Home About us Contact
|
Home About us Contact | ||
|
|
||
Pressing Questions (pressing + question)
Selected AbstractsMelanoma stem cells: targets for successful therapy?JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Issue 7 2008Roland Houben Summary Increasing evidence suggests that cancer is a disease in which the persistence of the tumor relies on a small population of tumor-initiating cells, the so called tumor stem cells (TSC). Only these cells are capable of self-renewal and thereby possess the ability for unlimited proliferation. One reason for the inability of conventional tumor treatments to achieve long-term cures seems to be that TSC are resistant to many therapeutic approaches. A detailed characterization of TSC should have a substantial impact on the optimization of therapeutic protocols. While TSC in hematopoietic malignancies have been most intensively studied, subpopulations with stem cell properties have been identified in some solid tumors including breast carcinomas, gliomas and melanomas. In case of melanoma, however, a clear-cut molecular characterization is still pending. Considerable research is needed to establish standard procedures for the isolation of melanoma stem cells to facilitate determining how these cells, critical for tumor persistence and progression, can be effectively eliminated. A pressing question is if melanoma stem cells are in principle sensitive to immunotherapy. [source] Fiddling While the World BurnsARCHITECTURAL DESIGN, Issue 3 2010Neil Spiller Abstract Neil Spiller sharpens his claws and puts some bite into his final ,Bits' in this closing edition of AD+. He addresses the pressing question of climate change and politicians', architects' and the construction industry's general proclivity to bury their heads in the sand or to ,fiddle' tangentially in another direction. Copyright © 2010 John Wiley & Sons, Ltd. [source] Seascape genetics and the spatial ecology of marine populationsFISH AND FISHERIES, Issue 4 2008Kimberly A Selkoe Abstract Molecular tools perform at their best when integrated with other data and approaches. The value of integrating approaches is especially high when the underlying genetic signal is relatively weak, as occurs in many marine species. Recently, studies combining genetic, oceanographic, behavioural and modelling approaches have provided new insights into the spatial ecology of marine populations, in particular regarding larval migration, barriers to dispersal and source-sink population dynamics. In this perspectives piece, we explore the advantages of a multidisciplinary approach to marine population genetics by (i) providing a synthesis of what has been learned about connectivity from studies that combine genetic data with other tools, (ii) discussing how incorporation of ecological and oceanographic information into alternative hypotheses can boost inference when genetic power is low, and (iii) summarizing recent innovations in statistical population genetics that enable seamless integration of ecological, environmental and genetic data. These topics are covered in the context of how genetic inferences of connectivity and dispersal can contribute to pressing questions facing marine conservation and management. [source] Evolution on ecological time-scalesFUNCTIONAL ECOLOGY, Issue 3 2007S. P. CARROLL Summary 1Ecologically significant evolutionary change, occurring over tens of generations or fewer, is now widely documented in nature. These findings counter the long-standing assumption that ecological and evolutionary processes occur on different time-scales, and thus that the study of ecological processes can safely assume evolutionary stasis. Recognition that substantial evolution occurs on ecological time-scales dissolves this dichotomy and provides new opportunities for integrative approaches to pressing questions in many fields of biology. 2The goals of this special feature are twofold: to consider the factors that influence evolution on ecological time-scales , phenotypic plasticity, maternal effects, sexual selection, and gene flow , and to assess the consequences of such evolution , for population persistence, speciation, community dynamics, and ecosystem function. 3The role of evolution in ecological processes is expected to be largest for traits that change most quickly and for traits that most strongly influence ecological interactions. Understanding this fine-scale interplay of ecological and evolutionary factors will require a new class of eco-evolutionary dynamic modelling. 4Contemporary evolution occurs in a wide diversity of ecological contexts, but appears to be especially common in response to anthropogenic changes in selection and population structure. Evolutionary biology may thus offer substantial insight to many conservation issues arising from global change. 5Recent studies suggest that fluctuating selection and associated periods of contemporary evolution are the norm rather than exception throughout the history of life on earth. The consequences of contemporary evolution for population dynamics and ecological interactions are likely ubiquitous in time and space. [source] Toward a Critical Phenomenology of "Illegality": State Power, Criminalization, and Abjectivity among Undocumented Migrant Workers in Tel Aviv, IsraelINTERNATIONAL MIGRATION, Issue 3 2007Sarah S. Willen ABSTRACT Given the vast scope and magnitude of the phenomenon of so-called "illegal" migration in the present historical moment, this article contends that phenomenologically engaged ethnography has a crucial role to play in sensitizing not only anthropologists, but also policymakers, politicians, and broader publics to the complicated, often anxiety-ridden and frightening realities associated with "the condition of migrant illegality," both of specific host society settings and comparatively across the globe. In theoretical terms, the article constitutes a preliminary attempt to link pressing questions in the fields of legal anthropology and anthropology of transnational migration, on one hand, with recent work by phenomenologically oriented scholars interested in the anthropology of experience, on the other. The article calls upon ethnographers of undocumented transnational migration to bridge these areas of scholarship by applying what can helpfully be characterized as a "critical phenomenological" approach to the study of migrant "illegality" (Willen, 2006; see also Desjarlais, 2003). This critical phenomenological approach involves a three-dimensional model of illegality: first, as a form of juridical status; second, as a sociopolitical condition; and third, as a mode of being-in-the-world. In developing this model, the article draws upon 26 non-consecutive months of ethnographic field research conducted within the communities of undocumented West African (Nigerian and Ghanaian) and Filipino migrants in Tel Aviv, Israel, between 2000 and 2004. During the first part of this period, "illegal" migrants in Israel were generally treated as benign, excluded "Others." Beginning in mid-2002, however, a resource-intensive, government-sponsored campaign of mass arrest and deportation reconfigured the condition of migrant "illegality" in Israel and, in effect, transformed these benign "Others" into wanted criminals. By analyzing this transformation the article highlights the profound significance of examining not only the judicial and sociopolitical dimensions of what it means to be "illegal" but also its impact on migrants' modes of being-in-the-world. [source] Making the Transition to a Food Science Curriculum Based on Assessment of Learning OutcomesJOURNAL OF FOOD SCIENCE EDUCATION, Issue 2 2003R.W. Hartel ABSTRACT: Despite the well-documented advantages of switching to instruction based on assessment of learning outcomes, many academic disciplines, including food science, are still based on the traditional mode of instruction. The problems of converting from traditional to assessment-driven instruction are numerous and change in the university setting is slow. However, certain guidelines can be followed to start the process for change and evaluate the effects on student learning. A partnership between the industry being served and academic instructors is needed to ensure that assessment-based instruction is focused on the proper principles. Methods of assessment of learning outcomes need to be carefully chosen and developed to bring industry standards and student learning together. This can be done only if both direct and indirect assessments at the program level provide faculty with means to answer their most pressing questions about what students know and are able to do as a result of Food Science education. [source] | ||||||||||