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Pertinent
Kinds of Pertinent Terms modified by Pertinent Selected AbstractsEPR OF Mn2+ IMPURITIES IN CALCITE: A DETAILED STUDY PERTINENT TO MARBLE PROVENANCE DETERMINATION,ARCHAEOMETRY, Issue 1 2009H. WEIHE We demonstrate that the electron paramagnetic resonance spectrum of Mn2+ impurities in calcite, and therefore also in marble, may be accurately reproduced by a traditional spin Hamiltonian formalism. The success of such a treatment, however, very much depends on the spin Hamiltonian parameters having the correct signs as well as magnitudes. We present data that determine the sign of the axial anisotropy parameter and thereby facilitate future quantum mechanical characterizations of marble electron paramagnetic resonance spectra that supplement provenance determination. [source] Voluntary simplicity: an exploration of market interactionsINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 2 2009Deirdre Shaw Abstract Voluntary simplicity is often considered to be a sustainable lifestyle phenomenon buttressed by environment-friendly consumption practices. Voluntary simplicity is shaped by the individual as well as the society, and marketplace interactions often impact voluntarily simplified approaches to consumption. Pertinent, therefore, is a consideration of how voluntary simplifiers negotiate the tensions between marketplace interactions and decisions (not) to consume, as the exploration of interactions between consumption and non-consumption choices has relevant implications for the advancement of sustainable consumption. Specifically, we seek to answer the following question: how have voluntary simplifiers in a rural context negotiated the relationship between voluntary simplicity and market-based (non-) consumption? This paper reports on a study of 28 rural voluntary simplifiers to explore the intersections between voluntary simplicity and rural markets. Findings highlight the convoluted nature and the multiple manifestations of voluntary simplicity, while the rural context allows an exploration of such tensions in relation to individual voluntary simplicity, local economy, supermarkets, fair trade and consumer culture. [source] Diagnoses and Interventions Pertinent to Intellectual Disability Nursing§INTERNATIONAL JOURNAL OF NURSING TERMINOLOGIES AND CLASSIFICATION, Issue 4 2008Fintan K. Sheerin BNS, PgDipEd PURPOSE.,The field of intellectual disability care in Ireland has been undergoing significant change, and this has called into question the role of specialist intellectual disability nursing. This review aims to identify the diagnoses and interventions that are employed by intellectual disability nurses. DATA SOURCES.,Exploration of the relevant professional literature, drawing on a broad scope of sources, was completed. DATA SYNTHESIS.,Examination and discussion within the taxonomic structure of the Nursing Interventions Classification. CONCLUSIONS.,Initial data set of diagnoses and interventions identified as a basis and justification for further systematic examination of specialist intellectual disability nursing practice. IMPLICATIONS FOR NURSING PRACTICE.,Explication and elaboration of the contribution of specialist nursing within intellectual disability care settings. CUSPÓIR.,D'aistrigh a lán rudaí sna cúram le daoine faoi mhíchumas intleachtach, in Eireann. Dá bharr sin, tháinig ceisteanna faoi páirt den banaltracht speisialta faoi mhíchumas intleachtach. Lorg an athbhreithniú seo cur ceist ar na fáthmheasa agus na headrána den speisialtóir san banaltract le daoine faoi mhíchumas intleachtach. FOINSÍ AN FAISNÉIS.,Taiscealaíocht den litríocht gairmiúil atáábhartha den ábhar. SINTÉIS AN FAISNÉIS.,Scrúdú agus suaitheadh sna cabhail den Nursing Interventions Classification. TÁTAIL.,Foireann na sonraí faoi na fáthmheasa agus na headrána chun scrúdaigh cleachtas den banaltracht speisialta faoi mhíchumas intleachtach. IMPLEACHTAÍ FAOI CLEACHTAS DEN BANALTRACHT.,sMíniú agus saothrú faoi dréacht den speisialtóir san banaltract le daoine faoi mhíchumas intleachtach sna seirbhís sláinte. [source] Review article: medical management of the liver transplant recipient , a primer for non-transplant doctorsALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 3 2007A. SETHI Summary Background Survival 10 years after orthotopic liver transplantation now approaches 65%. Consequently, community doctors must manage the metabolic and neoplastic complications of orthotopic liver transplantation in an ageing population. Aims To review common sources of morbidity and mortality in long-term orthotopic liver transplantation recipients, and to make evidence-based recommendations regarding their management. Methods Pertinent studies and reviews were identified by literature search through PubMed. Where evidence-based recommendations could not be gleaned from the literature, expert opinion was obtained from syllabi of national meetings. Results The two most common causes of morbidity and mortality in orthotopic liver transplantation recipients are atherosclerotic vascular disease and de novo malignancy. The pathogenesis of many complications begins before orthotopic liver transplantation, and many are potentially modifiable. Most complications, however, can be directly ascribed to immunosuppressive agents. Despite improvements in our understanding of the pathogenesis and epidemiology of the metabolic and neoplastic complications of orthotopic liver transplantation, remarkably few randomized-controlled studies exist to define their optimal management. Conclusions Orthotopic liver transplantation recipients experience and succumb to the same afflictions of old age as non-transplant patients, but with greater frequency and at an earlier age. Most recommendations regarding surveillance for, and treatment of, medical complications of orthotopic liver transplantation remain based upon expert opinion rather than evidence-based medicine. [source] Making the Leap from Researcher to Planner: Lessons from Avian Conservation Planning in the Dominican RepublicCONSERVATION BIOLOGY, Issue 1 2000Steven C. Latta Published accounts of national, multidisciplinary planning efforts and priority setting for avian conservation are not common. I describe the process and results of a broad-based, grassroots-oriented avian conservation planning workshop held in the Dominican Republic in which we designed a coordinated strategy for avian conservation in the country. The planning process sought to (1) increase communication and cooperation among conservationists; (2) familiarize participants with resources pertinent to avian conservation; (3) encourage the transfer of information between researchers and managers; (4) promote the concepts of long-term avian monitoring, avian conservation plans, and species management plans; and (5) develop a common, multidisciplinary strategy to promote the conservation of birds in the Dominican Republic. The workshop highlighted group discussions among research biologists, managers, educators, and public policy specialists to assess avian conservation needs and priorities with respect to each discipline and has since galvanized a significant portion of the conservation community around several cooperative projects involving diverse segments of the community. Avian biologists can play a significant role in conservation efforts through a willingness to work with key players in diverse fields and to envision holistic, multidisciplinary approaches to conservation issues. Resumen: Cuando los biologícos investigadores incursionan en la biología de la conservación enfrentan nuevos desafíos, especialmente en países extranjeros, al intentar prestar apoyo para esfuerzos de planificación de la conservación. Los informes publicados de esfuerzos de planificación nacional, multidisciplinaria y de establecimiento de prioridades para la conservación de aves no son comunes. Describo el proceso y los resultados de un taller nacional de planificación para conservación de aves en la República Dominicana que utilizaba un proceso fundamental de base amplia donde creamos una estrategia coordinada para la conservación de aves del país. El proceso de planeación buscaba (1) aumentar comunicación y cooperación entre conservacionistas, (2) familiarizar a los participantes con los recursos disponibles para la conservación de aves, (3) estimular la transferencia de información entre investigadores y manejadores, (4) promover los conceptos del monitoreo de aves a largo plazo, planes de conservación de especies y planes de manejo de especies y (5) desarrollar una estrategia multidisciplinaria común para promover la conservación de aves en la República Dominicana. El taller puso a relieve discusiones de grupo entre investigadores, manejadores, educadores y especialistas en política pública para evaluar las necesidaes y prioridades para la conservación de aves con respecto a cada disciplina, desde entonces se ha estimulado a una porción significativa de la comunidad conservacionista alrededor de proyectos de cooperación que involucran a diversos segmentos de la comunidad. Los ornitólogos pueden jugar un papel significativo en los esfuerzos de conservación mediante una buena disposición para trabajar con personas clave en diversas disciplinas y visualizar de una manera integral y multidisciplinaria las estrategias para abordar asuntos de conservación. [source] Airborne contact dermatitis from methylchloroisothiazolinone in wall paint.CONTACT DERMATITIS, Issue 4 2000Abolition of symptoms by chemical allergen inactivation Preservatives such as isothiazolinones in paints have been reported to cause airborne contact dermatitis. The patients whom we report experienced acute dermatitis on air-exposed skin and respiratory symptoms after staying in recently painted rooms. Kathon® (methylchloroisothiazolinone/ methylisothiazolinone) added as preservative to the wall paint was identified as causative agent. In one individual symptoms rapidly disappeared after treatment of the painted walls with inorganic sulfur salt, which leads to inactivation of the allergenic properties of methylchloroisothiazolinone/ methylisothiazolinone. We describe the patients, the clinical course and review the literature pertinent to such cases. In addition we report on the chemical analyses of the decorating paints used, and on experiments on emission and air concentration of methylchloroisothiazolinone/methylisothiazolinone from a painted surface before and after inactivation by sodium bisulfite. [source] Generalized Spitzer Function with Finite Collisionality in Toroidal PlasmasCONTRIBUTIONS TO PLASMA PHYSICS, Issue 8 2010W. Kernbichler Abstract The drift kinetic equation solver NEO-2 [1] which is based on the field line integration technique has been applied to compute the generalized Spitzer function in a tokamak with finite plasma collisionality. The resulting generalized Spitzer function has specific features which are pertinent to the finite plasma collisionality. They are absent in asymptotic (collisionless or highly collisional) regimes or in results drawn from interpolation between asymptotic limits. These features have the potential to improve the overall ECCD efficiency if one optimizes the microwave beam launch scenarii accordingly (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] The Machakos Case Study: Solid Outcomes, Unhelpful HyperboleDEVELOPMENT POLICY REVIEW, Issue 1 2006Jules Siedenburg This article revisits the well-known study of Machakos District, Kenya reported in the book More People, Less Erosion by Tiffen et al., which found dramatic, compelling evidence of successful endogenous adaptation to changing circumstances by rural Africans. The article seeks to elucidate discrepancies between the Machakos findings and other findings in the interest of both scientific accuracy and policy relevance. It is suggested that the Machakos study comprises hopeful data, on the one hand, and problematic calculations and assertions, on the other. After exploring problems with the study, the article suggests an alternative interpretation of the data that is arguably more pertinent to contemporary concerns with rural poverty and environmental degradation as well as more widely applicable in sub-Saharan Africa. [source] Development of the corneal stroma, and the collagen,proteoglycan associations that help define its structure and functionDEVELOPMENTAL DYNAMICS, Issue 10 2008Andrew J. Quantock Abstract The cornea of the eye is a unique, transparent connective tissue. It is comprised predominantly of collagen fibrils, remarkably uniform in diameter and regularly spaced, organized into an intricate lamellar array. Its establishment involves a precisely controlled sequence of developmental events in which the embryonic cornea undergoes major structural transformations that ultimately determine tissue form and function. In this article, we will review corneal developmental dynamics from a structural perspective, consider the roles and interrelationships of collagens and proteoglycans, and comment on contemporary concepts and current challenges pertinent to developmental processes that result in an optically clear, mature cornea. Developmental Dynamics 237:2607,2621, 2008. © 2008 Wiley-Liss, Inc. [source] Differential diagnosis of depressed mood in patients with schizophrenia: a diagnostic algorithm based on a reviewACTA PSYCHIATRICA SCANDINAVICA, Issue 2 2002A. Hausmann Objective:,To review the available literature on depressive symptomatology in schizophrenia in order to establish a diagnostic algorithm of depressive syndromes in schizophrenia. Method:,A literature search was performed using PubMed and Medline. Additional information was gained by cross-referencing from papers found in the database. Data from controlled studies as well as supplementary information from review articles and psychiatric manuals pertinent to the topic were used. Depressive symptoms were classified with respect to their temporal relationship to acute psychotic symptoms before the background of nosological entities as operationalized by Diagnostic Statistical Manual IV (DSM IV). Results:,Depression is a common and devastating comorbid syndrome in patients suffering from schizophrenic disorder. The paper summarizes the relevant diagnostic steps to guide the clinician towards therapeutic interventions, which differ depending on the nature of the depressive syndrome. Conclusion:,Differentiating depressives states in schizophrenia has consequences in terms of choosing therapeutic strategies. An algorithm which leads the practitioner to a reliable diagnosis and in consequence to a valid therapy is presented. [source] Addressing the Systems-based Practice Core Competency: A Simulation-based CurriculumACADEMIC EMERGENCY MEDICINE, Issue 12 2005Ernest E. Wang MD Systems-based practice is one of the six core competencies implemented by the Accreditation Council for Graduate Medical Education to direct residency educational outcome assessment and accreditation. Emergency medicine,specific systems-based practice criteria have been described to define the expected knowledge and skill sets pertinent to emergency medicine practitioners. High-fidelity patient simulation is increasingly used in graduate medical education to augment case-based learning. The authors describe a simulation-based curriculum to address the emergency medicine,specific systems-based practice core competency. [source] What is Art in Education?EDUCATIONAL PHILOSOPHY AND THEORY, Issue 2 2007New Narratives of Learning Abstract In this paper I address some questions pertinent to the development of school art education. I begin by considering how we relate to art and how we might understand the notion of this relation in terms of human subjectivity and the art object. To do this I describe particular art practices that have broadened social conceptions of art, which in turn, become part of art itself and shape performances of understanding, learning and practice. Implicit to this discussion is a change in how artists, art practice and engagement with art are conceived. I then consider some art events in school art education and analyse how human subjects, art practices and objects are understood in this context. This leads to further remarks about how learners and practice in school art education might be discerned in the light of the preceding discussion. [source] Effects of plant and prey characteristics on the predatory behavior of Delphastus catalinaeENTOMOLOGIA EXPERIMENTALIS ET APPLICATA, Issue 1 2006Moshe Guershon Abstract Nymphal setosity of the whitefly Bemisia tabaci Gennadius (Homoptera: Aleyrodidae) has been reported to be induced by mechanical stimuli such as leaf tomentosity, and related to the predatory performance of the coccinellid Delphastus catalinae (Horn) (Coleoptera: Coccinellidae). In this study, a possible adaptive value of this phenomenon for the whitefly is shown through the combined effects of leaf and prey characteristics on the walking and predatory behaviors of the beetle. Leaf tomentosity significantly affected the walking patterns of the beetle and therefore its searching abilities, thus indirectly increasing the influence of prey distribution upon predator's efficiency. Moreover, while searching on tomentose leaves, the beetles showed preference for the smooth prey phenotype. This behavior was found dependent on the experience of the beetle in previous encounters. These results are pertinent to intraspecific competition between the different nymphal phenotypes and to the predatory efficiency of this beetle, which is utilized in biological control of whiteflies. [source] Searching PubMed for molecular epidemiology studies: The case of chromosome aberrationsENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 4 2006Donatella Ugolini Abstract The available tools for searching literature in the field of Molecular Epidemiology are largely unsatisfactory. To identify major problems in retrieving information on this discipline, we comment here on the results of a literature search on cytogenetic biomarkers in children exposed to environmental pollutants. The search, done on the PubMed/MedLine database, was based on a strategy combining descriptors listed in the PubMed Medical Subject Headings (MeSH) Thesaurus and other available tools (free text or phrase search tools). 178 articles were retrieved by searching the period from January 1, 1980 to November 30, 2004. Only 2 of the 178 articles were indexed by the MeSH term "Epidemiology, molecular" (introduced in 1994) and 30 of 178 by the MeSH term "Biological markers" (introduced in 1989). The case of chromosome aberration (CA) was emblematic of the problem: 44 of 78 articles (56.4%) were not pertinent to the search. The reasons for this poor performance are reported and discussed. Authors and indexers may be able to improve the efficiency of article retrieval in the field of molecular epidemiology by using relevant terms in the title and abstract. This may suggest appropriate MeSH terms to the indexers for the indexing process. As regards the difficulty in identifiyng population studies using CA, the introduction of a specific MeSH term for chromosome aberrations when used as a biomarker would improve the search process. Environ. Mol. Mutagen., 2006. © 2006 Wiley-Liss, Inc. [source] Tolerance to metals and assessment of energy reserves in the polychaete Nereis diversicolor in clean and contaminated estuariesENVIRONMENTAL TOXICOLOGY, Issue 1 2005C. Durou Abstract Estuaries are subject to anthropogenic activities. Because the intrasedimentary worm Nereis diversicolor has ecological characteristics and bioindicator abilities, its use was pertinent in investigating the concepts and cost of tolerance to heavy metals (Cd, Cu, Zn). In this context, two approaches were carried out, performing toxicity tests and estimating energy reserves (glycogen and lipids), in populations originating from a contaminated site (Seine estuary) compared with those from a clean site (Authie estuary). Mean lethal times (LT50s) of organisms exposed to zinc from the Seine estuary were higher than those from the Authie estuary, but not of organisms exposed to Cd or Cu. The influence of animal weight and salinity on the sensitivity of worms also was studied. The biggest worms were more tolerant to zinc than the smallest ones, and worms survived longer at a reduced salinity (15,). Concentrations of glycogen and lipids in each sampling season were higher in specimens from the Authie estuary than in worms from the Seine estuary. No influence of salinity on glycogen and lipid levels was observed. Glycogen concentrations were not influenced by the weight of specimens, whereas lipid concentrations were significantly and positively correlated with weight. In conclusion, worms from the Seine estuary exhibited tolerance to Zn, and the depletion of energy reserves observed in this population could be interpreted as a cost of tolerance. © 2005 Wiley Periodicals, Inc. Environ Toxicol 20: 23,31, 2005. [source] Preventive Care in the Emergency Department: Should Emergency Departments Conduct Routine HIV Screening?ACADEMIC EMERGENCY MEDICINE, Issue 3 2003A Systematic Review Abstract Objective: To perform a systematic review of the emergency medicine literature to assess the appropriateness of offering routine HIV screening to patients in the emergency department (ED). Methods: The systematic review was conducted with the aid of a structured template, a companion explanatory guide, and a grading and methodological scoring system based on published criteria for critical appraisal. Two reviewers conducted independent searches using OvidR, PubMed, MD Consult, and Grateful Med. Relevant abstracts were reviewed; those most pertinent to the stated objective were selected for complete evaluation using the structured template. Results: Fifty-two relevant abstracts were reviewed; of these, nine were selected for detailed evaluation. Seven ED-based prospective cross-sectional seroprevalence studies found HIV rates of 2,17%. Highest rates of infection were seen among patients with behavioral risks such as male homosexual activity and intravenous drug use. Two studies demonstrated feasibility of both standard and rapid HIV testing in the ED, with more than half of the patients approached consenting to testing by either method, consistent with voluntary testing acceptance rates described in other settings. Several cost,benefit analyses lend indirect support for HIV screening in the ED. Conclusions: Multiple ED-based studies meeting the Centers for Disease Control and Prevention Guideline threshold to recommend routine screening, in conjunction with limited feasibility trials and extrapolation from cost,benefit studies, provide evidence to recommend that EDs offer HIV screening to high-risk patients (i.e., those with identifiable risk factors) or high-risk populations (i.e., those where HIV seroprevelance is at least 1%). [source] The Creation of a Vocational Sector in Swiss Higher Education: balancing trends of system differentiation and integrationEUROPEAN JOURNAL OF EDUCATION, Issue 4 2003Juan-Francisco Perellon The article discusses the establishment of a vocational sector in Swiss higher education as a complement to the existing two-tier system of cantonal Universities and federal Institutes of technology. The origins of this new player, its missions and organisational features are discussed. This overall discussion is placed into the context of changing landscape of Swiss higher education policy characterised by increasing pressures for geographical reorganisation of the higher education sector under the auspices of a more direct role of the federal government. The article makes two points. First, it argues that the creation of a vocational sector in Swiss higher education combines two contradictory trends. On the one hand, this new sector tends to provide differentiation at the system level, through the creation of a new, more marked-oriented sector of higher education. On the other hand, system differentiation at the system level is threatened by increased demands for greater inter-institutional cooperation and system integration, emanating principally from the federal level. Second, the article also argues that the distinction between ,academic/scientific' vs. ,vocational/professional' education generally referred to when studying the emergence of non-university sectors in higher education, is not pertinent for the analysis of the Swiss case. Two reasons are brought forward to sustain this argument. First, this distinction reinforces an artificial binary divide, no longer relevant to assess the evolution of higher education institutions placed in a context of academic and vocational drifts. Second, the ,academic' vs. ,professional' opposition does not take into consideration the political organisation of the country and how this impacts on policy making in higher education; a crucial element in the Swiss context. [source] Probiotics: do they have a role in oral medicine and dentistry?EUROPEAN JOURNAL OF ORAL SCIENCES, Issue 3 2005Jukka H. Meurman This review describes current knowledge on probiotic bacteriotherapy from the oral health perspective. Recent experimental studies and results from randomized controlled trials have shown that certain gut bacteria, in particular species of Lactobacillus and Bifidobacterium, may exert beneficial effects in the oral cavity by inhibiting cariogenic streptococci and Candida sp. Probiotics have been successfully used to control gastro-intestinal diseases. They also appear to alleviate symptoms of allergy and diseases with immunological pathology. The mechanisms of probiotic action appear to link with colonization resistance and immune modulation. Lactic acid bacteria can produce different antimicrobial components such as organic acids, hydrogen peroxide, carbon peroxide, diacetyl, low molecular weight antimicrobial substances, bacteriocins, and adhesion inhibitors, which also affect oral microflora. However, data is still sparse on the probiotic action in the oral cavity. More information is needed on the colonization of probiotics in the mouth and their possible effect on and within oral biofilms. There is every reason to believe that the putative probiotic mechanisms of action are the same in the mouth as they are in other parts of the gastrointestinal tract. Because of the increasing global problem with antimicrobial drug resistance, the concept of probiotic therapy is interesting and pertinent, and merits further research in the fields of oral medicine and dentistry. [source] The behaviour of soil process models of ammonia volatilization at contrasting spatial scalesEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 6 2008R. Corstanje Summary Process models are commonly used in soil science to obtain predictions at a spatial scale that is different from the scale at which the model was developed, or the scale at which information on model inputs is available. When this happens, the model and its inputs require aggregation or disaggregation to the application scale, and this is a complex problem. Furthermore, the validity of the aggregated model predictions depends on whether the model describes the key processes that determine the process outcome at the target scale. Different models may therefore be required at different spatial scales. In this paper we develop a diagnostic framework which allows us to judge whether a model is appropriate for use at one or more spatial scales both with respect to the prediction of variations at those scale and in the requirement for disaggregation of the inputs. We show that spatially nested analysis of the covariance of predictions with measured process outcomes is an efficient way to do this. This is applied to models of the processes that lead to ammonia volatilization from soil after the application of urea. We identify the component correlations at different scales of a nested scheme as the diagnostic with which to evaluate model behaviour. These correlations show how well the model emulates components of spatial variation of the target process at the scales of the sampling scheme. Aggregate correlations were identified as the most pertinent to evaluate models for prediction at particular scales since they measure how well aggregated predictions at some scale correlate with aggregated values of the measured outcome. There are two circumstances under which models are used to make predictions. In the first case only the model is used to predict, and the most useful diagnostic is the concordance aggregate correlation. In the second case model predictions are assimilated with observations which should correct bias in the prediction, and errors in the variance; the aggregate correlations would be the most suitable diagnostic. [source] A CENTENNIAL CELEBRATION FOR QUANTITATIVE GENETICSEVOLUTION, Issue 5 2007Derek A. Roff Quantitative genetics is at or is fast approaching its centennial. In this perspective I consider five current issues pertinent to the application of quantitative genetics to evolutionary theory. First, I discuss the utility of a quantitative genetic perspective in describing genetic variation at two very different levels of resolution, (1) in natural, free-ranging populations and (2) to describe variation at the level of DNA transcription. Whereas quantitative genetics can serve as a very useful descriptor of genetic variation, its greater usefulness is in predicting evolutionary change, particularly when used in the first instance (wild populations). Second, I review the contributions of Quantitative trait loci (QLT) analysis in determining the number of loci and distribution of their genetic effects, the possible importance of identifying specific genes, and the ability of the multivariate breeder's equation to predict the results of bivariate selection experiments. QLT analyses appear to indicate that genetic effects are skewed, that at least 20 loci are generally involved, with an unknown number of alleles, and that a few loci have major effects. However, epistatic effects are common, which means that such loci might not have population-wide major effects: this question waits upon (QTL) analyses conducted on more than a few inbred lines. Third, I examine the importance of research into the action of specific genes on traits. Although great progress has been made in identifying specific genes contributing to trait variation, the high level of gene interactions underlying quantitative traits makes it unlikely that in the near future we will have mechanistic models for such traits, or that these would have greater predictive power than quantitative genetic models. In the fourth section I present evidence that the results of bivariate selection experiments when selection is antagonistic to the genetic covariance are frequently not well predicted by the multivariate breeder's equation. Bivariate experiments that combine both selection and functional analyses are urgently needed. Finally, I discuss the importance of gaining more insight, both theoretical and empirical, on the evolution of the G and P matrices. [source] How best to halt and/or revert UV-induced skin ageing: strategies, facts and fictionEXPERIMENTAL DERMATOLOGY, Issue 3 2008Lübeck Ralf Paus Besides obvious market pressures, increasing insight into the mechanistic overlap between UV-induced skin cancer and UV-induced skin ageing has contributed to this development. Also, as strategies that work to antagonize intrinsic skin ageing/senescence may also be exploited against photoageing (and vice versa!), it has become an important skin research challenge to dissect both the differences and the overlap mechanisms between these interwined, yet distinct phenomena. Finally, the current surge in putative ,antiageing' products, devices, and strategies , too many of which boldly promise to fight and/or repair the perils that come along with a lifetime spent in the sun in the absence of convincing evidence of efficacy , makes it particularly pertinent to critically review the available evidence to support often made antiageing claims. The current CONTROVERSIES feature, therefore, aimed to provide both guidance through, and critical voices in, the antiageing circus. Here, a panel of experts defines relevant key problems, points the uninaugurated to intriguing aspects of photoageing that one may not have considered before, highlights promising strategies for how best to halt and/or revert it, and spiritedly debates some controversially discussed approaches. [source] The structures of Escherichia coli O-polysaccharide antigensFEMS MICROBIOLOGY REVIEWS, Issue 3 2006Roland Stenutz Abstract Escherichia coli is usually a non-pathogenic member of the human colonic flora. However, certain strains have acquired virulence factors and may cause a variety of infections in humans and in animals. There are three clinical syndromes caused by E. coli: (i) sepsis/meningitis; (ii) urinary tract infection and (iii) diarrhoea. Furthermore the E. coli causing diarrhoea is divided into different ,pathotypes' depending on the type of disease, i.e. (i) enterotoxigenic; (ii) enteropathogenic; (iii) enteroinvasive; (iv) enterohaemorrhagic; (v) enteroaggregative and (vi) diffusely adherent. The serotyping of E. coli based on the somatic (O), flagellar (H) and capsular polysaccharide antigens (K) is used in epidemiology. The different antigens may be unique for a particular serogroup or antigenic determinants may be shared, resulting in cross-reactions with other serogroups of E. coli or even with other members of the family Enterobacteriacea. To establish the uniqueness of a particular serogroup or to identify the presence of common epitopes, a database of the structures of O-antigenic polysaccharides has been created. The E. coli database (ECODAB) contains structures, nuclear magnetic resonance chemical shifts and to some extent cross-reactivity relationships. All fields are searchable. A ranking is produced based on similarity, which facilitates rapid identification of strains that are difficult to serotype (if known) based on classical agglutinating methods. In addition, results pertinent to the biosynthesis of the repeating units of O-antigens are discussed. The ECODAB is accessible to the scientific community at http://www.casper.organ.su.se/ECODAB/. [source] Prudent practices for the design and installation of heat-producing devices near wood materialsFIRE AND MATERIALS, Issue 2 2007Vytenis Babrauskas Abstract The conditions required to cause ignition of solid wood materials under short-term heating are examined, and it is found that the appropriate ignition temperature applicable under these conditions is 250°C. It is then shown that ignition requirements are different if long-term heating is involved and that ignition can occur at exposure temperatures much lower than the ignition temperature pertinent to short-term heating. It is shown that hot surfaces of 77 °C or higher, if located for a long duration next to a wood member are liable to lead to its ignition in a self-heating mode. Recommendation is made that prudent practices for design or installation must also involve a suitable safety factor. Copyright © 2006 John Wiley & Sons, Ltd. [source] Designing Polymers to Enable Nanoscale Thermomechanical Data StorageADVANCED FUNCTIONAL MATERIALS, Issue 8 2010B. Gotsmann Abstract Nanomechanics has been slow in entering nanotechnology because of extreme conditions resulting from scaling. This is an issue in particular for polymers, although widely used in macroscale applications. Highly repetitive nanoscale deformation cycling in combination with excellent shape retention and thermal stability is demonstrated. While generic principles described are pertinent to a range of applications, this demonstration is made on the example of polymer media in high-density data storage. The information, represented as indents, is written and erased using a heated tip. A high-performance polymer with a flexible aryletherketone backbone is designed with phenylethynyl crosslink chemistry. After optimization of crosslink density and topology, unprecedented performance is achieved in all relevant metrics. Demonstrations of endurance and retention are performed at 1 Tb in,2 density, showing 108 write cycles using the same tip, 103 erase cycles and 3,×,105 read cycles of the media, and extrapolated to 10 years of retention at 85,°C. [source] An Investigation of Reading Strategies Applied by American Learners of Chinese as a Foreign LanguageFOREIGN LANGUAGE ANNALS, Issue 4 2008Li-Chun Lee-Thompson Assistant ProfessorArticle first published online: 19 MAR 200 Abstract: Minimal research has been conducted in reading Chinese as a second/ foreign language (CSI/CFL). In an effort to further the understanding of the reading process, this study, utilizing think aloud and retelling procedures, focuses on the identification of strategies that American university students applied to read Chinese texts (narrative and argumentative), and the difficulties encountered when processing texts for meaning. Also it examines whether Bernhardt's constructivist model can account for the reading process of the CFL learners at the intermediate proficiency level. The results show that the CFL readers employed bottom-up and top-down processing strategies, that their difficulties were pertinent to vocabulary, orthography, grammar, and background knowledge, and that Bernhardt's reading model could account for the reading process of CFL learners with minor modification. [source] Induction of endogenous pathways by antiepileptics and clinical implicationsFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 5 2005M. Strolin Benedetti Abstract The aim of this study was to review modifications of the endogenous pathways (e.g. enzyme elevations, normal body constituent depletion or higher formation/excretion of endogenous metabolites) which could be ascribed to enzyme induction by antiepileptic drugs (AEDs). Information on older (e.g. phenobarbital, phenytoin and carbamazepine) and newer drugs (where information is available) is discussed together with clinical implications. The enzymes involved in the endogenous pathways and induced by the AEDs will not be limited to the hepatic microsomal enzymes; extrahepatic enzymes and/or enzymes present in other subcellular fractions will also be discussed, if pertinent. The induction of endogenous pathways by AEDs has been taken into account in the past, but much less emphasis has been given compared with the extensive literature on induction by AEDs of the metabolism of concomitantly administered drugs, either of the same or of different classes. Not all of the endogenous pathways examined and induced by AEDs appear to result in serious clinical consequences (e.g. induction of hepatic ALP, increased excretion of d -glucaric acid or of 6, -hydroxycortisol). In some cases, induction of some pathways (e.g. increase of high-density lipoprotein cholesterol or of conjugated bilirubin) might even be a beneficial side-effect, however enzyme induction is considered rather a detrimental aspect for an AED, as induction is generally a broad and a non-specific phenomenon. The new AEDs have generally less induction potential than the older agents. Yet some (felbamate, topiramate, oxcarbazepine and lamotrigine) have the potential for inducing enzymes, whereas others (levetiracetam, gabapentin and vigabatrin) appear to be completely devoid of enzyme inducing characteristics, at least as far as the enzymes investigated are concerned. [source] How good is the fossil record of arthropods?GEOLOGICAL JOURNAL, Issue 3-4 2001An assessment using the stratigraphic congruence of cladograms Abstract A total of 179 published cladograms of arthropods was tested for their congruence with the palaeontological record. Congruence for data sets including 510 tetrapod and 157 fish trees was also calculated for comparison. Results provide support for the hypothesis that the fossil record of arthropods is less complete (at levels of stratigraphic and taxonomic resolution pertinent to most macroevolutionary studies) than the records of several other taxa. Differences in tree size, shape, balance and the distribution of first stratigraphic appearances (potential sources of bias) were controlled for by various randomization procedures. Most measures of congruence for arthropods were statistically poorer than those for other groups, even when the sample was divided into broad temporal bins. Many of the most robust and widely reproduced sister groupings of arthropods are attended by ghost ranges of many tens or hundreds of millions of years. Fossils of a number of presently very diverse and abundant arthropod groups are conspicuously absent from the record, despite many spectacular examples of the detailed preservation of others. There is probably no single reason for the apparently poor record of arthropods. Low preservation potential, small size of individuals, small numbers of individuals, and restricted palaeobiogeography almost certainly play a role in particular cases. Copyright © 2001 John Wiley & Sons, Ltd. [source] Near-lithostatic pore pressure at seismogenic depths: a thermoporoelastic modelGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2006Francesca Zencher SUMMARY A model is presented for pore pressure migration through a transition layer separating a meteoric aquifer at hydrostatic pressure from a deeper reservoir at lithostatic pressure. This configuration is thought to be pertinent to the South Iceland seismic zone (SISZ) and to other tectonically active regions of recent volcanism, where volatiles are continuously released by ascending magma below the brittle,ductile transition. Poroelastic parameters are computed for basaltic rock. The model is 1-D, the fluid viscosity is temperature dependent and rock permeability is assumed to be pressure dependent according to a dislocation model of a fractured medium. Environment conditions are considered, pertinent to basalt saturated with water at shallow depth (case I) and at mid-crustal depth (case II). If the intrinsic permeability of the rock is high, no significant effects are observed in the pressure field but advective heat transfer shifts the brittle,ductile transition to shallower depths. If the intrinsic permeability is low, the pressure-dependent permeability can propagate near-lithostatic pore pressures throughout most of the transition layer, while the temperature is practically unaffected by advective contributions so that the rock in the transition layer remains in brittle condition. Geometrical parameters characterizing the fracture distribution are important in determining the effective permeability: in particular, if an interconnected system of fractures develops within the transition layer, the effective permeability may increase by several orders of magnitude and near-lithostatic pore pressure propagates upwards. These modelling results have important bearings on our understanding of seismogenic processes in geothermal areas and are consistent with several geophysical observations in the SISZ, in connection with the two 2000 June M= 6.5 earthquakes, including: (i) fluid pressure pulses in deep wells, (ii) low resistivity at the base of the seismogenic layer, (iii) low VP/VS ratio and time-dependent seismic tomography, (iv) heterogeneity of focal mechanisms, (v) shear wave splitting, (vi) high b -value of deep foreshocks, (vii) triggered seismicity and (viii) Radon anomalies. [source] Are Migraine and Coronary Heart Disease Associated?HEADACHE, Issue 2004An Epidemiologic Review In evaluating the cardiovascular risks of triptans (5-HT1B/1D agonists) for the treatment of migraine, the possible relationship between migraine and cardiovascular disease warrants careful assessment. The vascular nature of migraine is compatible with the possibility that migraine is a manifestation of cardiovascular disease or is linked to cardiovascular disease via a common mechanism. If so, then migraine itself,independent of the use of triptans,may be associated with an increased risk of cardiac events. This article considers the epidemiologic literature pertinent to evaluating the association of migraine with coronary heart disease. The research reviewed herein fails to support an association between migraine and coronary heart disease. First, data from several large cohort studies show that the presence of migraine does not increase risk of coronary heart disease. Furthermore, although migraineurs are generally more likely than nonmigraineurs to report chest pain, the presence of chest pain in most studies did not predict serious cardiac events such as myocardial infarction. That the gender- and age-specific prevalence of migraine does not overlap with that of coronary heart disease is also consistent with a lack of association between migraine and atherosclerotic cardiovascular disease. While migraine appears not to be associated with coronary heart disease, preliminary evidence suggests a possible link of migraine with vasospastic disorders such as variant angina and Raynaud's phenomenon. These results warrant further investigation in large prospective studies. [source] Qualitative Data Analysis for Health Services Research: Developing Taxonomy, Themes, and TheoryHEALTH SERVICES RESEARCH, Issue 4 2007Elizabeth H. Bradley Objective. To provide practical strategies for conducting and evaluating analyses of qualitative data applicable for health services researchers. Data Sources and Design. We draw on extant qualitative methodological literature to describe practical approaches to qualitative data analysis. Approaches to data analysis vary by discipline and analytic tradition; however, we focus on qualitative data analysis that has as a goal the generation of taxonomy, themes, and theory germane to health services research. Principle Findings. We describe an approach to qualitative data analysis that applies the principles of inductive reasoning while also employing predetermined code types to guide data analysis and interpretation. These code types (conceptual, relationship, perspective, participant characteristics, and setting codes) define a structure that is appropriate for generation of taxonomy, themes, and theory. Conceptual codes and subcodes facilitate the development of taxonomies. Relationship and perspective codes facilitate the development of themes and theory. Intersectional analyses with data coded for participant characteristics and setting codes can facilitate comparative analyses. Conclusions. Qualitative inquiry can improve the description and explanation of complex, real-world phenomena pertinent to health services research. Greater understanding of the processes of qualitative data analysis can be helpful for health services researchers as they use these methods themselves or collaborate with qualitative researchers from a wide range of disciplines. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||