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Possible Value (possible + value)
Kinds of Possible Value Selected AbstractsPericranial injection of botulinum toxin type A (Dysport®) for tension-type headache , A multicentre, double-blind, randomized, placebo-controlled studyEUROPEAN JOURNAL OF NEUROLOGY, Issue 3 2008A. Straube Increasingly, botulinum type A toxin is used to influence pathologically increased muscle activity in conditions such as dystonia and spasticity. Studies have also assessed its efficacy in tension-type headache, where muscle tenderness may be increased. We undertook a prospective, multicentre, randomized, double-blind, placebo-controlled trial. Patients received injections of Dysport® (total dose of 420 or 210 units) or saline placebo in 18 sites on the head and neck. Of 125 patients treated, 118 were included in the intention-to-treat dataset. No significant differences between each verum group and placebo were seen for the primary efficacy parameter , change in the number of headache-free days at 4,8 weeks after injection compared with 4 weeks before injection. The groups receiving 420 or 210 units of Dysport experienced 2.60 and 2.87 more headache-free days respectively, compared with 1.93 more headache-free days for the placebo group (P = 0.66 versus 420 units; P = 0.52 versus 210 units). Treatment with 420 units of Dysport was associated with significant improvements compared with placebo for two secondary efficacy parameters: mean change in headache duration from baseline to weeks 8,12 (P < 0.05) and improved global physician and patient assessment scores (P < 0.05). Further studies should address the possible value of multiple injections with extended observation periods, dose optimization, and whether duration of headache history and number of previous treatments are predictors of patient response. [source] Determining arresters best positions in power system for lightning shielding failure protection using simulation optimization approachEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 3 2010B. Vahidi Abstract The lightning stroke to power system structures especially overhead lines makes severe damages and results in less reliable power supply. The invention of surge arresters was a revolution in these systems for protecting the precise equipments from lightning stroke overvoltages. Nowadays, with ever decreasing prices, using arrester not only for protecting certain instruments but also for decreasing total risk of flashover in overall network, is investigated by academic and industrial pioneers in this area. In this paper, our goal is to introduce a heuristic method for determining optimum positions for placing transmission lines surge arresters (TLSAs) with acceptable approximation, to get lowest possible value of shielding failure risk of flashover in a selected set of overhead lines. Simulation optimization based on neural net (i.e. Meta Model) and genetic algorithm (optimization algorithm) is invoked to suggest best positions for placing TLSAs. A case study on Kerman 230,kV network shows good achievement of simulation optimization for finding optimum positions of TLSAs. Comparison is also made with the results of transient simulation to reveal the effectiveness of the method. Copyright © 2008 John Wiley & Sons, Ltd. [source] Environmental change and the phenology of European aphidsGLOBAL CHANGE BIOLOGY, Issue 8 2007RICHARD HARRINGTON Abstract Aphids, because of their short generation time and low developmental threshold temperatures, are an insect group expected to respond particularly strongly to environmental changes. Forty years of standardized, daily data on the abundance of flying aphids have been brought together from countries throughout Europe, through the EU Thematic Network ,EXAMINE'. Relationships between phenology, represented by date of first appearance in a year in a suction trap, of 29 aphid species and environmental data have been quantified using the residual maximum likelihood (REML) methodology. These relationships have been used with climate change scenario data to suggest plausible changes in aphid phenology. In general, the date of first record of aphid species in suction traps is expected to advance, the rate of advance varying with location and species, but averaging 8 days over the next 50 years. Strong relationships between aphid phenology and environmental variables have been found for many species, but they are notably weaker in species living all year on trees. Canonical variate analysis and principal coordinate analysis were used to determine ordinations of the 29 species on the basis of the presence/absence of explanatory variables in the REML models. There was strong discrimination between species with different life cycle strategies and between species feeding on herbs and trees, suggesting the possible value of trait-based groupings in predicting responses to environmental changes. [source] Optimal regenerator performance in Stirling enginesINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 9 2009P. C. T. de Boer Abstract The key component of a Stirling engine is its regenerative heat exchanger. This device is subject to losses due to dissipation arising from the flow through the regenerator as well as due to imperfect heat transfer between the regenerator material and the gas. The magnitudes of these losses are characterized by the Stanton number St and the Fanning friction factor f, respectively. Using available data for the ratio St/f, results are found for the Carnot efficiency and the power output of the regenerator. They depend on the conductance and on the ratio of pressures at the two sides of the regenerator. Optimum results for efficiency and power output of the regenerator are derived in the limit of zero Mach number. The results are applied to the Stirling engine. The efficiency and the power output of the engine are found for given amplitude of the compression piston. Optimization with respect to regenerator conductance and piston phase angle leads to a maximum possible value of the power output. Under optimal conditions, the Carnot efficiency just below this maximum is close to 100%. Copyright © 2009 John Wiley & Sons, Ltd. [source] Systemic medications: clinical significance in periodonticsJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 2002Sebastian G. Ciancio Abstract Systemic medications are of value as adjuncts to periodontal therapy. These medications can be divided into two major categories: antibiotics and agents for host modulation. Antibiotics have been shown to be valuable adjuncts in specialized types of periodontal disease, such as localized and generalized aggressive periodontitis, and of possible value in severe chronic periodontitis. Antibiotics have been studied individually, in combination and in sequential therapy. Host modulators include Periostat, non-steroidal anti-inflammatory agents, alendronate (Fosamax), hormone replacement therapy and anti-arthritic medications. These agents produce their beneficial effects by a variety of mechanisms of action, including inhibition of matrix metalloproteinases, inhibition of prostaglandin production, stimulation of osteoblasts, inhibition of osteoclasts, and other anti-inflammatory mechanisms of action. [source] On the calculation of the concentration dependence of drug binding to plasma proteins with multiple binding sites of different affinities: Determination of the possible variation of the unbound drug fraction and calculation of the number of binding sites of the proteinJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 2 2007Leonid M. Berezhkovskiy Abstract The measurement of the unbound drug fraction in plasma is routinely performed at drug concentrations much less than that of plasma proteins. Commonly, the protein has several binding sites of different affinities. The obtained value of the unbound drug fraction does not yield the affinity of each binding site separately. For drug binding to a single type of protein, it is shown that the assumption that all binding sites of the protein have the same affinity yields the slowest possible concentration increase of the unbound drug fraction, while the assumption that a drug binds to a single binding site yields the highest possible value of the unbound fraction for a given drug concentration. The conditions to be imposed on the affinities of binding sites, to provide the fastest and the slowest possible concentration increase of the unbound drug fraction are also obtained for the case of drug binding to several types of plasma proteins. The suggested approach is applied to the determination of the number of binding sites of the protein from the measured values of the unbound drug fraction at different drug concentrations. ©2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:249,257, 2007 [source] Two-point water-fat imaging with partially-opposed-phase (POP) acquisition: An asymmetric Dixon method,MAGNETIC RESONANCE IN MEDICINE, Issue 3 2006Qing-San Xiang Abstract A novel two-point water-fat imaging method is introduced. In addition to the in-phase acquisition, water and fat magnetization vectors are sampled at partially-opposed-phase (POP) rather than exactly antiparallel as in the original Dixon method. This asymmetric sampling encodes more valuable phase information for identifying water and fat. From the magnitudes of the two complex images, a big and a small chemical component are first robustly obtained pixel by pixel and then used to form two possible error phasor candidates. The true error phasor is extracted from the two error phasor candidates through a simple procedure of regional iterative phasor extraction (RIPE). Finally, least-squares solutions of water and fat are obtained after the extracted error phasor is smoothed and removed from the complex images. For noise behavior, the effective number of signal averages NSA* is typically in the range of 1.87,1.96, very close to the maximum possible value of 2. Compared to earlier approaches, the proposed method is more efficient in data acquisition and straightforward in processing, and the final results are more robust. At both 1.5T and 0.3T, well separated and identified in vivo water and fat images covering a broad range of anatomical regions have been obtained, supporting the clinical utility of the method. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc. [source] Augmentation block preconditioners for saddle point-type matrices with singular (1, 1) blocksNUMERICAL LINEAR ALGEBRA WITH APPLICATIONS, Issue 6 2008Zhi-Hao Cao Abstract We consider the use of block preconditioners for the application of the preconditioned Krylov subspace iterative methods to the solution of large saddle point-type systems with singular (1, 1) blocks. Two block triangular preconditioners are introduced and the block diagonal preconditioner in Greif and Schötzau (Electron. Trans. Numer. Anal. 2006; 22:114,121) is extended to nonsymmetric saddle point systems. All these preconditioners are based on augmentation, using nonsingular weight matrices. If the nullity of the (1, 1) block takes its highest possible value, the preconditioned matrix with either block triangular preconditioner has precisely three distinct eigenvalues, and the preconditioned matrix with the block diagonal preconditioner has precisely two distinct eigenvalues, giving rise to immediate convergence of preconditioned GMRES. Finally, numerical experiments that validate the analysis are reported. Copyright © 2008 John Wiley & Sons, Ltd. [source] Numerical solution of the free-surface viscous flow on a horizontal rotating elliptical cylinderNUMERICAL METHODS FOR PARTIAL DIFFERENTIAL EQUATIONS, Issue 4 2008Roland Hunt Abstract The numerical solution of the free-surface fluid flow on a rotating elliptical cylinder is presented. Up to the present, research has concentrated on the circular cylinder for which steady solutions are the main interest. However, for noncircular cylinders, such as the ellipse, steady solutions are no longer possible, but there will be periodic solutions in which the solution is repeated after one full revolution of the cylinder. It is this new aspect that makes the investigation of noncircular cylinders novel. Here we consider both the time-dependent and periodic solutions for zero Reynolds number fluid flow. The numerical solution is expedited by first mapping the fluid film domain onto a rectangle such that the position of the free-surface is determined as part of the solution. For the time-dependent case a simple time-marching method of lines approach is adopted. For the periodic solution the discretised nonlinear equations have to be solved simultaneously over a time period. The resulting large system of equations is solved using Newton's method in which the form of the Jacobian enables a straightforward decomposition to be implemented, which makes matrix inversion manageable. In the periodic case all derivatives have been approximated pseudospectrally with the time derivative approximated by a differentiation matrix which has been specially derived so that the weight of fluid is algebraically conserved. Of interest is the solution for which the weight of fluid is at its maximum possible value, and this has been obtained by increasing the weight until a consistency break-down occurs. Time-dependent solutions do not produce the periodic solution after a long time-scale but have protuberances which are constantly appearing and disappearing. Periodic solutions exhibit spectral accuracy solutions and maximum supportable weight solutions have been obtained for ranges of eccentricity and angular velocity. The maximum weights are less than and approximately proportional to those obtained for the circular case. The shapes of maximum weight solutions is distinctly different from sub-maximum weight solutions. © 2007 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2008 [source] Relaxor-based thin film memories and the depolarizing field problemPHYSICA STATUS SOLIDI (A) APPLICATIONS AND MATERIALS SCIENCE, Issue 6 2007Manuel I. Marqués Abstract A simple model for a thin film memory based on a first neighbor interacting model is studied in detail. We have found that the minimum possible value for the thickness (D) as a function of the lateral size of the memory (L), the screening of the charges at the substrate (S) and the strength of the ferroelectric interaction (J), in order to obtain spontaneous polarization is D = SL /2J. We propose a new mechanism to obtain miniaturization of thin film memories to a single layer based on the use of relaxor ferroelectrics instead of regular ferroelectrics. Under the hypothesis of an internal organization of the random fields inside the nanofilm we show analytically how it should be possible to miniaturize the memory to a width as small as D = 1 for any value of L, J and S. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] A new look at the quantum mechanics of the harmonic oscillatorANNALEN DER PHYSIK, Issue 7-8 2007H.A. Kastrup Abstract In classical mechanics the harmonic oscillator (HO) provides the generic example for the use of angle and action variables and I > 0 which played a prominent role in the "old" Bohr-Sommerfeld quantum theory. However, already classically there is a problem which has essential implications for the quantum mechanics of the (,,I)-model for the HO: the transformation is only locally symplectic and singular for (q,p) = (0,0). Globally the phase space {(q,p)} has the topological structure of the plane ,2, whereas the phase space {(,,I)} corresponds globally to the punctured plane ,2 -(0,0) or to a simple cone with the tip deleted. From the properties of the symplectic transformations on that phase space one can derive the functions h0 = I, h1 = Icos , and h2 = - Isin , as the basic coordinates on {(,,I)}, where their Poisson brackets obey the Lie algebra of the symplectic group of the plane. This implies a qualitative difference as to the quantum theory of the phase space {(,,I)} compared to the usual one for {(q,p)}: In the quantum mechanics for the (,,I)-model of the HO the three hj correspond to the self-adjoint generators Kj, j = 0,1,2, of certain irreducible unitary representations of the symplectic group or one of its infinitely many covering groups, the representations being parametrized by a (Bargmann) index k > 0. This index k determines the ground state energy of the (,,I)-Hamiltonian . For an m -fold covering the lowest possible value for k is k = 1/m, which can be made arbitrarily small by choosing m accordingly! This is not in contradiction to the usual approach in terms of the operators Q and P which are now expressed as functions of the Kj, but keep their usual properties. The richer structure of the Kj quantum model of the HO is "erased" when passing to the simpler (Q,P)-model! This more refined approach to the quantum theory of the HO implies many experimental tests: Mulliken-type experiments for isotopic diatomic molecules, experiments with harmonic traps for atoms, ions and BE-condensates, with charged HOs in external electric fields and the (Landau) levels of charged particles in external magnetic fields, with the propagation of light in vacuum, passing through strong external electric or magnetic fields. Finally it may lead to a new theoretical estimate for the quantum vacuum energy of fields and its relation to the cosmological constant. [source] For debate: problems with the DMF index pertinent to dental caries data analysisCOMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY, Issue 6 2005J. M. Broadbent Abstract , The Decayed, Missing, Filled (DMF) index has been used for over 50 years and is well established as the key measure of caries experience in dental epidemiology. Despite its long history of use, there is debate about the most appropriate number of surfaces to include for a missing tooth. Assigning the maximum possible value for the ,M' component of DMFS (Surfaces) leads to overestimation of an individual's caries experience, and in any associated comparisons of in-caries experience, whereas assigning the minimum possible value for the ,M' component has the opposite effect. Alternative methods of assigning the number of caries-affected surfaces for an extracted tooth are considered. The net caries increment and adjusted caries increment (common methods of correction of the crude increment measure for reversals) are discussed, along with incidence density, a measure of caries extent. Problems exist with the adjusted caries increment, particularly among cohorts with low mean baseline caries experience. Development of an alternative method of estimating the relationship of ,true' and ,examiner' reversals is advocated, as well as greater utilization of incidence density in dental epidemiology. [source] An empirical method for inferring species richness from samplesENVIRONMETRICS, Issue 2 2006Paul A. Murtaugh Abstract We introduce an empirical method of estimating the number of species in a community based on a random sample. The numbers of sampled individuals of different species are modeled as a multinomial random vector, with cell probabilities estimated by the relative abundances of species in the sample and, for hypothetical species missing from the sample, by linear extrapolation from the abundance of the rarest observed species. Inference is then based on likelihoods derived from the multinomial distribution, conditioning on a range of possible values of the true richness in the community. The method is shown to work well in simulations based on a variety of real data sets. Copyright © 2005 John Wiley & Sons, Ltd. [source] A stationary-wave model of enzyme catalysisJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 2 2010Carlo Canepa Abstract An expression for the external force driving a system of two coupled oscillators in the condensed phase was derived in the frame of the Debye theory of solids. The time dependence and amplitude of the force is determined by the size of the cell embedding the coupled oscillators and its Debye temperature (,D). The dynamics of the driven system of oscillators were followed in the two regimes of (a) low ,D and cell diameter, as a model of liquid water, and (b) large ,D and cell diameter, as a model of the core of a protein. The response in potential energy of the reference oscillator was computed for all possible values of the internal parameters of the system under investigation. For protein cores, the region in the parameter space of high maximum potential energy of the reference oscillator is considerably extended with respect to the corresponding simulation for water. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2010 [source] Eclipsing binaries in open clusters , III.MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 3 2004Persei, V621 Per in ABSTRACT V621 Persei is a detached eclipsing binary in the open cluster , Persei, which is composed of an early B-type giant star and a main-sequence secondary component. From high-resolution spectroscopic observations and radial velocities from the literature, we determine the orbital period to be 25.5 d and the primary velocity semi-amplitude to be K= 64.5 ± 0.4 km s,1. No trace of the secondary star has been found in the spectrum. We solve the discovery light curves of this totally eclipsing binary and find that the surface gravity of the secondary star is log gB= 4.244 ± 0.054. We compare the absolute masses and radii of the two stars in the mass,radius diagram, for different possible values of the primary surface gravity, with the predictions of stellar models. We find that log gA, 3.55, in agreement with values found from fitting Balmer lines with synthetic profiles. The expected masses of the two stars are 12 and 6 M, and the expected radii are 10 and 3 R,. The primary component is near the blue loop stage in its evolution. [source] On,off minimum-time control with limited fuel usage: near global optima via linear programmingOPTIMAL CONTROL APPLICATIONS AND METHODS, Issue 3 2006Brian J. Driessen Abstract A method for finding a global optimum to the on,off minimum-time control problem with limited fuel usage is presented. Each control can take on only three possible values: maximum, zero, or minimum. The simplex method for linear systems naturally yields nearly such a solution for the re-formulation presented herein because the simplex method always produces an extreme point solution to the linear program. Numerical examples for the benchmark linear flexible system are presented. Copyright © 2006 John Wiley & Sons, Ltd. [source] Estimating flame speeds for use with the BST blast curvesPROCESS SAFETY PROGRESS, Issue 1 2009Timothy A. Melton Abstract The Baker-Strehlow-Tang (BST) vapor cloud explosion model is one of the most common methods used to estimate overpressures for the purpose of locating buildings in relation to process units. This model suffers from a problem common to all simplified explosion models: the user is required to pick the "strength" of the explosion using one or more simple parameters. In the BST model, the fuel reactivity, flame expansion, and obstacle density parameters are used to select a flame speed from a limited matrix of possible values. This article presents the Quest Model for estimation of flame speeds (QMEFS), a systematic approach to estimating flame speed that does not rely on the BST categories. It provides for a continuous range of flame speeds that can then be used with the existing BST blast curves to calculate the characteristics of the vapor cloud explosion. The QMEFS approach provides the user with a method for describing a vapor cloud explosion that is more detailed than the BST model, and establishes a more refined system for predicting the consequences of vapor cloud explosions. © 2008 American Institute of Chemical Engineers Process Saf Prog, 2009 [source] The Value of Life and Health for Public PolicyTHE ECONOMIC RECORD, Issue SpecialIssue 2003Peter Abelson Expenditure on health and safety is a substantial part of GDP, but public agencies in many countries, including Australia, have only qualitative views about the value of life and health. Also, despite considerable work by economists on the value of life and health in recent years, some important issues, such as the value of a healthy life-year, remain unresolved. This paper presents a framework for valuing life and health. It then draws on international and Australian research to estimate possible values for life, healthy life-years, and various chronic and acute health states for public policy purposes in Australia. [source] | ||||||||||||||||||||||