Home About us Contact
|
Home About us Contact | ||
|
|
||
Paediatric Inflammatory Bowel Disease (paediatric + inflammatory_bowel_disease)
Selected AbstractsThiopurine S -methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patientsJOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 1 2010M. Gazouli PhD Summary Background and objective:, Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of paediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S -methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to investigate the frequency of the functional TPMT polymorphisms and their association with the occurrence of adverse events during azathioprine therapy in a paediatric IBD cohort. Methods:, Ninety-seven thiopurine-treated paediatric IBD patients (41ˇ24% boys and 58ˇ76% girls) with a mean age 11ˇ25 years (range 3,16), were assessed for TPMT polymorphisms and adverse events. Results:, Of the 97 patients enrolled in the study, 18 (18ˇ56%) were heterozygous mutated; two (2ˇ06%) were homozygous for a mutated TPMT gene. Ten patients (10ˇ31%) developed adverse effects, and four of them (40%) had one of the variant alleles. Conclusions:, In this small cohort of subjects, no association was found between TPMT polymorphisms and the occurrence of thiopurines-related adverse events. [source] Review article: the clinical importance of growth in children with inflammatory bowel disease: is it important to the gastroenterologist?ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 2007J. A. TAMINIAU Summary Background, Growth in children with inflammatory bowel disease is often compromised. Aim, To explore the origins of growth retardation in paediatric inflammatory bowel disease and to consider management strategies. Methods, Relevant literature was identified and reviewed. Results, A combination of the following factors results in growth retardation: insufficient food intake, malabsorption, increased catabolism, disease activity, disease extension, complications of disease and the side-effects of treatment. Conclusions, Failure of normal growth in a child with inflammatory bowel disease is an indicator of insufficient and unsuccessful therapy. The major causative factor is chronic anorexia because of chronic catabolic illness. Growth resumes to normal after effective control of the disease and nutritional intake. Regular follow-up of growth in these children is mandatory, and the measurement of both height and weight is an ideal indication of effective treatment. Failure of sustained growth in a child or adolescent with inflammatory bowel disease is a warning to consider a change of clinical strategy. [source] Association of the interleukin-23 receptor gene variant rs11209026 with Crohn's disease in German childrenACTA PAEDIATRICA, Issue 5 2010M Lacher Abstract Aim:, Genome-wide association studies have described variants within the interleukin-23 receptor (IL23R) locus to be associated with Crohn's disease (CD) and ulcerative colitis (UC). We investigated the association of rs11209026 (p.Arg381Gln) and rs7517847 (c.799-3588T>G) into German paediatric inflammatory bowel disease (IBD) patients and analysed IL23R transcriptional activity in colonic tissues. Methods:, The rs11209026 and rs7517847 nucleotide substitutions were determined in 353 German children with IBD (221 CD, 132 UC) and 253 controls using pre-designed TaqManŽ SNP genotyping assays. In selected IBD patients and controls, IL23R mRNA expression was measured using real-time PCR. Results:, The prevalence of the rs11209026 A allele was lower in CD patients, but not in UC patients, when compared with controls (1.8% vs 7.1%, p < 0.01). The rs7517847 variant, in contrast, was associated neither with CD nor with UC. IL23R expression was variable in IBD patients compared with controls without significant overexpression or downregulation. Conclusion:, Our study provides additional support for the strong protection of the rs11209026 (p.Arg381Gln) variant against paediatric CD. IL23R was expressed in both CD and UC with a great variability. However, expression levels showed no significant association with the disease. [source] Parents' views of their child's health and family function in paediatric inflammatory bowel diseaseACTA PAEDIATRICA, Issue 4 2010H Lindfred Abstract Aim:, The aim of this study was to explore parents' views and agreement of their child's current and future health, as well as the family's functioning in daily life with inflammatory bowel disease (IBD). Methods:, In this study, 119 parents (65 mothers and 54 fathers) of 66 adolescents (11,16 years) with IBD completed a questionnaire regarding their views of their child's IBD and health-related behaviour. Results:, The majority of the parents held a positive view of their child's current health status. However, the parents voiced a range of worries about their children's future health and life situation such as fear about the side effects of medication, concerns for future schooling, social life and employment options. Within the families, the parental pairs had more similar views about their child's current health status than about their future health. Factors that affected the parents' views consisted of cohabitation status, i.e. parents not living together, and severe disease course, both correlated with a more negative view of the child's current health and family functioning. Conclusion:, The majority of the parents in this study had a largely positive view of their child's current health status, but they expressed concerns about their child's future health. Knowledge about parents' thoughts may be of importance for healthcare teams supporting families with IBD. [source] | ||||||||||