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Perfusion Patterns (perfusion + pattern)

Distribution by Scientific Domains

Medical Sciences	100%

Kinds of Perfusion Patterns

cerebral perfusion pattern

Selected Abstracts

Tau haplotype influences cerebral perfusion pattern in frontotemporal lobar degeneration and related disorders

ACTA NEUROLOGICA SCANDINAVICA, Issue 5 2008
B. Borroni
Objective,,, The modulating factors on phenotypic expression of frontotemporal lobar degeneration (FTLD) remain still unknown. The aim of this study was to determine whether tau genetic variability modulates the brain functional and the clinical phenotypic expression of FTLD. Materials and methods,,, Clinical and neurological evaluations, a standardized neuropsychological assessments as well as a brain single photon emission tomography perfusion imaging studies were performed in 48 FTLD patients. Cerebral perfusion patterns were analysed according to H1 or H2 tau haplotypes by statistical parametric mapping and principal component analysis. Results,,, Two different patterns of cerebral dysfunction characterized the haplotypes, as hypoperfusion of frontal medial and cingulated cortex in H2-carriers and a prevalent involvement of posterior parietal regions in H1-carriers. Further, a significant increase of cerebrospinal fluid total tau and phospho tau levels was found in H2-carriers. Conclusions,,, These findings support a role of tau haplotype in modulating disease phenotype by influencing the hypoperfusion pattern and cerebrospinal fluid tau levels in FTLD. [source]

99mTc-ethyl cysteinate dimer brain SPECT findings in early stage of dementia with Lewy bodies and Parkinson's disease patients: a correlation with neuropsychological tests

EUROPEAN JOURNAL OF NEUROLOGY, Issue 1 2008
C.-C. Chang
We examined clinical presentations, neuropsychological findings, and perfusion patterns of 99mTc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients with early stage dementia with Lewy bodies (DLB) (n = 17) and Parkinson's disease (PD) (n = 16), with age-matched healthy controls (n = 10). Seven paired regions of interest (ROIs) were drawn manually including inferior frontal, temporal, parietal, occipital, parieto-occipital junction, striatum and thalamus for semiquantitative measurement. Neuropsychological tests were applied for clinical correlation. The SPECT results showed significant hypoperfusion in DLB group in frontal, parietal, thalamus, temporal ROIs compared with controls (P < 0.01) whilst signals in temporal areas was significantly reduced compared with PD group (P < 0.05). Neuropsychological tests showed that DLB patients had deficits in mental manipulation, short-term memory, abstract thinking, drawing and semantic verbal fluencies (P < 0.05, compared with control). In addition, DLB group had lower scores than those with PD in mental manipulation, drawing and semantic verbal fluency (P < 0.05). Our study showed that even in early stages of DLB, neuropsychological and perfusion patterns were evident and may be different from PD group, despite they shared certain similarities both in neuropsychological and image findings compared with age-matched controls. [source]

A SPECT study of wandering behavior in Alzheimer's disease

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 9 2005
Yves Rolland
Abstract Background Among behavior disturbance during Alzheimer's disease (AD), wandering is one of the most common. Different psychological processes have been suggested to explain the wandering behavior. The aim of this study was to examine whether wandering during AD was associated with cerebral perfusion patterns measured by (99,m)Tc-labeled bicisate (ECD) brain SPECT. Methods We compared SPECT scans of 13 AD subjects with wandering behavior (sex ratio M/F, 4/9; age, 73.1 years, SD 7.4; Mini Mental Status Examination score, median 20 interquartile range [16,23]), 13 AD subjects without wandering behavior (matched for age [,±,2 years], sex and MMSE score [,±,2 points]) and 13 healthy controls (matched for age [,±,2 years] and sex) without cognitive impairment. Wandering was defined on the Neuro-Psychiatric Inventory. Score of leukoaraiosis, assessed with the scale of Blennow and number of lacuna infarction were compared on CT scan. SPECT imaging was compared using statistical parametric mapping (SPM 2). Results There were no significant differences between the groups in term of educational level and CT scan analysis. SPECT imaging was consistent with the diagnosis of AD in both wanderers and AD subjects without wandering behavior. Despite similar clinical dementia severity, wanderers had more severely reduced regional cerebral blood flow (rCBF) in the left parietal-temporal lobe than AD subjects without wandering behavior. Conclusion Wandering behavior could be facilitated by a specific patterns of cerebral blood flow. Wandering, as a physical activity, could also enhance the recruitment of the cortical network. Copyright © 2005 John Wiley & Sons, Ltd. [source]

Subtraction brain SPECT imaging in a patient with gait ignition failure

MOVEMENT DISORDERS, Issue 12 2003
Phil Hyu Lee MD
Abstract The precise anatomical location and pathophysiology of gait ignition failure (GIF) is poorly understood. We investigated the cerebral perfusion patterns using subtraction brain single photon emission computed tomography (SPECT) in a patient with GIF. Subtraction brain SPECT imaging revealed an increased activity in the region of right ventrolateral midbrain and ventral medulla. © 2003 Movement Disorder Society [source]