Home About us Contact
|
Home About us Contact | ||
|
|
||
Personal Care Products (personal + care_products)
Selected AbstractsFormaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergyCONTACT DERMATITIS, Issue 1 2010Part 1. In this part of a series of review articles on formaldehyde-releasers and their relationship to formaldehyde contact allergy, formaldehyde-releasers in cosmetics are discussed. In this first part of the article, key data are presented including frequency of sensitization and of their use in cosmetics. In Europe, low frequencies of sensitization have been observed to all releasers: 2-bromo-2-nitropropane-1,3-diol 0.4,1.2%, diazolidinyl urea 0.5,1.4%, imidazolidinyl urea 0.3,1.4%, quaternium-15 0.6,1.9% (for DMDM hydantoin no recent data are available). All releasers score (far) higher prevalences in the USA; the possible explanations for this are discussed. The relevance of positive patch test reactions has been insufficiently investigated. In the USA, approximately 20% of cosmetics and personal care products (stay-on products: 17%, rinse-off products 27%) contain a formaldehyde-releaser. The use of quaternium-15 is decreasing. For Europe, there are no comparable recent data available. In the second part of the article, the patch test relationship of the releasers in cosmetics to formaldehyde contact allergy will be reviewed and it will be assessed whether products preserved with formaldehyde-releasers may contain enough free formaldehyde to pose a threat to individuals who have contact allergy to formaldehyde. [source] Sensory, clinical and physiological factors in sensitive skin: a reviewCONTACT DERMATITIS, Issue 1 2006Miranda A. Farage Certain individuals experience more intense and frequent adverse sensory effects than the normal population after topical use of personal care products, a phenomenon known in popular usage as sensitive skin. Consumer reports of sensitive skin are self-diagnosed and often not verifiable by objective signs of physical irritation. Companies who manufacture cosmetic and personal care products are challenged to provide safe products to an audience with tremendous differences in skin type, culture and habits. This review examines the still incomplete understanding of this phenomenon with respect to aetiology, diagnosis, appropriate testing methods, possible contributing host factors such as, sex, ethnicity, age, anatomical site, cultural and environmental factors, and the future directions needed for research. [source] Pharmaceuticals and personal care products (PPCPs): Disposal, scientific, and regulatory challengesENVIRONMENTAL QUALITY MANAGEMENT, Issue 1 2010Kathleen Gibson First page of article [source] Sampling in the Great Lakes for pharmaceuticals, personal care products, and endocrine-disrupting substances using the passive polar organic chemical integrative samplerENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 4 2010Hongxia Li Abstract The passive polar organic chemical integrative sampler in the pharmaceutical configuration (i.e., pharmaceutical-POCIS) was calibrated for sampling at water temperatures of 5, 15 and 25°C to determine the influence of temperature on chemical-specific sampling rates (RS), thus providing more robust estimates of the time-weighted average concentrations of pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting substances (EDS) in surface water. The effect of water temperature and flow on the RS of these analytes was evaluated in the laboratory with a static system. The loss of the test compounds from water by uptake into POCIS was linear over an 8-d period, and these experimental data yielded RS values in the range of 0.07 to 2.46 L/d across the temperature range for the 30 compounds tested. Water temperature and flow influenced POCIS uptake rates, but these effects were relatively small, which is consistent with the theory for uptake into POCIS samplers. Therefore, under a narrow range of water temperatures and flows, it may not be necessary to adjust the RS for POCIS. Except for acidic drugs and sulfonamide antibiotics, RS values were positively correlated with octanol,water partition coefficients (log KOW) of the test compounds. A linear relationship was also observed between RS and chromatographic retention times on a C18 reversed-phase column. These observations may provide a rapid method for estimating the RS of additional chemicals in the POCIS. The application of the RS to POCIS deployed for one month in Lake Ontario, Canada, during the summers of 2006 and 2008 yielded estimates of PPCP and EDS concentrations that are consistent with conventional concentration measurements of these compounds in Lake Ontario surface water. Environ. Toxicol. Chem. 2010;29:751,762. © 2009 SETAC [source] Pharmaceuticals and personal care products: Research needs for the next decade,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 12 2009Bryan W. Brooks First page of article [source] Interaction of stilbene compounds with human and rainbow trout estrogen receptorsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 2 2008Denina Bobbie Dawn Simmons Abstract Compounds with stilbene structures are widely used as pharmaceuticals and personal care products (PPCPs) and are present in plants. A suite of stilbene-related compounds, including PPCPs and plant-derived compounds were tested in vitro for interactions with the human and rainbow trout estrogen receptors and in vivo with rainbow trout using vitellogenin levels as a biomarker. Among the compounds with antagonistic activity, the common structural similarity was (in addition to the stilbene backbone) the presence of 4-hydroxy substitution. Stilbene-related compounds found to act as inhibitors at the estrogen receptor included the plant-derived compound resveratrol and two formulations of fluorescent whitening agents used in detergents, 4,4,-bis(2-sulfostyryl)biphenyl and diaminostilbene-1. In the yeast estrogenicity screening assay, the concentrations which caused a 50% inhibition in estrogenic response (IC50s) with the human estrogen receptor ranged from 2.56 × 10,6 to 2.56 × 10,6 M. In the rainbow trout estrogen receptor assay, the IC50s ranged from 7.75 × 10,8 to 1.11 × 10,5 M. However, in the in vivo rainbow trout vitellogenin assay, tamoxifen was the only stilbene of the compounds tested to have a significant effect as an inhibitor of estrogenicity. [source] Probabilistic risk evaluation for triclosan in surface water, sediments, and aquatic biota tissuesINTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, Issue 3 2010Jennifer Lyndall Abstract Triclosan, an antimicrobial compound used in personal care products, occurs in the aquatic environment due to residual concentrations in municipal wastewater treatment effluent. We evaluate triclosan-related risks to the aquatic environment, for aquatic and sediment-dwelling organisms and for aquatic-feeding wildlife, based on measured and modeled exposure concentrations. Triclosan concentrations in surface water, sediment, and biota tissue are predicted using a fugacity model parameterized to run probabilistically, to supplement the limited available measurements of triclosan in sediment and tissue. Aquatic toxicity is evaluated based on a species sensitivity distribution, which is extrapolated to sediment and tissues assuming equilibrium partitioning. A probabilistic wildlife exposure model is also used, and estimated doses are compared with wildlife toxicity benchmarks identified from a review of published and proprietary studies. The 95th percentiles of measured and modeled triclosan concentrations in surface water, sediment, and biota tissues are consistently below the 5th percentile of the respective species sensitivity distributions, indicating that, under most scenarios, adverse affects due to triclosan are unlikely. Integr Environ Assess Manag 2010;6:419,440. © 2010 SETAC [source] Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessmentINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 2 2010A. Kortenkamp Summary There is widespread exposure to anti-androgens, a group of chemicals able to disrupt androgen action in foetal life, with irreversible de-masculinizing consequences. Substances of concern include certain phthalates, pesticides and chemicals used in cosmetics and personal care products. Although people come into contact with several anti-androgens, chemicals risk assessment normally does not take account of the effects of combined exposures. However, a disregard for combination effects may lead to underestimations of risks and for this reason, we have assessed the feasibility of conducting cumulative risk assessment, where the focus is on considering the effects of exposure to multiple chemicals, via multiple routes and pathways. Following recent recommendations by the US National Research Council, we have, for the first time, included phthalates and other anti-androgenic chemicals, a total of 15 substances. On the basis of exposure estimates for the individual chemicals and reference doses for anti-androgenicity, we have used the hazard index approach. We show that the cumulative risks from anti-androgen exposures exceed acceptable levels for people on the upper end of exposure levels. The value obtained for median exposures to the 15 substances can be judged tolerable. However, significant knowledge gaps exist that prevent us from arriving at definitive conclusions. Of greatest concern is an absence of appropriate in vivo toxicity data about large numbers of in vitro androgen receptor antagonists. Knowledge about the effect profiles of these chemicals will lead to higher risk estimates. Our analysis suggests that risk reductions can be achieved by limiting exposures to the plasticizer diethyl hexyl phthalate, the cosmetic ingredients butyl- and propyl paraben, the pesticides vinclozolin, prochloraz and procymidone and bisphenol A. [source] Human exposure to phthalates via consumer productsINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 1 2006TED SCHETTLER Summary Phthalate exposures in the general population and in subpopulations are ubiquitous and widely variable. Many consumer products contain specific members of this family of chemicals, including building materials, household furnishings, clothing, cosmetics, pharmaceuticals, nutritional supplements, medical devices, dentures, children's toys, glow sticks, modelling clay, food packaging, automobiles, lubricants, waxes, cleaning materials and insecticides. Consumer products containing phthalates can result in human exposures through direct contact and use, indirectly through leaching into other products, or general environmental contamination. Historically, the diet has been considered the major source of phthalate exposure in the general population, but all sources, pathways, and their relative contributions to human exposures are not well understood. Medical devices containing di-(2-ethylhexyl) phthalate are a source of significant exposure in a susceptible subpopulation of individuals. Cosmetics, personal care products, pharmaceuticals, nutritional supplements, herbal remedies and insecticides, may result in significant but poorly quantified human exposures to dibutyl phthalate, diethyl phthalate, or dimethyl phthalate. Oven baking of polymer clays may cause short-term, high-level inhalation exposures to higher molecular weight phthalates. [source] Natural surfactants used in cosmetics: glycolipidsINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 4 2009N. Lourith Synopsis Cosmetic surfactant performs detergency, wetting, emulsifying, solubilizing, dispersing and foaming effects. Adverse reactions of chemical synthesis surfactant have an effect on environment and humans, particularly severe in long term. Biodegradability, low toxicity and ecological acceptability which are the benefits of naturally derived surfactant that promises cosmetic safety are, therefore, highly on demand. Biosurfactant producible from microorganisms exhibiting potential surface properties suitable for cosmetic applications especially incorporate with their biological activities. Sophorolipids, rhamnolipids and mannosylerythritol lipids are the most widely used glycolipids biosurfactant in cosmetics. Literatures and patents relevant to these three glycolipids reviewed were emphasizing on the cosmetic applications including personal care products presenting the cosmetic efficiency, efficacy and economy benefits of glycolipids biosurfactant. Résumé Les tensioactifs sont utilisés en cosmétique pour leur pouvoir détergent, mouillant, émulsionnant, solubilisant, dispersant ou moussant. Les conséquences graves des surfactants chimiques de synthèse sur l'environnement et sur l'homme agissent particulièrement à long terme. Aussi, la demande de surfactant d'origine naturelle plus biodégradable avec une faible toxicité et une meilleure acceptation écologique est en hausse. Les tensioactifs issus de microorganismes offrent des propriétés de surface convenables pour des applications cosmétiques et en particulier combinés avec leurs activités biologiques. Les sophorolipides, les rhamnolipides et les lipides mannosylérythritol sont les glycolipides tensioactifs les plus largement utilisés en cosmétique. Les applications cosmétiques de ces trois glycolipides sont examinées dans la littérature et les brevets particulièrement pour leurs bénéfices en termes d'efficacité et d'économie. [source] Biocatalytic Route to Ascorbic Acid-Modified Polymers for Free-Radical ScavengingADVANCED MATERIALS, Issue 15 2003A. Singh Ascorbic acid functionalized polymers (see Figure) for free radical scavenging have been synthesized via a two step biocatalytic route. The ascorbic acid retained antioxidant activity, and this functional antioxidant on a polymer backbone has implications for consumer-related applications like foods, pharmaceuticals, and personal care products. [source] MOTIVATIONS FOR PRODUCT CONSUMPTION: APPLICATION OF A PROBABILISTIC MODEL TO ADOLESCENT SMOKINGJOURNAL OF SENSORY STUDIES, Issue 2 2004DANIEL M. ENNIS ABSTRACT This paper describes a method that can be used to investigate consumers' reported reasons for using a particular product. This method is applied to ratings of degree of agreement with statements about reasons for product use. The method is illustrated using data on self-reported reasons for smoking among adolescents. The approach used is based on a probabilistic model of similarity (Ennis et al. 1988) and provides a display of the density of respondents' individual motivations concurrent with their perceptions of the statements. Factor analysis and its derived factor scores provide complementary information which is used to understand the interdependence of smoking motivations with the age of respondents and their degree of smoking. The probabilistic similarity model has many applications in studying consumer motivations such as those involved in the consumption of particular food and personal care products. [source] GC-MS analysis of organic compounds in wastewater and sewage sludgeJOURNAL OF SEPARATION SCIENCE, JSS, Issue 1 2008Axel Patrick Ligon Abstract A multimethod based on liquid,liquid extraction and solid,liquid extraction for the analysis of persistent organic pollutants in water and sludge from sewage treatment plants has been established. Traces of 22 organic compounds used in industry and personal care products (PCPs) were analyzed by GC/MS. The LODs for the analytes were less than 2.3 ng/L for wastewater and 31 ,g/kg (dry weight matter) for sewage sludge. Satisfactory recoveries (70,130%) were achieved. The validated method permits the analysis of water and sludge samples at various stages of the treatment from different sewage treatment plants. Thus, the distribution between water and sludge as well as the dissipation of the compounds analyzed were balanced. By this means, the efficiency of different wastewater treatment plants (WWTPs) can be evaluated and measures can be taken to optimize the treatment process at different stages. [source] Environmental Exposure of Aquatic and Terrestrial Biota to Triclosan and Triclocarban,JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 1 2009Talia E. A. Chalew Abstract:, The synthetic biocides triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) and triclocarban (3,4,4,-trichlorocarbanilide) are routinely added to a wide array of antimicrobial personal care products and consumer articles. Both compounds can persist in the environment and exhibit toxicity toward a number of biological receptors. Recent reports of toxicological effects in wildlife, human cell cultures, and laboratory animals have heightened the interest in the occurrence of these biocide and related toxic effects. The present study aimed to summarize published environmental concentrations of biocides and contrast them with toxicity threshold values of susceptible organisms. Environmental occurrences and toxicity threshold values span more than six orders of magnitude in concentration. The highest biocide levels, measured in the mid parts-per-million range, were determined to occur in aquatic sediments and in municipal biosolids destined for land application. Crustacea and algae were identified as the most sensitive species, susceptible to adverse effects from biocide exposures in the parts-per-trillion range. An overlap of environmental concentrations and toxicity threshold values was noted for these more sensitive organisms, suggesting potential adverse ecological effects in aquatic environments. Affirmative evidence for this is lacking, however, since studies examining environmental occurrences of biocides vis-à-vis the health and diversity of aquatic species have not yet been conducted. [source] Adaptive drug resistance mediated by root,nodulation,cell division efflux pumpsCLINICAL MICROBIOLOGY AND INFECTION, Issue 2009C. Daniels Abstract Bacterial resistance to antibiotics is a major therapeutic problem. Bacteria use the same mechanisms for developing resistance to antibiotics as they do for developing resistance to biocide compounds present in some cleaning and personal care products. Root,nodulation,cell division (RND) family efflux pumps are a common means of multidrug resistance, and induction of their expression can explain the observed cross-resistance found between antibiotics and biocides in laboratory strains. Hence, there is a relationship between the active chemicals used in household products, organic solvents and antibiotics. The widespread use of biocide-containing modern-day household products may promote the development of microbial resistance and, in particular, cross-resistance to antibiotics. [source] Phthalate Esters in Foods: Sources, Occurrence, and Analytical MethodsCOMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, Issue 1 2010Xu-Liang Cao ABSTRACT:, Phthalates are a group of diesters of ortho-phthalic acid (dialkyl or alkyl aryl esters of 1,2-benzenedicarboxylic acid). Higher-molecular-weight phthalates, such as di-2-ethylhexyl phthalate (DEHP), are primarily used as plasticizers to soften polyvinyl chloride (PVC) products, while the lower-molecular-weight phthalates, such as diethyl phthalate (DEP), di-n-butyl phthalate (DBP), and butyl benzyl phthalate (BBzP), are widely used as solvents to hold color and scent in various consumer and personal care products. Phthalates have become ubiquitous environmental contaminants due to volatilization and leaching from their widespread applications, and thus contamination of the environment has become another important source for phthalates in foods in addition to migration from packaging materials. Human exposure to phthalates has been an increased concern due to the findings from toxicology studies in animals. DEHP, one of the important and widely used phthalates, is a rodent liver carcinogen. DEHP, DBP, BBzP, and several phthalate metabolites, such as monobutyl phthalate, monobenzyl phthalate, and mono-(2-ethylhexyl) phthalate, are teratogenic in animals. Since foods are the major source of exposure to phthalates, information on levels of phthalates in foods is important for human exposure assessment. The objective of this review is to identify the knowledge gaps for future investigations by reviewing levels of a wide range of phthalates in a variety of foods, such as bottled water, soft drinks, infant formula, human milk, total diet foods, and others, migration of phthalates from various food-packaging materials, and traditional and new methodologies for the determination of phthalates in foods. [source] | ||||||||||||||||