Paraneoplastic Cerebellar Degeneration (paraneoplastic + cerebellar_degeneration)

Distribution by Scientific Domains


Selected Abstracts


Paraneoplastic cerebellar degeneration and antibodies to P/Q-type calcium channels

ANNALS OF NEUROLOGY, Issue 2 2003
Ashwin Pinto MRCP, DPhil
No abstract is available for this article. [source]


The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction

ANNALS OF NEUROLOGY, Issue 1 2003
Luis Bataller MD
Probing a cerebellar expression library with TrAb sera from patients with Hodgkin's disease and paraneoplastic cerebellar degeneration resulted in the isolation of MAZ (myc -associated zinc-finger protein). Eleven of 19 TrAb sera and 16 of 131 controls reacted with MAZ, indicating a significant, although not specific, association between Tr and MAZ immunities (p < 0.001). Interestingly, 9 of 16 positive control patients also had cerebellar dysfunction. Purified MAZ antibodies reacted with Purkinje cells. In neuronal cells, MAZ interacts with DCC (Deleted in Colorectal Cancer product), the receptor for netrin-1, a neuronal survival factor. These findings suggest epitope spreading between the Tr antigen and the MAZ,DCC complex and offer a possible model of immune-mediated cerebellar disease. Ann Neurol 2003;53:000,000 [source]


Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies

ACTA NEUROLOGICA SCANDINAVICA, Issue 1 2009
A. Storstein
Introduction,,, Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. Materials and methods,,, We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. Results,,, The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. Conclusion,,, PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer. [source]