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Terms modified by Premature Selected AbstractsLong chain polyunsaturated fatty acids (LC-PUFA) and perinatal developmentACTA PAEDIATRICA, Issue 4 2001B Koletzko This paper reports on the conclusions of a workshop on the role of long chain polyunsaturated fatty acids (LC-PUFA) in maternal and child health The attending investigators involved in the majority of randomized trials examining LC-PUFA status and functional outcomes summarize the current knowledge in the field and make recommendations for dietary practice. Only studies published in full or in abstract form were used as our working knowledge base. Conclusions: For healthy infants we recommend and strongly support breastfeeding as the preferred method of feeding, which supplies preformed LC-PUFA. Infant formulas for term infants should contain at least 0.2% of total fatty acids as docosahexaenoic acid (DHA) and 0.35% as arachidonic acid (AA). Since preterm infants are born with much less total body DHA and AA, we suggest that preterm infant formulas should include at least 0.35% DHA and 0.4% AA. Higher levels might confer additional benefits and should be further investigated because optimal dietary intakes for term and preterm infants remain to be defined. For pregnant and lactating women we consider it premature to recommend specific LC-PUFA intakes. However, it seems prudent for pregnant and lactating women to include some food sources of DHA in their diet in view of their assumed increase in LC-PUFA demand and the relationship between maternal and foetal DHA status. [source] Inflammatory pathways between placenta and foetusACTA PAEDIATRICA, Issue 1 2001Mikko Hallman Recent evidence indicates that intra-amniotic endotoxin (LPS) and interleukin-1 alpha (IL-1,) accelerate foetal lung maturity and protect from respiratory distress syndrome (RDS) more effectively than does antenatal glucocorticoid. Inflammatory cytokines promote development of chronic lung disease in the premature, acute RDS (ARDS) in children and adults. Systemic exposure to LPS or cytokines can result in generalized multiorgan damage. The abnormal host defence in the foetus and the premature newborn need to be considered in therapeutic interventions. [source] Infants born very premature,more prospective studies neededACTA PAEDIATRICA, Issue 10 2000M Hallman First page of article [source] The development of a specialist hostel for the community management of personality disordered offendersCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 1 2009Stephen Blumenthal Background,Since the late 1990s, in England and in Wales, there has been increasing interest in the particular challenges of managing offenders with personality disorder (PD). In 1999, a specialist hostel, managed by the probation service but with a high level of forensic mental health service input, was opened to high-risk PD offenders. Aims,To describe the first 93 high-risk residents with PD who were completing sentences under life licence, parole or probation, and their outcome. Methods,We investigated the nature of the offences residents had previously committed, their psychological profile in terms of personality patterns on the Millon Clinical Multiaxial Inventory (MCMI-III) and the Psychopathy Checklist-Revised (PCL-R), as well as staff commentary on their progress, to establish whether these factors related to outcome in terms of completion of stay in the hostel or premature discharge. Curfew failures and rearrest rates were also measured. Results,Of the 80 men who completed their residency within the two years of the study, the majority (50) left the hostel for positive reasons under mutual agreement. One-fifth were rearrested while resident, which is a lower rate than would be expected for such a group of offenders. PCL-R scores were predictive of outcome, but so was previous offending history. Self-defeating traits on the MCMI-III and negative comments written by hostel staff were also associated with failure. Conclusions,The hostel development demonstrated that probation and health services can work together to manage violent offenders with high levels of psychological dysfunction, and the evaluation provided some indications of how such arrangements might be enhanced. Copyright © 2009 John Wiley & Sons, Ltd. [source] Mortality among mentally disordered offenders: a community based follow-up studyCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2005Tabita Björk Background Follow-up information about outcome for hospitalized mentally disordered offenders (MDO) is necessary for evaluation and improvement in quality of forensic psychiatric care. Aim A study was undertaken to estimate the standard mortality rate (SMR) of a population based sample of people sentenced to forensic psychiatric care. Method All MDOs in Örebro County, Sweden, discharged from a forensic psychiatric treatment unit between 1992 and 1999 were identified (n = 46). The variables were gender, age, offence, diagnosis and duration of admission. Case linkage was made with the National Cause-of-Death register. Median follow-up time was 53 months (0,93). Results The sample yielded a significantly elevated SMR 13.4 (95% CI 4.35,31.3) times higher than that in the general population, mostly due to suicide. Conclusions The cohort size is small but representative, and it provides data from an additional country for the growing international pool confirming the high risk of premature, generally self-inflicted death among MDOs. Resettlement and rehabilitation services for them may need to take as much account of mortality risk as that of reoffending. Copyright © 2005 Whurr Publishers Ltd. [source] Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma: A Systematic Review of the English LiteratureDERMATOLOGIC SURGERY, Issue 11 2006AMY SIMON ROSS MD BACKGROUND Although most cutaneous squamous cell carcinoma (SCC) is curable by a variety of treatment modalities, a small subset of tumors recur, metastasize, and result in death. Although risk factors for metastasis have been described, there are little data available on appropriate workup and staging of patients with high-risk SCC. OBJECTIVE We reviewed reported cases and case series of SCC in which sentinel lymph node biopsy (SLNB) was performed to determine whether further research is warranted in developing SLNB as a staging tool for patients with high-risk SCC. METHODS The English medical literature was reviewed for reports of SLNB in patients with cutaneous SCC. Data from anogenital and nonanogenital cases were collected and analyzed separately. The percentage of cases with a positive sentinel lymph node (SLN) was calculated. False negative and nondetection rates were tabulated. Rates of local recurrence, nodal and distant metastasis, and disease-specific death were reported. RESULTS A total of 607 patients with anogenital SCC and 85 patients with nonanogenital SCC were included in the analysis. A SLN could not be identified in 3% of anogenital and 4% of nonanogenital cases. SLNB was positive in 24% of anogenital and 21% of nonanogenital patients. False-negative rates as determined by completion lymphadenectomy were 4% (8/213) and 5% (1/20), respectively. Most false-negative results were reported in studies from 2000 or earlier in which the combination of radioisotope and blue dye was not used in the SLN localization process. Complications were reported rarely and were limited to hematoma, seroma, cutaneous lymphatic fistula, wound infection, and dehiscence. CONCLUSIONS Owing to the lack of controlled studies, it is premature to draw conclusions regarding the utility of SLNB in SCC. The available data, however, suggest that SLNB accurately diagnoses subclinical lymph node metastasis with few false-negative results and low morbidity. Controlled studies are needed to demonstrate whether early detection of subclinical nodal metastasis will lead to improved disease-free or overall survival for patients with high-risk SCC. [source] Activity of nAChRs containing ,9 subunits modulates synapse stabilization via bidirectional signaling programsDEVELOPMENTAL NEUROBIOLOGY, Issue 14 2009Vidya Murthy Abstract Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development. We have previously demonstrated abnormal presynaptic terminal morphology following loss of nicotinic acetylcholine receptor (nAChR) ,9 subunit expression in adult cochleae. However, the molecular mechanisms underlying these changes have remained obscure. To better understand synapse formation and the role of cholinergic activity in the synaptogenesis of the inner ear, we exploit the nAChR ,9 subunit null mouse. In this mouse, functional acetylcholine (ACh) neurotransmission to the hair cells is completely silenced. Results demonstrate a premature, effusive innervation to the synaptic pole of the outer hair cells in ,9 null mice coinciding with delayed expression of cell adhesion proteins during the period of effusive contact. Collapse of the ectopic innervation coincides with an age-related hyperexpression pattern in the null mice. In addition, we document changes in expression of presynaptic vesicle recycling/trafficking machinery in the ,9 null mice that suggests a bidirectional information flow between the target of the neural innervation (the hair cells) and the presynaptic terminal that is modified by hair cell nAChR activity. Loss of nAChR activity may alter transcriptional activity, as CREB binding protein expression is decreased coincident with the increased expression of N-Cadherin in the adult ,9 null mice. Finally, by using mice expressing the nondesensitizing ,9 L9,T point mutant nAChR subunit, we show that increased nAChR activity drives synaptic hyperinnervation. © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2009 [source] The role of environmental gradients in non-native plant invasion into burnt areas of Yosemite National Park, CaliforniaDIVERSITY AND DISTRIBUTIONS, Issue 2 2006Rob Klinger ABSTRACT Fire is known to facilitate the invasion of many non-native plant species, but how invasion into burnt areas varies along environmental gradients is not well-understood. We used two pre-existing data sets to analyse patterns of invasion by non-native plant species into burnt areas along gradients of topography, soil and vegetation structure in Yosemite National Park, California, USA. A total of 46 non-native species (all herbaceous) were recorded in the two data sets. They occurred in all seven of the major plant formations in the park, but were least common in subalpine and upper montane conifer forests. There was no significant difference in species richness or cover of non-natives between burnt and unburnt areas for either data set, and environmental gradients had a stronger effect on patterns of non-native species distribution, abundance and species composition than burning. Cover and species richness of non-natives had significant positive correlations with slope (steepness) and herbaceous cover, while species richness had significant negative correlations with elevation, the number of years post-burn, and cover of woody vegetation. Non-native species comprised a relatively minor component of the vegetation in both burnt and unburnt areas in Yosemite (percentage species = 4%, mean cover < 6.0%), and those species that did occur in burnt areas tended not to persist over time. The results indicate that in many western montane ecosystems, fire alone will not necessarily result in increased rates of invasion into burnt areas. However, it would be premature to conclude that non-native species could not affect post-fire succession patterns in these systems. Short fire-return intervals and high fire severity coupled with increased propagule pressure from areas used heavily by humans could still lead to high rates of invasion, establishment and spread even in highly protected areas such as Yosemite. [source] External exoskeletal cavities in Coleoptera and their possible mycangial functionsENTOMOLOGICAL SCIENCE, Issue 1 2010Vasily V. GREBENNIKOV Abstract This paper reviews the occurrence of external exoskeletal cavities in beetles and provides critical reassessment of their possible mycangial function. In most reported cases, the decision to attribute mycangial function to exoskeletal cavities was based solely on the combination of two factors: (i) observation of these cavities on beetle's body; and (ii) knowledge that this particular beetle species uses fungi as a food source. Such reasoning resulted in the assumption, occasionally premature and not supported by other evidence, that exoskeletal pits in the following families may function as mycangia: Rhysodidae, Ptiliidae, Staphylinidae, Hybosoridae, Scarabaeidae, Derodontidae, Ptinidae, Jacobsoniidae, Boganiidae, Cryptophagidae, Endomychidae, Erotylidae, Latridiidae, Nitidulidae, Phloeostichidae, Silvanidae, Sphindidae, Pyrochroidae, Anthribidae, Attelabidae and Curculionidae. We conclude that only two beetle families include species with adequately documented cases of external exoskeletal mycangia: (i) Curculionidae (some Scolytinae and Platypodinae); and (ii) the structurally complex mycangia of Attelabidae (Euops females). One or more species of Sphindidae, Erotylidae, Silvanidae, and Latridiidae have likely functional mycangia. Exoskeletal pits with uncertain function are additionally reported from the following families: Cupedidae, Ommatidae, Lepiceridae, Carabidae, Histeridae, Hydraenidae, Leiodidae, Elmidae, Artematopodidae, Throscidae, Elateridae, Rhinorhipidae, Biphyllidae, Cerylonidae, Cyclaxyridae, Monotomidae, Mycetophagidae and Zopheridae. We also discuss the transport of fungal spores and conidia by waxy exudates or debris build up on beetle exoskeleton, as well as their passive attachment to the body. [source] A view of extraterrestrial soilsEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 6 2009G. Certini Summary The nature of soils on celestial bodies other than Earth is a growing area of research in planetary geology. However, disagreement over the significance of these deposits arises, in part, through the lack of a unified concept and definition of soil in the literature. The pragmatic definition ,medium for plant growth' is taken by some to imply the necessity of biota for soil to exist, and has been commonly adopted in the planetary science community. In contrast, a more complex and informative definition is based on scientific theory: soil is the (bio)geochemically/physically altered material at the surface of a planetary body that encompasses surficial extraterrestrial telluric deposits. This definition is based on the premise that soil is a body that retains information about its environmental history and that it does not need the presence of life to form. Four decades of missions have gathered geochemical information regarding the surface of planets and bodies within the Solar System, and information is quickly increasing. Reviewing the current knowledge on properties of extraterrestrial regoliths, we conclude that the surficial deposits of Venus, Mars and our moon should be considered to be soils in a pedological sense, and that Mercury and some large asteroids are covered in mantles that are soil candidates. A key environmental distinction between Earth and other Solar System bodies is the presence of life, and because of this dissimilarity in soil-forming processes, it is reasonable to distinguish these (presently) abiotic soils as Astrosols. Attempts to provide detailed classifications of extraterrestrial soils are premature, given our poor current knowledge of the Universe, but they highlight the fact that Earth possesses almost-abiotic environments that lend themselves to providing more understanding about telluric bodies of the Solar System. "He found himself in the neighbourhood of the asteroids 325, 326, 327, 328, 329, and 330. He began, therefore, by visiting them, in order to add to his knowledge." (Excerpt from the The Little Prince by Antoine de Saint-Exupéry) [source] THE LOCUS OF EVOLUTION: EVO DEVO AND THE GENETICS OF ADAPTATIONEVOLUTION, Issue 5 2007Hopi E. Hoekstra An important tenet of evolutionary developmental biology ("evo devo") is that adaptive mutations affecting morphology are more likely to occur in the cis -regulatory regions than in the protein-coding regions of genes. This argument rests on two claims: (1) the modular nature of cis -regulatory elements largely frees them from deleterious pleiotropic effects, and (2) a growing body of empirical evidence appears to support the predominant role of gene regulatory change in adaptation, especially morphological adaptation. Here we discuss and critique these assertions. We first show that there is no theoretical or empirical basis for the evo devo contention that adaptations involving morphology evolve by genetic mechanisms different from those involving physiology and other traits. In addition, some forms of protein evolution can avoid the negative consequences of pleiotropy, most notably via gene duplication. In light of evo devo claims, we then examine the substantial data on the genetic basis of adaptation from both genome-wide surveys and single-locus studies. Genomic studies lend little support to the cis -regulatory theory: many of these have detected adaptation in protein-coding regions, including transcription factors, whereas few have examined regulatory regions. Turning to single-locus studies, we note that the most widely cited examples of adaptive cis -regulatory mutations focus on trait loss rather than gain, and none have yet pinpointed an evolved regulatory site. In contrast, there are many studies that have both identified structural mutations and functionally verified their contribution to adaptation and speciation. Neither the theoretical arguments nor the data from nature, then, support the claim for a predominance of cis -regulatory mutations in evolution. Although this claim may be true, it is at best premature. Adaptation and speciation probably proceed through a combination of cis -regulatory and structural mutations, with a substantial contribution of the latter. [source] Relationships among vertically structured in situ measures of turbulence, larval fish abundance and feeding success and copepods on Western Bank, Scotian ShelfFISHERIES OCEANOGRAPHY, Issue 3 2002ChristianS. Using vertically stratified data of the abundance of silver hake (Merluccius bilinearis) larvae and concentrations of copepods collected in the field, we examine relationships among the vertical distribution of larval fish, their potential prey, feeding success and water column turbulence. Water column turbulence and associated stratification parameters were estimated from: (i) in situ measures of turbulent kinetic energy dissipation (,) provided by an EPSONDE profiler; (ii) in situ wind speed; (iii) the Richardson number (Ri); and (iv) the buoyancy frequency (N2). Small (< 5 mm total length) silver hake were more abundant in the least turbulent waters (i.e. at a minimum in the rate of dissipation of turbulent kinetic energy, , < 10,7 W kg,1; Ri > 0.25; N2 > 0.001 (rad s,1)2). Partial correlations amongst ,, N2 and small hake larvae were significant only for N2. The abundance of larger (> 5 mm total length) hake larvae was positively correlated with depth and was not associated with either , or N2. Vertical distributions of three potential prey (classified by stage) were variable. Early stage copepodids were positively correlated with N2 and negatively correlated with ,. We found no evidence of diel distribution patterns for small (< 5 mm total length) hake larvae or for any of the developmental stages of the copepods examined. Neither estimate of water column turbulence inferred from wind speed nor from Ri was meaningfully related to in situ estimates of , or to larval fish abundance. Feeding success, measured either as prey items (gut),1, average prey length, or total prey volume (gut),1, was not related to predicted encounter rates between days. However, the average prey length (gut),1 was significantly (P < 0.01) related to water column turbulence. These conflicting results suggest that the relationship between larval feeding and the environment is more complicated than assumed. We conclude that without substantial high resolution in situ examination of the relationship between the vertical distributions of turbulence, larvae and their prey, the growing acceptance in the secondary literature that turbulence has a positive and biologically meaningful effect on trophic interactions between fish and their zooplankton prey (a generalization based largely on modelling and laboratory experiments) is premature. [source] On future non-medical costs in economic evaluationsHEALTH ECONOMICS, Issue 5 2008Bengt Liljas Abstract Economic evaluation in health care is still an evolving discipline. One of the current controversies in cost-effectiveness analysis regards the inclusion or exclusion of future non-medical costs (i.e. consumption net of production) due to increased survival. This paper examines the implications of a symmetry rule stating that there should be consistency between costs included in the numerator and utility aspects included in the denominator. While the observation that no quality-adjusted life year (QALY) instruments explicitly include consumption and leisure seems to give support to the notion that future non-medical costs should be excluded when QALYs are used as the outcome measure, a better understanding of what respondents actually consider when reporting QALY weights is required. However, the more fundamental question is whether QALYs can be interpreted as utilities. Or more precisely, what are the assumptions needed for a general utility model also including consumption and leisure to be consistent with QALYs? Once those assumptions are identified, they need to be experimentally tested to see whether they are at least approximately valid. Until we have answers to these areas for future research, it seems premature to include future non-medical costs. Copyright © 2007 John Wiley & Sons, Ltd. [source] Maternal health: does prenatal care make a difference?HEALTH ECONOMICS, Issue 5 2006Karen Smith Conway Abstract This research attempts to close an important gap in health economics regarding the efficacy of prenatal care and policies designed to improve access to that care, such as Medicaid. We argue that a key beneficiary , the mother , has been left completely out of the analysis. If prenatal care significantly improves the health of the mother, then concluding that prenatal care is ,ineffective' or that the Medicaid expansions are a ,failure' is premature. This paper seeks to rectify the oversight by estimating the impact of prenatal care on maternal health and the associated cost savings. We first set up a joint maternal,infant health production framework that informs our empirical analysis. Using data from the National Maternal and Infant Health Survey, we estimate the effects of prenatal care on several different measures of maternal health such as body weight status and excessive hospitalizations. Our results suggest that receiving timely and adequate prenatal care may increase the probability of maintaining a healthy weight after the birth and, perhaps for blacks, of avoiding a lengthy hospitalization after the delivery. Given the costs to society of obesity and hospitalization, these are benefits worth exploring before making conclusions about the effectiveness of prenatal care , and Medicaid. Copyright © 2006 John Wiley & Sons, Ltd. [source] Synthesis and insecticidal evaluation of novel N-oxalyl derivatives of diacylhydrazines containing methylcarbamate moietiesHETEROATOM CHEMISTRY, Issue 6 2005Chunhui Mao A series of new N -oxalyl derivatives of diacylhydrazines containing methylcarbamate moieties were synthesized by the reaction of N -oxalyl chloride of N -methylcarbmates with N - tert -butyl- N,N,-diacylhydrazines in the presence of sodium hydride. The reaction of oxalyl chloride with N - tert -butyl- N, N,-diacylhydrazines to yield 1,3,4-oxadiazole and 4- tert -butyl-2-substituted-phenyl-4H -1,3,4-oxadiazine-5,6-dione was found, and the reaction was studied in some detail. The title compounds were evaluated for molting hormone mimicking activity. The results of bioassay showed that the title compounds exhibit moderate larvicidal activities, and toxicity assays indicated that these compounds can induce a premature, abnormal, and lethal larval molt. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:472,475, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20135 [source] Organizational entrepreneurship: Theoretical background, some empirical tests, and directions for future researchHUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 1 2005Mariusz Bratnicki The widely held contemporary perspective on entrepreneurship is dangerously premature. Currently existing theories are insufficient to understand the dynamic interplay among entrepreneurship, the state, and external environment forces, as well as the organization's capacity to facilitate entrepreneurship and resulting effectiveness. In this exploratory paper I identify organizational architecture variables that help to shape a firm's entrepreneurship. The topic of organizational enablers is introduced. The primary purpose of the investigation falls under a category of exploration of dialectics' potential for entrepreneurship theory and development concept that refers to strategic contradictions, organizational enablers, and entrepreneurial behaviors. In particular, it focuses on understanding the organizational context of entrepreneurship and understanding the entrepreneurial reconciliation made by managers who seek to increase their company's growth. I investigate empirically how reconciliation of primary and secondary contradictions is related to entrepreneurial behaviors. The in-depth examination of organizational enablers and entrepreneurial behavior is only one example of how a dialectical approach can reshape our understanding of the complex, multilevel entrepreneurship process, which may have less to do with the behavior of individual members than with impersonal and seemingly insignificant forces. Finally, implications for future research are discussed. © 2005 Wiley Periodicals, Inc. Hum Factors Man 15: 15,33, 2005. [source] Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis,HUMAN MUTATION, Issue 8 2006Niels Teich Abstract Ten years ago, the groundwork for the discovery of the genetic basis of chronic pancreatitis was laid by linkage analyses of large kindreds with autosomal dominant hereditary chronic pancreatitis. Subsequent candidate gene sequencing of the 7q35 chromosome region revealed a strong association of the c.365G>A (p.R122 H) mutation of the PRSS1 gene encoding cationic trypsinogen with hereditary pancreatitis. In the following years, further mutations of this gene were discovered in patients with hereditary or idiopathic chronic pancreatitis. In vitro the mutations increase autocatalytic conversion of trypsinogen to active trypsin and thus probably cause premature, intrapancreatic trypsinogen activation in vivo. The clinical presentation is highly variable, but most affected mutation carriers have relatively mild disease. In this review, we summarize the current knowledge on trypsinogen mutations and their role in pancreatic diseases. Hum Mutat 27(8), 721,730, 2006. © 2006 Wiley-Liss, Inc. [source] Beyond the Producer-driven/Buyer-driven Dichotomy The Evolution of Global Value Chains in the Internet EraIDS BULLETIN, Issue 3 2001Gary Gereffi Summaries The Internet is still in the early stages of its development, but its impact on global value chains is already evident. While it may be premature to try to identify lasting changes on producer-driven and buyer-driven chains, several possible scenarios are emerging and they are not mutually exclusive. The first scenario is that electronic commerce will lead to the emergence of infomediary-based value chains that privilege direct on-line access to consumers. A second scenario is that the Internet is really just extending the logic of buyer-driven chains as both information and power continue to shift inexorably from manufacturers, marketers and retailers to consumers. A third scenario is that the impact of the Internet will be captured and integrated into the practices of large established companies, thus reinforcing power relationships in existing producer-driven and buyer-driven governance structures. Although there is evidence to support all three scenarios, the third model currently seems to be dominant. [source] Sexual dysfunction in subjects with Klinefelter's syndromeINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 4 2010G. Corona Summary While the association of Klinefelter's Syndrome (KS) with infertility is well-known, very few investigations have evaluated the prevalence of sexual dysfunction in KS. The aim of the present study was to systematically analyse the prevalence of KS in a consecutive series of adult male patients consulting for sexual problems and to investigate its specific correlates. Among a consecutive series of 1386 men (mean age 48.9 ± 12.7 years old), 23 (1.7%) subjects with KS were found. Patients with KS were younger and more often hypogonadal when compared with the rest of the sample. Among patients with KS, five (22.7%) subjects reported severe erectile dysfunction, 14 (60.9%) hypoactive sexual desire (HSD), two (9.5%) premature and two (9.5%) delayed ejaculation. Only the association between KS and HSD was confirmed after adjustment for age [HR = 3.2 (1.37,7.5)], however, when patients with KS were compared with age, smoking habit, and testosterone matched controls, even the association between KS with HSD disappeared. In comparison to matched hypogonadal controls, subjects with KS had lower levels of education, a higher frequency of cryptorchidism and poorer pubertal progression. In conclusion, our results indicate that sexual dysfunction present in KS is not specifically associated with the syndrome but is caused by the underlying hypogonadal state. Further studies are needed to evaluate the efficacy of testosterone substitution in ameliorating the hypoactive sexual desire often reported in subjects with KS. [source] Discover dependency pattern among attributes by using a new type of nonlinear multiregressionINTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 8 2001Kebin Xu Multiregression is one of the most common approaches used to discover dependency pattern among attributes in a database. Nonadditive set functions have been applied to deal with the interactive predictive attributes involved, and some nonlinear integrals with respect to nonadditive set functions are employed to establish a nonlinear multiregression model describing the relation between the objective attribute and predictive attributes. The values of the nonadditive set function play a role of unknown regression coefficients in the model and are determined by an adaptive genetic algorithm from the data of predictive and objective attributes. Furthermore, such a model is now improved by a new numericalization technique such that the model can accommodate both categorical and continuous numerical attributes. The traditional dummy binary method dealing with the mixed type data can be regarded as a very special case of our model when there is no interaction among the predictive attributes and the Choquet integral is used. When running the algorithm, to avoid a premature during the evolutionary procedure, a technique of maintaining diversity in the population is adopted. A test example shows that the algorithm and the relevant program have a good reversibility for the data. © 2001 John Wiley & Sons, Inc.16: 949,962 (2001) [source] Immigrant Place Entrepreneurs in Los Angeles, 1970,99INTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 2 2002Ivan Light Proclamations of the death of Los Angeles' growth machine are premature. These proclamations overlook the growing role of immigrant Korean and Chinese entrepreneurs in regional property development. Since 1970, Korean and Chinese entrepreneurs have seriously restructured Los Angeles' morphology, creating hierarchically arranged residential and business clusters for co,ethnic immigrants. Koreatown and Monterey Park are the brand names most familiar to outsiders, but these prominent localities really coexist with a multiplicity of less well,known ethnic communities that owe their origins to immigrant property developers. The immigrant property developers use the classic methods of the growth machine: buy land cheaply, promote it in Chinese or Korean emigration basins, then sell it to co,ethnic immigrants at a profit. In the process, the immigrant property developers reduce the difficulty of immigration to Los Angeles at the same time that they enhance its perceived desirability. The success of the Chinese and Korean developers highlights the hazard of assuming, as is conventionally done, that ethnic residential clustering arises from leaderless social processes. In both these highlighted cases, entrepreneurial elites created residential clusters of co,ethnics from conscious, long,term plans that required political as well as economic savoir,faire. In so doing, the immigrant property developers joined the Los Angeles growth machine whose fortunes, admittedly, have been waning among the native born population of the region. La mort annoncée de la dynamique de croissance de Los Angeles est prématurée. Ce serait oublier le rôle grandissant des chefs d'entreprise immigrés coréens et chinois dans l'aménagement immobilier régional. Depuis 1970, ces entrepreneurs ont considérablement restructuré la morphologie de Los Angeles, créant des ,agglomérats' commerciaux et résidentiels hiérarchisés pour migrants de m?,me ethnie. Si Koreatown et Monterey Park sont des noms bien connus des étrangers, ces lieux dominants coexistent en réalité avec une multiplicité de communautés ethniques moins renommées qui doivent leurs origines à des promoteurs immigrés. Ces derniers appliquent les mécanismes classiques de la prospérité: acheter le terrain bon marché, le promouvoir dans des bassins d'émigration chinois ou coréens, puis le vendre à profità des immigrants co,ethniques. Ainsi, les promoteurs immigrés facilitent l'immigration vers Los Angeles tout en en accentuant l'aspect attractif. La réussite des aménageurs chinois et coréens souligne le risque qu'il y a à supposer, comme bien souvent, que tout regroupement résidentiel ethnique naît de processus sociaux non dirigés. Dans les deux cas exposés, les élites commerciales ont créé des regroupements résidentiels de m?,me ethnie selon des plans délibérés à long terme, impliquant un savoir,faire à la fois politique et économique. Ce faisant, les promoteurs immigrés ont rejoint la dynamique de croissance de Los Angeles qui, il est vrai, a vu décliner les succès au sein de sa population de souche. [source] Some Problems and Possibilities in the Study of Dynamical Social ProcessesJOURNAL FOR THE THEORY OF SOCIAL BEHAVIOUR, Issue 1 2000John E. Puddifoot The recent challenge of Dynamical Systems Theory (also known as ComplexityTheory or Chaos Theory) to the social sciences, is based largely on the beliefthat processes in the social arena can be considered as analogous to those of the natural world, and that in consequence general theoretical advances in explaining the latter might with advantage be applied to the former. This paper aims to show that claims for Dynamical Systems Theory with respect to the understanding or measurement of social processes would be premature; the reasons for this lying not only in the unfamiliarity and operational difficulties of Dynamical Systems Theory in itself, but also in the problematic nature and history of our usage of the term ,social process'. Reviewing some examples of such usage from Sociology and Social Psychology, it is concluded that Dynamical Systems Theory might serve as a catalyst for a re-examination of existing orthodoxies and major concepts, but that progress would be retarded by the uncritical application of it's terminology, concepts, and techniques of mathematical modelling, without this prior and demanding first step. [source] Positive Regulation of Adult Bone Formation by Osteoblast-Specific Transcription Factor Osterix,,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 6 2009Wook-Young Baek Abstract Osterix (Osx) is essential for osteoblast differentiation and bone formation, because mice lacking Osx die within 1 h of birth with a complete absence of intramembranous and endochondral bone formation. Perinatal lethality caused by the disruption of the Osx gene prevents studies of the role of Osx in bones that are growing or already formed. Here, the function of Osx was examined in adult bones using the time- and site-specific Cre/loxP system. Osx was inactivated in all osteoblasts by Col1a1-Cre with the activity of Cre recombinase under the control of the 2.3-kb collagen promoter. Even though no bone defects were observed in newborn mice, Osx inactivation with 2.3-kb Col1a1-Cre exhibited osteopenia phenotypes in growing mice. BMD and bone-forming rate were decreased in lumbar vertebra, and the cortical bone of the long bones was thinner and more porous with reduced bone length. The trabecular bones were increased, but they were immature or premature. The expression of early marker genes for osteoblast differentiation such as Runx2, osteopontin, and alkaline phosphatase was markedly increased, but the late marker gene, osteocalcin, was decreased. However, no functional defects were found in osteoclasts. In summary, Osx inactivation in growing bones delayed osteoblast maturation, causing an accumulation of immature osteoblasts and reducing osteoblast function for bone formation, without apparent defects in bone resorption. These findings suggest a significant role of Osx in positively regulating osteoblast differentiation and bone formation in adult bone. [source] Effects of Low-Dose Prednisone on Bone Metabolism,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 3 2005Francine N Ton MD Abstract Prednisone 5 mg/day suppresses multiple indices of bone formation in a randomized placebo-controlled trial in healthy postmenopausal females. This suggests that even low doses of prednisone may reduce bone repair or renewal and may have adverse effects on bone mass and/or bone strength. Introduction: High doses of chronic glucocorticoids are known to have adverse effects on bone, and measures to prevent bone loss are well established for doses >7.5 mg daily, because these doses can cause premature or exaggerated osteoporosis. However, it is unclear if chronic prednisone doses of 5 mg daily have the same effects on bone. There are no established recommendations for preventing glucocorticoid-induced osteoporosis in people taking prednisone 5 mg daily, a dose used frequently in medical practice to treat diseases of the lungs, joints, skin, muscles, eyes, nerves, etc. Our primary objective was to test whether prednisone 5 mg daily affects serum and urine indices of bone metabolism in healthy postmenopausal women. Our secondary objectives were to determine if prednisone 5 mg affected systolic or diastolic blood pressure or causes side effects. Materials and Methods: A double-blinded randomized placebo-controlled 8-week trial in 50 healthy postmenopausal women was conducted at the Massachusetts General Hospital Outpatient General Clinical Research Center. Patients were randomly assigned to prednisone 5 mg daily or matching placebo for 6 weeks, followed by a 2-week recovery phase. Markers of bone formation and resorption were determined at weeks 0, 2, 4, 6, and 8. Indices of osteoblast activity included serum propeptide of type I N-terminal procollagen (PINP), propeptide of type I C-terminal procollagen (PICP), osteocalcin, and bone-specific alkaline phosphatase (BSALP). Indices of osteoclast activity included urine and serum type I collagen N-telopeptide (NTX) and free urinary deoxypyridinoline (DPD). Results and Conclusions: Prednisone rapidly and significantly decreased serum PINP (p < 0.01), PICP (p < 0.01), and osteocalcin (p < 0.01) and free urinary deoxypyridinoline (p = 0.017). These changes were largely reversed during the recovery period. Side effects were indistinguishable in the two groups. Neither systolic nor diastolic blood pressure changed significantly throughout the study between the two groups. In conclusion, low-dose prednisone significantly decreases indices of bone formation and may decrease indices of bone resorption in postmenopausal women. Further studies are needed to assess the effects of low-dose prednisone on BMD and fracture risk. [source] Keeping Our Ambition Under Control: The Limits of Data and Inference in Searching for the Causes and Consequences of Vanishing Trials in Federal CourtJOURNAL OF EMPIRICAL LEGAL STUDIES, Issue 3 2004Stephen B. Burbank This article offers some reflections stimulated by Professor Galanter's materials, which were the common springboard for the Vanishing Trials Symposium. It suggests that other data, quantitative and qualitative, may be helpful in understanding the vanishing trials phenomenon in federal civil cases, notably data available for years prior to 1962, and questions whether it is meaningful to use total dispositions as the denominator in calculating a trial termination rate. The article argues that care should be taken in using data from state court systems, as also data from criminal cases, administrative adjudication, and ADR, lest one put at risk through careless assimilation of data or muddled thinking a project quite difficult enough without additional baggage. The article describes the limitations of data previously collected by the Administrative Office of the U.S. Courts and highlights unique opportunities created by the AO's switch to a new Case Management/Electronic Case Files system. It argues that Professor Galanter may underestimate the influence of both changing demand for court services (docket makeup) and of changing demand for judicial services (resources) on the trial rate. Finally, the article argues that conclusions about either the causes or consequences of the vanishing trials phenomenon in federal civil cases are premature, suggesting in particular reasons to be wary of emphasis on "institutional factors" such as the discretionary power of first-instance judges and the ideology of managerial judging. [source] Firm-level Disclosures and the Relative Roles of Culture and Legal OriginJOURNAL OF INTERNATIONAL FINANCIAL MANAGEMENT & ACCOUNTING, Issue 3 2003Ole-Kristian Hope In this paper, I investigate the relative roles of legal origin and national culture in explaining firm-level disclosure levels internationally. Using a significantly larger and more representative sample than prior research, I document, using univariate and multivariate analyses, that both legal origin and culture (as operationalized by Hofstede and Schwartz) are important in explaining firm disclosure. Neither legal origin nor culture dominates with respect to overall explanatory power for variations in disclosure levels. Consequently, it is premature to write off culture as an important factor in the financial reporting environment. Furthermore, I find that legal origin is an important conditioning variable for the role of culture. Finally, although legal origin is a key determinant of disclosure levels, I hypothesize and find that its importance decreases with the richness of a firm's information environment. [source] An Examination of Cross-Racial Comparability of Mother-Child Interaction Among African American and Anglo American FamiliesJOURNAL OF MARRIAGE AND FAMILY, Issue 3 2001Leanne Whiteside-Mansell This study examined the cross-racial comparability of maternal quality of assistance and supportive presence coded from a video protocol using data from the Infant Health and Development Program for low-birth-weight, premature 30-month-olds and their mothers. Evidence of equivalence of measures is necessary before comparisons can be made across groups. Multiple-group mean and covariance structures analysis was used to demonstrate the invariance of the measures and make comparisons for Anglo American and African American treatment and comparison groups of dyads. Comparisons across groups indicated similar variances and correlation between child and maternal behavior. Differences were found between the mean scores, with Anglo American treatment families scoring the highest. [source] Development of synthetic double helical polymers and oligomersJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 20 2009Yoshio Furusho Abstract There is growing interest in the design and synthesis of artificial helical polymers and oligomers, in connection with biological importance as well as development of novel chiral materials. Since the discovery of the helical structure of isotactic polypropylene, a significant advancement has been achieved for synthetic polymers and oligomers with a single helical conformation for about half a century. In contrast, the chemistry of double helical counterparts is still premature. This short review highlights the recent advances in the synthesis, structures, and functions of double helical polymers and oligomers, featuring an important role of supramolecular chemistry in the design and synthesis of double helices. Although the artificial double helices reported to date are still limited in number, recent advancement of supramolecular chemistry provides plenty of structural motifs for new designs. Therefore, artificial double helices hold great promise as a new class of compounds. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5195,5207, 2009 [source] In Utero Ethanol Exposure Impairs Defenses Against Experimental Group B Streptococcus in the Term Guinea Pig LungALCOHOLISM, Issue 2 2009Theresa W. Gauthier Background:, The effects of fetal alcohol exposure on the risks of neonatal lung injury and infection remain under investigation. The resident alveolar macrophage (AM) is the first line of immune defense against pulmonary infections. In utero ethanol (ETOH) exposure deranges the function of both premature and term guinea pig AM. We hypothesized that fetal ETOH exposure would increase the risk of pulmonary infection in vivo. Methods:, We developed a novel in vivo model of group B Streptococcus (GBS) pneumonia using our established guinea pig model of fetal ETOH exposure. Timed-pregnant guinea pigs were pair fed ±ETOH and some were supplemented with the glutathione (GSH) precursor S -adenosyl-methionine (SAM-e). Term pups were given GBS intratracheally while some were pretreated with inhaled GSH prior to the experimental GBS. Neonatal lung and whole blood were evaluated for GBS while isolated AM were evaluated using fluorescent microscopy for GBS phagocytosis. Results:, Ethanol-exposed pups demonstrated increased lung infection and sepsis while AM phagocytosis of GBS was deficient compared with control. When SAM-e was added to the maternal diet containing ETOH, neonatal lung and systemic infection from GBS was attenuated and AM phagocytosis was improved. Inhaled GSH therapy prior to GBS similarly protected the ETOH-exposed pup from lung and systemic infection. Conclusions:, In utero ETOH exposure impaired the neonatal lung's defense against experimental GBS, while maintaining GSH availability protected the ETOH-exposed lung. This study suggested that fetal alcohol exposure deranges the neonatal lung's defense against bacterial infection, and support further investigations into the potential therapeutic role for exogenous GSH to augment neonatal AM function. [source] Dementia and Driving: Autonomy Versus SafetyJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 10 2005Article first published online: 23 SEP 200, Charlene Hoffman Snyder MSN, NP-BC Purpose This article reviews the effects of various types of dementia on driving skills, the available assessment measures, legal considerations, and the important role played by the nurse practitioner (NP) in the process of recommending driving cessation. It provides strategies and resources that may offer guidance to NPs who are attempting to balance the continued independence of patients with dementia, as represented by driving, with the safety not only of such patients but also of the public at large. Data sources A review of the biomedical literature, resources available on the World Wide Web, and illustrative case studies were used. Conclusions The diagnosis of dementia alone is often insufficient to determine driver competence because the topographic losses of dementia are complex. Recognizing when cessation should occur is made more difficult because objective assessment tools do not exist to predict impaired driving skills. Recommending driving cessation at the appropriate time can be a challenge for NPs, who must balance such a significant impact on the driver's autonomy with concerns about public safety if the patient continues to drive despite progressive impairment. Implications for practice The progressive loss of cognitive abilities in dementia presents a series of ongoing challenges for the patient throughout the disease continuum. Unfortunately, the recommendation to stop driving can present one of the more immediate issues confronting the patient, the family, and the healthcare provider. Failure to assess diminished driving skill can lead either to premature or to delayed driving cessation. Either outcome can have adverse effects on the patient, the patient's family, and public safety. [source] | |||||||||||||||||||||||||||||||