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Preliminary Validation (preliminary + validation)
Selected AbstractsThe Danish version of the Medication Adherence Report Scale: Preliminary Validation in Cancer Pain PatientsPAIN PRACTICE, Issue 1 2009Ramune Jacobsen MS Abstract Objective: To examine the psychometric properties of the Danish version of the Medication Adherence Report Scale (DMARS-4) adapted to measure adherence to analgesic regimen among cancer patients. Methods: The validated English version of the Medication Adherence Report Scale was translated into Danish following the repeated back-translation procedure. Cancer patients for the study were recruited from specialized pain management facilities. Thirty-three patients responded to the DMARS-4, the Danish Barriers Questionnaire II, The Danish version of Patient Perceived Involvement in Care Scale measuring the quality of patient-physician pain communication, and the Danish Brief Pain Inventory pain severity scale. Results: A factor analysis of the DMARS-4 resulted in one factor. Mean (SD) score on the cumulative scale ranging from 4 to 20, with higher scores indicating better medication adherence, was 17.8 (0.42). The DMARS-4 scores were related to the measures of patients' concerns about pain management and patients' pain communication. The internal consistency of the DMARS-4 was 0.70. Conclusions: The DMARS-4 seems to be a valid and reliable measure of self-reported adherence to analgesic regimen in the context of cancer pain. [source] Capillary electrophoresis-time of flight-mass spectrometry using noncovalently bilayer-coated capillaries for the analysis of amino acids in human urineELECTROPHORESIS, Issue 12 2008Rawi Ramautar Abstract A capillary electrophoresis-time of flight-mass spectrometry (CE-TOF-MS) method for the analysis of amino acids in human urine was developed. Capillaries noncovalently coated with a bilayer of Polybrene (PB) and poly(vinyl sulfonate) (PVS) provided a considerable EOF at low pH, thus facilitating the fast separation of amino acids using a BGE of 1,M formic acid (pH,1.8). The PB,PVS coating proved to be very consistent yielding stable CE-MS patterns of amino acids in urine with favorable migration time repeatability (RSDs <2%). The relatively low sample loading capacity of CE was circumvented by an in-capillary preconcentration step based on pH-mediated stacking allowing 100-nL sample injection (i.e. ca. 4% of capillary volume). As a result, LODs for amino acids were down to 20,nM while achieving satisfactory separation efficiencies. Preliminary validation of the method with urine samples showed good linear responses for the amino acids (R2 >0.99), and RSDs for peak areas were <10%. Special attention was paid to the influence of matrix effects on the quantification of amino acids. The magnitude of ion suppression by the matrix was similar for different urine samples. The CE-TOF-MS method was used for the analysis of urine samples of patients with urinary tract infection (UTI). Concentrations of a subset of amino acids were determined and compared with concentrations in urine of healthy controls. Furthermore, partial least squares,discriminant analysis (PLS,DA) of the CE-TOF-MS dataset in the 50,450,m/z region showed a distinctive grouping of the UTI samples and the control samples. Examination of score and loadings plot revealed a number of compounds, including phenylalanine, to be responsible for grouping of the samples. Thus, the CE-TOF-MS method shows good potential for the screening of body fluids based on the analysis of endogenous low-molecular weight metabolites such as amino acids and related compounds. [source] Development of a measure to assess the impact of epilepsy on people with an intellectual disability: the Glasgow Epilepsy Outcome Scale , Client version (GEOS-C)JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 3 2006J. Watkins Abstract Background Epilepsy is common in people with intellectual disability, yet clinicians and researchers seldom obtain information directly from the client. The development and preliminary validation of a novel measure for use with people with mild to moderate intellectual disabilities is described. Methods Focus group methods (6 groups; 24 participants) identified issues of concern, and qualitative analysis (NUD*IST) was applied to derive items and themes for a draft scale. Psychometric scale development techniques were then used in a pilot study and subsequent field-testing to investigate validity and reliability (n = 46). Results A total of 148 issues of concern was reduced initially to 52 and then to 42 items using these methods. The derived scale comprised sub-scales reflecting (1) concerns about having seizures; (2) about injury; (3) about issues during; and (4) after seizures; (5) about medication; (6) about what people think; and (7) about daily life. Cronbach , for the Glasgow Epilepsy Outcome Scale , Client version (GEOS-C) was 0.92, and ranged from 0.64,0.81 for the sub-scales. Relatively weak associations (r , 0.40), between client and family carer, staff carer or clinician views, suggests that proxy reports are not good predictors of how people with epilepsy themselves are feeling. Preliminary validation suggests that the GEOS-C can discriminate on variables of clinical importance. Conclusions The GEOS-C complements existing GEOS measures, can be completed in 5,15 min depending upon the level of support required, and may provide a valuable clinical and research tool. Further validational work and appraisal of sensitivity are required. [source] A mass-conservative version of the semi-implicit semi-Lagrangian HIRLAMTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 635 2008P. H. Lauritzen Abstract A mass-conservative version of the semi-implicit semi-Lagrangian High-Resolution Limited-Area Model (HIRLAM) is presented. The explicit continuity equation is solved with the so-called cell-integrated semi-Lagrangian (CISL) method. To allow for long time steps, the CISL scheme is coupled with a recently developed semi-implicit time-stepping scheme that involves the same non-complicated elliptic equation as in HIRLAM. Contrarily to the traditional semi-Lagrangian method, the trajectories are backward in the horizontal and forward in the vertical, i.e. cells moving with the flow depart from model layers and arrive in a regular column, and their vertical displacements are computed from continuity of mass and hydrostatic balance in the arrival column. This involves just two-dimensional upstream integrals and allows for a Lagrangian discretization of the energy conversion term in the thermodynamic equation. Preliminary validation of the new model version is performed using an idealized baroclinic wave test case. The accuracy of the new formulation of HIRLAM is comparable to the reference version though it is slightly more diffusive. A main finding is that the new discretization of the energy conversion term leads to more accurate simulations compared to the traditional ,Eulerian' treatment. Copyright © 2008 Royal Meteorological Society [source] Preliminary validation of a Chinese version of the State-Trait Anger Expression Inventory-2ASIAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 1 2009Jonathan P. Maxwell The increased globalization of psychology and related fields necessitates the availability of psychometric instruments in a number of languages, countries and cultures. Unfortunately, research on anger and aggression in Chinese populations has suffered from a lack of valid and reliable measurement instruments. Therefore, the State-Trait Anger Expression Inventory-2 (STAXI-2) was translated into Chinese (Chinese STAXI-2). Two samples of Hong Kong Chinese (N = 489 and N = 775) completed the Chinese STAXI-2. Participants in the second sample also completed measures of anger rumination and aggression. Confirmatory factor analysis (CFA) of responses from the first sample resulted in the loss of nine items from the 57 original items due to misspecification. A second CFA, using responses from the second sample, supported the construct validity of the modified scale. Moderate correlations were observed with measures of aggression and anger rumination, and significant differences were found between males and females on three anger expression subscales (Anger Expression-In, Anger Control-Out, and Anger Control-In). The preliminary evidence suggests that the abbreviated inventory may be a useful measure of state and trait anger, and anger expression in some Chinese populations. [source] French adaptation and preliminary validation of a questionnaire to evaluate understanding of informed consent documents in phase I biomedical researchFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 1 2006Adeline Paris Abstract The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to describe the different steps in the French adaptation and preliminary validation of the Qualité de Compréhension des Formulaires d'information et de consentement (QCFic) questionnaire (http://www.lyon.inserm.fr/cic-grenoble) based on the American Quality of Informed Consent (QuIC) questionnaire. Adaptation and preliminary validation of the QuIC for use in France was composed of five principal steps: translation, scientific validation, lexical validation, edition of gold-standard answers and a pilot study. Each stage was conducted by independent groups of experts, under the coordination of the study board. Thirteen questions were added and one was suppressed. Two steps were required for the scientific validation and for lexical validation, 21 modifications were proposed. Relative to gold-standard answers, the three experts gave the same answer for 24 questions and for nine other questions, two of the three gave identical answers, which were validated by the study board. Results of a pilot study showed a global QCFic score of 88.99 (84.13,90.92) and no specific commentary was made about the content of the questions, so no more modification needed to be made. A preliminary validated French questionnaire, the QCFic, is now available to evaluate the quality of an informed consent document in phase I clinical trials. It is quick and easy to use. [source] Ensuring Quality Information for Patients: development and preliminary validation of a new instrument to improve the quality of written health care informationHEALTH EXPECTATIONS, Issue 2 2004Beki Moult BA(Hons) MSc Abstract Background, Despite the recent focus on improving the quality of patient information, there is no rigorous method of assessing quality of written patient information that is applicable to all information types and that prescribes the action that is required following evaluation. Objective, The aims of this project were to develop a practical measure of the presentation quality for all types of written health care information and to provide preliminary validity and reliability of the measure in a paediatric setting. Methods, The Ensuring Quality Information for Patients (EQIP) tool was developed through a process of item generation, testing for concurrent validity, inter-rater reliability and utility. Patient information managers and health care professionals tested EQIP in three annual audits of health care leaflets produced by a children's hospital. Results, The final tool comprised 20 items. Kendall's , B rank correlation between EQIP and DISCERN was 0.56 (P = 0.001). There was strong agreement between intuitive rating and the EQIP score (Kendall's , B = 0.78, P = 0.009). Internal consistency using Cronbach's , was 0.80. There was good agreement between pairs of raters (mean , = 0.60; SD = 0.18) with no differences based on types of leaflets. Audits showed significant improvement in the number of leaflets achieving a higher quality EQIP rating over a 3-year period. Conclusions, EQIP demonstrated good preliminary validity, reliability and utility when used by patient information managers and healthcare professionals for a wide variety of written health care information. EQIP uniquely identifies actions to be taken as a result of the quality assessment. Use of EQIP improved the quality of written health care information in a children's hospital. Wider evaluation of EQIP with written information for other populations and settings is recommended. [source] Criminal attitudes to violence: Development and preliminary validation of a scale for male prisonersAGGRESSIVE BEHAVIOR, Issue 6 2004Devon L.L. Polaschek Abstract Two studies report on the development and preliminary psychometric properties of a new scale measuring criminal attitudes to violence. In Study 1, the responses of a mixed sample of male prisoners were used to select 20 scale items from a larger pool. The final scale (the Criminal Attitudes to Violence Scale; CAVS) was designed so that it had a single-factor structure and was uncorrelated with a measure of social desirability bias. It demonstrated high internal reliability, and a strong relationship to a self-report measure of physical aggression. Significant differences were found in CAVS mean scores for various offence history comparisons, such as whether or not the offender was currently on sentence for a violent conviction. In the second study, most results from the first study were replicated with an independent sample of male prisoners. Further, compared to another scale measuring attitudes to aggression [the EXPAGG Instrumental subscale; Archer and Haigh, 1997b], the CAVS was a better predictor of general attitudes to crime. Mean CAVS scores were again significantly higher for current violent offenders than those on sentence for other types of offences. Lastly, the CAVS was moderately predictive of estimated risk of reconviction and re-imprisonment. Overall these results suggest that this scale measures the construct of attitudes to criminal violence, which partially overlaps two other constructs: attitudes to aggression and attitudes to crime. Aggr. Behav. 30:484,503, 2004. © 2004 Wiley-Liss, Inc. [source] The Danish version of the questionnaire on pain communication: preliminary validation in cancer patientsACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 6 2009R. JACOBSEN Background: The modified version of the patients' Perceived Involvement in Care Scale (M-PICS) is a tool designed to assess cancer patients' perceptions of patient,health care provider pain communication process. The objective of this study was to examine the psychometric properties of the shortened Danish version of the M-PICS (SDM-PICS). Methods: The validated English version of the M-PICS was translated into Danish following the repeated back-translation procedure. Cancer patients were recruited for the study from specialized pain management facilities. Results: Thirty-three patients responded to the SDM-PICS, Danish Barriers Questionnaire II, Hospital Anxiety and Depression Scale, and Brief Pain Inventory Pain Severity Scale. A factor analysis of the SDM-PICS resulted in two factors: Factor one, patient information, consisted of four items assessing the extent to which the patient shared information with his/her health care provider, and Factor two, health care provider information, consisted of four items measuring the degree to which a health care provider was perceived as the one who shares information. Two separate items addressed the perceived level of information exchange between the patient and the health care provider. The SDM-PICS total had an internal consistency of 0.88. The SDM-PICS scores were positively related to pain relief and inversely related to the measures of cognitive pain management barriers, anxiety, and reported pain levels. Conclusion: The SDM-PICS seems to be a reliable and valid measure of perceived patient,health care provider communication in the context of cancer pain. [source] Development of a measure to assess the impact of epilepsy on people with an intellectual disability: the Glasgow Epilepsy Outcome Scale , Client version (GEOS-C)JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 3 2006J. Watkins Abstract Background Epilepsy is common in people with intellectual disability, yet clinicians and researchers seldom obtain information directly from the client. The development and preliminary validation of a novel measure for use with people with mild to moderate intellectual disabilities is described. Methods Focus group methods (6 groups; 24 participants) identified issues of concern, and qualitative analysis (NUD*IST) was applied to derive items and themes for a draft scale. Psychometric scale development techniques were then used in a pilot study and subsequent field-testing to investigate validity and reliability (n = 46). Results A total of 148 issues of concern was reduced initially to 52 and then to 42 items using these methods. The derived scale comprised sub-scales reflecting (1) concerns about having seizures; (2) about injury; (3) about issues during; and (4) after seizures; (5) about medication; (6) about what people think; and (7) about daily life. Cronbach , for the Glasgow Epilepsy Outcome Scale , Client version (GEOS-C) was 0.92, and ranged from 0.64,0.81 for the sub-scales. Relatively weak associations (r , 0.40), between client and family carer, staff carer or clinician views, suggests that proxy reports are not good predictors of how people with epilepsy themselves are feeling. Preliminary validation suggests that the GEOS-C can discriminate on variables of clinical importance. Conclusions The GEOS-C complements existing GEOS measures, can be completed in 5,15 min depending upon the level of support required, and may provide a valuable clinical and research tool. Further validational work and appraisal of sensitivity are required. [source] Coalescence of deformable granules in wet granulation processesAICHE JOURNAL, Issue 3 2000L. X. Liu In this work, the coalescence of deformable granules in wet granulation processes is modelled. The model accounts for both the mechanical properties of the granules and the effect of the liquid layer at the granule surface. It is an extension to the model of Ennis et al. (1991) to include the possibility of granule plastic deformation during collisions. The model is written in dimensionless groups such as viscous and deformation Stokes numbers and the ratio of granule dynamic yield strength to granule Young's modulus (Yd/E*). These variables are bulk parameters of the powder-binder mixture and also functions of the process intensity. The model gives the conditions for two types of coalescence,type I and type II. Type I coalescence occurs when granules coalesce by viscous dissipation in the surface liquid layer before their surfaces touch. Type II coalescence occurs when granules are slowed to a halt during rebound, after their surfaces have made contact. The model explains some of the trends observed in the literature, are preliminary validation of the coalescence criterion with drum granulation data is encouraging. An extension is also made to the case of surface dry granules, where liquid is squeezed to the surface during granule deformation. [source] | |||||||||||||