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Selected AbstractsThe relationship between non-working-side occlusal contacts and mandibular positionJOURNAL OF ORAL REHABILITATION, Issue 10 2001T. Ogawa No clear description can be found regarding the lateral position when examining non-working-side occlusal contacts. The objective of this study was to test the hypothesis that the non-working-side contact pattern varies with the mandibular position. The characteristics of the non-working-side contact pattern were also determined relative to the working-side contact pattern. Occlusal contacts of 86 young adults were examined using shim stock in standardized lateral positions: 0·5, 1, 2 and 3 mm from the maximum intercuspation (MI), where the 0·5, 1 and 2 mm positions were defined as lateral positions close to the MI and the 3 mm position as an edge-to-edge position. The frequency of non-working-side occlusal contacts decreased gradually from 0·5 to 3 mm position. The frequency of non-working-side contacts was significantly greater in the 0·5 and 1 mm positions than in the 3 mm position. Non-working-side occlusal contacts occurred in nearly half of the 0·5 mm positions. Non-working-side contacts were significantly less frequent with canine protection than with group function for the 0·5 and 1 mm positions. There were no significant differences between the two occlusal schemes for the 2 and 3 mm positions. In conclusions, the non-working-side contact pattern varied with the mandibular position. These results suggest that clinical examination should include contact patterns both in a position close to the MI and in an edge-to-edge position, i.e. in functional and parafunctional ranges. Likewise, data from occlusal contact research should include a standardized definition of mandibular position. [source] Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discoveryACTA CRYSTALLOGRAPHICA SECTION D, Issue 8 2010Paul K. Fyfe The medium-resolution structure of adenylosuccinate lyase (PurB) from the bacterial pathogen Staphylococcus aureus in complex with AMP is presented. Oxalate, which is likely to be an artifact of crystallization, has been modelled in the active site and occupies a position close to that where succinate is observed in orthologous structures. PurB catalyzes reactions that support the provision of purines and the control of AMP/fumarate levels. As such, the enzyme is predicted to be essential for the survival of S. aureus and to be a potential therapeutic target. Comparisons of this pathogen PurB with the enzyme from Escherichia coli are presented to allow discussion concerning the enzyme mechanism. Comparisons with human PurB suggest that the close similarity of the active sites would make it difficult to identify species-specific inhibitors for this enyme. However, there are differences in the way that the subunits are assembled into dimers. The distinct subunit,subunit interfaces may provide a potential area to target by exploiting the observation that creation of the enzyme active site is dependent on oligomerization. [source] The relationship between non-working-side occlusal contacts and mandibular positionJOURNAL OF ORAL REHABILITATION, Issue 10 2001T. Ogawa No clear description can be found regarding the lateral position when examining non-working-side occlusal contacts. The objective of this study was to test the hypothesis that the non-working-side contact pattern varies with the mandibular position. The characteristics of the non-working-side contact pattern were also determined relative to the working-side contact pattern. Occlusal contacts of 86 young adults were examined using shim stock in standardized lateral positions: 0·5, 1, 2 and 3 mm from the maximum intercuspation (MI), where the 0·5, 1 and 2 mm positions were defined as lateral positions close to the MI and the 3 mm position as an edge-to-edge position. The frequency of non-working-side occlusal contacts decreased gradually from 0·5 to 3 mm position. The frequency of non-working-side contacts was significantly greater in the 0·5 and 1 mm positions than in the 3 mm position. Non-working-side occlusal contacts occurred in nearly half of the 0·5 mm positions. Non-working-side contacts were significantly less frequent with canine protection than with group function for the 0·5 and 1 mm positions. There were no significant differences between the two occlusal schemes for the 2 and 3 mm positions. In conclusions, the non-working-side contact pattern varied with the mandibular position. These results suggest that clinical examination should include contact patterns both in a position close to the MI and in an edge-to-edge position, i.e. in functional and parafunctional ranges. Likewise, data from occlusal contact research should include a standardized definition of mandibular position. [source] Structural Coupling of 11- cis -7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 2 2009Ṃnica Aguilà It was previously shown that opsin can be regenerated with the newly synthesized 11- cis -7-methyl-retinal forming an artificial visual pigment. We now extend this study to include mutants at positions close to the retinal to further dissect the interactions of native and artificial chromophores with opsin. Several mutants at M207, W265 and Y268 have been obtained and regenerated with 11- cis -retinal and the 7-methyl analog. M207 is the site of the point mutation M207R associated with the retinal degenerative disease retinitis pigmentosa. All the studied mutants regenerated with 11- cis -retinal except for M207C which proved to be completely misfolded. The naturally occurring M207R mutant formed a pigment with an unprotonated Schiff base linkage, altered photobleaching and low MetarhodopsinII stability. Mutants regenerated with the 7-methyl analog showed altered photobleaching reflecting a structural perturbation in the vicinity of M207. The newly obtained mutants at M207 also showed reduced levels of transducin activation with M207R showing essentially no transducin activation. Our results highlight the tight coupling of the vicinity of C7 of retinal and M207 and support the involvement of this amino acid residue in the conformational changes associated with rhodopsin photoactivation. [source] Projecting group liking and ethnocentrism on in-group members: False consensus effect of attitude strengthASIAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 2 2003Minoru Karasawa The purpose of the present study was to examine the social projection effect concerning the strength of national attitudes. Japanese respondents sampled from the general population judged how patriotic and nationalistic opinions were distributed among Japanese (i.e. in-group) and American (out-group) citizens. The respondents' own positions regarding these attitude dimensions were also measured. As predicted, the respondents inflated estimates of the endorsement for positions close to their own, particularly when the target was the in-group. Estimates of opinion distributions in the out-group converged around stereotypic positions. The apparent projection effect in patriotism (i.e. in-group liking) was likely mediated by abstract trait evaluations of the home country, while the projection of nationalism (i.e. ethnocentrism) appeared to be a direct result of projection without such mediation. Different processes such as the motivation for cognitive consistency and the need to achieve social identity of the group were suggested to underlie projection effects in different domains. Implications of the results for the study of stereotyping and intergroup conflict are discussed. [source] Continuous scalable blood filtration device using inertial microfluidicsBIOTECHNOLOGY & BIOENGINEERING, Issue 2 2010Albert J. Mach Abstract Cell separation is broadly useful for applications in clinical diagnostics, biological research, and potentially regenerative medicine. Recent attention has been paid to label-free size-based techniques that may avoid the costs or clogging issues associated with centrifugation and mechanical filtration. We present for the first time a massively parallel microfluidic device that passively separates pathogenic bacteria cells from diluted blood with macroscale performance. The device was designed to process large sample volumes in a high-throughput, continuous manner using 40 single microchannels placed in a radial array with one inlet and two rings of outlets. Each single channel consists of a short focusing, gradual expansion and collection region and uses unique differential transit times due to size-dependent inertial lift forces as a method of cell separation. The gradual channel expansion region is shown to manipulate cell equilibrium positions close to the microchannel walls, critical for higher efficiency collection. We demonstrate >80% removal of pathogenic bacteria from blood after two passes of the single channel system. The massively parallel device can process 240,mL/h with a throughput of 400 million cells/min. We expect that this parallelizable, robust, and label-free approach would be useful for filtration of blood as well as for other cell separation and concentration applications from large volume samples. Biotechnol. Bioeng. 2010;107: 302,311. © 2010 Wiley Periodicals, Inc. [source] | ||||||||||