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Selected AbstractsEscherichia coli mediated urinary tract infections: Are there distinct uropathogenic E. coli (UPEC) pathotypes?FEMS MICROBIOLOGY LETTERS, Issue 2 2005Carl F. Marrs Abstract A variety of virulence genes are associated with Escherichia coli mediated urinary tract infections. Particular sets of virulence factors shared by bacterial strains directing them through a particular pathogenesis process are called a "pathotype." Comparison of co-occurrence of potential urinary tract infection (UTI) virulence genes among different E. coli isolates from fecal and UTI collections provides evidence for multiple pathotypes of uropathogenic E. coli, but current understanding of critical genetic differences defining the pathotypes is limited. Discovery of additional E. coli genes involved in uropathogenesis and determination of their distribution and co-occurrences will further define UPEC pathotypes and allow for a more detailed analysis of how these pathotypes might differ in how they cause disease. [source] Curriculum-Context Knowledge: Teacher Learning From Successive Enactments of a Standards-Based Mathematics CurriculumCURRICULUM INQUIRY, Issue 2 2009JEFFREY MARTIN CHOPPIN ABSTRACT This study characterizes the teacher learning that stems from successive enactments of innovative curriculum materials. This study conceptualizes and documents the formation of curriculum-context knowledge (CCK) in three experienced users of a Standards-based mathematics curriculum. I define CCK as the knowledge of how a particular set of curriculum materials functions to engage students in a particular context. The notion of CCK provides insight into the development of curricular knowledge and how it relates to other forms of knowledge that are relevant to the practice of teaching, such as content knowledge and pedagogical content knowledge. I used a combination of video-stimulated and semistructured interviews to examine the ways the teachers adapted the task representations in the units over time and what these adaptations signaled in terms of teacher learning. Each teacher made noticeable adaptations over the course of three or four enactments that demonstrated learning. Each of the teachers developed a greater understanding of the resources in the respective units as a result of repeated enactments, although there was some important variation between the teachers. The learning evidenced by the teachers in relation to the units demonstrated their intricate knowledge of the curriculum and the way it engaged their students. Furthermore, this learning informed their instructional practices and was intertwined with their discussion of content and how best to teach it. The results point to the larger need to account for the knowledge necessary to use Standards-based curricula and to relate the development and existence of well-elaborated knowledge components to evaluations of curricula. [source] Markets, Institutions and Technology: Missing Links in Livelihoods AnalysisDEVELOPMENT POLICY REVIEW, Issue 3 2003Andrew Dorward The benefits of livelihoods thinking and approaches are widely recognised. This article focuses on an important gap in much of the conceptualization and application of ,livelihood approaches', a lack of emphasis on markets and their roles in livelihood development and poverty reduction. The omission is important, as it can lead to failure to identify and act on a wider range of market, institutional and technological opportunities and constraints. An alternative conceptualisation is proposed, with markets as one particular set of institutional mechanisms for co-ordination and exchange in an economy. It is argued that more explicit attention to interactions between institutions, technology and assets in livelihood analysis may be valuable in conceptualising and managing programmes for livelihood development and poverty reduction. [source] Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogenEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2003P. J. McCaffery Abstract Retinoic acid (RA) is essential for both embryonic and adult growth, activating gene transcription via specific nuclear receptors. It is generated, via a retinaldehyde intermediate, from retinol (vitamin A). RA levels require precise regulation by controlled synthesis and catabolism, and when RA concentrations deviate from normal, in either direction, abnormal growth and development occurs. This review describes: (i) how the pattern of RA metabolic enzymes controls the actions of RA; and (ii) the type of abnormalities that result when this pattern breaks down. Examples are given of RA control of the anterior/posterior axis of the hindbrain, the dorsal/ventral axis of the spinal cord, as well as certain sex-specific segments of the spinal cord, using varied animal models including mouse, quail and mosquitofish. These functions are highly sensitive to abnormal changes in RA concentration. In rodents, the control of neural patterning and differentiation are disrupted when RA concentrations are lowered, whereas inappropriately high concentrations of RA result in abnormal development of cerebellum and hindbrain nuclei. The latter parallels the malformations seen in the human embryo exposed to RA due to treatment of the mother with the acne drug Accutane (13- cis RA) and, in cases where the child survives beyond birth, a particular set of behavioural anomalies can be described. Even the adult brain may be susceptible to an imbalance of RA, particularly the hippocampus. This report shows how the properties of RA as a neural induction agent and organizer of segmentation can explain the consequences of RA depletion and overexpression. [source] Pharmacogenetics and personalised medicineFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 5 2002Werner Kalow ABSTRACT The traditional concern of pharmacogenetics was Mendelian (monogenic) variation, which visibly affected some drug responses. Pharmacogenetics was broadened by the observation that multifactorial genetic influences, in conjunction with environmental factors, usually determine drug responses. Variability of gene expression, a new theme of the science of genetics, also affects pharmacogenetics; for example, enhanced enzyme activity does not necessarily indicate a mutation, but may be the consequence of a drug-induced enhancement of gene expression. Methodological advances permit the conversion of pharmacogenetics into the broad practice of pharmacogenomics; this improves the possibility of identifying genetic causes of common diseases, which means establishing new drug targets, thereby stimulating the search for new drugs. While the main medical effect of pharmacogenetics was an improvement of drug safety, pharmacogenomics is hoped to improve drug efficacy. On the way to personalized medicine, we may stepwise improve the chances of choosing the right drug for a patient by categorizing patients into genetically definable classes that have similar drug effects (as, for example, human races, or any population group carrying a particular set of genes). It is wise to expect that, even after we have reached the goal to establish personalized medicine, we will not have eliminated all uncertainties. [source] Modelling opportunity in health under partial observability of circumstancesHEALTH ECONOMICS, Issue 3 2010Pedro Rosa Dias Abstract This paper proposes a behavioural model of inequality of opportunity in health that integrates John Roemer's framework of inequality of opportunity with the Grossman model of health capital and demand for health. The model generates a recursive system of equations for health and lifestyles, which is then jointly estimated by full information maximum likelihood with freely correlated error terms. The analysis innovates by accounting for the presence of unobserved heterogeneity, therefore addressing the partial-circumstance problem, and by extending the examination of inequality of opportunity to health outcomes other than self-assessed health, such as long-standing illness, disability and mental health. The results provide evidence for the existence of third factors that simultaneously influence health outcomes and lifestyle choices, supporting the empirical relevance of the partial-circumstance problem. Accounting for these factors, the paper corroborates that the effect of parental and early circumstances on adult health disparities is paramount. However, the particular set of circumstances that affect each of the analysed health outcomes differs substantially. The results also show that differences in educational opportunities, and in social development in childhood, are crucial determinants of lifestyles in adulthood, which, in turn, shape the observed health inequalities. Copyright © 2010 John Wiley & Sons, Ltd. [source] Improved non-staggered central NT schemes for balance laws with geometrical source termsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 8 2004rnjari Abstract In this paper we extend the non-staggered version of the central NT (Nessyahu,Tadmor) scheme to the balance laws with geometrical source term. This extension is based on the source term evaluation that includes balancing between the flux gradient and the source term with an additional reformulation that depends on the source term discretization. The main property of the scheme obtained by the proposed reformulation is preservation of the particular set of the steady-state solutions. We verify the improved scheme on two types of balance laws with geometrical source term: the shallow water equations and the non-homogeneous Burger's equation. The presented results show good behaviour of the considered scheme when compared with the analytical or numerical results obtained by using other numerical schemes. Furthermore, comparison with the numerical results obtained by the classical central NT scheme where the source term is simply pointwise evaluated shows that the proposed reformulations are essential. Copyright © 2004 John Wiley & Sons, Ltd. [source] Evidence-based practice and health visiting: the need for theoretical underpinnings for evaluationJOURNAL OF ADVANCED NURSING, Issue 6 2000Ruth Elkan BA(Hons) Evidence-based practice and health visiting: the need for theoretical underpinnings for evaluation In this paper we argue that evidence-based practice, which is being introduced throughout the British National Health Service to make decisions about the allocation of limited resources, provides a welcome opportunity for health visitors to demonstrate their efficacy, skills and professionalism. However, the paper argues that to view health visiting as evidence-based is not to reduce health visiting merely to a technology through which scientific solutions are applied to social problems. Rather, health visiting needs to be viewed as a political movement, based on a particular model of society, which shapes the goals which health visitors pursue and influences the strategies they adopt to achieve their goals. The paper describes various models of health visiting as a way of showing how the goals of health visiting are always framed within a particular set of assumptions and causal explanations. The paper then turns to look at the issue of evaluating health visiting services. It is argued that evaluation should properly take account of the models which shape health visitors' goals and intervention strategies, and in turn, health visitors need to be explicit about the theoretical frameworks underpinning their interventions. Finally, it is argued that health visitors' knowledge and understanding of a range of models of society enables them to move between the various models to choose the most appropriate and effective means of intervention. Hence it is concluded that the emphasis on evidence-based practice provides health visitors with a valuable opportunity to show that their unique, professional skills and understanding are the preconditions for effective intervention. [source] THE CEO: A VISIBLE HAND IN WEALTH CREATION?JOURNAL OF APPLIED CORPORATE FINANCE, Issue 3 2000C. K. Prahalad Commensurate with the growth of their pay packages and public visibility, the role of the CEO in the corporate value creation process has increased significantly in recent years. This article argues that sustained wealth creation in a corporation has three distinct elements. The first and most basic is the selection of the lines of business in which to operate; this element is probably the most visible manifestation of CEO action in large corporations today. The second element is the value creation model, which answers the question: How is this particular set of businesses expected to add value over and above the sum of the values of each business or asset category standing alone? The third element is the internal governance system, which establishes the corporate structure and administrative processes of the firm and, perhaps even more important, defines the corporate values that drive the strategic and operational priorities of the different business units. The authors suggest that the essence of the work of the CEO is to develop and maintain a balanced relationship among these three elements of wealth creation and to ensure that the relationship evolves in the face of changing circumstances. CEOs are inevitably faced with dilemmas in managing this process,in particular, the need to balance continuity and change and to maintain the integrity of short-term performance disciplines while encouraging not only investment in growth opportunities (which can hurt near term performance), but also experimentation and collaboration among business units (which are difficult to measure and reward with most performance measurement and incentive schemes). Adding to the difficulties of managing such dilemmas, visibility and a strong public image are often thrust upon (if not sought by) CEOs, who must then determine how they can use that image to strengthen the commitment of their employees and investors. [source] Conundrums in mixed woody,herbaceous plant systemsJOURNAL OF BIOGEOGRAPHY, Issue 11 2003Joanna I. House Abstract Aims To identify approaches to improve our understanding of, and predictive capability for, mixed tree,grass systems. Elucidation of the interactions, dynamics and determinants, and identification of robust generalizations that can be broadly applied to tree,grass systems would benefit ecological theory, modelling and land management. Methods A series of workshops brought together scientific expertise to review theory, data availability, modelling approaches and key questions. Location Ecosystems characterized by mixtures of herbaceous and woody plant life-forms, often termed ,savannas', range from open grasslands with few woody plants, to woodlands or forests with a grass layer. These ecosystems represent a substantial portion of the terrestrial biosphere, an important wildlife habitat, and a major resource for provision of livestock, fuel wood and other products. Results Although many concepts and principles developed for grassland and forest systems are relevant to these dual life-form communities, the novel, complex, nonlinear behaviour of mixed tree,grass systems cannot be accounted for by simply studying or modelling woody and herbaceous components independently. A more robust understanding requires addressing three fundamental conundrums: (1) The ,treeness' conundrum. What controls the relative abundance of woody and herbaceous plants for a given set of conditions at given site? (2) The coexistence conundrum. How do the life-forms interact with each other? Is a given woody,herbaceous ratio dynamically stable and persistent under a particular set of conditions? (3) The net primary productivity (NPP) conundrum. How does NPP of the woody vegetation, the herbaceous vegetation, and the total ecosystem (woody + herbaceous) change with changes in the tree,grass ratio? Tests of the theory and conceptual models of determinants of mixed woody,herbaceous systems have been largely site- or region-specific and have seldom been broadly or quantitatively evaluated. Cross-site syntheses based on data and modelling are required to address the conundrums and identify emerging patterns, yet, there are very few data sets for which either biomass or NPP have been quantified for both the woody and the herbaceous components of tree,grass systems. Furthermore, there are few cross-site comparisons spanning the diverse array of woody,herbaceous mixtures. Hence, initial synthesis studies should focus on compiling and standardizing a global data base which could be (1) explored to ascertain if robust generalizations and consistent patterns exist; and (2) used to evaluate the performance of savanna simulation models over a range of woody,herbaceous mixtures. Savanna structure and productivity are the result of complex and dynamic interactions between climate, soils and disturbances, notably fire and herbivory. Such factors are difficult to isolate or experimentally manipulate in order to evaluate their impacts at spatial and temporal scales appropriate for assessing ecosystem dynamics. These factors can, however, be evaluated with simulation models. Existing savanna models vary markedly with respect to their conceptual approach, their data requirements and the extent to which they incorporate mechanistic processes. Model intercomparisons can elucidate those approaches most suitable for various research questions and management applications. Conclusion Theoretical and conceptual advances could be achieved by considering a broad continuum of grass,shrub,tree combinations using data meta-analysis techniques and modelling. [source] The common patterns of natureJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 8 2009S. A. FRANK Abstract We typically observe large-scale outcomes that arise from the interactions of many hidden, small-scale processes. Examples include age of disease onset, rates of amino acid substitutions and composition of ecological communities. The macroscopic patterns in each problem often vary around a characteristic shape that can be generated by neutral processes. A neutral generative model assumes that each microscopic process follows unbiased or random stochastic fluctuations: random connections of network nodes; amino acid substitutions with no effect on fitness; species that arise or disappear from communities randomly. These neutral generative models often match common patterns of nature. In this paper, I present the theoretical background by which we can understand why these neutral generative models are so successful. I show where the classic patterns come from, such as the Poisson pattern, the normal or Gaussian pattern and many others. Each classic pattern was often discovered by a simple neutral generative model. The neutral patterns share a special characteristic: they describe the patterns of nature that follow from simple constraints on information. For example, any aggregation of processes that preserves information only about the mean and variance attracts to the Gaussian pattern; any aggregation that preserves information only about the mean attracts to the exponential pattern; any aggregation that preserves information only about the geometric mean attracts to the power law pattern. I present a simple and consistent informational framework of the common patterns of nature based on the method of maximum entropy. This framework shows that each neutral generative model is a special case that helps to discover a particular set of informational constraints; those informational constraints define a much wider domain of non-neutral generative processes that attract to the same neutral pattern. [source] Pigment study by Raman microscopy of 23 paintings by the Portuguese artist Henrique Pousão (1859,1884)JOURNAL OF RAMAN SPECTROSCOPY, Issue 11 2007Andreia M. Correia Abstract Twenty-three paintings by Henrique Pousão,a 19th century Portuguese painter,belonging to the collection of Museu Nacional Soares dos Reis, Porto, Portugal, were analysed by Raman microscopy. The fine focus of a 100× objective allowed the visualisation and individual identification of small grains. As a result, thirty-seven compounds, namely, anatase, barium white, basic lead sulfate, brochantite, cadmium red, cadmium yellow, calcium carbonate, carbon-based black, celadonite, chrome green, chrome orange, chrome yellow, cobalt blue, cochineal lake, copper sulfide, emerald green, iron(III) oxyhydroxide, iron(III) oxide, kaolinite, lead antimonate yellow, lead carbonate, lead white, lead sulfate, madder lake, malachite, Prussian blue, quartz, realgar/pararealgar, red lead, rutile, Scheele's green, strontium yellow, ultramarine blue, vermilion, viridian, zinc white and zinc yellow, were identified. Not all these compounds are pigments; some are extenders, others trace components and others probably products of reactions between pigments. Special attention was given to the Raman characterisation of celadonite, chrome orange, basic lead sulfate and lead antimonate yellow. Complementary techniques were used to confirm the identities of certain pigments and to characterise reference samples. Pousão, whose work has not previously been studied spectroscopically, was found to have used a remarkably wide range of pigments over his painting periods, without showing significant preference for any particular set of pigments. Copyright © 2007 John Wiley & Sons, Ltd. [source] A penalized likelihood approach to image warpingJOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES B (STATISTICAL METHODOLOGY), Issue 3 2001C. A. Glasbey A warping is a function that deforms images by mapping between image domains. The choice of function is formulated statistically as maximum penalized likelihood, where the likelihood measures the similarity between images after warping and the penalty is a measure of distortion of a warping. The paper addresses two issues simultaneously, of how to choose the warping function and how to assess the alignment. A new, Fourier,von Mises image model is identified, with phase differences between Fourier-transformed images having von Mises distributions. Also, new, null set distortion criteria are proposed, with each criterion uniquely minimized by a particular set of polynomial functions. A conjugate gradient algorithm is used to estimate the warping function, which is numerically approximated by a piecewise bilinear function. The method is motivated by, and used to solve, three applied problems: to register a remotely sensed image with a map, to align microscope images obtained by using different optics and to discriminate between species of fish from photographic images. [source] Practical Hydrodynamic Design of Bulbous Bows for ShipsNAVAL ENGINEERS JOURNAL, Issue 1 2005R. Sharma Although in modern times, bulbous bows have become an integral part of commercial ships, the hydrodynamic design of bulbous bows is still difficult because of costly tank tests and patent-driven knowledge banks. The design of a bulbous bow is needed even at the preliminary design level to predict speed and power. In this work, a design method is presented that combines and extends two famous theories i.e., Kracht (1978a) and Yim (1980) for a particular set of requirements within a narrow range of parameters. The method uses a reanalysis of an approximate linear theory with sheltering effect for resistance estimation, and re-correlation with statistical analysis via a non-linear multivariate regression analysis from existing literature and tank test results available in the public domain. The optimization of design parameters has been done for the design speed. The effect of change in the speed has been discussed and suit-ably incorporated in the design process. In the present work, the effect of production constraints on the design of bulb parameters has also been briefly examined. The results of this study are presented in the form of design parameters related to main hull parameters for a set of input data in a narrow range. The first six parameters have been derived by re-correlation with statistical analysis and the seventh parameter by reanalysis of an approximate linear theory with sheltering effect for resistance estimation. Finally, a design example, which includes tank test results, of an additive bulbous bow for a container ship has been presented. [source] Stability and coexistence in a lawn community: mathematical prediction of stability using a community matrix with parameters derived from competition experimentsOIKOS, Issue 2 2000Stephen H. Roxburgh Community matrix theory has been proposed as a means of predicting whether a particular set of species will form a stable mixture. However, the approach has rarely been used with data from real communities. Using plant competition experiments, we use community matrix theory to predict the stability and competitive structuring of a lawn community. Seven species from the lawn, including the six most abundant, were grown in boxes, in conditions very similar to those on the lawn. They were grown alone (monocultures), and in all possible pairs. The species formed a transitive hierarchy of competitive ability, with most pairs of species showing asymmetric competition. Relative competitive ability (competitive effect) was positively correlated with published estimates of the maximum relative growth rate (RGRmax) for the same species. A seven-species community matrix predicted the mixture of species to be unstable. Simulations revealed two topological features of this community matrix. First, the matrix was closer to the stability/instability boundary than predicted from a range of null (random) models, suggesting that the lawn may be close to stability. Second, the tendencies of the lawn species to compete asymmetrically, and to be arranged in competitive hierarchies, were found to be positively associated with stability, and hence may be contributing factors to the near-stability seen in the matrix. The limitations of using competition experiments for constructing community matrices are discussed. [source] USING AND ABANDONING ROUNDHOUSES: A REINTERPRETATION OF THE EVIDENCE FROM LATE BRONZE AGE,EARLY IRON AGE SOUTHERN ENGLANDOXFORD JOURNAL OF ARCHAEOLOGY, Issue 2 2007LEO WEBLEY Summary. It has recently been demonstrated that a number of roundhouses of the early first millennium BC in southern England show a concentration of finds in the southern half of the building. It has thus been argued that this area was used for domestic activities such as food preparation, an idea which has formed the basis for discussion of later prehistoric ,cosmologies'. However, reconsideration of the evidence suggests that this finds patterning does not relate to the everyday use of the buildings, being more likely to derive from a particular set of house abandonment practices. Furthermore, evidence can be identified for the location of domestic activities within contemporary roundhouses that appears to contradict the established model. [source] Correlation of peel and burst tests for pouchesPACKAGING TECHNOLOGY AND SCIENCE, Issue 2 2001Rosamari Feliú-Báez Abstract Theoretical equations based on force diagrams were developed in order to explain pouch behaviour during a restrained burst test. According to the resulting equation, P,=,2 S/D, the burst pressure (P) increases directly with seal strength (S) and inversely with the distance between the restraining plates (D). After performing a restrained burst test and a peel test on Tyvek/plastic pouches, it was found that the theoretical development did not exactly explain burst test results in terms of peel test values. The test results demonstrate that even though the peeling times for the peel and burst tests were controlled to be the same, the theoretical formula (P,=,2 S/D) tends to overestimate the burst pressure. The overestimation increases at smaller gaps. These results are an indication that the formula is not universal and they suggest that it is an oversimplification. It might work for some materials at a particular set of testing conditions but not for others. Copyright © 2001 John Wiley & Sons, Ltd. [source] Introduction to the Epistemology of CausationPHILOSOPHY COMPASS (ELECTRONIC), Issue 6 2009Frederick Eberhardt This survey presents some of the main principles involved in discovering causal relations. They belong to a large array of possible assumptions and conditions about causal relations, whose various combinations limit the possibilities of acquiring causal knowledge in different ways. How much and in what detail the causal structure can be discovered from what kinds of data depends on the particular set of assumptions one is able to make. The assumptions considered here provide a starting point to explore further the foundations of causal discovery procedures, and how they can be improved. [source] Clinical application of antibody microarray in chronic kidney disease: How far to go?PROTEOMICS - CLINICAL APPLICATIONS, Issue 7-8 2008Lin-Li Lv Abstract Chronic kidney disease (CKD) that affects about 10% of the adult population has been shown as a worldwide public health problem in recent years. Both basic and clinical investigations have identified complex disease-associated protein networks involved in the pathophysiologic processes of CKD. The traditional single-assay approach and proteomic analysis of those related proteins have given birth to a steadily increasing panel of molecules that may have the potential to serve as biomarkers for CKD. However, both approaches suffered from some shortcomings from a technological point of view. Antibody microarray (AbM) is characterized by high sensitivity, specificity, and quantitative ability for a particular set of known proteins. However, its application in CKD has been very limited so far. The objective of this review, therefore, is to address the potential applications of AbM in studying of CKD. We will briefly discuss the proteins involved in the development of CKD, future directions in which AbM approaches would probably display its potential and also some key issues that need to be considered in application of this novel technique. [source] Explaining Institutional Change in Tough Cases of Collaboration: "Ideas" in the Blackfoot WatershedPUBLIC ADMINISTRATION REVIEW, Issue 2 2009Edward P. Weber Current theories of community-based collaborative governance arrangements rely on the presence (or absence) of certain antecedent community conditions as well as incentives for institutional change deriving from the sociopolitical and economic environment. The combination of antecedent conditions and incentives is helpful in understanding why collaboratives emerge and succeed in "easy" cases (strong incentives, conducive antecedent conditions). Yet the combination is of little help in understanding the institutional change puzzle for collaboratives in "tough" cases (strong incentives, poor antecedent conditions). Examination of a "tough" case in the Blackfoot watershed (Montana), which eventually blossomed into a successful collaborative, shows the importance of a particular set of new ideas, or shared norms, around which participants coalesced. These new ideas for understanding public problems, the community itself, and the relationships among stakeholders, became a broad conceptual framework for guiding stakeholder interaction as they attempted to manage the many public problems facing the watershed. [source] Keeping Public Officials Accountable through Dialogue: Resolving the Accountability ParadoxPUBLIC ADMINISTRATION REVIEW, Issue 6 2002Nancy C. Roberts How can public officials be held accountable, and yet avoid the paradoxes and pathologies of the current mechanisms of accountability? The answer, claims Harmon (1995), is dialogue. But what exactly is dialogue, and how is it created? More importantly, how can dialogue ensure accountability? To address these questions, I begin with a brief description of dialogue and its basic features, distinguishing it from other forms of communication. An example illustrates how dialogue occurs in actual practice. Not only does dialogue demonstrate the intelligent management of contradictory motives and forces, it also supports Harmon's claim that it can resolve the accountability paradox and avoid the atrophy of personal responsibility and political authority. I suggest that dialogue's advantage outweighs its cost as a mechanism of accountability under a particular set of conditions: when public officials confront "wicked problems" that defy definition and solution, and when traditional problem,solving methods have failed, thus preventing any one group from imposing its definition of the problem or its solutions on others. [source] Closing Ranks: Fundamentals in History, Politics and AnthropologyTHE AUSTRALIAN JOURNAL OF ANTHROPOLOGY, Issue 2 2006Kirsten Hastrup In this presentation, I discuss fundamentalism from a processual perspective, seeking to tease out some general qualities of the processes involved in a return to fundamentals amidst social change. I start with an analysis of the historical dynamics of Icelandic society in the period 1400,1800, showing how the increasing insistence on old patterns and cultural fundamentals contributed to the gradual destruction of a one time flourishing medieval society. This devolution, I suggest, is closely correlated with a process of amplification (Sahlins) of a particular set of values, leading to a loss of flexibility in the response to environmental and other changes. Next follows a discussion of present day concerns with nationalism and other interests in bounding oneself off from the surrounding world, and demanding recognition in return. One of the processes discussed is a process of transvaluation (Tambiah), assimilating particulars to a larger and less context-bound scheme and thereby gradually deepening the cleavage between selves and others, sometimes to the point of epistemological closure (Ignatieff). Finally, one of the anthropological fundamentals, holism, is discussed with a view to reassessing its potential for present-day anthropology. It is argued that through the process of knowing implied in fieldwork, anthropologists arrive at a dual understanding of perceived wholes and creative agents. A new sense of holism may still grant both consistency and uniqueness to the anthropological discipline. [source] Cluster Formation as a Measure of Interpretability in Multiple TestingBIOMETRICAL JOURNAL, Issue 5 2008Juliet Popper Shaffer Abstract Multiple test procedures are usually compared on various aspects of error control and power. Power is measured as some function of the number of false hypotheses correctly identified as false. However, given equal numbers of rejected false hypotheses, the pattern of rejections, i.e. the particular set of false hypotheses identified, may be crucial in interpreting the results for potential application. In an important area of application, comparisons among a set of treatments based on random samples from populations, two different approaches, cluster analysis and model selection, deal implicitly with such patterns, while traditional multiple testing procedures generally focus on the outcomes of subset and pairwise equality hypothesis tests, without considering the overall pattern of results in comparing methods. An important feature involving the pattern of rejections is their relevance for dividing the treatments into distinct subsets based on some parameter of interest, for example their means. This paper introduces some new measures relating to the potential of methods for achieving such divisions. Following Hartley (1955), sets of treatments with equal parameter values will be called clusters. Because it is necessary to distinguish between clusters in the populations and clustering in sample outcomes, the population clusters will be referred to as P -clusters; any related concepts defined in terms of the sample outcome will be referred to with the prefix outcome. Outcomes of multiple comparison procedures will be studied in terms of their probabilities of leading to separation of treatments into outcome clusters, with various measures relating to the number of such outcome clusters and the proportion of true vs. false outcome clusters. The definitions of true and false outcome clusters and related concepts, and the approach taken here, is in the tradition of hypothesis testing with attention to overall error control and power, but with added consideration of cluster separation potential. The pattern approach will be illustrated by comparing two methods with apparent FDR control but with different ways of ordering outcomes for potential significance: The original Benjamini,Hochberg (1995) procedure (BH), and the Newman,Keuls (Newman, 1939; Keuls, 1952) procedure (NK). (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Characterization of the Surface Properties of Commercially Available Dental Implants Using Scanning Electron Microscopy, Focused Ion Beam, and High-Resolution Transmission Electron MicroscopyCLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Issue 1 2008Tobias Jarmar PhD ABSTRACT Background:, Since osseointegration of the respective implant is claimed by all manufacturing companies, it is obvious that not just one specific surface profile including the chemistry controls bone apposition. Purpose:, The purpose was to identify and separate out a particular set of surface features of the implant surfaces that can contribute as factors in the osseointegration process. Material and Methods:, The surface properties of several commercially available dental implants were extensively studied using profilometry, scanning electron microscopy, and transmission electron microscopy. Ultrathin sections prepared with focused ion beam microscopy (FIB) provided microstructural and chemical data which have not previously been communicated. The implants were the Nobel Biocare TiUnite® (Nobel Biocare AB, Göteborg, Sweden), Nobel Biocare Steri-Oss HA-coated (Nobel Biocare AB, Yorba Linda, CA, USA), Astra-Tech OsseoSpeedÔ (Astra Tech AB, Mölndal, Sweden), Straumann SLA® (Straumann AG, Waldenburg, Switzerland), and the Brånemark Integration Original Fixture implant (Brånemark Integration, Göteborg, Sweden). Results:, It was found that their surface properties had differences. The surfaces were covered with crystalline TiO2 (both anatase and rutile), amorphous titanium oxide, phosphorus doped amorphous titanium oxide, fluorine, titanium hydride, and hydroxyapatite, respectively. Conclusion:, This indicates that the provision of osseointegration is not exclusively linked to a particular set of surface features if the implant surface character is a major factor in that process. The studied methodology provides an effective tool to also analyze the interface between implant and surrounding bone. This would be a natural next step in understanding the ultrastructure of the interface between bone and implants. [source] State of mind organization in personality disorders.CLINICAL PSYCHOLOGY AND PSYCHOTHERAPY (AN INTERNATIONAL JOURNAL OF THEORY & PRACTICE), Issue 5 2005Typical states, the triggering of inter-state shifts It is possible to portray patients suffering from personality disorders using Horowitz's States of Mind Theory, according to which each disorder features its own particular set of forms of subjective experience (states of mind) and the shifting from one state to another is done under compulsion. If we want to define personality disorders correctly we need to define the rules causing inter-state shifts and, as a result, creating personality organization. The prime candidates to acting as these rules constraining the shifts are interpersonal patterns and shortfalls in the ability to metarepresent internal experience and others' psychological worlds. We shall illustrate these hypotheses with some session transcript extracts involving patients suffering from personality disorders. In the transcripts we have pinpointed the initial state of mind, the cause of the shift and the state of mind the patient has moved into. The discussion of the theory that personality disorders are organizations of states of mind in which the inter-state shifts are constrained will be on the basis of some clinical examples.,Copyright © 2005 John Wiley & Sons, Ltd. [source] The conceptual relationship between health indicators and quality of life: results from the cross-cultural analysis of the EUROHIS field studyCLINICAL PSYCHOLOGY AND PSYCHOTHERAPY (AN INTERNATIONAL JOURNAL OF THEORY & PRACTICE), Issue 1 2005Silke Schmidt The aim of this study was to determine the performance of various health indicators to predict quality of life, mental health and general health from a conceptual point of view. The EUROHIS study (see Nosikov and Gudex, 2003) includes a broad range of health care and health behaviour related indicators, such as preventive care, health care utilization, use of medicine, physical health, mental health, alcohol consumption, physical activity and quality of life. Data on various health indicators and quality of life were collected from 10 countries, amounting to a sample size of 4849 (2750 females and 2099 males). An analytical approach was employed to investigate the interrelationship between indicators of each particular indicator set (such as alcohol consumption) and between conceptually different indicator sets. Regression analyses as well as structural equation modelling were employed, pooled across all countries as well as separately for different groups of countries. Findings indicate a higher extent of cross-cultural variation in health behaviour and the QOL measures than in mental health and physical health. In regression analyses, results showed strong and consistent effects of various health behaviour indicators to predict quality of life (R2 = 0.48), mental health (R2 = 0.48) or general health (R2 = 0.45). However, a differential effect of socio-demographic variables, in particular education, and health behavioural determinants was found in different groups of countries. In the structural equation modelling, good fit indices were observed for the model determining physical and mental health factors by different health behaviour factors. Findings suggest that quality of life rather mediates mental outcomes in this particular set of health indicators in a European sample than functions as an outcome variable. However, it was not possible to include sociodemographic data in the whole model but only in each of the latent factors. This finding still requires replication, both in different clinical groups and in longitudinal data.,Copyright © 2005 John Wiley & Sons, Ltd. [source] What Can Be Learned From Taxometric Analyses?CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 4 2001Thomas A. Widiger Taxometric analyses can be useful in indicating that a particular set of beliefs, attitudes, feelings, or behaviors have coherence as manifest class taxa. However, there is little reason to believe that taxometric analyses identify latent class taxa with specific etiologies, pathologies, or treatment implications. Taxometric analyses can, in fact, be quite misleading if their results are taken too seriously. Mental disorders are most likely the result of polygenetic dispositions and multifactorial etiologies. The optimal understanding of the etiology, pathology, and treatment of mental disorders is more likely to be multifactorial than taxonic. [source] THE COST OF MELANIZATION: BUTTERFLY WING COLORATION UNDERENVIRONMENTAL STRESSEVOLUTION, Issue 2 2004W. Talloen Abstract Evolutionary studies typically focus on adaptations to particular environmental conditions, thereby often ignoring the role of possible constraints. Here we focus on the case of variation in dorsal wing melanization in a satyrine butterfly Pararge aegeria. Because melanin is a complex polymer, its synthesis may be constrained if ambient conditions limit the resource budget. This hypothesis was tested by comparing melanization among butterflies that fed as larvae on host grasses experiencing different drought-stress treatments. Treatment differences were validated both at the level of the host plant (nitrogen, carbonate, and water content) and of the butterfly (life-history traits: survival, development time, and size at maturity). Melanization rate was measured as average gray value of the basal dorsal wing area. This area, close to the thorax, is known to be functionally significant for basking in order to thermoregulate. Individuals reared on drought-stressed host plants developed paler wings, and development of darker individuals was slower and less stable as estimated by their level of fluctuating asymmetry. These results provide evidence that melanin is indeed costly to synthesize, and that differences in environmental quality can induce phenotypic variation in wing melanization. Therefore, studies dealing with spatial and/or temporal patterns of variation in wing melanization should not focus on adaptive explanations alone, but rather on a cost-benefit balance under particular sets of environmental conditions. [source] Silence in the Context of ,Child Voice'CHILDREN & SOCIETY, Issue 1 2010Ann Lewis Recent decades have seen growing enthusiasm internationally for the concept and practice of ,child voice'. This was encapsulated in, and stimulated, by Article 12 of the 1989 United Nations Convention on the Rights of the Child. This article presents the case for incorporating the equally important concept of ,child silence' in both research and applied contexts. ,Child voice' has become a powerful moral crusade and consequently criticism of voice has been muted. This is despite the growing articulation of reservations about ,child voice' in various research and applied contexts. Two particular sets of emerging concerns are discussed: one set is around the purposes behind such engagement with children; and one set relates to the ethical protocols involved. Finally, the article makes a series of recommendations for researchers working in the fields of ,child voice'. These concern five methodological aspects: recognising, noting, responding to, interpreting and reporting silence from children. It is concluded that it is timely to take a step back from assumed support for ,child voice' as necessarily ,a good thing'. Rather, we need to consider more reflexively how, why and when ,child voice' is realised in co-constructed research and professional contexts. [source] | |||||||||||||||||||||||||||||||