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Propargyl Amines (propargyl + amine)

Distribution by Scientific Domains
Chemistry75%

Selected Abstracts

A Versatile Synthetic Platform Based on Strained Propargyl Amines,

ANGEWANDTE CHEMIE, Issue 9 2010
Zhi He
Divergente Reaktivität: Verschiedenartige Ethinylaziridine, die sich wie sterisch gespannte Propargylamine verhalten, können durch hoch diastereoselektiven SN2,-Hydridtransfer direkt in ungeschützte ,-Aminoallene umgewandelt werden (siehe Schema). Weitere Reaktionsrouten umfassen die chemo- und regioselektive Umwandlung in Bicyclen mit Aziridin- und Enolethereinheit oder in hoch gespannte Alkinylazirine. [source]

ChemInform Abstract: Nickel- and Rhodium-Catalyzed Addition of Terminal Silylacetylenes to Propargyl Amines: Catalyst-Dependent Complementary Regioselectivity.

CHEMINFORM, Issue 37 2009
Naoto Matsuyama
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Solid-phase synthesis of C -terminally modified peptides

JOURNAL OF PEPTIDE SCIENCE, Issue 11 2006
Hefziba T. Ten Brink
Abstract In this paper, a straightforward and generic protocol is presented to label the C -terminus of a peptide with any desired moiety that is functionalized with a primary amine. Amine-functional molecules included are polymers (useful for hybrid polymers), long alkyl chains (used in peptide amphiphiles and stabilization of peptides), propargyl amine and azido propyl-amine (desirable for ,click' chemistry), dansyl amine (fluorescent labeling of peptides) and crown ethers (peptide switches/hybrids). In the first part of the procedure, the primary amine is attached to an aldehyde-functional resin via reductive amination. To the secondary amine that is produced, an amino acid sequence is coupled via a standard solid-phase peptide synthesis protocol. Since one procedure can be applied for any given amine-functional moiety, a robust method for C -terminal peptide labeling is obtained. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd. [source]

Novel Biopolymer Structures Synthesized by Dendronization of 6-Deoxy-6-aminopropargyl cellulose

MACROMOLECULAR RAPID COMMUNICATIONS, Issue 21 2008
Matthias Pohl
Abstract Propargyl cellulose with regioselective functionalization pattern was synthesized by nucleophilic displacement reaction of 6- O -toluenesulfonyl ester of cellulose (degree of substitution, DS 0.58) with propargyl amine. The novel 6-deoxy-6-aminopropargyl cellulose provides an excellent starting material for the selective dendronization of cellulose at position 6 via the copper-catalyzed Huisgen reaction yielding 6-deoxy-6-amino-(4-methyl-[1,2,3-triazolo]-1-propyl-polyamido amine) cellulose derivatives of first- (DS 0.33) and second (DS 0.25) generation, which are soluble in polar aprotic solvents. The novel biopolymer derivatives were characterized by elemental analysis, FT-IR spectroscopy, and one- and two dimensional NMR spectroscopy, showing no side reactions (cross-linking) or impurities and no conversion at the secondary positions. [source]