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Aspirin Sensitivity (aspirin + sensitivity)

Distribution by Scientific Domains

Medical Sciences	85%

Selected Abstracts

Aspirin sensitivity: acetylsalicylate or excipients

INTERNAL MEDICINE JOURNAL, Issue 8 2009
B. S. Hebron
Abstract We present three patients who developed urticaria while taking an enteric formulation of aspirin, confirmed on a second exposure. Although hypersensitivity reactions to aspirin, especially in asthmatic patients or those with nasal polyps, are well reported, our patients did not exhibit any underlying history of atopy. Furthermore, two of the patients were able to tolerate a soluble formulation. We review the literature and discuss whether these symptoms might be caused by pharmaceutical excipients, present in very small amounts in the enteric coating, rather than the active ingredient acetylsalicylate. Adverse reactions to excipients are fortunately rare but are occasionally reported. [source]

Oxylipin studies expose aspirin as antifungal

FEMS YEAST RESEARCH, Issue 8 2007
Johan L. F. Kock
Abstract The presence of aspirin-sensitive 3-hydroxy fatty acids (i.e. 3-OH oxylipins) in yeasts was first reported in the early 1990s. Since then, these oxidized fatty acids have been found to be widely distributed in yeasts. 3-OH oxylipins may: (1) have potent biological activity in mammalian cells; (2) act as antifungals; and (3) assist during forced spore release from enclosed sexual cells (asci). A link between 3-OH oxylipin production, mitochondria and aspirin sensitivity exists. Research suggests that: (1) 3-OH oxylipins in some yeasts are probably also produced by mitochondria through incomplete ,-oxidation; (2) aspirin inhibits mitochondrial ,-oxidation and 3-OH oxylipin production; (3) yeast sexual stages, which are probably more dependent on mitochondrial activity, are also characterized by higher 3-OH oxylipin levels as compared to asexual stages; (4) yeast sexual developmental stages as well as cell adherence/flocculation are more sensitive to aspirin than corresponding asexual growth stages; and (5) mitochondrion-dependent asexual yeast cells with a strict aerobic metabolism are more sensitive to aspirin than those that can also produce energy through an alternative anaerobic glycolytic fermentative pathway in which mitochondria are not involved. This review interprets a wide network of studies that reveal aspirin to be a novel antifungal. [source]

Variable number of tandem repeats polymorphism of platelet glycoprotein Ib , in Chinese people and CC genotype with aspirin sensitivity in patients with cerebral infarction

JOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 2 2009
Y.-Y. Jin MM
Summary Background and objective:, To study the prevalence of variable number of tandem repeats (VNTR) polymorphism in platelet membrane glycoprotein (GP) Ib , in a Chinese Han population and to determine the relationship between VNTR polymorphisms and aspirin resistance. Methods:, Three hundred healthy individuals and 110 patients with cerebral infarction volunteered to participate in this study. The genotype status of all participants was determined by polymerase chain reaction-restriction fragment length polymorphism analysis. Platelet aggregation in patients with cerebral infarction receiving aspirin (100 mg/day) for at least 7 days, was measured by optical transmission aggregometry. Results and discussion:, Only three alleles of GP Ib ,, namely, B, C and D, were found. Type A was not found in the Chinese Han participants. Aspirin-sensitive patients were significantly more often of CC genotype than aspirin-semi-responders. Conclusions:, Only three types of alleles B, C and D were detected in the north-eastern region of China. The CC genotype of the VTNR polymorphism in GPIb appears to be more sensitive to the inhibitory action of low-dose aspirin. [source]

Urinary leukotriene E4 and 9,, 11,-prostaglandin F2 concentrations in mild, moderate and severe asthma, and in healthy subjects

CLINICAL & EXPERIMENTAL ALLERGY, Issue 4 2004
N. L. A. Misso
Summary Background Airway inflammation in asthma is associated with cysteinyl leukotriene and prostaglandin D2 production. Measurement of urinary metabolites of these eicosanoids may be useful for monitoring asthma patients. However, the influence of asthma phenotype and severity on basal urinary excretion of these metabolites is unknown. Objective To compare urinary leukotriene (LT)E4 and 9,, 11,-prostaglandin (PG)F2 concentrations in large groups of mild, moderate and severe asthmatic patients and healthy control subjects. Methods Asthma severity, treatment and aspirin sensitivity were assessed by questionnaire in 168 asthmatic patients. Basal LTE4 and 9,, 11,-PGF2 concentrations were measured in urine samples from these patients and from 175 control subjects using enzyme immunoassays. Results Urinary LTE4 was correlated with 9,, 11,-PGF2 in both control subjects and asthmatic patients (P<0.002). Median LTE4 and 9,, 11,-PGF2 concentrations in patients with severe asthma were significantly reduced compared with mild asthmatic patients (P<0.05 and <0.001, respectively). Urinary 9,, 11,-PGF2, but not LTE4 was lower in asthmatic patients using inhaled corticosteroids (P<0.02). Multiple regression analysis indicated that urinary 9,, 11,-PGF2 concentration was negatively correlated with asthma severity (P=0.003) and also with % predicted FEV1 (forced expiratory volume in 1 s) (P=0.005). Conclusions Baseline urinary LTE4 and 9,, 11,-PGF2 concentrations are of limited value in discriminating between patients with different severities of asthma. Reduced urinary LTE4 and 9,, 11,-PGF2 in patients with severe asthma suggest that direct or indirect effects of high-dose corticosteroid therapy combined with other factors associated with severe asthma may influence eicosanoid production. However, the negative association of urinary 9,, 11,-PGF2 with lung function suggests an adverse effect of chronic PGD2 production on lung function in asthma, irrespective of severity. [source]

Subclinical aspirin sensitivity in subjects with nasal polyposis

CLINICAL OTOLARYNGOLOGY, Issue 6 2003
J.W.W. Killen
Subclinical aspirin sensitivity in subjects with nasal polyposis It is unclear whether subclinical airway responses to aspirin occur in subjects with nasal polyps and/or asthma without overt sensitivity. Sixty-three subjects without known aspirin sensitivity (13 controls, 17 nasal polyps alone, 15 nasal polyps and asthma and 18 asthma alone) inhaled increasing concentrations of nebulized lysine aspirin. Forced expiratory volume in 1 s (FEV1), symptoms and other potential markers of an airway response were measured. Four subjects (one polyps alone, one asthma alone, two with both) had a positive response to lysine aspirin predefined as symptoms plus a >10% fall in FEV1 from baseline. However, there was no evidence of a general subclinical response in any of the subject groups: mean (95% CI) change in FEV1; control 0.07 (,0.02,0.16) L, nasal polyps alone ,0.05 (,0.16,0.05) L, nasal polyps with asthma ,0.03 (,0.10,0.04) L, asthma alone ,0.03 (,0.09,0.03) L. We concluded that in the absence of a suggestive clinical history, only a small proportion of patients with nasal polyposis are likely to be sensitive to aspirin. There is no evidence of general subclinical sensitivity to aspirin in subjects with nasal polyps and no relevant history. [source]