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Peri-implantitis Lesions (peri-implantitis + lesion)

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Medical Sciences100%

Selected Abstracts

Immunohistochemical characteristics of inflammatory lesions at implants

JOURNAL OF CLINICAL PERIODONTOLOGY, Issue 1 2003
Federico Gualini
Abstract Objective: The aim of the present investigation was to study some immunohistochemical features of peri-implant mucositis and peri-implantitis lesions. Materials and methods: Two groups of subjects (Groups A and B) were included. Group A consisted of 10 partially edentulous subjects (eight females and two males; 45,72 years of age) who had been restored with implants (Brånemark System®, Nobel Biocare AB, Göteborg, Sweden). The implants had been in function between 2 and 5 years. In each subject, one implant site demonstrating signs of peri-implant mucositis, i.e. soft tissue inflammation but no bone loss, was selected. The site was anaesthetized and a soft tissue biopsy was collected. In Group B, six subjects were included. They had been restored with implants (Brånemark System®, Nobel Biocare AB, Göteborg, Sweden) between 5 and 11 years prior to the current study. In each individual ,,1 implant site exhibited signs of peri-implantitis and was selected for biopsy. All sites of peri-implantitis had (i) a history of continuous marginal bone loss (assessed in radiographs), (ii) clinical symptoms of soft tissue inflammation (bleeding on probing and suppuration) but (iii) no implant mobility. From each selected peri-implantitis site a 4 × 4 mm large soft tissue biopsy was obtained. All specimens were snap frozen and prepared for immunohistochemical analysis regarding the proportions of cells positive for the CD3, CD4, CD8, CD19 and elastase markers. Results: Peri-implantitis lesions were considerably larger and contained significantly greater proportions of B cells (CD19+) and elastase-positive cells than mucositis lesions. Peri-implantitis sites, in contrast to sites with mucositis, consistently displayed elastase-positive cells in the central portions of the infiltrate. Conclusion: It is suggested that peri-implantitis lesions exhibit properties that are different from mucositis lesions. [source]

Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane

JOURNAL OF CLINICAL PERIODONTOLOGY, Issue 1 2008
Frank Schwarz
Abstract Objectives: The aim of the present case series was to evaluate the 2-year results obtained following treatment of peri-implantitis lesions using either a nanocrystalline hydroxyapatite (NHA) or a natural bone mineral in combination with a collagen membrane (NBM+CM). Material and Methods: Twenty-two patients suffering from moderate peri-implantitis (n=22 intra-bony defects) were randomly treated with (i) access flap surgery (AFS) and the application of NHA, or with AFS and the application of NBM+CM. Clinical parameters were recorded at baseline and after 12, 18, and 24 months of non-submerged healing. Results: Two patients from the NHA group were excluded from the study due to severe pus formation at 12 months. At 24 months, both groups revealed clinically important probing depth (PD) reductions (NHA: 1.5±0.6 mm; NBM+CM: 2.4±0.8 mm) and clinical attachment level (CAL) gains (NHA: 1.0±0.4 mm; NBM+CM: 2.0±0.8 mm). However, these clinical improvements seemed to be better in the NBM+CM group (difference between groups: PD reduction: 0.9±0.2 mm; CAL gain: 1.0±0.3 mm). Conclusion: Both treatment procedures have shown efficacy over a period of 24 months, however, the application of NBM+CM may result in an improved outcome of healing. [source]

Influence of different treatment approaches on non-submerged and submerged healing of ligature induced peri-implantitis lesions: an experimental study in dogs

JOURNAL OF CLINICAL PERIODONTOLOGY, Issue 8 2006
Frank Schwarz
Abstract Objective: The aim of the present study was to evaluate non-submerged and submerged healing of ligature induced peri-implantitis in dogs. Material and Methods: Peri-implantitis was induced by ligature placement in five beagle dogs (n=30 implants). The defects were randomly and equally allocated in a split-mouth design to either closed treatment+non-submerged healing (CNS), or open treatment+submerged healing (OS) using an Er:YAG laser (ERL), an ultrasonic device (VUS), or plastic curettes+local application of metronidazole gel (PCM), respectively. The animals were sacrificed after 3 months. Clinical, radiological and histological (e.g. new bone-to-implant contact (BIC)) parameters were assessed. Results: All treatment procedures resulted in statistically significant improvements of all clinical parameters at both CNS and OS implants. Radiological improvements were merely observed at OS implants. Histomorphometrical analysis revealed that all CNS implants exhibited comparable low amounts of new BIC (1.0,1.2%), while mean BIC was statistically significant higher in the respective OS groups [ERL (44.8%), PCM (14.8%), VUS (8.7%)]. Conclusion: Within the limits of the present study, it was concluded that (i) OS improved the outcome of treatment in comparison with CNS and (ii) ERL seemed to be more suitable to promote re-osseointegration than PCM and VUS. [source]

Immunohistochemical characteristics of inflammatory lesions at implants

JOURNAL OF CLINICAL PERIODONTOLOGY, Issue 1 2003
Federico Gualini
Abstract Objective: The aim of the present investigation was to study some immunohistochemical features of peri-implant mucositis and peri-implantitis lesions. Materials and methods: Two groups of subjects (Groups A and B) were included. Group A consisted of 10 partially edentulous subjects (eight females and two males; 45,72 years of age) who had been restored with implants (Brånemark System®, Nobel Biocare AB, Göteborg, Sweden). The implants had been in function between 2 and 5 years. In each subject, one implant site demonstrating signs of peri-implant mucositis, i.e. soft tissue inflammation but no bone loss, was selected. The site was anaesthetized and a soft tissue biopsy was collected. In Group B, six subjects were included. They had been restored with implants (Brånemark System®, Nobel Biocare AB, Göteborg, Sweden) between 5 and 11 years prior to the current study. In each individual ,,1 implant site exhibited signs of peri-implantitis and was selected for biopsy. All sites of peri-implantitis had (i) a history of continuous marginal bone loss (assessed in radiographs), (ii) clinical symptoms of soft tissue inflammation (bleeding on probing and suppuration) but (iii) no implant mobility. From each selected peri-implantitis site a 4 × 4 mm large soft tissue biopsy was obtained. All specimens were snap frozen and prepared for immunohistochemical analysis regarding the proportions of cells positive for the CD3, CD4, CD8, CD19 and elastase markers. Results: Peri-implantitis lesions were considerably larger and contained significantly greater proportions of B cells (CD19+) and elastase-positive cells than mucositis lesions. Peri-implantitis sites, in contrast to sites with mucositis, consistently displayed elastase-positive cells in the central portions of the infiltrate. Conclusion: It is suggested that peri-implantitis lesions exhibit properties that are different from mucositis lesions. [source]

Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes

CLINICAL ORAL IMPLANTS RESEARCH, Issue 3 2007
Giovanni E. Salvi
Abstract Aim: To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri-implantitis. Material and methods: In 25 partially edentulous subjects, 31 implants diagnosed with peri-implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin®) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) ,5 mm. Rescue therapy with Arestin® was allowed at Days 180 and 270 at any site exhibiting an increase in PPD,2 mm from the previous visit. The following clinical parameters were recorded at four sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI). Results: Six implants in six subjects were either rescued or exited because of persisting active peri-implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (P<0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI: 0.9,2.2 mm, P<0.001) and was accompanied by a statistically significant reduction of the BOP value (P<0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point. Conclusion: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months. [source]