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Potential Scaffold (potential + scaffold)

Distribution by Scientific Domains

Polymers and Materials Science	50%
Chemistry	50%

Selected Abstracts

ChemInform Abstract: Kinetically Controlled Ring-Closing Metathesis: Synthesis of a Potential Scaffold for 12-Membered Salicylic Macrolides.

CHEMINFORM, Issue 42 2008
Yuji Matsuya
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Electrospun Composite Mats of Poly[(D,L -lactide) -co- glycolide] and Collagen with High Porosity as Potential Scaffolds for Skin Tissue Engineering

MACROMOLECULAR MATERIALS & ENGINEERING, Issue 9 2009
Ye Yang
Abstract Electrospun composite mats of poly[(D,L -lactide) -co- glycolide] and collagen with high porosities of 85,90% and extended pore sizes of 90,130,µm were prepared to mimic the ECM morphologically and chemically. The existence of collagen molecules on the fiber surface was confirmed, enabling the cells to find enhanced binding sites for their integrin receptors. The mechanical data for the blended fibrous mats indicated that they were sufficiently durable for dermal tissue engineering. Fibroblasts derived from GFP transgenic C57BL/6 mice were used to directly observe cell proliferation, and the inoculation of collagen enhanced cell attachment, proliferation and extracellular matrix secretion, which were found to be dependent on the amount of collagen in the composite scaffold. [source]

Nonpeptide Integrin Antagonists: RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 8 2007
Leonardo Manzoni
Abstract Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of the RGD signaling motif of integrin. Two sets of functionalized azabicycloalkanes have been examined. In vitro assays established that 21 has a good affinity specifically for ,v,3. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source]

Development of Electrospun Three-arm Star Poly(, -caprolactone) Meshes for Tissue Engineering Applications

MACROMOLECULAR BIOSCIENCE, Issue 8 2010
Dario Puppi
Abstract We have developed three-dimensional electrospun microfibrous meshes of a novel star branched three-arm poly(, -caprolactone) (*PCL) as potential scaffolds for tissue engineering applications. The processing conditions required to obtain uniform fibers were optimized by studying their influence on fiber morphology and size. Polymer molecular weight and solution feed rate influenced both the mesh microstructure and the tensile properties of the developed mats. Electrospun samples were also tested for their mechanical properties in wet conditions, showing higher yield strength and strain in comparison to that observed in dry conditions. Cell culture experiments employing MC3T3-E1 osteoblast like cells showed good cell viability adhesion and collagen production on the *PCL scaffolds. [source]