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Parental History (parental + history)

Distribution by Scientific Domains

Medical Sciences	93%

Selected Abstracts

Parental history of myocardial infarction and risk of heart failure in male physicians

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 12 2008
L. Djoussé
Abstract Background, Although heart failure (HF) remains a major public health issue, limited data are available on the utility of parental information on the risk of HF in offspring. Materials and methods, We prospectively examined the association between parental history of myocardial infarction (MI) and incident HF among 20 187 offspring in the Physicians' Health Study I. Parental history and age at MI was assessed by a questionnaire and a Cox regression was used to estimate relative risks of HF. Results, After an average follow-up of 19·6 years, 1036 new HF cases were documented. Overall, while a history of early parental MI (before age 55) was associated with a 32% increased risk of HF in offspring compared with subjects whose parent did not have MI, parental MI at older ages was not associated with HF risk. However, the relation between parental history of MI and HF was stronger and mainly observed for HF with antecedent MI. Compared with subjects without parental history of MI, multivariable adjusted hazard ratios (95% CI) for HF with antecedent MI were 3·44 (2·15,5·51), 2·24 (1·20,4·21), 1·26 (0·63,2·51), and 1·37 (0·92,2·03) for parental MI occurred at the age of < 55, 55,59, 60,64, and 65 + y, respectively. Conclusions, Our data suggest that parental MI at an early age is a strong and independent predictor of HF with antecedent MI among US male physicians. This information, along with existing tools, may help clinicians identify patients at risk of HF with antecedent MI. [source]

Parental history and early onset type 2 diabetes among African,American and Latino children in Chicago

PAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 4 2001
K Onyemere
No abstract is available for this article. [source]

When doctors disagree: a qualitative study of doctors' and parents' views on the risks of childhood food allergy

HEALTH EXPECTATIONS, Issue 3 2008
Wendy Hu MBBS Dip Paed MHA PhD FRACGP
Abstract Objective, To examine the views of doctors which underpin clinical practice variation concerning an uncertain health risk, and the views of parents who had sought advice from these doctors, using the example of childhood food allergy. Study design, Qualitative study involving in-depth interviews and participant observation over 16 months. Focus groups and consultation audio-recordings provided corroborative data. Setting, Three specialist allergy clinics located in one metropolitan area. Participants, Eighteen medical specialists and trainees in allergy, and 85 parents (from 69 families) with food allergic children. Results, Doctors expressed a spectrum of views. The most divergent views were characterized by: scientific scepticism rather than precaution in response to uncertainty; emphasis on quantifiable physical evidence rather than parental histories; professional roles as providers of physical diagnosis and treatment rather than of information and advocacy; libertarian rather than communitarian perspectives on responsibility for risk; and values about allergy as a disease and normal childhood. Parents held a similar, but less divergent range of views. The majority of parents preferred more moderate doctors' views, with 43% (30 of 69) of families expressing their dissatisfaction by seeking another specialist opinion. Many were confused by variation in doctors' opinions, preferring relationships with doctors that recognized their concerns, addressed their information needs, and confirmed that they were managing their child's allergy appropriately. Conclusions, In uncertain clinical situations, parents do not expect absolute certainty from doctors; inflexible certainty may not allow parental preferences to be acknowledged or accommodated, and is associated with the seeking of second opinions. [source]

Memory deficits in children with and at risk for anxiety disorders

DEPRESSION AND ANXIETY, Issue 2 2007
Roma A. Vasa M.D.
Abstract There are limited data on the neurocognitive correlates of childhood anxiety disorders. The objective of this study was to examine whether visual and verbal memory deficits of nonemotional stimuli are (1) a shared feature of three common childhood anxiety disorders (social phobia, separation anxiety disorder, and generalized anxiety disorder) or whether these deficits are restricted to specific anxiety disorders, and (2) present in offspring who possess at least one of the following established risk factors for anxiety disorders, parental history of panic disorder (PD), or major depressive disorder (MDD). One hundred and sixty offspring, ages 9,20 years, were recruited from parents with lifetime diagnoses of PD, MDD, PD plus MDD, or neither illness. Different clinicians blindly administered semistructured diagnostic interviews to offspring and parents. Verbal and visual memory subtests of the Wide Range Assessment of Memory and Learning were administered to offspring. The results showed that offspring with ongoing social phobia demonstrated reduced visual but not verbal memory scores compared to those without social phobia when controlling for offspring IQ, separation anxiety disorder, and generalized anxiety disorder. No other offspring anxiety disorder predicted memory performance. Neither parental PD nor parental MDD was associated with offspring memory performance. These findings are relevant to understanding the phenomenology of childhood anxiety disorders and may provide insights into the neural circuits underlying these disorders. Depression and Anxiety 24:85,94, 2007. Published 2006 Wiley-Liss, Inc. [source]

Familial factors in diabetic nephropathy: an offspring study

DIABETIC MEDICINE, Issue 3 2006
E. Agius
Abstract Aims Familial clustering of diabetic nephropathy in patients with Type 2 diabetes suggests that inherited factors predispose to diabetic nephropathy, but the nature of these factors is uncertain. The aim of the study was to compare the prevalence of known risk factors for nephropathy in non-diabetic offspring of Type 2 diabetic patients with and without nephropathy and in control subjects. Methods Three groups of patients were recruited with 40 or 41 subjects in each group. These were subjects having one Type 2 diabetic parent with nephropathy (DN); subjects having one parent with Type 2 diabetes without nephropathy (DnoN), and non-diabetic unrelated control subjects with no personal or parental history of diabetes (Control subjects). Results The median (interquartile range) albumin/creatinine ratio (ACR) was 1.40 (0.96,2.90) mg/mmol in DN; 0.94 (0.50,1.46) mg/mmol in DnoN and 1.22 (0.66,1.83) mg/mmol in Controls (anova: P = 0.03). ACR was higher in group DN than in DnoN (P < 0.006) and in Control subjects (P < 0.03), but there was no difference between DnoN and Control subjects. Twenty-four-hour ambulatory blood pressure monitoring showed mean daytime systolic blood pressure to be significantly higher in group DN than in DnoN (P < 0.02) or Control subjects (P < 0.01) (anova: P = 0.004). Fasting insulin, HOMA-IR, interleukin-6 (IL-6) and C-reactive protein (CRP) were similar in the three groups. Conclusion Our data provide further evidence that genetic factors are important in determining urinary albumin excretion and renal disease associated with Type 2 diabetes and suggest that genes that affect systemic arterial blood pressure but not those relating to insulin resistance or inflammation are likely to be implicated. [source]

Heterogeneity in young adult onset diabetes: aetiology alters clinical characteristics

DIABETIC MEDICINE, Issue 9 2002
K. R. Owen
Abstract Aims To describe the characteristics of hepatocyte nuclear factor (HNF) 1, mutation carriers diagnosed with diabetes after 25 years and compare them with young-onset Type 2 diabetic patients (YT2D) diagnosed at the same age. Subjects and methods We studied 44 (21 male, 23 female) patients with HNF-1, mutations diagnosed with diabetes at ages 25,45 years and 44 YT2D subjects matched for sex and age of diagnosis. Results Median age of onset of diabetes was 35 years in both groups. The HNF-1, group demonstrated: lower body mass index (25.1 vs. 30.7 kg/m2; P < 0.001) and lower fasting triglycerides (1.37 vs. 2.96 mmol/l; P = 0.001) with similar fasting cholesterol level. They had lower glycated haemoglobin A1c (7.3 vs. 8.5%; P = 0.015) despite greater duration of diabetes (24 vs. 16 years; P = 0.02) and less frequent treatment with insulin (21% vs. 55%; P = 0.002). They were less likely to be treated for hypertension (13.3% vs. 56.3%; P = 0.009). Importantly, no difference was observed in reported parental history of diabetes between the two groups (65.9% vs. 63.6%; P = 0.92). Logistic regression showed that triglyceride levels and presence of anti-hypertensive treatment were the most important independent variables. Conclusions Patients with HNF-1, mutations may present with diabetes as young adults between the ages of 25,45 years. In this age range a wide differential diagnosis of diabetes is observed. Conventional criteria of age of onset and family history will not differentiate HNF-1, mutation carriers from YT2D subjects in this age range, but features of the metabolic syndrome, in particular fasting triglycerides and hypertension, are helpful. In patients diagnosed before 45 years without features of insulin resistance the diagnosis of HNF-1, should be considered. [source]

Parental history of myocardial infarction and risk of heart failure in male physicians

Sleep electroencephalogram in children with a parental history of alcohol abuse/dependence

JOURNAL OF SLEEP RESEARCH, Issue 1p2 2010
LEILA TAROKH
Summary We examined the sleep electroencephalogram (EEG) in 9- and 10-year-old children with (PH+) and without (PH,) a parental history of alcohol abuse/dependence to determine whether sleep disturbances associated with alcohol precede the onset of alcohol use. Participants slept on a fixed sleep schedule that ensured at least a 10-h time in bed for 1 week before an adaptation and baseline night. Data were collected in a four-bed sleep research laboratory. Thirty healthy boys and girls aged 9 or 10 years were classified as either PH+ or PH, based on DSM-IV criteria applied to structured parental interviews. All-night polysomnography was performed, sleep data were scored visually in 30-s epochs, and EEG power spectra were calculated for each epoch. All-night EEG spectra were calculated for rapid eye movement (REM) and non-REM (NREM) sleep, and cycle-by-cycle spectra were calculated for NREM sleep. The two groups did not differ on any sleep stage variable. All-night analyses revealed normalized power in the delta band and spindle range were lower in PH+ children. Within NREM sleep cycles PH+ children exhibited less normalized power in the delta band and spindle range compared with PH, children. This effect occurred in the first four cycles and was most pronounced in the first sleep cycle of the night. We found no signs of sleep disruption in sleep stages for PH+ children. Sleep EEG spectral differences, however, suggest that certain circuits responsible for ,protecting' sleep may be impaired in PH+ children, which may lead to disrupted sleep later in life. [source]

Integrating Person-Centered and Variable-Centered Approaches in the Study of Developmental Courses and Transitions in Alcohol Use: Introduction to the Special Section

ALCOHOLISM, Issue 6 2000
Marsha E. Bates
This special section consists of research from the symposium "Integrating Person-Centered and Variable-Centered Approaches to the Study of Developmental Courses and Transitions in Alcohol Use," presented at the 1999 Annual Meeting of the Research Society on Alcoholism. The section focuses on ways to integrate variable-centered and person-centered approaches to better understand longitudinal trajectories of alcohol use and associated problems. Our aim is to increase awareness and discussion of alternative conceptual and quantitative approaches that involve both a person-centered and a variable-centered component, and to make these methods more accessible to alcohol and other drug researchers. The first paper provides a general latent variable modeling framework within which to conceptualize developmental questions that involve the combination of continuous latent variables and categorical variables that represent classifications of individuals into meaningful subgroups. This is followed by three empirical papers that use integrative methods to examine early adult outcomes of adolescent binge drinking; potential mediators of familial alcoholism effects on alcohol and tobacco use disorder comorbidity; and the ability of psychopathology, substance use, and parental history of alcohol problems to predict individual differences in the likelihood of transitions in drinking behavior during adolescence. The section concludes with a discussion of the statistical basis for integrating person-centered and variable-centered methods, a comparison of study findings, and directions for future research. [source]

Risk factors for allergic rhinitis in Costa Rican children with asthma

ALLERGY, Issue 2 2010
S. Bunyavanich
To cite this article: Bunyavanich S, Soto-Quiros ME, Avila L, Laskey D, Senter JM, Celedón JC. Risk factors for allergic rhinitis in Costa Rican children with asthma. Allergy 2010; 65; 256,263 DOI: 10.1111/j.1398-9995.2009.02159.x. Abstract Background:, Risk factors for allergic rhinitis (AR) in asthmatics are likely distinct from those for AR or asthma alone. We sought to identify clinical and environmental risk factors for AR in children with asthma. Methods:, We performed a cross-sectional study of 616 Costa Rican children aged 6,14 years with asthma. Candidate risk factors were drawn from questionnaire data, spirometry, methacholine challenge testing, skin testing, and serology. Two outcome measures, skin test reaction (STR)-positive AR and physician-diagnosed AR, were examined by logistic regression. Results:, STR-positive AR had high prevalence (80%) in Costa Rican children with asthma, and its independent risk factors were nasal symptoms after exposure to dust or mold, parental history of AR, older age at asthma onset, oral steroid use in the past year, eosinophilia, and positive IgEs to dust mite and cockroach. Physician-diagnosed AR had lower prevalence (27%), and its independent risk factors were nasal symptoms after pollen exposure, STR to tree pollens, a parental history of AR, inhaled steroid and short-acting ,2 agonist use in the past year, household mold/mildew, and fewer older siblings. A physician's diagnosis was only 29.5% sensitive for STR-positive AR. Conclusions:, Risk factors for AR in children with asthma depend on the definition of AR. Indoor allergens drive risk for STR-positive AR. Outdoor allergens and home environmental conditions are risk factors for physician-diagnosed AR. We propose that children with asthma in Costa Rica and other Latin American nations undergo limited skin testing or specific IgE measurements to reduce the current under-diagnosis of AR. [source]

Risk factors for asthma among children in Maputo (Mozambique)

ALLERGY, Issue 4 2004
S. Mavale-Manuel
Background:, Few studies have looked at risk factors for asthma in African children. We aimed to identify the risk factors associated with childhood asthma in Maputo (Mozambique). Methods:, This case,control study included 199 age-matched children (100 asthmatic and 99 nonasthmatic) who attended Maputo Central Hospital between January 1999 and July 2000. We collected information concerning their familial history of atopy, birth weight, environment and breast-feeding. Detailed information about morbidity and treatment was obtained for each asthmatic child. Results:, The children were aged between 18 months and 8 years; 60% were male. The asthmatic children were hospitalized more frequently than the nonasthmatic children (P < 0.0001). Most of the asthmatic children lived in the urban area of Maputo [odd ratio (OR) = 6.73, CI = 3.1,14.0, P < 0.0001], had a parental history of asthma (OR = 26.8, CI = 10.8,68.2, P < 0.0001) or rhinitis (OR = 4, CI = 1.2,13.3, P = 0.005), had at least parent who smoked and were weaned earlier than the nonasthmatic children (OR = 2.4, CI = 1.3,4.4, P < 0.001). Conclusion:, Childhood asthma was strongly associated with a family history of asthma and rhinitis, the place of residence, having smokers as parents and early weaning from maternal breast milk. These results highlight the need to reassess the management of asthmatic children in Maputo. [source]

Attenuation of positive and negative affect in men and women at increased risk for hypertension: A function of endogenous barostimulation?

PSYCHOPHYSIOLOGY, Issue 1 2009
Daniel Z. Wilkinson
Abstract We hypothesized that activation of endogenous baroreflexes would be associated with reduced responsivity to affective stimuli and that this effect would be enhanced in individuals at risk for hypertension. Images from the International Affective Picture System were presented during systolic and diastolic phases of the cardiac cycle. Affective responsivity was measured using electromyographic activity, skin conductance, and ratings of arousal and valence. Compared to offspring of normotensives, individuals with a parental history of hypertension showed reduced responsivity to both positive and negative affective stimuli; however, responsivity did not differ as a function of cardiac cycle phase. Although these findings do not support a barostimulation mechanism of affective dampening, it is premature to discount the baroreflex inhibition hypothesis given the limited affective reactions elicited by visual stimuli presented in the laboratory. [source]

Allergy in day care children: prevalence and environmental risk factors

ACTA PAEDIATRICA, Issue 5 2009
Katja Hatakka
Abstract Aim: To investigate the prevalence of atopic disease among Finnish day care children and the relationship between atopy and environmental factors. Methods: A cross-sectional study of 594 day care children aged 1,6 years from Helsinki, Finland. Each child's history of atopic diseases and environmental exposure was collected in a questionnaire completed by the parents. Results: The prevalence of diagnosed asthma was 0.9% for the 1,3-year olds and 5.5% for the 4,6-year olds, atopic eczema/dermatis was 16% in both groups, and allergic rhinitis 5% in the younger group, 9% in the older group. According to multivariable logistic regression models, breastfeeding (exclusive ,4 months or partial ,6 months) reduced the risk of atopic diseases (OR = 0.60; CI95 0.39,0.93, p = 0.021). Atopic diseases were more common in the oldest age group, 5,6-year olds, compared to the youngest, 1,2-year olds (OR = 2.18; CI95 1.14,4.15, p = 0.018). One parent with atopic disease increased the child's risk (OR = 1.89; CI95 1.20,2.97, p = 0.006), more so if both parents had a history (OR = 3.17; CI95 1.48,6.78, p = 0.003). Conclusion: Our results support the hypothesis that breastfeeding for at least six months may protect against atopic diseases. The child's greater age (5,6 years) and parental history of atopic diseases increased the risk of atopy. [source]

Family history of myopia is not related to the final amount of refractive error in low and moderate myopia

CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 3 2005
Rafael Iribarren MD
Abstract Background:, Previous research has found an association between family history and presence of myopia. It is possible that family history also could be related to the final amount of refractive error developed. If that were true, then family history of myopia could have predictive value for the amount of refractive error a child or young adult would develop after first lens prescription. Methods:, Consecutive myopic adult outpatients were enrolled during the year 2003. They received a refractive examination and a questionnaire concerning age of onset of lens use, academic achievement, and parental history of myopia. Results:, In the group of 271 mild and moderate myopes (myopia lower than ,6 D) there were 157 subjects with at least one myopic parent and 114 subjects without family history. The presence or absence of a family history of myopia was not associated with either the final myopic refractive error (,3.2 ± 1.5 D and ,2.9 ± 1.3 D, respectively, P = 0.08) or the age of onset of lens use (17.0 ± 6.2 years vs 18.1 ± 6.7 years, respectively, P = 0.15). Conclusions:, In the present retrospective study of a clinical sample of mild and moderate myopic subjects, family history of myopia did not show predictive value for either the age of first prescription, or the final refractive error developed in adulthood. [source]