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Practical Considerations (practical + consideration)
Selected AbstractsDeveloping a Transition Program from Pediatric- to Adult-Focused Cardiology Care: Practical ConsiderationsCONGENITAL HEART DISEASE, Issue 4 2009Arwa Saidi MB First page of article [source] Practical Considerations in Acne Treatment and the Clinical Impact of Topical Combination TherapyPEDIATRIC DERMATOLOGY, Issue 2008Andrew C. Krakowski M.D. The effects of acne are profound both physically and psychosocially across all age groups and ethnicities; therefore, prompt recognition and appropriate treatment are critical. Pharmacotherapeutic approaches range from simple monotherapy to multimodal treatments with a variety of topical and systemic agents. Optimal patient outcomes in acne management, however, are based both on treatment efficacy as well as overall patient satisfaction. In an effort to comprehensively address these key clinical considerations in acne management, we examine the diverse nature of acne patients, the factors in optimizing treatment outcomes, and the clinical impact of current medications, particularly topical combination therapy. [source] Microstereo-Laryngoscopic Lipoinjection: Practical ConsiderationsTHE LARYNGOSCOPE, Issue 10 2004James A. Burns MD First page of article [source] Feuchtetransport in Bauteilen aus wasserundurchlässigem Beton: Grundlagen und PraxisbetrachtungenBETON- UND STAHLBETONBAU, Issue 6 2007Udo Wiens Dr.-Ing. Bei WU-Konstruktionen übernimmt der Beton neben seiner tragenden auch eine abdichtende Funktion. Eine flächenförmige Hautabdichtung entfällt. Die Eigenschaft der Wasserundurchlässigkeit kann hierbei als zusätzliche Gebrauchstauglichkeitseigenschaft gesehen werden. Eine sehr häufig auftretende Fragestellung ist, ob trotz im Erdreich vorhandener Bodenfeuchte oder anstehendem Wasser sowie der im Beton enthaltenen Baufeuchte trockene Innenräume erreichbar sind. Zur Beantwortung der Fragen wurden Untersuchungen mit einem bauphysikalischen Rechenprogramm durchgeführt. Wichtige Eingangsgrößen für das Rechenprogramm wurden an Laborversuchen kalibriert. Ein Vergleich von Baufeuchte zu abführbarer Feuchte durch Lüften und zu nutzungsbedingter Feuchte wird vorgenommen. Moisture Transport in Components made of Water-Tight Concrete Basics and Practical Considerations In water-tight constructions, the concrete takes charge of a sealing function beside a load bearing function. A skin-sealing on the surface is not necessary. The property of water-tightness can be seen herewith as additional serviceability-property. A very often occurring question is, whether despite the in soil appearing ground-humidity or the upcoming water and the in concrete existing building moisture, dry interior rooms are achievable. To give answer to the questions, examinations by the help of a building physical calculation programme were carried out. Essential input parameters were calibrated in laboratory tests. A comparison of the inherent material moisture to the removable humidity by ventilation and to the humidity caused by using is given. [source] Monitoring Delamination Progression in Thermal Barrier Coatings by Mid-Infrared Reflectance ImagingINTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, Issue 2 2006Jeffrey I. Eldridge Mid-infrared (MIR) reflectance imaging is shown to be a reliable diagnostic tool for monitoring delamination progression in thermal barrier coatings (TBCs). MIR reflectance imaging utilizes the maximum transparency of TBCs in the 3,6 ,m wavelength region to probe below-surface delamination crack propagation that is typically hidden from visible wavelength inspection. The image contrast that identifies delamination progression arises from the increased reflectance produced by a large component of total internal reflection at the TBC/buried-crack interface. Imaging was performed at a wavelength of 4 ,m to take advantage of the relatively high transmittance of plasma-sprayed 8 wt% yttria-stabilized zirconia (8YSZ) TBCs along with a desirable relative insensitivity to potentially interfering absorptions by atmospheric constituents at that wavelength. A key advantage of MIR reflectance imaging over competing techniques is that it is sensitive to delamination progression even at very early stages before delamination cracks start linking together; therefore, TBC health assessment can be achieved throughout the life of the TBC well before TBC failure is imminent. Examples are presented to demonstrate monitoring delamination progression by MIR reflectance imaging in 8YSZ TBC-coated specimens subjected to furnace cycling to 1163°C. The experimental results were in good agreement with reflectance values predicted by a four-flux Kulbelka,Munk approximation applied to the extreme cases of a completely adherent and a completely detached TBC. Practical considerations, including potential interfering effects from surface contamination, sintering, and erosion are discussed. [source] Practical considerations in development of solid dosage forms that contain cyclodextrinJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 7 2007Lee A. Miller Abstract The following is a review of the literature that addresses the use of cyclodextrin in solid dosage forms. Care was taken to exclude physical and chemical characteristics of cyclodextrin, which have been discussed in the literature. A flow diagram is provided to outline the decision-making steps that are involved in the development process. Both preparation of physical mixtures and inclusion complexes are considered. Analytical techniques to determine the presence of inclusion complexes, the effect of other excipients on complex formation, the effect of size limitation of solid dosages forms, powder processing, and storage of solid dosage forms are discussed. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1691,1707, 2007 [source] Supported liquid membranes in hollow fiber liquid-phase microextraction (LPME) , Practical considerations in the three-phase modeJOURNAL OF SEPARATION SCIENCE, JSS, Issue 9 2007Kari Folde Bårdstu Abstract In this work, three-phase liquid-phase microextraction (LPME) based on a supported liquid membrane (SLM) sustained in the wall of a hollow fiber was investigated with special focus on optimization of the experimental procedures in terms of recovery and repeatability. Recovery data for doxepin, amitriptyline, clomipramine, and mianserin were in the range of 67.8,79.8%. Within-day repeatability data for the four basic drugs were in the range of 4.1,7.7%. No single factor was found to be responsible for these variations, and the variability was caused by several factors related to the LPME extractions as well as to the final HPLC determination. Although the volume of the SLM varied within 0.4,3.1% RSD depending on the preparation procedure, and the volume of the acceptor solution varied within 4.8% RSD, both recoveries and repeatability were found to be relative insensitive to these variations. Thus, the handling of microliters of liquid in LPME was not a very critical factor, and the preparation of the SLM was accomplished in several different ways with comparable performance. Reuse of hollow fibers was found to suffer from matrix effects due to built-up of analytes in the SLM, whereas washing of the hollow fibers in acetone was beneficial in terms of recovery, especially for the extraction of the most hydrophobic substances. Several of the organic solvents used in the literature as SLM suffered from poor long-term stability, but silicone oil AR 20 (polyphenyl-methylsiloxane), 2-nitrophenyl octyl ether (NPOE), and dodecyl acetate (DDA) all extracted with unaltered performance even after 60 days of storage at room temperature. [source] Issues in monitoring medication effects in the classroomPSYCHOLOGY IN THE SCHOOLS, Issue 9 2009Laura Anderson The task of medication monitoring in the schools has increased for school psychologists, yet there is little research specific to pediatric psychoactive medication. The current article reviews issues pertinent to school-based medication monitoring. Feasibility, acceptability, and perception of effectiveness are reviewed as fundamental considerations before implementing a medication-monitoring plan in the schools. The importance of individualization, ecological implementation, and development of socially valid objectives is stressed along with the need for additional research, tools, and measures in this area. Practical considerations for school psychologists include discussion of parental consent and confidentiality, multilevel assessment and monitoring, data recording, and determining clinical significance. © 2009 Wiley Periodicals, Inc. [source] Dynamic Comparison of Kaplan,Meier Proportions: Monitoring a Randomized Clinical Trial with a Long-Term Binary EndpointBIOMETRICS, Issue 1 2008Erica Brittain Summary The approach to early termination for efficacy in a trial where events occur over time but the primary question of interest relates to a long-term binary endpoint is not straightforward. This article considers comparison of treatment groups with Kaplan,Meier (KM) proportions evaluated at increasing times from randomization, at increasing calendar testing times. This strategy is employed to improve the ability to detect important treatment effects and provide critical treatments to patients in a timely manner. This dynamic Kaplan,Meier (DKM) approach is shown to be robust; that is, it produces high power and early termination time across a wide range of circumstances. In contrast, a fixed time KM comparison and the log-rank test are both shown to be more variable in performance. Practical considerations of implementing the DKM method are discussed. [source] Looking Forward by Looking Back: May Day Protests in London and the Strategic Significance of the UrbanANTIPODE, Issue 4 2004Justus Uitermark This paper deals with the question of how oppositional movements can adapt their protest strategies to meet recent socio-spatial transformations. The work of Lefebvre provides several clues as to how an alternative discourse and appropriation of space could be incorporated in such protest strategies. One of the central themes in Lefebvre's work is that the appearances, forms and functions of urban space are constitutive elements of contemporary capitalism and thus that an alternative narrative of urban space can challenge or undermine dominant modes of thinking. What exactly constitutes the "right" kind of alternative discourse or narrative is a matter of both theoretical and practical consideration. The paper analyses one case: the May Day protests in London in 2001, in which a protest group, the Wombles, managed to integrate theoretical insights into their discourse and practice in a highly innovative manner. Since cities, and global cities in particular, play an ever more important role in maintaining the consumption as well as production practices of global capitalism; they potentially constitute local sites where global processes can be identified and criticised. It is shown that the Wombles effectively made use of these possibilities and appropriated the symbolic resources concentrated in London to exercise a "lived critique" of global capitalism. Since the Wombles capitalised on trends that have not yet ended, their strategies show a way forward for future anti-capitalist protests. [source] Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studiesDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 3 2009Philip A. May Abstract Researching the epidemiology and estimating the prevalence of fetal alcohol syndrome (FAS) and other fetal alcohol spectrum disorders (FASD) for mainstream populations anywhere in the world has presented a challenge to researchers. Three major approaches have been used in the past: surveillance and record review systems, clinic-based studies, and active case ascertainment methods. The literature on each of these methods is reviewed citing the strengths, weaknesses, prevalence results, and other practical considerations for each method. Previous conclusions about the prevalence of FAS and total FASD in the United States (US) population are summarized. Active approaches which provide clinical outreach, recruitment, and diagnostic services in specific populations have been demonstrated to produce the highest prevalence estimates. We then describe and review studies utilizing in-school screening and diagnosis, a special type of active case ascertainment. Selected results from a number of in-school studies in South Africa, Italy, and the US are highlighted. The particular focus of the review is on the nature of the data produced from in-school methods and the specific prevalence rates of FAS and total FASD which have emanated from them. We conclude that FAS and other FASD are more prevalent in school populations, and therefore the general population, than previously estimated. We believe that the prevalence of FAS in typical, mixed-racial, and mixed-socioeconomic populations of the US is at least 2 to 7 per 1,000. Regarding all levels of FASD, we estimate that the current prevalence of FASD in populations of younger school children may be as high as 2,5% in the US and some Western European countries. © 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009; 15:176,192. [source] Use of the oligochaete, Lumbriculus variegatus, as a prey organism for toxicant exposure of fish through the dietENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 10 2006David R. Mount Abstract The oligochaete, Lumbriculus variegatus, has several characteristics that make it desirable as a prey organism for conducting dietary exposure studies with fish. We conducted 21- and 30-d experiments with young fathead minnows (Pimephales promelas) and rainbow trout (Oncorhynchus mykiss), respectively, to determine whether a diet consisting solely of L. variegatus would support normal growth and to compare performance with standard diets (Artemia nauplii, frozen brine shrimp, or trout chow). All diets were readily accepted, and fish survived and grew well. Food conversion in both fathead minnows and rainbow trout was as high as or higher for the oligochaete diet compared with others, although this comparison is influenced by differences in ration, ingestion rate, or both. The oligochaete diet had gross nutritional analysis similar to the other diets, and meets fish nutrition guidelines for protein and essential amino acids. Methodologies and practical considerations for successfully using oligochaetes as an experimental diet are discussed. Considering their ready acceptance by fish, their apparent nutritional sufficiency, the ease of culturing large numbers, and the ease with which they can be loaded with exogenous chemicals, we believe that L. variegatus represents an excellent choice of exposure vector for exposing fish to toxicants via the diet. [source] Design, analysis, and synthesis of generalized single step single solve and optimal algorithms for structural dynamicsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 5 2004X. Zhou Abstract The primary objectives of the present exposition are to: (i) provide a generalized unified mathematical framework and setting leading to the unique design of computational algorithms for structural dynamic problems encompassing the broad scope of linear multi-step (LMS) methods and within the limitation of the Dahlquist barrier theorem (Reference [3], G. Dahlquist, BIT 1963; 3: 27), and also leading to new designs of numerically dissipative methods with optimal algorithmic attributes that cannot be obtained employing existing frameworks in the literature, (ii) provide a meaningful characterization of various numerical dissipative/non-dissipative time integration algorithms both new and existing in the literature based on the overshoot behavior of algorithms leading to the notion of algorithms by design, (iii) provide design guidelines on selection of algorithms for structural dynamic analysis within the scope of LMS methods. For structural dynamics problems, first the so-called linear multi-step methods (LMS) are proven to be spectrally identical to a newly developed family of generalized single step single solve (GSSSS) algorithms. The design, synthesis and analysis of the unified framework of computational algorithms based on the overshooting behavior, and additional algorithmic properties such as second-order accuracy, and unconditional stability with numerical dissipative features yields three sub-classes of practical computational algorithms: (i) zero-order displacement and velocity overshoot (U0-V0) algorithms; (ii) zero-order displacement and first-order velocity overshoot (U0-V1) algorithms; and (iii) first-order displacement and zero-order velocity overshoot (U1-V0) algorithms (the remainder involving high-orders of overshooting behavior are not considered to be competitive from practical considerations). Within each sub-class of algorithms, further distinction is made between the design leading to optimal numerical dissipative and dispersive algorithms, the continuous acceleration algorithms and the discontinuous acceleration algorithms that are subsets, and correspond to the designed placement of the spurious root at the low-frequency limit or the high-frequency limit, respectively. The conclusion and design guidelines demonstrating that the U0-V1 algorithms are only suitable for given initial velocity problems, the U1-V0 algorithms are only suitable for given initial displacement problems, and the U0-V0 algorithms are ideal for either or both cases of given initial displacement and initial velocity problems are finally drawn. For the first time, the design leading to optimal algorithms in the context of a generalized single step single solve framework and within the limitation of the Dahlquist barrier that maintains second-order accuracy and unconditional stability with/without numerically dissipative features is described for structural dynamics computations; thereby, providing closure to the class of LMS methods. Copyright © 2003 John Wiley & Sons, Ltd. [source] What potential role is there for medication treatment in anorexia nervosa?INTERNATIONAL JOURNAL OF EATING DISORDERS, Issue 1 2009Scott J. Crow MD Abstract Objective: To review selected issues regarding the development of drug treatments for anorexia nervosa (AN). Method: The existing pharmacotherapy literature for AN is reviewed, and the theoretical and practical considerations are discussed. Results: A very wide variety of drugs have been examined in AN, generally with negative results. There are a number of potential reasons for this finding, including compliance, nutritional deficits, selection of the wrong targets or the wrong outcome measures, use of monotherapy, lack of animal models, or factors intrinsic to AN. Conclusion: Pharmacotherapy provides little benefit in the treatment of AN at present. Several strategies might lead to the identification of more effective agents, including new measurement strategies, identification of novel pharmacologic targets, and consideration of a clinical trials network. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009 [source] Comparing managerial careers, management development and management education in the UK and the USA: some theoretical and practical considerationsINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 3 2000Graeme Martin This article explores some of the issues surrounding changing patterns of managerial careers, management development and management education in the UK and the USA. It addresses three lines of questioning: the new rhetoric of careers in the new economy, the evidence on changing organisational forms and the implications for careers and management development and education, and the future of management education and the role of business schools. The article is intended as a ,think piece' and acts as a backdrop for a comparative study of management development in Scotland and California currently being undertaken by the authors. [source] Qualitative and quantitative responses of Diabroticina (Coleoptera: Chrysomelidae) to cucurbit extracts linked to species, sex, weather and deployment methodJOURNAL OF APPLIED ENTOMOLOGY, Issue 3 2008G. Cabrera Walsh Abstract Toxic baits and traps for Diabroticina, based on bitter cucurbit extracts, have been utilized for a number of years with inconsistent results. Four species of bitter Cucurbitaceae were compared in the field for their attractancy to species of Diabroticina in Argentina and the United States. The comparisons were made with polyester fabrics treated with known volumes of different cucurbit extracts, against a standard cucurbit extract of bitter Hawkesbury watermelon (Citrullus lanatus (Thunberg) Matsumura and Nakai). The factors evaluated were: the attractancy of the different extracts in terms of beetle numbers, species and sex of the Diabroticina caught; influence of different fabrics on such attraction; and influence of several weather variables on the catches. The most attractive species was Cayaponia bonariensis (Miller) Martinez Crovetto, however, practical considerations indicated that Cucumis myriocarpus Naudin and Hawkesbury watermelon may be better choices from the commercial perspective. No single weather factor could explain the catches throughout the sample range, but different temperature and barometric pressure ranges provided some predictive value. Although the susceptibility to weather conditions and a strong male dominance in the catches raise the question of the usefulness of cucurbitacins as the main component in toxic baits or traps, these drawbacks may prove to be less important in widespread bait applications and Diabroticina management in vegetable crops. [source] Basic Income, Self-Respect and ReciprocityJOURNAL OF APPLIED PHILOSOPHY, Issue 2 2003Catriona Mckinnon Why should I let the toad work Squat on my life? Can't I use my wit as a pitchfork And drive the brute off? Six days of the week it soils With its sickening poison , Just for paying a few bills! That's out of proportion. From Philip Larkin, ,Toads'. ABSTRACT This paper mounts a Rawlsian argument for unconditional basic income on the grounds that it maximins the distribution of income and wealth understood as a social basis of self-respect. The most important objection to this argument available to Rawlsians is that basic income violates the demands of reciprocity, where reciprocity in any scheme of distribution is a requirement of justice. The second half of the paper addresses this objection. It is argued there that even if the objection can be made successfully by Rawlsians (and this is not clear), it is not sufficient to divest them of a commitment to basic income, given some practical considerations about the implementation of alternatives to basic income. [source] Design of a clustered observational study to predict emergency admissions in the elderly: statistical reasoning in clinical practiceJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 2 2007Gillian A. Lancaster MSc PhD CStat Abstract Objective, To describe the statistical design issues and practical considerations that had to be addressed in setting up a clustered observational study of emergency admission to hospital of elderly people. Study design and setting, Clustered observational study (sample survey) of elderly people registered with 18 general practices in Halton Primary Care Trust in the north-west of England. Results, The statistical design features that warranted particular attention were sample size determination, intra-class correlation, sampling and recruitment, bias and confounding. Pragmatic decisions based on derived scenarios of different design effects are discussed. A pilot study was carried out in one practice. From the remaining practices, a total of 4000 people were sampled, stratified by gender. The average cluster size was 200 and the intra-class correlation coefficient for the emergency admission outcome was 0.00034, 95% confidence interval (0,0.008). Conclusion, Studies that involve sampling from clusters of people are common in a wide range of healthcare settings. The clustering adds an extra level of complexity to the study design. This study provides an empirical illustration of the importance of statistical as well as clinical reasoning in study design in clinical practice. [source] Guidelines for using quantitative magnetization transfer magnetic resonance imaging for monitoring treatment of multiple sclerosis,JOURNAL OF MAGNETIC RESONANCE IMAGING, Issue 4 2003Mark A. Horsfield PhD Abstract Quantitative evaluation of brain magnetic resonance imaging (MRI) scans is now an accepted part of the trial of new putative treatments for multiple sclerosis (MS). However, conventional MRI is not pathologically specific, and it does not reveal the details of the pathological processes that underlie the progression of the disease. Magnetization transfer (MT) imaging is a relatively new quantitative technique that appears to offer some pathological specificity, and can be used to monitor the changes over time in both individual lesions and the central nervous system as a whole. This paper considers the case for incorporating MT imaging into new clinical trials, so that the utility of MT for monitoring the modification of MS progression by treatment can be assessed. Specific guidelines for implementing MT imaging as part of a large multicenter clinical trial are given, and practical considerations when planning such a trial are detailed. It is anticipated that MT imaging will be incorporated into many new trials in the near future. J. Magn. Reson. Imaging 2003;17:389,397. © 2003 Wiley-Liss, Inc. [source] N-in-1 dosing pharmacokinetics in drug discovery: Experience, theoretical and practical considerationsJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 7 2008Kan He Abstract N-in-1 (or cassette) dosing pharmacokinetics (PK) has been used in drug discovery for rapid assessment of PK properties of new chemical entities. However, because of potential for drug,drug interactions this procedure is still controversial. This study was to retrospectively evaluate the N-in-1 dosing approach in drug discovery with an emphasis on the potential for drug,drug interactions. The systemic clearance, volume of distribution, oral bioavailability, and renal excretion of the 31 lead compounds in rats, dogs or chimpanzees were significantly correlated between the N-in-1 dosing and discrete studies with r values of 0.69, 0.91, 0.53, and 0.83 (p,<,0.005 for all), respectively. PK parameters for 11 quality control compounds which were involved in 194 N-in-1 studies for screening approximately 1000 compounds had coefficient of variations of less than 70%. The intrinsic microsomal clearances generated from the N-in-1 and discrete incubations were nearly identical (r,=,0.97, p,<,0.0001). The intrinsic clearances of quality control compound from the N-in-1 incubations were consistent with its discrete CLint estimate (cv: 5.4%). Therefore, N-in-1 dosing is a useful approach in drug discovery to quickly obtain initial PK estimates. Potential drug,drug interactions that result in confounding PK estimates do not occur as frequently as expected. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:2568,2580, 2008 [source] EARLY INITIATION OF PHOSPHATE LOWERING DIETARY THERAPY IN NON-DIALYSIS CHRONIC KIDNEY DISEASE: A CRITICAL REVIEWJOURNAL OF RENAL CARE, Issue 2009M.K. Sigrist SUMMARY Dietary management of hyperphosphatemia and hyperparathyroidism have long been important elements in the clinical management of CKD stage 4 and 5 for the prevention of mineral bone disease. The rationale for phosphate lowering has been further justified, given the accumulating data to support the association of phosphate with vascular damage, in this population who are at high risk of cardiovascular (CV) death. Phosphate is a novel CV risk factor in both CKD and in the general population, and a growing body of literature suggests that high normal serum phosphate may be a risk factor for progression of CKD. Few studies have examined hard outcomes after phosphate lowering. Nonetheless, given the balance of data both in cell, animal and human studies, the use of phosphate lowering strategies at earlier stages of CKD, perhaps even prior to serum phosphate level rising, may well be justified. This review will discuss the complications associated with higher serum phosphate, the potential benefits of early phosphate intervention, practical considerations of low phosphate diets and novel strategies for evaluating these strategies in clinical practice. [source] Who captures the marks for the Petersen estimator?JOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES A (STATISTICS IN SOCIETY), Issue 3 2007I. B. J. Goudie Summary., We examine the claim that the well-known Petersen estimator which is used in population size estimation was not in fact used by the scientist after whom it is named. We show how, in the early years of the last century, the modern use of the Petersen estimator grew from that of the fishing coefficient. Contending with the somewhat conflicting claims that were made at the time, and what by modern standards is poor referencing of sources, we investigate where the credit lies for these concepts, and the principles and protocols which support them. We assess also how far attributions of credit were affected by practical considerations, and the history of the estimator by the nature of the problems being pursued. We identify scientists whose early work on marking and estimating fish populations deserves more credit than it has received. [source] A comparison of capillary-scale LC,NMR with alternative techniques: spectroscopic and practical considerations,MAGNETIC RESONANCE IN CHEMISTRY, Issue 9 2005Richard J. Lewis Abstract Experimental and practical details for the use of capillary LC (CapLC),NMR are reported. The capillary NMR probe has high sensitivity and excellent flow characteristics and we found CapLC,NMR to be best suited to samples that are truly mass limited. CapLC,NMR relies on good capillary-scale chromatography where highly concentrated peaks with a volume closely matched to the NMR flow cell are achievable. Provided that the loading capacity of the capillary column is not limiting, the combination of high sensitivity and high solvent suppression quality makes CapLC,NMR an excellent choice. For many real samples, however, the loading is limiting and we found the combination of LC,SPE,MS,NMR with a cryoprobe enables more material to be purified for NMR analysis, while retaining sensitivity. Copyright © 2005 John Wiley & Sons, Ltd. [source] Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerationsNMR IN BIOMEDICINE, Issue 8 2004Afonso C. Silva Abstract Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connections in the brain; and to enhance the brain cytoarchitecture after a systemic dose. Based on an ever-growing number of applications, MEMRI is proving useful as a new molecular imaging method to visualize functional neural circuits and anatomy as well as function in the brain in vivo. Paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest at an appropriate dose and in a time-efficient manner. A major drawback to the use of Mn2+ as a contrast agent is its cellular toxicity. Therefore, it is critical to use as low a dose as possible. In the present work the different approaches to MEMRI are reviewed from a practical standpoint. Emphasis is given to the experimental methodology of how to achieve significant, yet safe, amounts of Mn2+ to the target areas of interest. Copyright © 2004 John Wiley & Sons, Ltd. [source] The Treating Physician as Expert Witness: Ethical and Pragmatic ConsiderationsPAIN MEDICINE, Issue 5 2006Ben A. Rich JD ABSTRACT Objective., The objective of this analysis is to apprise pain physicians of the ethical concerns and practical considerations that arise when a treating physician is called upon to testify as an expert witness in a legal proceeding involving his or her own patient. The provision of expert testimony in medico-legal proceedings has come under heightened scrutiny in recent years. When a physician testifies as an expert witness, such testimony is considered to be the practice of medicine, and hence subject to the same ethical and professional obligations as patient care. Increasingly, medical professional organizations have promulgated guidelines for such activities, and even implemented oversight mechanisms to review complaints concerning expert testimony by their members. Additional issues are raised when the expert witness is also the treating physician for the patient who is a party to the legal proceeding in which the expert testimony is offered. Conclusions., While it is not categorically unethical or inadvisable for a physician to testify as an expert witness in a medico-legal proceeding involving his or her own patient, such activity raises special issues and concerns. Prospective expert witnesses in such situations should be cognizant of these issues and insure that they have been adequately addressed before and during the testimony. [source] Developmental, gender, and practical considerations in scoring curriculum-based measurement writing probesPSYCHOLOGY IN THE SCHOOLS, Issue 4 2003Christine Kerres Malecki The present study focused on CBM written language procedures by conducting an investigation of the developmental, gender, and practical considerations surrounding three categories of CBM written language scoring indices: production-dependent, production-independent, and accurate-production. Students in first- through eighth-grade generated a three-minute writing sample in the fall and spring of the school year using standard CBM procedures. The writing samples were scored using all three types of scoring indices to assess the trends in scoring indices for students of varying ages and gender and of the time required to score writing samples using various scoring indices. With only one exception, older students outperformed younger students on all of the scoring indices. Although at the middle school level students' levels of writing fluency and writing accuracy were not closely associated, at the younger grade levels the CBM indices were significantly related. With regard to gender differences, girls outperformed boys on measures of writing fluency at all grade levels. The average scoring time per writing sample ranged from 1-1/2 to 2-1/2 minutes (depending on grade level). © 2003 Wiley Periodicals, Inc. Psychol Schs 40: 379,390, 2003. [source] Technical note: Prediction of sex based on five skull traits using decision analysis (CHAID)AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 3 2009Joan C. Stevenson Abstract Osteologists commonly assess the sex of skeletal remains found in forensic and archaeological contexts based on ordinal scores of subjectively assessed sexually dimorphic traits. Using known-sex samples, logistic regression (LR) discriminant functions have been recently developed, which allow sex probabilities to be determined. A limitation of LR is that it emphasizes main effects and not interactions. Chi-square automatic interaction detection (CHAID) is an alternative classification strategy that emphasizes the information in variable interactions and uses decision trees to maximize the probability of correct sex determinations. We used CHAID to analyze the predictive value of the 31 possible combinations of five sexually dimorphic skull traits that Walker used previously to develop logistic regression sex determination equations. The samples consisted of 304 individuals of known sex of English, African American, and European American origin. Based on practical considerations, selection criteria for the best sex predictive trait combinations (SPTCs) were set at accuracies for both sexes of 75% or greater and sex biases lower than 5%. Although several of the trees meeting these criteria were produced for the English and European American samples, none met them for the African American sample. In the series of out-of-sample tests we performed, the trees from the English and combined sample of all groups predicted best. Am J Phys Anthropol, 2009. © 2009 Wiley-Liss, Inc. [source] The Addiction Severity Index at 25: Origins, Contributions and TransitionsTHE AMERICAN JOURNAL ON ADDICTIONS, Issue 2 2006A. Thomas McLellan PhD The Addiction Severity Index (ASI) is a multidimensional interview used to measure the substance use, health, and social problems of those with alcohol and other drug problems, both at admission to treatment and subsequently at follow-up contacts. This article first discusses the conceptual and practical importance of the ASI's multi-dimensional approach to measuring addiction severity, as illustrated by two case presentations. The second section of the paper reviews how this measurement approach has led to some important findings regarding the prediction and measurement of addiction treatment effectiveness. The third section describes the historical and practical considerations that have changed the instrument over time, details the problems with the instrument, and describes our efforts to correct those problems with the ASI-6. Finally, some recent ASI data collected from over 8,400 patients admitted to a nationally representative sample of U.S. addiction treatment programs are presented. [source] PLUG-IN ESTIMATION OF GENERAL LEVEL SETSAUSTRALIAN & NEW ZEALAND JOURNAL OF STATISTICS, Issue 1 2006Antonio Cuevas Summary Given an unknown function (e.g. a probability density, a regression function, ,) f and a constant c, the problem of estimating the level set L(c) ={f,c} is considered. This problem is tackled in a very general framework, which allows f to be defined on a metric space different from . Such a degree of generality is motivated by practical considerations and, in fact, an example with astronomical data is analyzed where the domain of f is the unit sphere. A plug-in approach is followed; that is, L(c) is estimated by Ln(c) ={fn,c}, where fn is an estimator of f. Two results are obtained concerning consistency and convergence rates, with respect to the Hausdorff metric, of the boundaries ,Ln(c) towards ,L(c). Also, the consistency of Ln(c) to L(c) is shown, under mild conditions, with respect to the L1 distance. Special attention is paid to the particular case of spherical data. [source] Evaluating a novel ,needlecatcher' device in dermatological surgery: practical considerationsBRITISH JOURNAL OF DERMATOLOGY, Issue 1 2009W. Hussain No abstract is available for this article. [source] | |||||||||||||||||||||||||||||||||||||||||||