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Possible Mediator (possible + mediator)
Selected AbstractsIncreased expression of VEGF following exercise training in patients with heart failureEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 4 2001T. Gustafsson Background and aims During the last decades several angiogenic factors have been characterized but so far it is unknown whether local muscle exercise training increases the expression of these factors in patients with moderate heart failure. Expression of the major putative angiogenic factor vascular endothelial growth factor (VEGF) at the level of messneger RNA (mRNA) and/or protein was therefore studied before and after 8 weeks of training in patient with chronic heart failure. Methods VEGF mRNA and protein concentrations were determined in skeletal muscle biopsies before and after 8 weeks of one-legged knee extension training in patients with chronic heart failure (New York Heart Association II,III). Results Exercise training increased the citrate synthase activity and peripheral exercise capacity by 46% and 36%, respectively, in parallel with a two-fold increase in VEGF at both the mRNA (P = 0·03) and protein (P = 0·02) levels Conclusion The increase in VEGF gene expression in response to exercise training indicates VEGF to be one possible mediator in exercise-induced angiogenesis and may therefore regulate an important and early step in adaptation to increased muscle activity in patient with chronic heart failure. [source] Inhibition of CCAAT/enhancer binding protein , expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effectsJOURNAL OF NEUROCHEMISTRY, Issue 2 2010Núria Gresa-Arribas J. Neurochem. (2010) 115, 526,536. Abstract The control of neuroinflammation is a potential target to be considered in the treatment of neurodegenerative diseases. It is therefore important to find anti-inflammatory drugs and study new targets that inhibit neuroinflammation. We designed an experimental model of neuroinflammation in vitro to study the anti-inflammatory and neuroprotective effects of the flavonoid chrysin and the involvement of nuclear factor-,B p65 and CCAAT/enhancer binding proteins (C/EBPs) , and , transcription factors in its mechanism of action. We used primary cultures of mouse embryonic cortical neurons and cultures of BV2 (murine microglial cell line) or mouse primary microglia. We induced neuronal death in neuronal-BV2/microglial co-cultures using lipopolysaccharide of Escherichia coli and interferon-,. Chrysin pre-treatment inhibited nitric oxide and tumor necrosis factor-, production, as well as inducible nitric oxide synthase expression in lipopolysaccharide E. coli and interferon-,-treated microglial cells, but did not affect cyclooxygenase-2 expression. Chrysin pre-treatment also protected neurons against the neurotoxicity induced by reactive microglial cells. These effects were associated to a decrease in C/EBP, protein level, mRNA expression, and DNA-binding activity, with no effect on C/EBP, and p65 nuclear protein levels or DNA-binding activity, pointing out C/EBP, as a possible mediator of chrysin effects. Consequently, C/EBP, is a possible target to act against neuroinflammation in neurodegenerative processes. [source] Involvement of Acetaldehyde in Alcohol AddictionALCOHOLISM, Issue 1 2002William J. McBride This article presents the proceedings of a symposium at the 2001 RSA Meeting in Montreal, Canada. The organizers and chairs were William J. McBride and Ting-Kai Li. The presentations were (1) Metabolism of ethanol in the brain and the behavioral consequences, by Richard A. Deitrich and Sergey Zimatkin; (2) Catalase production of acetaldehyde as a possible mediator of the psychopharmacological effects of ethanol, by Brian R. Smith; (3) The reinforcing actions of acetaldehyde in the ventral tegmental area, by Zachary A. Rodd-Henricks; and (4) Salsolinol and alcohol addiction, by William J. McBride. [source] Adult attachment, intimacy and psychological distress in a clinical and community sampleCLINICAL PSYCHOLOGY AND PSYCHOTHERAPY (AN INTERNATIONAL JOURNAL OF THEORY & PRACTICE), Issue 6 2005Suzanne B. Pielage Attachment theory predicts that early experiences with caregivers affect the quality of individuals' later (romantic) relationships and, consequently, their mental health. The present study examined the role of intimacy in the current romantic relationship as a possible mediator of the relationship between adult attachment and psychological distress in a clinical and community sample. Results indicated that attachment security was positively, whereas attachment insecurity was negatively, related to intimacy in the current romantic relationship. Furthermore, security of attachment was negatively related to loneliness and depression and positively to satisfaction with life. The reverse held for attachment insecurity. Mediational analyses revealed that intimacy in the current relationship only partially mediated the relationship between attachment and psychological distress. Although near perfect mediation was found for fearful attachment in the clinical sample and for preoccupied attachment in the community sample, the findings with regard to the other attachment styles were less clear-cut. Apart from the hypothesized indirect effect of attachment on psychological distress through intimacy, a direct effect of attachment on psychological distress remains. The implications of these findings and suggestions for future research are discussed.,Copyright © 2005 John Wiley & Sons, Ltd. [source] Improving mother,child interaction in low-income Turkish,Dutch families: A study of mechanisms mediating improvements resulting from participating in a home-based preschool intervention programINFANT AND CHILD DEVELOPMENT, Issue 4 2004Cathy van Tuijl Abstract This study examined whether the effects on cognitive and language outcomes of a recently developed home-based educational intervention program, Opstap Opnieuw, for 4,6-years-old disadvantaged children could be explained by improved mother,child interaction. The present sample (n=30) was drawn from a larger sample of Turkish,Dutch families (n=181) for which in a previous study significant effects of Opstap Opnieuw were found on children's (first) language and cognitive pre-math skill, 5 months after the program ended. The present study focused on two facets of interaction quality as possible mediators of these program effects: the mean cognitive distancing level of mothers' communication and instruction behaviour as an indicator of the cognitive and verbal stimulation provided, and the degree of cooperation as an indicator of mothers' social-emotional support to their children. Both measures were based on systematic observation of mother,child interaction during sorting tasks. Participation in the program appeared to improve mothers' social-emotional support behaviour substantially, but not their cognitive distancing behaviour. For Turkish (first language) vocabulary, about half of the program effect appeared to be mediated by the improved social-emotional support. For cognitive pre-mathematical skills, two-thirds of the program effect appeared to be mediated by improved social-emotional support. Mothers' cognitive distancing was moderately-strongly related to children's vocabulary development, but did not mediate program effects. Some implications of the results are discussed. Copyright © 2004 John Wiley & Sons, Ltd. [source] Gender Differences in the Expression of Galanin and Vasoactive Intestinal Peptide in Oestrogen-Induced Prolactinomas of Fischer 344 RatsJOURNAL OF NEUROENDOCRINOLOGY, Issue 1 2004G. G. Piroli Abstract We have previously described a sexual dimorphism in oestrogen-induced anterior pituitary tumorigenesis in Fischer 344 rats, with female tumours averaging twice the size of those of males. Neonatal androgenization of female Fischer 344 rats with 100 µg of testosterone propionate reverted that effect, causing a ,male-like' phenotype. The peptides galanin and vasoactive intestinal peptide (VIP) are possible mediators of oestrogen effects on the anterior pituitary, including hyperprolactinemia and lactotroph proliferation. To further extend our previous findings, we investigated the expression of galanin and VIP in the anterior pituitary of control and oestrogenized male, female and neonatally androgenized female Fischer 344 rats. At 3 months of age, rats were deprived of their gonads and divided into control and diethylstilbestrol (DES)-treated groups. In the anterior pituitary of control rats, galanin and VIP immunoreactive cells were absent. However, in DES-treated rats, pituitaries from normal ovariectomized females showed higher number of galanin and VIP positive cells than pituitaries from neonatally androgenized ovariectomized females and gonadectomized males. This pattern correlated with changes in anterior pituitary weight and serum prolactin. Our study suggests that sexual differences in oestrogen-induced pituitary tumorigenesis could be due to the differential expression of galanin and VIP. Furthermore, our data support the fact that neonatal exposure to androgens, as in normal males and androgenized females, may condition the response of the pituitary gland to oestrogens in adult life. [source] Mothers' Violence Victimization and Child Behavior Problems: Examining the LinkAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 2 2007Richard Thompson PhD The current study examined the link between parents' experience of violence victimization and child outcomes, in 197 mother-child dyads recruited from low-income urban neighborhoods. At recruitment (when children were between 6 and 18 months old), demographic factors, child behavioral outcomes, mother-child interactions, mothers' psychosocial functioning, and mothers' history of violence victimization were assessed. Child behavioral outcomes, mother-child interactions, and mothers' psychosocial functioning were assessed again at age 4. Mothers' history of victimization as children (but not as adults) uniquely predicted child behavior problems at age 4. Three classes of possible mediators were examined: demographics, maternal psychosocial functioning, and mother-child interactions. Of these, only mother psychological aggression toward child met preliminary criteria for mediation; it partially mediated the link between mother childhood victimization and child behavioral outcomes. Maternal depressive symptoms and young age at child's birth independently predicted child behavior problems, but did not act as mediators. Mothers' early experiences with violence victimization appear to exert an important influence on child behavioral outcomes; this influence appears to be mediated, in part, by mothers' psychological aggression toward their children. [source] Growth hormone deficiency and vascular riskCLINICAL ENDOCRINOLOGY, Issue 1 2002Roland W. McCallum Summary The importance of growth hormone deficiency (GHD) in adult life has become more apparent over the last decade. As well as a distinct clinical syndrome there is a significant excess risk of cardiovascular disease. Although it is difficult to ascertain what part is played by the original pituitary disorder and the concomitant replacement hormonal therapies, there is clear evidence that GHD is associated with known cardiovascular risk factors such as body shape, lipid profile, insulin resistance, blood pressure, vessel wall morphology and haemostatic factors. Novel means of assessing vascular risk such as pulse wave velocity and flow-mediated dilatation can also estimate the risk without invasive procedures. The role of possible mediators of endothelial function such as nitric oxide and free radicals is being investigated further. Replacement of GH in GH-deficient patients leads to many effects on the above indices, some but not all of which are associated with reduced vascular risk. Long-term follow-up studies of morbidity and mortality are required for an accurate assessment of the beneficial effects of therapy. [source] | |||||||||||||