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Preliminary Indication (preliminary + indication)

Distribution by Scientific Domains

Medical Sciences	42%

Selected Abstracts

Schizophrenia treatment: content versus delivery

ACTA PSYCHIATRICA SCANDINAVICA, Issue 2009
J. Van Os
Objective:, To review the evidence supporting the importance of ensuring that patients with psychiatric disorders receive an optimal and appropriate level of non-pharmacological treatment, and how Assertive Community Treatment (ACT) may be able to contribute to this aim. Method:, Analysis of data from selected individual published studies on ACT, in addition to reviews from the Cochrane Library, and other study groups. Results:, Treatment management using ACT appears to offer benefits in terms of reduction in hospitalisation, although there is some debate as to whether this is the most representative outcome measure. Preliminary indications using remission as an outcome measure have also shown promising results in favour of ACT. Conclusion:, While further investigation and validation are necessary, current data indicate that ACT may be an appropriate strategy to facilitate the delivery of treatment to patients with psychotic disorders. [source]

Catastrophic incident prevention and proactive risk management in the new biofuels industry,

ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 1 2009
Judy A. Perry
Abstract This article is directed at assisting bioethanol manufacturers with preventing catastrophic incidents which could impact the entire Biofuels Industry. The biofuels industry has common hazards and potential consequences like other industries, related to the handling of flammables, dust explosion hazards and toxic or corrosive materials handling. This article ensures the reader understands these specific bioethanol manufacturer's process hazards are very real as demonstrated by past incidents and their catastrophic results. Regulatory obligations are discussed, as well as key engineering resources and design practices to ensure adequate safeguards are incorporated into the design of a new bioethanol manufacturing facility. The industry is fairly new, however, the hazards and safeguards to reduce the risk level with the common hazards are not new. Preliminary indications are this industry has yet to establish the proactive risk management efforts that are required to reduce the risks to a tolerable level. This article is to provide the supporting data and direction to the Biofuels Industry to ensure each are headed down a path of preventing a future catastrophe. © 2009 American Institute of Chemical Engineers Environ Prog, 2009 [source]

Association Between Birth Control Pills and Voice Quality

THE LARYNGOSCOPE, Issue 6 2004
Ofer Amir PhD
Abstract Objectives/Hypothesis: The objective was to extend our knowledge of the effect of birth control pills on voice quality in women based on various acoustic measures. Study Design: A longitudinal comparative study of 14 healthy young women over a 36- to 45-day period. Methods: Voices of seven women who used birth control pills and seven women who did not were recorded repeatedly approximately 20 times. Voice samples were analyzed acoustically, using an extended set of frequency perturbation parameters (jitter, relative average perturbation, pitch period perturbation quotient), amplitude perturbation parameters (shimmer, amplitude average perturbation quotient), and noise indices (noise-to-harmonics ratio, voice turbulence index). Results: Voice quality and stability were found to be better among the women who used birth control pills. Lower values were found for all acoustic measures with the exception of voice turbulence index. Results also provided preliminary indication for vocal changes associated with the days preceding ovulation. Conclusion: In contrast to the traditional view of oral contraceptives as a risk factor for voice quality, and in keeping with the authors' previous work, the data in the present study showed that not only did oral contraceptives have no adverse effect on voice quality but, in effect, most acoustic measures showed improved voice quality among women who used the birth control pill. The differences in the noise indices between groups may also shed light on the nature of the effect of sex hormones on vocal fold activity. It was suggested that hormonal fluctuations may have more of an effect on vocal fold regulation of vibration than on glottal adduction. [source]

Assessing the long-term impact of Ranavirus infection in wild common frog populations

ANIMAL CONSERVATION, Issue 5 2010
A. G. F. Teacher
Abstract Amphibians are declining worldwide, and one cause of this is infectious disease emergence. Mass mortalities caused by a virus or a group of viruses belonging to the genus Ranavirus have occurred in wild common frogs Rana temporaria in England since the 1980s, and ranaviral disease is widespread in amphibians in North America and Canada, where it can also cause mass die-offs. Although there have been numerous reports of Ranavirus -associated mass mortality events, no study has yet evaluated the long-term impacts of this disease. This study follows up archived records of English common frog mortalities likely caused by Ranavirus. There is a preliminary indication that common frog populations can respond differently to the emergence of disease: emergence may be transient, catastrophic, or persistent with recurrent mortality events. We subsequently focused on populations that had recurring mortality events (n=18), and we report median declines of 81% in the number of adult frogs in these populations from 1996 to 2008. Comparable uninfected populations (n=16) showed no change in population size over the same time period. Regressions show that larger frog populations may be more likely to experience larger declines than smaller populations, and linear models show that percentage population size change is significantly correlated with disease status, but that habitat age (a possible proxy for environmental quality) has no significant effect on population size change. Our results provide the first evidence of long-term localized population declines of an amphibian species which appear to be best explained by the presence of Ranavirus infection. [source]

Implantation of ethylene vinyl alcohol copolymer for faecal incontinence management

ANZ JOURNAL OF SURGERY, Issue 5 2010
Jacqueline H. Stephens
Abstract Purpose:, The primary objectives of this trial were to evaluate the safety and feasibility of treatment and to gain a preliminary indication of the effectiveness of ethylene vinyl alcohol injections into the anal sphincters of faecally incontinent patients. Methods:, Between April 2004 and February 2006, we conducted a prospective, single-arm, procedure optimization study of ethylene vinyl alcohol injections in 21 subjects with well-characterized faecal incontinence and an intact external anal sphincter at two Australian hospitals. Results:, There was a significant decrease in the Cleveland Clinic Florida Faecal Incontinence Score (CCFFIS) (P= 0.0005) and the Faecal Incontinence Severity Index score (P= 0.005) after treatment. At 12 months post-treatment, the mean CCFFIS had decreased by 37% (P= 0.0021), and 47% of subjects had a ,50% improvement in CCFFIS. There were significant improvements in embarrassment (P= 0.0455) and coping/behaviour (P= 0.0056) domains of the Faecal Incontinence Quality of Life. At 12 months, the mean anal canal length had increased by 29% (P= 0.066), with 40% of patients demonstrating increases of 50% or more. There were no further improvements following retreatment. Conclusions:, Ethylene vinyl alcohol injection into the anal intersphincteric plane is feasible and well tolerated. Improvement in faecal incontinence compared with baseline was seen. Retreating initial non-responders was not successful. [source]

A Dilmun temple in Bilad al-Qadim, Bahrain: A preliminary indication?

ARABIAN ARCHAEOLOGY AND EPIGRAPHY, Issue 1 2005
Dr Timothy Insoll
Excavations and surveys completed in the putative former Early Islamic capital, Bilad al-Qadim in Bahrain, uncovered a variety of structural remains of seemingly pre-Islamic date. These, an altar, ashlars and column drums recorded at the disused spring of Abu Zaydan, are conceivably from a Dilmun period structure, perhaps a temple. This idea is briefly explored and the relevant material described. [source]

Insight Into the Kinetic of Amyloid , (1,42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action

CHEMBIOCHEM, Issue 17 2007
Manuela Bartolini Dr.
Abstract The initial transition of amyloid , (1,42) (A,42) soluble monomers/small oligomers from unordered/,-helix to a ,-sheet-rich conformation represents a suitable target to design new potent inhibitors and to obtain effective therapeutics for Alzheimer's disease. Under optimized conditions, this reliable and reproducible CD kinetic study showed a three-step sigmoid profile that was characterized by a lag phase (prevailing unordered/,-helix conformation), an exponential growth phase (increasing ,-sheet secondary structure) and a plateau phase (prevailing ,-sheet secondary structure). This kinetic analysis brought insight into the inhibitors' mechanism of action. In fact, an increase in the duration of the lag phase can be related to the formation of an inhibitor,A, complex, in which the non-amyloidogenic conformation is stabilized. When the exponential rate is affected exclusively, such as in the case of Congo red and tetracycline, then the inhibitor affinity might be higher for the pleated ,-sheet structure. Finally, by adding the inhibitor at the end of the exponential phase, the soluble protofibrils can be disrupted and the A, amyloidogenic structure can revert into monomers/small oligomers. Congo red and tetracycline preferentially bind to amyloid in the ,-sheet conformation because both decreased the slope of the exponential growth, even if to a different extent, whereas no effect was observed for tacrine and galantamine. Some very preliminary indications can be derived about the structural requirements for binding to nonamyloidogenic or ,-sheet amyloid secondary structure for the development of potent antiaggregating agents. On these premises, memoquin, a multifunctional molecule that was designed to become a drug candidate for the treatment of Alzheimer's disease, was investigated under the reported circular dichroism assay and its anti-amyloidogenic mechanism of action was elucidated. [source]