Home  About us  Contact
 

Piperazine Derivatives (piperazine + derivative)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

ChemInform Abstract: Synthesis of Piperazine Derivatives by Cp*Ir Complex-Catalyzed N-Alkylative Reactions of Ethanolamines.

CHEMINFORM, Issue 28 2009
Ken-ichi Fujita
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Acaricidal properties of piperazine and its derivatives against house-dust and stored-food mites

PEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 6 2009
Chi-Hoon Lee
Abstract BACKGROUND: Piperazine derivatives possess pharmacological properties, yet the acaricidal activity of these compounds has not been investigated. This study was conducted to evaluate the colour alteration and acaricidal activity of piperazine derivatives against Dermatophagoides spp. and Tyrophagus putrescentiae (Schrank) using filter paper and fumigant methods. RESULTS: In a fumigant bioassay, 1-phenylpiperazine (7.83 µg cm,2) against D. farinae (Hughes) was found to be 4.7 times more toxic than DEET (36.84 µg cm,2), followed by benzyl benzoate (9.72 µg cm,2), piperazine (11.41 µg cm,2), 1-ethoxycarbonylpiperazine (20.14 µg cm,2) and 1-(2-methoxyphenyl)piperazine (22.14 µg cm,2). In a filter paper bioassay, 1-(2-methoxyphenyl)piperazine (3.65 µg cm,2) was 5.7 times more toxic than DEET (20.64 µg cm,2), followed by 1-ethoxycarbonylpiperazine (4.02 µg cm,2), 1-phenylpiperazine (4.75 µg cm,2), benzyl benzoate (7.83 µg cm,2) and piperazine (10.59 µg cm,2). Similar results have been exhibited with piperazine derivatives against D. pteronyssinus (Troussart). However, no activity against T. putrescentiae was observed for piperazine derivatives, except for piperazine. CONCLUSIONS: These results indicate that piperazine derivatives may be suitable as vapour-phase acaricide fumigants owing to their high volatility, acaricidal activity and safety. 1-Phenylpiperazine was found to be an excellent mite indicator based on the colour change it induced. Taken together, these findings indicate that piperazine derivatives may be used to replace existing problematical acaricides owing to their activity and ability to act as a mite indicator. Copyright © 2009 Society of Chemical Industry [source]

Synthesis and Antimalarial Evaluation of New N1 -(7-Chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine Derivatives.

CHEMINFORM, Issue 20 2005
Adina Ryckebusch
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Synthesis of bis-heteroaryl piperazine derivatives as potential reverse transcriptase inhibitors

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 4 2001
Jean Guillaumel
Vinylogous analogs of non-nucleoside reverse transcriptase inhibitors belonging to the bis-(hetero-aryl)piperazine (BHAP) series were synthesized by coupling a piperazine derivative with (E)-propenoyl derivatives of heterocyclic moieties. [source]

Acaricidal properties of piperazine and its derivatives against house-dust and stored-food mites

PEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 6 2009
Chi-Hoon Lee
Abstract BACKGROUND: Piperazine derivatives possess pharmacological properties, yet the acaricidal activity of these compounds has not been investigated. This study was conducted to evaluate the colour alteration and acaricidal activity of piperazine derivatives against Dermatophagoides spp. and Tyrophagus putrescentiae (Schrank) using filter paper and fumigant methods. RESULTS: In a fumigant bioassay, 1-phenylpiperazine (7.83 µg cm,2) against D. farinae (Hughes) was found to be 4.7 times more toxic than DEET (36.84 µg cm,2), followed by benzyl benzoate (9.72 µg cm,2), piperazine (11.41 µg cm,2), 1-ethoxycarbonylpiperazine (20.14 µg cm,2) and 1-(2-methoxyphenyl)piperazine (22.14 µg cm,2). In a filter paper bioassay, 1-(2-methoxyphenyl)piperazine (3.65 µg cm,2) was 5.7 times more toxic than DEET (20.64 µg cm,2), followed by 1-ethoxycarbonylpiperazine (4.02 µg cm,2), 1-phenylpiperazine (4.75 µg cm,2), benzyl benzoate (7.83 µg cm,2) and piperazine (10.59 µg cm,2). Similar results have been exhibited with piperazine derivatives against D. pteronyssinus (Troussart). However, no activity against T. putrescentiae was observed for piperazine derivatives, except for piperazine. CONCLUSIONS: These results indicate that piperazine derivatives may be suitable as vapour-phase acaricide fumigants owing to their high volatility, acaricidal activity and safety. 1-Phenylpiperazine was found to be an excellent mite indicator based on the colour change it induced. Taken together, these findings indicate that piperazine derivatives may be used to replace existing problematical acaricides owing to their activity and ability to act as a mite indicator. Copyright © 2009 Society of Chemical Industry [source]