore and identify diagnostic components to amplify NANDA nursing diagnoses by modifying the root violence. Whereas violence is nondebatable as a diagnostic concept in nursing, other alternatives have not been identified in the two existing diagnoses. METHODS Using the case study method, this qualitative study sought to identify commonalties in a population of women who were "donnas da casa" (homemakers) in a small rural community of approximately 100 families, typical of the Brazilian northeast. The sample of 7 women was identified through a larger study that had been based on health needs of the community. Data were obtained through observation during a home visit and a semistructured interview based on NANDA Taxonomy II. Observations were focused on hygiene, manner of dress, home environment, and physical and emotional state. Data were analyzed by content and clustered into major categories. From these a profile of the women and another of the partners emerged. FINDINGS Subjects ranged in age from 33 to 43 years, and number of children between 3 and 7. One of the 7 women was literate; 5 were underweight; all were slovenly attired. They appeared sad and older than their age. The majority seemed relieved to unburden themselves to the interviewers as they went through a gamut of emotions such as sadness, anguish, and irritability expressed through crying, restlessness, changes in body language, and tone of voice. The shortage of beds was supplemented by hammocks and mats or cardboard. The women spoke of being confined to their home and of male partners who drank on weekends, thus leaving them with little money for necessities of life. There were accounts of beatings when the partner returned home after drinking, overt nonacceptance of children from previous marriages, and general destruction of the family environment. New children were regarded as just another mouth to feed. DISCUSSION The profiles pointed to the necessity of identifying a new nursing diagnosis that would be linked, only tangentially, by the root violence to the two diagnoses in NANDA Taxonomies I and II. This insight led us to consider that a new method of listing NANDA diagnoses, by root only, is imperative in the evolution of Taxonomy II. Proposed descriptors, Victims of (Axis 3) and Domestic (Axis 6) would be identified by Axes, thereby facilitating the process of classifying in the Domains and Classes. The two existing NANDA diagnoses, risk for other-directed violence and risk for self-directed violence, are proposed for classification in Class 3, Violence, in Domain 11 of Taxonomy II. Safety/Protection could, by virtue of their modification power, find anchor in another domain such as Domain 6, Self-Perception. CONCLUSIONS Although Safety/Protection seems the most logical domain for classification by root, the axes, dimensions of human responses, could pull the diagnosis in another direction, thereby dictating other nursing interventions and nursing outcomes [source] Environmental Nursing Diagnoses: A Proposal for Further Development of Taxonomy IIINTERNATIONAL JOURNAL OF NURSING TERMINOLOGIES AND CLASSIFICATION, Issue 1 2003Pauline M. Green PhD PURPOSE. To propose further development of environmental diagnoses and to offer recommendations for expanding Taxonomy II to include more diagnostic labels that encompass the environmental domain. SOURCES. Literature in the disciplines of nursing, biology, toxicology, public health, sociology, and anthropology. DATA SYNTHESIS. Nurses need language to describe the human responses of individuals, families, communities, and global society to environmental health threats. CONCLUSIONS. New environmental diagnoses will lead to refinement of language that describes the contribution of nursing to an emerging international and community health priority. PRACTICE IMPLICATIONS. Environmental diagnostic labels will allow nurses to name responses and plan interventions that respond to instances or risks of exposure to threats from the physical and sociocultural environment. Search terms: Environmental contamination, environmental health threats, exposure, nursing diagnoses [source] Revamping Pentecostal Evangelism: Appropriating Walter J. Hollenweger's Radical ProposalINTERNATIONAL REVIEW OF MISSION, Issue 382-383 2007Tony Richie As the Christian Church endeavours to be faithful to its evangelistic mission, increasingly intense problems arise in international contexts of cultural diversity and religious plurality. Pentecostal, noted for "aggressive evangelism", are frequently at the forefront of such negative encounters. Walter J. Hollenweger offers Pentecostals a complementary paradigm of "dialogical evangelism" that is sensitive to this situation without stilling the voice of evangelism. The present project overviews Hollenweger's "radical proposal" and traditional Pentecostal evangelism and its current trends before assessing their compatibility or contradictoriness and exploring possible appropriation. [source] Douglas Darden's Sex Shop: An Immodest ProposalJOURNAL OF ARCHITECTURAL EDUCATION, Issue 2 2004PETER SCHNEIDER When once we resort to the arena of representation, we remove the weightiest and most obvious restrictions on imaginative flight. We are free at least to depict those things which architecture might do in certain circumstances,circumstances bounded only by the remotest confines of probability. Here is the sphere of the maker of architectural fantasies. He can explore a great margin of territory,nearly virgin territory,capable of yielding architectural treasure, unique and enthralling. [source] In Silico Modeling and Simulation of Bone Biology: A ProposalJOURNAL OF BONE AND MINERAL RESEARCH, Issue 7 2005Nadine A Defranoux Abstract Contemporary, computer-based mathematical modeling techniques make it possible to represent complex biological mechanisms in a manner that permits hypothesis testing in silico. This perspective shows how such approaches might be applied to bone remodeling and therapeutic research. Currently, the dominant conceptual model applied in bone research involves the dynamic balance between the continual build-up and breakdown of bone matrix by two cell types, the osteoblasts and osteoclasts, acting together as a coordinated, remodeling unit. This conceptualization has served extraordinarily well as a focal point for understanding how mutations, chemical mediators, and mechanical force, as well as external influences (e.g., drugs, diet) affect bone structure and function. However, the need remains to better understand and predict the consequences of manipulating any single factor, or combination of factors, within the context of this complex system's multiple interacting pathways. Mathematical models are a natural extension of conceptual models, providing dynamic, quantitative descriptions of the relationships among interacting components. This formalization creates the ability to simulate the natural behavior of a system, as well as its modulation by therapeutic or dietetic interventions. A number of mathematical models have been developed to study complex bone functions, but most include only a limited set of biological components needed to address a few specific questions. However, it is possible to develop larger, multiscale models that capture the dynamic interactions of many biological components and relate them to important physiological or pathological outcomes that allow broader study. Examples of such models include Entelos' PhysioLab platforms. These models simulate the dynamic, quantitative interactions among a biological system's biochemicals, cells, tissues, and organs and how they give rise to key physiologic and pathophysiologic outcomes. We propose that a similar predictive, dynamical, multiscale mathematical model of bone remodeling and metabolism would provide a better understanding of the mechanisms governing these phenomena as well as serve as an in silico platform for testing pharmaceutical and clinical interventions on metabolic bone disease. [source] Developing Codes of Conduct: Regulatory Conversations as Means for Detecting Institutional ChangeLAW & POLICY, Issue 4 2007KARIN JONNERGÅRD The introduction of a new corporate governance code in Sweden, modeled after prevailing Anglo-Saxon norms of corporate governance, offers the opportunity to investigate global regulatory convergence. Using the metaphor of regulatory space, this article analyzes the positions of the parties who submitted formal responses to the introduction of "The Swedish Code of Corporate Governance,A Proposal from the Code Group." While the globalization of financial markets might forecast unconditional acceptance of the proposed code by business and financial interests, the analysis of who made comments, and what was said, reveals three categorically distinct groups: Swedish business "insiders" connected to the existing institutional framework who opposed changes that would erode traditional division of functions, including collective responsibility for the actions of company boards; "outsiders" (i.e., foreign investors and more marginal Swedish investors) aligned with Anglo-Saxon internationalization of the markets who would change the system of corporate accountability; and the professions (i.e., auditors), who advocated for their professional interests. Of the three groups, Swedish business insiders were most successful in gaining support for their positions. Although international financial and political interests were key to the introduction of the Code in the first place, the article demonstrates how the dynamics of national (local) culture and power structures influence the transfer of regulatory law across jurisdictions. [source] The National Civic Congress: A Proposal for Movement BuildingNATIONAL CIVIC REVIEW, Issue 1 2002Carmen Sirianni [source] Cyclic pamidronate treatment in Bruck syndrome: Proposal of a new modality of treatmentPEDIATRICS INTERNATIONAL, Issue 6 2008Nesibe Andiran No abstract is available for this article. [source] Presidential Fitness and Presidential Lies: The Historical Record and a Proposal for ReformPRESIDENTIAL STUDIES QUARTERLY, Issue 1 2010ROBERT DALLEK Since at least the late nineteenth century, U.S. presidents have engaged in substantial and unjustified deception in a variety of domains, and future presidents will continue to do so unless new mechanisms are created to ensure greater accountability and oversight. The problem is particularly apparent in two very different domains: personal health and foreign policy. Several presidents and presidential candidates have concealed grave health conditions that impaired their ability to govern. As future presidential candidates are unlikely to be more forthcoming about their health, the public interest should be protected by an independent medical panel to evaluate presidential candidates. In foreign policy, recent decades have seen several egregious cases of presidential deception, including Lyndon B. Johnson on Vietnam, Richard M. Nixon on the Chilean coup, and George W. Bush on weapons of mass destruction in Iraq. Such ethical lapses justify a constitutional recall amendment, under which a congressional supermajority could subject the continued service of a sitting president to a popular vote. [source] Recarving Content: Hale's Final ProposalPROCEEDINGS OF THE ARISTOTELIAN SOCIETY (HARDBACK), Issue 1 2002Michael Potter First page of article [source] | |||||||||||||||||||||||||||||||||||||||||||