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Probable Explanation (probable + explanation)
Selected AbstractsContact allergy to epoxy (meth)acrylatesCONTACT DERMATITIS, Issue 1 2009Kristiina Aalto-Korte Background: Contact allergy to epoxy (meth)acrylates, 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]propane (bis-GMA), 2,2-bis[4-(2-hydroxy-3-acryloxypropoxy)phenyl]-propane (bis-GA), 2,2-bis[4-(methacryl-oxyethoxy)phenyl] propane (bis-EMA), 2,2-bis[4-(methacryloxy)phenyl]-propane (bis-MA), and glycidyl methacrylate (GMA) is often manifested together with contact allergy to diglycidyl ether of bisphenol A (DGEBA) epoxy resin. Objective: To analyse patterns of concomitant allergic reactions to the five epoxy (meth)acrylates in relation to exposure. Methods: We reviewed the 1994,2008 patch test files at the Finnish Institute of Occupational Health (FIOH) for reactions to the five epoxy (meth)acrylates, and examined the patients' medical records for exposure. Results: Twenty-four patients had an allergic reaction to at least one of the studied epoxy (meth)acrylates, but specific exposure was found only in five patients: two bis-GMA allergies from dental products, two bis-GA allergies from UV-curable printing inks, and one bis-GA allergy from an anaerobic glue. Only 25% of the patients were negative to DGEBA epoxy resin. Conclusions: The great majority of allergic patch test reactions to bis-GMA, bis-GA, GMA and bis-EMA were not associated with specific exposure, and cross-allergy to DGEBA epoxy resin remained a probable explanation. However, independent reactions to bis-GA indicated specific exposure. Anaerobic sealants may induce sensitization not only to aliphatic (meth)acrylates but also to aromatic bis-GA. [source] Incretins and other peptides in the treatment of diabetesDIABETIC MEDICINE, Issue 3 2007J. F. Todd Abstract Glucagon-like peptide-1 (7-36) amide (GLP-1) is a gut hormone, released postprandially, which stimulates insulin secretion and insulin gene expression as well as pancreatic B-cell growth. Together with glucose-dependent insulinotropic polypeptide (GIP), it is responsible for the incretin effect which is the augmentation of insulin secretion following oral administration of glucose. Patients with Type 2 diabetes have greatly impaired or absent incretin-mediated insulin secretion which is mainly as a result of decreased secretion of GLP-1. However, the insulinotropic action of GLP-1 is preserved in patients with Type 2 diabetes, and this has encouraged attempts to treat Type 2 diabetic patients with GLP-1. GLP-1 also possesses a number of potential advantages over existing agents for the treatment of Type 2 diabetes. In addition to stimulating insulin secretion and promoting pancreatic B-cell mass, GLP-1 suppresses glucagon secretion, delays gastric emptying and inhibits food intake. Continuous intravenous and subcutaneous administration significantly improves glycaemic control and causes reductions in both HbA1c and body weight. However, GLP-1 is metabolized extremely rapidly in the circulation by the enzyme dipeptidyl peptidase IV (DPP-IV). This is the probable explanation for the short-lived effect of single doses of native GLP-1, making it an unlikely glucose-lowering agent. The DPP-IV resistant analogue, exenatide, has Food and Drug Administration (FDA) approval for the treatment of Type 2 diabetes and selective DPP-IV inhibitors are under development. Both approaches have demonstrated remarkable efficacy in animal models and human clinical studies. Both are well tolerated and appear to have advantages over current therapies for Type 2 diabetes, particularly in terms of the effects on pancreatic B-cell restoration and potential weight loss. [source] Day-of-the-Week Effect in High MomentsFINANCIAL MARKETS, INSTITUTIONS & INSTRUMENTS, Issue 3 2005by Dan Galai C14; C31; G14 Evidence from equity markets worldwide indicates that the Day-of-the-Week anomaly appears to fade from the first moment of the distribution of daily returns. We report highly significant pair-wise weekend effects in high moments when comparing the first and last trading days of the week. The second moment alone appears to distinguish the return distribution of the first trading day from all others. A probable explanation of the phenomena appears to be information dissemination: corporate announcements released after closing of the last trading day of the week spill-over to the opening of the first trading day, increasing its variability and carrying the closing sign. [source] Multiple introductions promote range expansion of the mollusc Cyclope neritea (Nassariidae) in France: evidence from mitochondrial sequence dataMOLECULAR ECOLOGY, Issue 6 2006B. SIMON-BOUHET Abstract Since the 1970s, the nassariid gastropod Cyclope neritea has been extending its range north along the French Atlantic coasts from the Iberian Peninsula. This may be due to natural spread because of the recent warming of the northeastern Atlantic. However, human-mediated introductions related to shellfish culture may also be a probable explanation for this sudden range expansion. To examine these two hypotheses, we carried out a comprehensive study based on mitochondrial gene sequences (cytochrome oxidase I) of the five recently colonized French bays as well as 14 populations located in the recognized native range of the species. From a total of 594 individuals, we observed 29 haplotypes to split into three divergent clades. In the native range, we observed a low molecular diversity, strong genetic structure and agreement between geography and gene genealogies. Along the French coasts, we observed the opposite: high genetic diversity and low genetic structure. Our results show that recurrent human-mediated introductions from several geographical areas in the native range may be a source for the French Atlantic populations. However, despite the low dispersal ability of C. neritea, the isolation-by-distance pattern in France suggested that this gastropod may have been present (although unnoticed) on the French Atlantic coasts before the 1970s. As C. neritea shows characteristics of a cryptogenic species, the classification of Atlantic populations as either native or introduced is not straightforward. Cryptogenic species should be studied further to determine the status of new populations close to their recognized native range. [source] Non-neurogenic urinary retention (Fowler's syndrome) in two sistersNEUROUROLOGY AND URODYNAMICS, Issue 7 2006Simon Podnar Abstract Aims To report for the first time occurrence of obstructed voiding due to excessive activity of the urethral sphincter (US) muscle in two sisters with polycystic ovaries (Fowler's syndrome). Methods In both patients precise micturition history was obtained. In addition, clinical neurological and gynecological examinations, cystometry, urethral pressure profile measurements, gynecological ultrasound, measurement of gonadotropic hormone levels, and concentric needle electromyography (EMG) of the US muscle were performed. Results Both sisters reported symptoms of severely obstructed voiding. Clinical examination, and filling cystometries were normal. Urethral pressures were increased (99,134 cm water). The first sister was not able to void, and the urinary flow was slow and intermittent in the second on voiding studies. Profuse complex repetitive discharges and decelerating burst activity were found on concentric needle EMG of the US in both of them. Both sisters had increased LH/FSH ratio (2.96 and 2.64), and ultrasonographic abnormalities compatible with polycystic ovaries. Conclusions Diagnosis of Fowler's syndrome was made in both sisters. Due to very low incidence rate of this syndrome (0.2/100.000 per year), we think that it is highly unlikely to find it in two sisters just by chance. We suggest that the probable explanation is a genetic predisposition to polycystic ovaries, with which this condition has been shown to be associated. Neurourol. Urodynam. 25:739,741, 2006. © 2006 Wiley-Liss, Inc. [source] Cold-climate origin of the enclosed depressions and wetlands (,spungs') of the Pine Barrens, southern New Jersey, USAPERMAFROST AND PERIGLACIAL PROCESSES, Issue 4 2001Hugh M. French Abstract The ,frost-thaw' or thermokarst-lake-basin hypothesis, first invoked by P. E. Wolfe in 1953 to explain the enclosed depressions and shallow basins (,spungs') of southern New Jersey, is re-examined. The most probable explanation is that they formed in late Wisconsinan times as deflation hollows, or ,blowouts', when strong katabatic winds flowed southwards from the continental ice margin across the sparsely vegetated, tundra terrain of the Pine Barrens. Wedge structures and cryoturbation phenomena suggest the existence of either permafrost or deep seasonal frost, and imply mean annual air temperatures of between ,0.5 °C and ,6 °C. When the groundwater table rose in late-glacial times, the hollows became ponds or wetlands. These were utilized as early as 12,000 years ago by palaeoindian and early archaic cultures as hunting camp sites. Today, many of these wetlands are drying up as the regional water table falls in response to increased water usage from agriculture and urbanization. Copyright © 2001 John Wiley & Sons, Ltd. RÉSUMÉ L'hypothèse gel-dégel ou de bassins thermokarstiques, invoquée pour la première fois par P.E. Wolfe en 1953 pour expliquer les dépressions fermées et les bassins peu profonds (spungs) du sud du New Jersey, est réexaminée. L'explication la plus probable est que ces dépressions se sont formées à la fin du Wisconsin comme des creux de déflation au moment où des vents catabatiques violents soufflaient vers le sud sur la marge de la calotte glaciaire et sur la végétation éparse de la toundra qui couvrait les Pine Barrens. Des structures en coin et des cryoturbations suggèrent l'existence, soit d'un pergélisol, soit d'un gel profond saisonnier, et impliquent des températures annuelles de l'air comprises entre , 0.5 et , 6°C. Quand la nappe aquifère s'est élevée à la fin de la glaciation, les dépressions sont devenues des mares ou des zones humides. Elles furent utilisées comme sites de camps de chasse, il y a 12000 ans par des Paléoindiens et des cultures archaïques primitives. Aujourd'hui, beaucoup de ces terres humides disparaissent à la suite de l'abaissement régional de la nappe aquifère résultant d'un accroissement de l'utilisation d'eau par l'agriculture et l'urbanisation. Copyright © 2001 John Wiley & Sons, Ltd. [source] Modulation of ongoing cognitive processes by emotionally intense wordsPSYCHOPHYSIOLOGY, Issue 2 2008Luis Carretié Abstract Contrary to what occurs with negative pictures, negative words are, in general, not capable of interfering with performance in ongoing cognitive tasks in normal subjects. A probable explanation is the limited arousing power of linguistic material. Especially intense words (insults and compliments), neutral personal adjectives, and pseudowords were presented to 28 participants while they executed a lexical decision task. Insults were associated with the poorest performance in the task and compliments with the best. Amplitude of the late positive component of the event-related potentials, originating at parietal areas, was maximal in response to compliments and insults, but latencies were delayed in response to the latter. Results suggest that intense emotional words modulate ongoing cognitive processes through both bottom-up (attentional capture by insults) and top-down (facilitation of cognitive processing by arousing words) mechanisms. [source] Advances in Polychrome Ceramics in the Islamic World of the 12th Century ADARCHAEOMETRY, Issue 2 2001R. B. Mason As part of a multidisciplinary programme of research on Islamic glazed pottery, the development of polychrome decoration during the 12th century AD has been investigated by examining polished sections through glazed pottery in an analytical scanning electron microscope. The two main decorative techniques used were underglaze and overglaze painting. The results suggest that true underglaze decoration, involving the application of pigment without any associated slip, was first developed in Syria, from where it spread to Iran, on to China and ultimately across wide areas of the world. In contrast, the overglaze technique used on mina'i ware was both very short-lived and confined to Iran. The analytical results suggest that the probable explanation for this was the technical problems associated with maturing the overglaze paint and the consequent risk of unsatisfactory products. [source] Ultra-cool and extra-vigorous: Rotation and activity in Mand L dwarfsASTRONOMISCHE NACHRICHTEN, Issue 10 2007A. Reiners, Article first published online: 27 DEC 200 Abstract The study of rotation and activity in low-mass stars or brown dwarfs of spectral classes M and L has seen enormous progress during the last years. I summarize the results from different works that measured activity, rotation, and sometimes magnetic fields. The generation of magnetic activity seems to be unchanged at the threshold to completely convective stars, i.e. no change in the efficiency of the magnetic dynamos is observed. On the other hand, a sudden change in the strength of rotational braking appears at the threshold mass to full convection, and strong evidence exists for rotational braking weakening with lower mass. A probable explanation is that the field topology changes from dipolar to small scale structure as the objects become fully convective. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Latitudinal variation in axial patterning of the medaka (Actinopterygii: Adrianichthyidae): Jordan's rule is substantiated by genetic variation in abdominal vertebral numberBIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 4 2009KAZUNORI YAMAHIRA Because the body axes of fish consist of two anatomically distinct vertebrae, abdominal and caudal, one type may be more variable in number than the other and thus contribute more to morphological diversification. Jordan's rule, a geographical tendency for fish from higher latitudes to have more vertebrae, has not been examined in terms of numbers of abdominal and/or caudal vertebrae, despite its prevalence. Vertebral observations of wild populations of the medaka (Oryzias latipes) revealed that the latitudinal increase in vertebral number is caused by an increase in abdominal vertebrae; caudal vertebrae did not vary systematically across latitudes. Laboratory experiments revealed that this latitudinal cline in abdominal vertebral number persists in a range of common environments, demonstrating a genetic basis. Phenotypic plasticity was also evident: lower developmental temperatures resulted in more abdominal vertebrae. This indicates that greater numbers of abdominal vertebrae in higher latitude individuals in the wild may be caused not only by genetic factors but by lower habitat temperatures, although the contribution of the former to Jordan's rule is assessed to be much greater. The genetic basis of the latitudinal variation in abdominal vertebral number suggests that selection on functions associated with abdominal regions is the probable explanation for Jordan's rule in this fish. © 2009 The Linnean Society of London, Biological Journal of the Linnean Society, 2009, 96, 856,866. [source] Hepatitis B virus markers in anti-HBc only positive individuals,JOURNAL OF MEDICAL VIROLOGY, Issue 3 2001Bernard Weber Abstract Isolated reactivity to hepatitis B virus (HBV) core antigen (anti-HBc) is observed relatively frequently in immunocompromised individuals, intravenous drug abusers (IVDA), and in the presence of HCV infection. The reason for the lack of HBsAg is not clear. The aim of the present study was to investigate which factors (genetic variability of S gene, low-level HBsAg, and immune complexes may be responsible for the failure of HBsAg detection with commercial HBsAg screening assays. Dilution series of two recombinant HBsAg escape mutants and dilutions of serum samples from chronic HBV carriers with multiple insertions in the a determinant and different HBsAg subtypes were tested with a highly sensitive assay that detects wild-type HBsAg (Elecsys HBsAg, Roche Diagnostics, Penzberg, Germany) and two assays that detect HBV wild-type and escape mutants (Murex HBsAg Version 3, Murex and Enzygnost HBsAg 5.0, Dade Behring, Marburg, Germany). Elecsys HBsAg showed in comparison to Murex HBsAg Version 3 and Enzygnost HBsAg 5.0 a reduced sensitivity for escape mutant detection. On the other hand, the best performance for HBsAg subtype detection was obtained with Elecsys HBsAg. In the second part of the study, a selected panel of isolated anti-HBc reactive (n,=,104) serum samples (AxSYM Core) was submitted to testing by Elecsys HBsAg, Murex HBsAg Version 3, Enzygnost HBsAg 5.0, and HBsAg detection after immune complex dissociation (ICD) and anti-HBs determination with two different assays (AxSYM Ausab and Elecsys Anti-HBs). To assess the specificity of anti-HBc test results, all the samples were tested by a second anti-HBc assay (Elecsys Anti-HBc). Quantitative HBV DNA detection was undertaken with a commercially available HBV PCR assay (Amplicor HBV Monitor). HCV infection was present in 65.4% of anti-HBc only reactive individuals. Five AxSYM Core positive samples were negative by Elecsys Anti-HBc. Overall, 15 (14.4%) AxSYM Ausab negative samples gave positive results with Elecsys Anti-HBs (median value: 21 IU/ml). No low-level HBsAg carrier was detected among the isolated anti-HBc reactive individuals with Elecsys HBsAg. There was no evidence for the presence of immune complexes. Only one sample was repeatedly reactive by the Murex HBsAg, suggesting that the a mutant form of HBsAg was responsible for the isolated anti-HBc reactivity, however neutralisation assay was not interpretable and HBV DNA PCR was negative. Fifteen (14.4%) anti-HBc only positive individuals were HBV DNA carriers with concentrations ranging from 800 to more than >4,000,000 copies of viral DNA/ml. In conclusion, the most probable explanations for isolated anti-HBc reactivity in our study group are a possible interference of HBsAg synthesis by HCV infection (65.4%) and divergence of results of anti-HBs assays (14.4%). There is no evidence for the presence of low-level HBsAg carriers and immune complexes. HBsAg mutants cannot be excluded definitively by the test strategy used in the present evaluation. J. Med. Virol. 64:312,319, 2001. © 2001 Wiley-Liss, Inc. [source] | ||||||||||||||||