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Asymmetric Aza-Henry Reaction (asymmetric aza-henry + reaction)
Selected AbstractsDoubly Stereocontrolled Asymmetric Aza-Henry Reaction with in situ Generation of N -Boc-Imines Catalyzed by Novel Rosin-Derived Amine Thiourea CatalystsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 13 2009Xianxing Jiang Abstract The doubly stereocontrolled organocatalytic aza-Henry reaction of nitroalkanes to N -Boc-imines generated in situ from a variety of substituted ,-amido sulfones was investigated for the first time, in general, affording the corresponding products with high to excellent yields (up to 93% yield) and enantioselectivities (up to 98% ee), and satisfactory diastereoselectivies (anti/syn up to 98:2). Furthermore, these organocatalysts based on rosin have been proved to be the very effective promoters for this catalytic asymmetric process along side the Cinchona alkaloid-derived catalysts. [source] A Novel Bis-Thiourea Organocatalyst for the Asymmetric Aza-Henry ReactionADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2008Constantinos Rampalakos Abstract A novel bis-thiourea/2,2,-diaminobinaphthalene (BINAM)-based catalyst for the asymmetric aza-Henry reaction has been developed. This catalyst promotes the reaction of N -Boc imines with nitroalkanes to afford ,-nitroamines with good yields and high enantioselectivities. This catalyst has the advantage that it can be prepared in a single step from commercially available materials. A model is proposed for the catalyst action where both components of the reaction are activated simultaneously by hydrogen bonding. Regardless of the mechanism, the success of the present catalyst demonstrates the potential of bis-thioureas as an interesting class of relatively unexplored catalysts. [source] ChemInform Abstract: A Novel Bis-Thiourea Organocatalyst for the Asymmetric Aza-Henry Reaction.CHEMINFORM, Issue 50 2008Constantinos Rampalakos Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Asymmetric Aza-Henry Reaction under Phase Transfer Catalysis: An Experimental and Theoretical Study.CHEMINFORM, Issue 44 2008Enrique Gomez-Bengoa Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] A Novel Bis-Thiourea Organocatalyst for the Asymmetric Aza-Henry ReactionADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2008Constantinos Rampalakos Abstract A novel bis-thiourea/2,2,-diaminobinaphthalene (BINAM)-based catalyst for the asymmetric aza-Henry reaction has been developed. This catalyst promotes the reaction of N -Boc imines with nitroalkanes to afford ,-nitroamines with good yields and high enantioselectivities. This catalyst has the advantage that it can be prepared in a single step from commercially available materials. A model is proposed for the catalyst action where both components of the reaction are activated simultaneously by hydrogen bonding. Regardless of the mechanism, the success of the present catalyst demonstrates the potential of bis-thioureas as an interesting class of relatively unexplored catalysts. [source] | ||||||||||