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Potential COX-2 Inhibitors (potential + cox-2_inhibitor)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors.

CHEMINFORM, Issue 7 2005
Meena V. Patel
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Synthesis of 4-(4-Methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole Thione Derivatives as New Potential COX-2 Inhibitors

CHINESE JOURNAL OF CHEMISTRY, Issue 6 2006
Saeed Emami
Abstract Synthesis of novel 4-(4-methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole thione derivatives with functionalized diarylheterocycle pharmacophore as potential COX-2 inhibitors was described. The title compounds were synth- esized by cyclocondensation of corresponding dithiocarbamate and 2-bromo-1-(4-methylsulfonylphenyl)ethanone, followed by dehydration with H2SO4. All of the target compounds were characterized by 1H NMR, IR and mass spectral data. [source]

Novel Chemical Transformations of Tenoxicam

HELVETICA CHIMICA ACTA, Issue 8 2005
Kristóf Kóczián
Both N - and O -substituted derivatives of the anti-inflammatory drug tenoxicam (=,4-hydroxy-2-methyl- N -(pyridin-2-yl)-2H -thieno[2,3 -e],[1,2]thiazine-3-carboxamide 1,1-dioxide; 1) were synthesized, and various chemical transformations were investigated. Both selective hydrolysis and reaction of 1,- N -methyltenoxicam (5) with a variety of N-nucleophiles were performed (Scheme,1). Also, five new 4- O -acyl derivatives 10 were prepared as potential prodrugs (Scheme,2). The 4-chloro derivatives of 1 and its analog 8 could be successfully transformed into the novel tetra- and tricyclic ring systems 12 and 13, respectively, the latter being a conformationally restricted 1,5-diaryl-pyrazole designed as a potential COX-2 inhibitor. [source]

Synthesis of 4-(4-Methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole Thione Derivatives as New Potential COX-2 Inhibitors

CHINESE JOURNAL OF CHEMISTRY, Issue 6 2006
Saeed Emami
Abstract Synthesis of novel 4-(4-methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole thione derivatives with functionalized diarylheterocycle pharmacophore as potential COX-2 inhibitors was described. The title compounds were synth- esized by cyclocondensation of corresponding dithiocarbamate and 2-bromo-1-(4-methylsulfonylphenyl)ethanone, followed by dehydration with H2SO4. All of the target compounds were characterized by 1H NMR, IR and mass spectral data. [source]