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Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

Influence of Antisocial and Psychopathic Traits on Decision-Making Biases in Alcoholics

ALCOHOLISM, Issue 5 2009
Robert Miranda Jr
Background:, Although decision-making processes have become a principal target of study among addiction researchers, few studies have specifically examined decision-making among individuals with alcohol dependence (AD) and findings to date are mixed. The present study examined the relationship between AD and decision-making, and tested whether different facets of antisocial and psychopathic traits explain this association. Methods:, Participants were men with AD (n = 22), AD and comorbid antisocial personality disorder (AD + ASPD; n = 17), or a history of recreational alcohol use, but no current or lifetime symptoms of a substance use disorder, conduct disorder, or ASPD (n = 21). Decision-making was tested using the Iowa Gambling Task (IGT). Results:, Across groups, participants reported similar levels of awareness of the contingencies of the task, but the AD groups with and without ASPD had poorer IGT performance compared with controls (p < 0.05). A block-by-block analysis revealed that while AD had slow but steady improvement across the task, AD + ASPD exhibited initial improvement followed by a significant decrease in advantageous decision-making during the last 20 trials (p < 0.05). This was further confirmed via evidence that impulsive/antisocial personality traits but not psychopathic traits mediated poor IGT performance beyond ASPD diagnosis. Conclusions:, Alcohol-dependent males favored risky choices regardless of whether they met criteria for ASPD. However, decision-making deficits were more pronounced among those with ASPD, and personality traits characterized by impulsive and antisocial tendencies mediated the relationship between AD and decision-making. [source]

Non-growing Escherichia coli cells starved for glucose or phosphate use different mechanisms to survive oxidative stress,

MOLECULAR MICROBIOLOGY, Issue 4 2001
Patrice L. Moreau
Recent data suggest that superoxide dismutases are important in preventing lethal oxidative damage of proteins in Escherichia coli cells incubated under aerobic, carbon starvation conditions. Here, we show that the alkylhydroperoxide reductase AhpCF (AHP) is specifically required to protect cells incubated under aerobic, phosphate (Pi) starvation conditions. Additional loss of the HP-I (KatG) hydroperoxidase activity dramatically accelerated the death rate of AHP-deficient cells. Investigation of the composition of spent culture media indicates that ,ahpCF katG cells leak nutrients, which suggests that membrane lipids are the principal target of peroxides produced in Pi-starved cells. In fact, the introduction of various mutations inactivating repair activities revealed no obvious role for protein or DNA lesions in the viability of ahp cells. Because the death of ahp cells was directly related to ongoing aerobic glucose metabolism, we wondered how glycolysis, which requires free Pi, could proceed. 31P nuclear magnetic resonance spectra showed that Pi-starved cells consumed Pi but were apparently able to liberate Pi from phosphorylated products, notably through the synthesis of UDP-glucose. Whereas expression of the ahpCF and katG genes is enhanced in an OxyR-dependent manner in response to H2O2 challenge, we found that the inactivation of oxyR and both oxyR and rpoS genes had little effect on the viability of Pi-starved cells. In stark contrast, the inactivation of both oxyR and rpoS genes dramatically decreased the viability of glucose-starved cells. [source]

Effect of Cd transferred via food product on spermatogenesis in the rat

ANDROLOGIA, Issue 1 2010
L. Hachfi
Summary The aim of this work was to assess the effect of organic Cd on the pituitary-testicular axis in rats given diet containing Cd incorporated in radish bulb. A control group was assigned a diet containing ordinary radish for 12 week and second received for the same period a diet containing Cd-contaminated radish at the rate of 20 + 2 ,g g,1 of dry weight. At the end of treatments, the rats were anaesthetized, blood samples were collected and epididymides were removed for establishing sperm count. Circulating FSH, LH and testosterone levels were determined by electrochemiluminescence using automate (Elecsys 2110; Rochediagnostics). A decrease in FSH levels was observed in Cd-exposed animals. This seems to be at the origin of the large drop in the number of spermatozoa. Concerning the plasma testosterone levels we observed a significant increase in contaminated animals. Surprisingly, LH does not exhibit any variation, leading to the conclusion that the feedback control between testosterone and LH was disrupted by the use of Cd. In conclusion, our data indicate that the hypothalamic-pituitary axis is the principal target of Cd toxicity. [source]

Psychiatric services for people with severe mental illness across western Europe: what can be generalized from current knowledge about differences in provision, costs and outcomes of mental health care?

ACTA PSYCHIATRICA SCANDINAVICA, Issue 2006
T. Becker
Objective:, To report recent findings regarding differences in the provision, cost and outcomes of mental health care in Europe, and to examine to what extent these studies can provide a basis for improvement of mental health services and use of findings across countries. Method:, Findings from a number of studies describing mental health care in different European countries and comparing provision of care across countries are reported. Results:, The development of systems of mental health care in western Europe is characterized by a common trend towards deinstitutionalization, less in-patient treatment and improvement of community services. Variability between national mental healthcare systems is still substantial. At the individual patient level the variability of psychiatric service systems results in different patterns of service use and service costs. However, these differences are not reflected in outcome differences in a coherent way. Conclusion:, It is conceivable that the principal targets of mental healthcare reform can be achieved along several pathways taking into account economic, political and sociocultural variation between countries. Differences between mental healthcare systems appear to affect service provision and costs. However, the impact of such differences on patient outcomes may be less marked. The empirical evidence is limited and further studies are required. [source]