Home About us Contact
|
Home About us Contact | ||
|
|
||
Overlying
Kinds of Overlying Terms modified by Overlying Selected AbstractsA Method of Augmenting the Cheek Area Through SMAS, subSMAS, and Subcutaneous Tissue Recruitment During Facelift SurgeryDERMATOLOGIC SURGERY, Issue 3 2003Dominic A. Brandy MD BACKGROUND As the human face ages, there is a depletion of fat that occurs in the submalar region. Various techniques such as fat transfers, fillers, alloplastic implants, and composite rhytidectomies have been used to augment this area in the past. OBJECTIVE To describe a technique that augments the submalar areas during facelift surgery without the use of fat transfer, fillers, alloplastic implants, or a risky composite technique. METHOD An oval is scribed over the depressed submalar areas preoperatively. During facelift surgery, a fusiform area is scribed over the SMAS. This fusiform is scribed so that the medial end is directed at the center of the submalar depression, and the lateral end is toward the posterior earlobe. A defect is created within the lateral aspect of the fusiform, but not the medial portion. The fusiform is subsequently closed with a 2-0 Ethibond suture using three horizontal mattress sutures and two interrupted sutures. Upon closure of this defect, SMAS, subSMAS, and subcutaneous tissue overlying the SMAS are recruited into the submalar defect by the simple phenomenon of dog-ear formation. Additionally, there is a component of frank elevation of the tissues inferior to the medial aspect of the fusiform and submalar space. RESULTS The aforementioned technique has been performed on 123 patients over 7 years and has resulted in consistently good improvement in the submalar space. The procedure is not difficult to learn, and good results can be achieved with initial cases. The learning curve was not found to be steep, with good results being achieved quickly. CONCLUSION Depression of the submalar space plays a significant role in creating an aged face. In the past, various fillers and/or alloplastic implants have been used to augment this region. A low-risk method is described that mobilizes SMAS, subSMAS, and subcutaneous tissues into the submalar space through the phenomenon of dog-ear formation after fusiform closure. [source] The Surgical Looking Glass: A Readily Available Safeguard Against Eye Splash Injury/Contamination During Infiltration of Anesthesia for Cysts and Other "Porous" Lesions of the SkinDERMATOLOGIC SURGERY, Issue 4 2002Patrick R. Carrington MD Background. "Breaks" in barrier precautions are a definite abrogating influence on the effectiveness of "universal precautions." Dermatologists and dermatologic surgeons are exposed to significant infectious agents on a daily basis, especially due to the high number of minor surgical procedures performed. Backsplash, spray, and eye splash of bodily fluids during these procedures place the surgeon at a high risk of contamination/infection via the conjunctival membranes. The surgical looking glass is a simple utility based on inexpensive equipment already in place in the physician's office which protects the eyes and face during infiltrative anesthesia or incision of cysts and other lesions. Objective. To offer a simple and inexpensive utility to assist with protection from and reduction of contamination/infection of the ocular mucous membranes during surgical procedures. Methods. Utilizing one or two readily available microscope slides overlying the injection site during local infiltrative anesthesia, backsplash or spray can be contained. Results. This utility is effective in containment of backsplash or spray of anesthesia or bodily fluids during even minor surgical procedures. Conclusion. The surgical looking glass can enhance safety and promote "universal precautions" during even minor surgical procedures or infiltration of anesthesia into more porous areas or lesions for the practicing dermatologist or dermatologic surgeon. The pragmatic, practical, and inexpensive nature of the surgical looking glass invites its use on a daily basis by the practicing dermatologist. [source] Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2,5DEVELOPMENT GROWTH & DIFFERENTIATION, Issue 4 2009Inna Sabirzhanova Mammalian Tolloid-like 1 (Tll-1) is a pleiotropic metalloprotease that is expressed by a small subset of cells within the precardiac mesoderm and is necessary for proper heart development. Following heart tube formation Tll-1 is expressed by the endocardium and regions of myocardium overlying the region of the muscular interventricular septum. Mutations in Tll-1 lead to embryonic lethality due to cardiac defects. We demonstrate that the Tll-1 promoter contains Nkx2,5 binding sites and that the Tll-1 promoter is activated by and directly binds Nkx2,5. Tll-1 expression is ablated by a dominant negative Nkx2,5 or by mutation of the Nkx2,5 binding sites within the Tll-1 promoter. In vivo, Tll-1 expression is decreased in the hearts of Nkx2,5 knockout embryos when compared with hemizygous and wild-type embryos. These results show that Nkx2,5 is a direct activator of Tll-1 expression and provide insight into the mechanism of the defects found in both the Tll-1 and Nkx2,5 knockout mice. [source] Identification of molecular markers that are expressed in discrete anterior,posterior domains of the endoderm from the gastrula stage to mid-gestationDEVELOPMENTAL DYNAMICS, Issue 7 2007Billie A. Moore-Scott Abstract Little is known about how the endoderm germ layer is patterned along the anterior,posterior (A-P) axis before the formation of a gut tube (embryonic day [e] 7.5,8.5 in mouse), largely due to a paucity of molecular markers of endoderm. In particular, there are few genes that mark posterior domains of endoderm that give rise to the midgut and hindgut. We have identified 8 molecular markers that are expressed in discrete domains of the gastrula stage endoderm (e7.5), suggesting that a significant level of pattern exists in the endoderm before the formation of a gut tube. Three genes Tmprss2, NM_029639, and Dsp are expressed in a presumptive midgut domain overlying the node, a domain for which molecular markers have not previously been identified. Two genes, Klf5 and Epha2 are expressed in posterior endoderm associated with the primitive streak. Expression of these five genes persists in the midgut and/or hindgut at e8.5, 9.5 and 10.5, suggesting that these genes are markers of these domains throughout these stages of development. We have identified three genes Slc39a8, Amot, and Dp1l1, which are expressed in the visceral endoderm at e7.5. Starting at e9.5, Dp1l1 is expressed de novo in the liver, midgut, and hindgut. Our findings suggest that presumptive midgut and hindgut domains are being established at the molecular level by the end of gastrulation, earlier than previously thought, and emphasize the importance of endoderm patterning before the formation of the fetal gut. Developmental Dynamics 236:1997,2003, 2007. © 2007 Wiley-Liss, Inc. [source] Endoscopically managed superficial carcinoma overlying esophageal lipomaDIGESTIVE ENDOSCOPY, Issue 1 2004Shinsuke Usui The occurrence of superficial carcinoma over a benign tumor of the esophagus is considered to be rare. Only a few reports have been reported and all of them were treated surgically. We now report one case of superficial carcinoma overlying an esophageal lipoma that was successfully resected endoscopically. The patient was a 61-year-old man who had no symptoms. A submucosal tumor was found at the thoracic esophagus by upper gastrointestinal endoscopy. The top of the tumor was slightly depressed with mild redness and its surface was irregular. This depressed lesion was not stained by iodine. Histological examination of endoscopic biopsy revealed squamous cell carcinoma. To completely remove this tumor in a single fragment, we used an insulation-tipped electrosurgical knife. An en bloc resection of the tumor was completed without complications. [source] Assessing sediment contamination in estuariesENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 1 2001Peter M. Chapman Abstract Historic and ongoing sediment contamination adversely affects estuaries, among the most productive marine ecosystems in the world. However, all estuaries are not the same, and estuarine sediments cannot be treated as either fresh or marine sediments or properly assessed without understanding both seasonal and spatial estuarine variability and processes, which are reviewed. Estuaries are physicochemically unique, primarily because of their variable salinity but also because of their strong gradients in other parameters, such as temperature, pH, dissolved oxygen, redox potential, and amount and composition of particles. Salinity (overlying and interstitial) varies spatially (laterally, vertically) and temporally and is the controlling factor for partitioning of contaminants between sediments and overlying or interstitial water. Salinity also controls the distribution and types of estuarine biota. Benthic infauna are affected by interstitial salinities that can be very different than overlying salinities, resulting in large-scale seasonal species shifts in salt wedge estuaries. There are fewer estuarine species than fresh or marine species (the paradox of brackish water). Chemical, toxicological, and community-level assessment techniques for estuarine sediment are reviewed and assessed, including chemistry (grain size effects, background enrichment, bioavailability, sediment quality values, interstitial water chemistry), biological surveys, and whole sediment toxicity testing (single-species tests, potential confounding factors, community level tests, laboratory-to-field comparisons). Based on this review, there is a clear need to tailor such assessment techniques specifically for estuarine environments. For instance, bioavailability models including equilibrium partitioning may have little applicability to estuarine sediments, appropriate reference comparisons are difficult in biological surveys, and there are too few full-gradient estuarine sediment toxicity tests available. Specific recommendations are made to address these and other issues. [source] fMRI Lateralization of Expressive Language in Children with Cerebral LesionsEPILEPSIA, Issue 6 2006Dianne P. Anderson Summary:,Purpose: Lateralization of language function is crucial to the planning of surgery in children with frontal or temporal lobe lesions. We examined the utility of functional magnetic resonance imaging (fMRI) as a determinant of lateralization of expressive language in children with cerebral lesions. Methods: fMRI language lateralization was attempted in 35 children (29 with epilepsy) aged 8,18 years with frontal or temporal lobe lesions (28 left hemisphere, five right hemisphere, two bilateral). Axial and coronal fMRI scans through the frontal and temporal lobes were acquired at 1.5 Tesla by using a block-design, covert word-generation paradigm. Activation maps were lateralized by blinded visual inspection and quantitative asymmetry indices (hemispheric and inferior frontal regions of interest, at p < 0.001 uncorrected and p < 0.05 Bonferroni corrected). Results: Thirty children showed significant activation in the inferior frontal gyrus. Lateralization by visual inspection was left in 21, right in six, and bilateral in three, and concordant with hemispheric and inferior frontal quantitative lateralization in 93% of cases. Developmental tumors and dysplasias involving the inferior left frontal lobe had activation overlying or abutting the lesion in five of six cases. fMRI language lateralization was corroborated in six children by frontal cortex stimulation or intracarotid amytal testing and indirectly supported by aphasiology in a further six cases. In two children, fMRI language lateralization was bilateral, and corroborative methods of language lateralization were left. Neither lesion lateralization, patient handedness, nor developmental versus acquired nature of the lesion was associated with language lateralization. Involvement of the left inferior or middle frontal gyri increased the likelihood of atypical language lateralization. Conclusions: fMRI lateralizes language in children with cerebral lesions, although caution is needed in interpretation of individual results. [source] Effects of temperature and sediment properties on benthic CO2 production in an oligotrophic boreal lakeFRESHWATER BIOLOGY, Issue 8 2010IRINA BERGSTRÖM Summary 1. Temperature and many other physical and chemical factors affecting CO2 production in lake sediments vary significantly both seasonally and spatially. The effects of temperature and sediment properties on benthic CO2 production were studied in in situ and in vitro experiments in the boreal oligotrophic Lake Pääjärvi, southern Finland. 2. In in situ experiments, temperature of the water overlying the shallow littoral sediment varied seasonally between 0.5 and 15.7 °C, but in deep water (,20 m) the range was only 1.1,6.6 °C. The same exponential model (r2 = 0.70) described the temperature dependence at 1.2, 10 and 20 m depths. At 2.5 and 5 m depths, however, the slopes of the two regression models (r2 = 0.94) were identical but the intercept values were different. Sediment properties (wet, dry, mineral and organic mass) varied seasonally and with depth, but they did not explain a significantly larger proportion of variation in the CO2 output rate than temperature. 3. In in vitro experiments, there was a clear and uniform exponential dependence of CO2 production on temperature, with a 2.7-fold increase per 10 °C temperature rise. The temperature response (slope of regression) was always the same, but the basic value of CO2 production (intercept) varied, indicating that other factors also contributed to the benthic CO2 output rate. 4. The annual CO2 production of the sediment in Lake Pääjärvi averaged 62 g CO2 m,2, the shallow littoral at 0,3 m depth releasing 114 g CO2 m,2 and deep profundal (>15 m) 30 g CO2 m,2. On the whole lake basis, the shallow littoral at 0,3 m depth accounted for 53% and the sediment area in contact with the summer epilimnion (down to a depth c. 10 m) 75% of the estimated total annual CO2 output of the lake sediment, respectively. Of the annual production, 83% was released during the spring and summer. 5. Using the temperature-CO2 production equations and climate change scenarios we estimated that climatic warming might increase littoral benthic CO2 production in summer by nearly 30% from the period 1961,90 to the period 2071,2100. [source] A micromorphological and mineralogical study of site formation processes at the late Pleistocene site of Obi-Rakhmat, UzbekistanGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 5 2009Carolina Mallol Site formation processes at the Late Pleistocene rockshelter deposit of Obi-Rakhmat were reconstructed through soil micromorphology and Fourier transform infrared spectroscopy (FTIR). The entire sequence has undergone limited diagenesis and is well preserved. The base of the stratified sequence represents a karstic setting with intermittent, low-energy deposition of autochthonous gravitational debris and anthropogenic material in a wet, muddy environment. These sediments were post-depositionally affected by episodic waterlogging. The bulk of the sequence overlying the karstic layers comprises a continuous series of primary freshwater spring deposits containing reworked anthropogenic material that was buried penecontemporaneously with calcium carbonate deposition. The top of the sequence is weakly cryoturbated, indicating a periodically cold, wet environment. No alluvial elements that could suggest sediment inputs from the nearby river terraces were documented. A single exogenous layer was identified, representing an episode of colluviation from directly above the rockshelter preceding a major roofspall event. The basal part of the sequence contains slightly reworked anthropogenic remnants of intense activities, including combustion. The anthropogenic elements present in the spring deposits show higher degrees of reworking, suggesting within-layer translocation. The development of spring activity at the site did not cause humans to abandon the rockshelter; they continued to carry out their activities throughout a changing local environment. © 2009 Wiley Periodicals, Inc. [source] Geothermal activity at the archaeological site of Aghia Kyriaki and its significance to Roman industrial mineral exploitation on Melos, GreeceGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 3 2003A. J. Hall The geothermal setting of the archaeological site at Aghia Kyriaki, Southeast Melos (or Milos) was investigated in order to help clarify the possible role of the site in mineral exploitation on Melos in Roman times. There are active sulfurous fumaroles in the area and these were also potential sources of sulfur and alum-group minerals in Roman times. However, geothermal activity has been ongoing in Southeast Melos for hundreds of thousands of years, and extensive hydrothermal alteration of basement rocks to the northeast of the site has produced "white rocks" containing additional potential industrial minerals such as kaolin and alunite. The archaeological remains occur within, but mainly near the surface, of a deeply gullied sequence of late Quaternary alluvial sediments, which consist mainly of metamorphic detritus but are rich in sulfates; the remains contain pottery sherds through the entire sequence of about 40 m. They were deposited on an earlier gullied topography of felsic tuffs overlying the metamorphic basement. Pervasive and veinlike intense reddish alteration of these sediments is probably mainly due to superheated fluid escaping from depth. Field observations demonstrate that this took place after the main phase of building but was likely to be ongoing during occupation of the site. While industrial minerals and geothermal energy would therefore have been available in the Roman period, any relationship of the site to mineral exploitation will have to be determined by archaeological excavation. © 2003 Wiley Periodicals, Inc. [source] FxJj43: A window into a 1.5-million-year-old palaeolandscape in the Okote Member of the Koobi Fora Formation, northern KenyaGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 4 2002Nicola Stern FxJj43 differs from most other archaeological sites preserved in the Okote Member of the Koobi Fora Formation in ways that make it especially suited to the problem of clarifying the behavioral information encapsulated in fine time-lines. At this site in northern Kenya, a continuous strip of outcrops, preserving a set of interlocking landforms, can be traced around the modern erosion front for more than half a kilometer. The characteristics and three-dimensional geometries of the beds making up these outcrops show that they have preserved the southern bank, levee, and floodplain of a westerly flowing sandy channel. Both stone tools and animal bones are strewn across the eroding surfaces of these outcrops, and excavations show that they are derived from a narrow stratigraphic horizon immediately overlying the volcanic ash at the base of the sequence. The blue tuff, and the archaeological horizon that overlies it, have been dated using the 40Ar- 39Ar method on single crystals of alkali feldspar. Although there is no direct measure of how long it took the archaeological horizon to accumulate, it probably accumulated over a time span of 102,103 years. Thus the locality may be used to test the proposition that the analysis of archaeological debris from fine-time lines will help to resolve ambiguities in the interpretation of early Pleistocene archaeological assemblages. © 2002 Wiley Periodicals, Inc. [source] Overpressure and petroleum generation and accumulation in the Dongying Depression of the Bohaiwan Basin, ChinaGEOFLUIDS (ELECTRONIC), Issue 4 2001X. Xie Abstract The occurrence of abnormally high formation pressures in the Dongying Depression of the Bohaiwan Basin, a prolific oil-producing province in China, is controlled by rapid sedimentation and the distribution of centres of active petroleum generation. Abnormally high pressures, demonstrated by drill stem test (DST) and well log data, occur in the third and fourth members (Es3 and Es4) of the Eocene Shahejie Formation. Pressure gradients in these members commonly fall in the range 0.012,0.016 MPa m,1, although gradients as high as 0.018 MPa m,1 have been encountered. The zone of strongest overpressuring coincides with the areas in the central basin where the principal lacustrine source rocks, which comprise types I and II kerogen and have a high organic carbon content (>2%, ranging to 7.3%), are actively generating petroleum at the present day. The magnitude of overpressuring is related not only to the burial depth of the source rocks, but to the types of kerogen they contain. In the central basin, the pressure gradient within submember Es32, which contains predominantly type II kerogen, falls in the range 0.013,0.014 MPa m,1. Larger gradients of 0.014,0.016 MPa m,1 occur in submember Es33 and member Es4, which contain mixed type I and II kerogen. Numerical modelling indicates that, although overpressures are influenced by hydrocarbon generation, the primary control on overpressure in the basin comes from the effects of sediment compaction disequilibrium. A large number of oil pools have been discovered in the domes and faulted anticlines of the normally pressured strata overlying the overpressured sediments; the results of this study suggest that isolated sandstone reservoirs within the overpressured zone itself offer significant hydrocarbon potential. [source] Viscoelastic displacement and gravity changes due to point magmatic intrusions in a gravitational layered solid earthGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 1 2001José Fernández Summary We present a method for the computation of time-dependent geodetic and geophysical signatures (deformation, potential and gravity changes) due to magmatic intrusions in a layered viscoelastic,gravitational medium. This work is an extension of a deformation model previously developed to compute effects due to volcanic loading in an elastic gravitational layered media. The model assumes a planar earth geometry, useful for near field problems, and consists of welded elastic and viscoelastic layers overlying a viscoelastic half-space. Every layer can either be considered elastic or viscoelastic. The intrusion (treated as a point source) can be located at any depth, in any of the layers or in the half-space. Several examples of theoretical computations for different media are also presented. We have found that, in line with previous results obtained by other authors, introducing viscoelastic properties in all or part of the medium can extend the effects (displacements, gravity changes, etc.) considerably and therefore lower pressure increases are required to model given observed effects. The viscoelastic effects seem to depend mainly on the rheological properties of the layer (zone) where the intrusion is located, rather than on the rheology of the whole medium. We apply our model to the 1982,1984 uplift episode at Campi Flegrei, modelling simultaneously the observed vertical displacement and gravity changes. The results clearly show that for a correct interpretation of observed effects it is necessary to include the gravitational field in the anelastic theoretical models. This factor can change the value and pattern of time-dependent deformation as well as the gravity changes, explaining cases of displacement without noticeable gravity changes or vice versa, cases with uplift and incremental gravity values, and other cases. The combination of displacement and gravity changes is found to be especially effective in constraining the possible characteristics of the magmatic intrusion as well as the rheology of the medium surrounding it. [source] P- and S-wave velocities of consolidated sediments from a seafloor seismic survey in the North Celtic Sea Basin, offshore IrelandGEOPHYSICAL PROSPECTING, Issue 2 2008Donna J. Shillington ABSTRACT A geophysical survey was conducted over a hydrocarbon prospect in the North Celtic Sea Basin using a small array of ocean-bottom seismographs (OBSs). The purpose of this study was to determine the ratio of compressional (P)- to shear (S)-wave velocity of consolidated sedimentary rocks in order to constrain possible subsurface variations in pore-fluid content. The ratio of VP and VS is known to be particularly sensitive to lithology, porosity and pore-fluid content, making it a useful parameter for evaluating hydrocarbon prospects. OBSs offer a relatively cheap and time-effective means of acquiring multi-component data compared with ocean-bottom cables. In this contribution, we demonstrate the ability of an OBS survey comprising three pairs of two OBSs spaced at 1.6 km to recover lateral variations in the VP/VS ratio. A key requirement of this type of study is that S waves will be generated by mode conversions in the subsurface, since they cannot be generated in nor travel through fluids. In this survey, the contrast in physical properties of the hard seabed of the North Celtic Sea Basin provided a means of generating converted S waves. Two-dimensional ray-tracing and forward modelling was used to create both VP and VS models along a profile crossing the Blackrock prospect in the North Celtic Sea Basin. These models comprise four layers and extend to a maximum depth of 1.1 km. The observed northward decrease in the VP/VS ratio at depths of 500,1000 m below the seafloor in the study area is interpreted to represent lateral variation in the amount of gas present in the pore space of Upper Cretaceous chalks and shales overlying the prospective reservoir. [source] Antiepileptic Drugs in the Management of Cluster Headache and Trigeminal NeuralgiaHEADACHE, Issue 2001Todd D. Rozen MD Cluster headache and trigeminal neuralgia are relatively rare but debilitating neurologic conditions. Although they are clinically and diagnostically distinct from migraine, many of the same pharmacologic agents are used in their management. For many patients, the attacks are so frequent and severe that abortive therapy is often ineffective; therefore, chronic preventive therapy is necessary for adequate pain control. Cluster headache and trigeminal neuralgia have several distinguishing clinical features. Cluster headache is predominantly a male disorder; trigeminal neuralgia is more prevalent in women. Individuals with cluster headaches often develop their first attack before age 25; most patients with trigeminal neuralgia are between age 50 and 70. Cluster headaches are strongly associated with tobacco smoking and triggered by alcohol consumption; trigeminal neuralgia can be triggered by such stimuli as shaving and toothbrushing. Although the pain in both disorders is excruciating, cluster headache pain is episodic and unilateral, typically surrounds the eye, and lasts 15 to 180 minutes; the pain of trigeminal neuralgia lasts just seconds and is usually limited to the tissues overlying the maxillary and mandibular divisions of the trigeminal nerve. Cluster headache is unique because of its associated autonomic symptoms. Although the pathophysiology of cluster headache and trigeminal neuralgia are not completely understood, both appear to have central primary processes, and these findings have prompted investigations of the effectiveness of the newer antiepileptic drugs for cluster headache prevention and for the treatment of trigeminal neuralgia. The traditional antiepileptic drugs phenytoin and carbamazepine have been used for the treatment of trigeminal neuralgia for a number of years, and while they are effective, they can sometimes cause central nervous system effects such as drowsiness, ataxia, somnolence, and diplopia. Reports of studies in small numbers of patients or individual case studies indicate that the newer antiepileptic drugs are effective in providing pain relief for trigeminal neuralgia and cluster headache sufferers, with fewer central nervous system side effects. Divalproex has been shown to provide effective pain control and to reduce cluster headache frequency by more than half in episodic and chronic cluster headache sufferers. Topiramate demonstrated efficacy in a study of 15 patients, with a mean time to induction of cluster headache remission of 1.4 weeks (range, 1 day to 3 weeks). In the treatment of trigeminal neuralgia, gabapentin has been shown to be effective in an open-label study. When added to an existing but ineffective regimen of carbamazepine or phenytoin, lamotrigine provided improved pain relief; it also may work as monotherapy. Topiramate provided a sustained analgesic effect when administered to patients with trigeminal neuralgia. The newer antiepileptic drugs show considerable promise in the management of cluster headache and trigeminal neuralgia. [source] The effect of terrace geology on ground-water movement and on the interaction of ground water and surface water on a mountainside near Mirror Lake, New Hampshire, USA,HYDROLOGICAL PROCESSES, Issue 1 2008Thomas C. Winter Abstract The west watershed of Mirror Lake in the White Mountains of New Hampshire contains several terraces that are at different altitudes and have different geologic compositions. The lowest terrace (FSE) has 5 m of sand overlying 9 m of till. The two next successively higher terraces (FS2 and FS1) consist entirely of sand and have maximum thicknesses of about 7 m. A fourth, and highest, terrace (FS3) lies in the north-west watershed directly adjacent to the west watershed. This highest terrace has 2 m of sand overlying 8 m of till. All terraces overlie fractured crystalline bedrock. Numerical models of hypothetical settings simulating ground-water flow in a mountainside indicated that the presence of a terrace can cause local ground-water flow cells to develop, and that the flow patterns differ based on the geologic composition of the terrace. For example, more ground water moves from the bedrock to the glacial deposits beneath terraces consisting completely of sand than beneath terraces that have sand underlain by till. Field data from Mirror Lake watersheds corroborate the numerical experiments. The geology of the terraces also affects how the stream draining the west watershed interacts with ground water. The stream turns part way down the mountainside and passes between the two sand terraces, essentially transecting the movement of ground water down the valley side. Transects of water-table wells were installed across the stream's riparian zone above, between, and below the sand terraces. Head data from these wells indicated that the stream gains ground water on both sides above and below the sand terraces. However, where it flows between the sand terraces the stream gains ground water on its uphill side and loses water on its downhill side. Biogeochemical processes in the riparian zone of the flow-through reach have resulted in anoxic ground water beneath the lower sand terrace. Results of this study indicate that it is useful to understand patterns of ground-water flow in order to fully understand the flow and chemical characteristics of both ground water and surface water in mountainous terrain. Copyright © 2007 John Wiley & Sons, Ltd. [source] Causes and consequences of fire-induced soil water repellencyHYDROLOGICAL PROCESSES, Issue 15 2001J. Letey Abstract A wettable surface layer overlying a water-repellent layer is commonly observed following a fire on a watershed. High surface temperatures ,burn' off organic materials and create vapours that move downward in response to a temperature gradient and then condense on soil particles causing them to become water repellent. Water-repellent soils have a positive water entry pressure hp that must be exceeded or all the water will runoff. Water ponding depths ho that exceeds hp will cause infiltration, but the profile is not completely wetted. Infiltration rate and soil wetting increase as the value of ho/hp increases. The consequence is very high runoff, which also contributes to high erosion on fire-induced water-repellent soils during rain storms. Grass establishment is impaired by seeds being eroded and lack of soil water for seeds that do remain and germinate. Extrapolation of these general findings to catchment or watershed scales is difficult because of the very high temporal and spatial variabilities that occur in the field. Copyright © 2001 John Wiley & Sons, Ltd. [source] Cleaning effectiveness of root canal irrigation with electrochemically activated anolyte and catholyte solutions: a pilot studyINTERNATIONAL ENDODONTIC JOURNAL, Issue 6 2000A. M. Solovyeva Abstract Aim The aim of this study was to evaluate the potential of electrochemically activated (ECA) anolyte and catholyte solutions to clean root canals during conventional root canal preparation. Methodology Twenty extracted single-rooted human mature permanent teeth were allocated randomly into four groups of five teeth. The pulp chambers were accessed and the canals prepared by hand with conventional stainless steel endodontic instruments using a double-flared technique. One or other of the following irrigants was used during preparation: distilled water, 3% NaOCl, anolyte neutral cathodic (ANC) (300 mg L,1 of active chlorine), and a combination of anolyte neutral cathodic (ANC) (300 mg L,1 of active chlorine) and catholyte. The teeth were split longitudinally and the canal walls examined for debris and smear layer by scanning electron microscopy. SEM photomicrographs were taken separately in the coronal, middle and apical parts of canal at magnification of ×800 to evaluate the debridement of extra-cellular matrix and at a magnification of ×2500 to evaluate the presence of smear layer. Results Irrigation with distilled water did not remove debris in the apical part of canals and left a continuous and firm smear layer overlying compressed low-mineralized predentine. All chemically active irrigants demonstrated improved cleaning potential compared to distilled water. The quality of loose debris elimination was similar for NaOCl and the anolyte ANC solution. The combination of anolyte ANC and catholyte resulted in improved cleaning, particularly in the apical third of canals. The evaluation of smear layer demonstrated that none of the irrigants were effective in its total removal; however, chemically active irrigants affected its surface and thickness. Compared to NaOCl, the ECA solutions left a thinner smear layer with a smoother and more even surface. NaOCl enhanced the opening of tubules predominantly in the coronal and middle thirds of canals, whereas combination of ANC and catholyte resulted in more numerous open dentine tubules throughout the whole length of canals. Conclusions Irrigation with electrochemically activated solutions cleaned root canal walls and may be an alternative to NaOCl in conventional root canal treatment. Further investigation of ECA solutions for root canal irrigation is warranted. [source] Simplified estimation of seismically induced settlementsINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 8 2003E. Vincens Abstract This paper proposes a predictive expression of settlements for a dry sand deposit overlying a bedrock and subjected to a seismic motion. The proposed formula combines geometrical and mechanical properties of the soil profile with classical characteristics of the input motion. One of the main concepts developed herein consists in regarding the input motion and the dynamical response as samples of random processes; another key concept consists in the common densification curve from Sawicki. The model introduces a parameter k identified by means of an extensive set of accelerograms. The main advantage of the proposed method consists in allowing fast comparisons of earthquake induced settlements for different soil and motion characteristics and therefore quantifying the damage power of a time-history input motion. Copyright © 2003 John Wiley & Sons, Ltd. [source] Bone repair in mandibular body osteotomy after using 2.0 miniplate system , histological and histometric analysis in dogsINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 2 2008Cássio Edvard Sverzut Summary The objective of this study was to evaluate the bone repair along a mandibular body osteotomy after using a 2.0 miniplate system. Nine adult mongrel dogs were subjected to unilateral continuous defect through an osteotomy between the mandibular 3rd and 4th premolars. Two four-hole miniplates were placed in accordance with the Arbeitgeimeinschaft für Osteosynthesefragen Manual. Miniplates adapted to the alveolar processes were fixed monocortically with 6.0-mm-length titanium alloy self-tapping screws, whereas miniplates placed near the mandible bases were fixed bicortically. At 2, 6 and 12 weeks, three dogs were sacrificed per period, and the osteotomy sites were removed, divided into three thirds (Tension Third, TT; Intermediary Third, IT; Compression Third, CT) and prepared for conventional and polarized light microscopy. At 6 weeks, while the CT repaired faster and showed bone union by woven bone formation, the TT and IT exhibited a ligament-like fibrous connective tissue inserted in, and connecting, newly formed woven bone overlying the parent lamellar bone edges. At 12 weeks, bone repair took place at all thirds. Histometrically, proportions of newly formed bone did not alter at TT, IT and CT, whereas significantly enhanced bone formation was observed for the 12-week group, irrespective of the third. The results demonstrated that although the method used to stabilize the mandibular osteotomy allowed bone repair to occur, differences in the dynamics of bone healing may take place along the osteotomy site, depending on the action of tension and compression forces generated by masticatory muscles. [source] Leukaemic infiltration of the mandible in a young girlINTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 2 2007RACHAEL E. BENSON Background., This report presents a case of leukaemic infiltration of the mandible in a 10-year-old female of Sudanese extraction. Case report., The patient was in remission from acute lymphoblastic leukaemia when she presented with pain localized to the alveolar ridge overlying the unerupted lower right second permanent molar. Two days later, she developed right inferior alveolar nerve paraesthesia. Radiographic imaging demonstrated cortical line absence around the developing lower right second and third permanent molars, and distal displacement of the lower right third molar. In addition, the cortical outline of the right inferior dental canal lacked clarity. Biopsy confirmed leukaemia recurrence demonstrating the Philadelphia chromosome. Tailored chemotherapy was commenced, and a bone marrow transplant was carried out 12 weeks later. At 6-month dental review, the patient remained exceptionally well with no bone pain and normal sensation in the right lower lip. Conclusion., The importance of regular and long-term dental examination of patients with leukaemia is discussed. [source] The Cansiwang Melange of Southeast Bohol (Central Philippines): Origin and tectonic implicationsISLAND ARC, Issue 4 2000Joel V. De Jesus Abstract The Cansiwang Melange underlies the Southeast Bohol Ophiolite Complex (SEBOC) and is composed mainly of sheared ophiolite-derived blocks such as harzburgites, microgabbros, basalts and cherts in a pervasive serpentinite matrix. Available field, as well as geophysical evidence show that this melange unit is not diapiric, nor does it have a sedimentary origin considering that it lacks slump and flow structures. A tectonic origin for the Cansiwang Melange is favored in view of the numerous thrust faults, which cut across the exposures, as well as the tectonic contacts that the melange has with the overlying and underlying formations. The presence of the Cansiwang Melange in between the SEBOC and the Alicia Schist provides evidence that the amphibolite of the Alicia Schist do not correspond to the metamorphic sole of SEBOC. Similar to what is recognized in the Josephine Ophiolite, this suggests a ,cold' emplacement of the ophiolite over the Alicia Schist. The Cansiwang Melange represents an accretionary prism product which marks the location of an ancient subduction zone in what is now Central Philippines. [source] Overview of the geology, petrology and tectonic framework of the high-pressure,ultrahigh-pressure metamorphic belt of the Kokchetav Massif, KazakhstanISLAND ARC, Issue 3 2000S. Maruyama Abstract High- to ultrahigh-pressure metamorphic (HP,UHPM) rocks crop out over 150 km along an east,west axis in the Kokchetav Massif of northern Kazakhstan. They are disposed within the Massif as a 2 km thick, subhorizontal pile of sheet-like nappes, predominantly composed of interlayered pelitic and psammitic schists and gneisses, amphibolite and orthogneiss, with discontinuous boudins and lenses of eclogite, dolomitic marble, whiteschist and garnet pyroxenite. On the basis of predominating lithologies, we subdivided the nappe group into four north-dipping, fault-bounded orogen-parallel units (I,IV, from base to top). Constituent metabasic rocks exhibit a systematic progression of metamorphic grades, from high-pressure amphibolite through quartz,eclogite and coesite,eclogite to diamond,eclogite facies. Coesite, diamond and other mineral inclusions within zircon offer the best means by which to clarify the regional extent of UHPM, as they are effectively sequestered from the effects of fluids during retrogression. Inclusion distribution and conventional geothermobarometric determinations demonstrate that the highest grade metamorphic rocks (Unit II: T = 780,1000°C, P = 37,60 kbar) are restricted to a medial position within the nappe group, and metamorphic grade decreases towards both the top (Unit III: T = 730,750°C, P = 11,14 kbar; Unit IV: T = 530°C, P = 7.5,9 kbar) and bottom (Unit I: T = 570,680°C; P = 7,13.5 kbar). Metamorphic zonal boundaries and internal structural fabrics are subhorizontal, and the latter exhibit opposing senses of shear at the bottom (top-to-the-north) and top (top-to-the-south) of the pile. The orogen-scale architecture of the massif is sandwich-like, with the HP,UHPM nappe group juxtaposed across large-scale subhorizontal faults, against underlying low P,T metapelites (Daulet Suite) at the base, and overlying feebly metamorphosed clastic and carbonate rocks (Unit V). The available structural and petrologic data strongly suggest that the HP,UHPM rocks were extruded as a sequence of thin sheets, from a root zone in the south toward the foreland in the north, and juxtaposed into the adjacent lower-grade units at shallow crustal levels of around 10 km. The nappe pile suffered considerable differential internal displacements, as the 2 km thick sequence contains rocks exhumed from depths of up to 200 km in the core, and around 30,40 km at the margins. Consequently, wedge extrusion, perhaps triggered by slab-breakoff, is the most likely tectonic mechanism to exhume the Kokchetav HP,UHPM rocks. [source] Erythrokeratodermia variabilis (EKV) , eine Störung der epidermalen Expression von Gap-Junction-ProteinenJOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Issue 5 2005Erythrokeratodermia variabilis (EKV), a disorder due to altered epidermal expression of gap junction proteins Connexin,31; Connexin,43; Erythrokeratodermia variabilis; Gap Junctions Zusammenfassung Die Erythrokeratodermia variabilis (EKV) ist eine seltene autosomal-dominant vererbte Genodermatose mit einer epidermalen Verhornungsstörung. Das klinische Bild der EKV wird von zwei Morphen geprägt: transiente, schnell wandernde Erytheme und persistierende braune Hyperkeratosen. Vor kurzem wurde der zugrunde liegende Gendefekt der EKV auf dem kurzen Arm von Chromosom,1 lokalisiert, der für das Gap-Junction-Protein Connexin,31 kodiert. Wir stellen einen 48jährigen Patienten vor, bei dem seit dem dreißigsten Lebensjahr großflächige, scharf begrenzte, randständig schuppende Erytheme an den Extremitäten, Gesäß und Rumpf auftreten. Histologisch fand sich eine orthokeratotische Hyperkeratose mit fokaler Parakeratose bei Akanthose der Epidermis. Immunhistochemisch konnte eine vermindert Expression des Gap-Junction-Proteins Connexin,31 sowie vermehrte Expression von Connexin,43 dargestellt werden. Ultrastrukturell zeigten sich erweiterte Interzellularräume in der oberen Epidermis mit unauffälligen Desmosomen, Adherensjunktionen und regulären Gap Junctions. In der Epidermis wird u. a. die Zellproliferation und -differenzierung über die Gap Junctions reguliert. Die Mutation im Connexin,31 wird daher als ursächlich für das klinische Bild der EKV angesehen. Die Überexpression von Connexin,43, die hier erstmals beschrieben wird, entsteht möglicherweise reaktiv als Folge der CX31-Mutation und kompensiert vorübergehend den Defekt. Summary Erythrokeratodermia variabilis (EKV) is a rare autosomal dominant genodermatosis with disturbed epidermal differentiation. Its clinical picture varies from transient, fast moving erythema to persistent brown hyperkeratoses. The gene defect in EKV was recently located on the short arm of chromosome,1 encoding the gap junction protein connexin,31. We report on a 48-year-old patient with sharply circumscribed, scaling erythema on the extremities, buttocks and trunk starting since 30,years of age. Histological investigation showed orthokeratotic hyperkeratosis with focal parakeratosis overlying an acanthotic epidermis. Immunohistochemistry revealed a decreased expression of the gap junction protein connexin,31 as well as increased expression of connexin,43. At the ultrastructural level, widened intercellular spaces in the upper epidermis were present with regular desmosomes, adherens junctions and gap junctions. Epidermal cell proliferation and differentiation are regulated by gap junctions. The mutation in connexin,31 is regarded therefore as causal for the clinical picture of the EKV. The unique up-regulation of connexin,43 may occur as a consequence of the Cx31 mutation and temporarily compensate for this defect. [source] Characterization of cartilagenous tissue formed on calcium polyphosphate substrates in vitroJOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 3 2002Stephen D. Waldman Abstract Successful joint resurfacing by tissue-engineered cartilage has been limited, in part, by an inability to secure the implant to bone. To overcome this, we have developed the methodology to form a cartilage implant in vitro consisting of a layer of cartilagenous tissue overlying a porous, biodegradable calcium polyphosphate (CPP) substrate. As bone will grow into the CPP after implantation, it will result in anchorage of the cartilage. In this study, the cartilagenous tissue formed in vitro after 8 weeks in culture was characterized and compared to native articular cartilage. Light microscopic examination of histological sections showed that there was a continuous layer of cartilagenous tissue on, and integrated with the subsurface of, the CPP substrate. The in vitro -formed tissue achieved a similar thickness to native articular cartilage (mean ± SEM: in vitro = 0.94 ± 0.03 mm; ex vivo = 1.03 ± 0.01 mm). The cells in the in vitro -formed tissue synthesized large proteoglycans (Kav ± SEM: in vitro = 0.27 ± 0.01; ex vivo = 0.27 ± 0.01) and type II collagen similar to the chondrocytes in the ex-vivo cartilage. The in vitro -formed tissue had a similar amount of proteoglycan (GAG ,g/mg dry wt.: in vitro = 198 ± 10; ex vivo = 201 ± 13) but less collagen than the native cartilage (hydroxyproline ,g/mg dry wt.: in vitro = 21 ± 1; ex vivo = 70 ± 8). The in vitro -formed tissue had only about 3% of the load-bearing capacity and stiffness of the native articular cartilage, determined from unconfined mechanical compression testing. Although low, this was within the range of properties reported by others for tissue-engineered cartilage. It is possible that the limited load-bearing capacity is the result of the low collagen content and further studies are required to identify the conditions that will increase collagen synthesis. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 62:323,330, 2002 [source] High-Density Mapping of Left Atrial Endocardial Activation During Sinus Rhythm and Coronary Sinus Pacing in Patients with Paroxysmal Atrial FibrillationJOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 10 2004TIMOTHY R. BETTS M.D. Introduction: This study was designed to record global high-density maps of left atrial endocardial activation during sinus rhythm and coronary sinus pacing. Method and Results: Noncontact mapping of the left atrium was performed in nine patients with paroxysmal atrial fibrillation undergoing pulmonary vein ablation procedures. High-density isopotential and isochronal activation maps were superimposed on three-dimensional reconstructions of left atrial geometry. Mapping was repeated during pacing from sites within the coronary sinus. Earliest left atrial endocardial activation occurred anterior to the right pulmonary veins in seven patients and on the anterosuperior septum in two patients. A line of conduction block was seen in the posterior wall and inferior septum in all patients. The direction of activation in the left atrial myocardium overlying the coronary sinus was different from the electrogram sequence in the coronary sinus catheter in 6 of 9 patients. During coronary sinus pacing, activation entered the left atrium a mean (SD) of 41 (13) ms after the pacing stimulus at a site 12 (10) mm from the endocardium overlying the pacing electrode. Lines of conduction block were present in the posterior wall and inferior septum. Conclusion: In patients with paroxysmal atrial fibrillation, lines of conduction block are present in the left atrium during sinus rhythm and coronary sinus pacing. Electrograms recorded in the coronary sinus infrequently correspond to the direction of activation in the overlying left atrial myocardium. [source] Eruption cyst formation associated with cyclosporin AJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 5 2003A case report Abstract Background: Cyclosporin A (CyA) is a potent immunomodulatory agent with a wide range of applications. Despite its therapeutic value, multiple adverse effects of CyA have been identified. This case report describes eruption cyst formation as a possible adverse effect of CyA administration during tooth eruption in a boy treated with CyA as a consequence of a cardiac transplantation. The clinical diagnosis of eruption cyst was confirmed by histopathological examination. Treatment: The periodontal treatment consisted of supragingival and subgingival scaling, followed by surgical removal of the tissues overlying the crowns of the teeth associated with eruption cysts, and flap surgery in the region of gingival overgrowth. The patient was then placed on quarterly periodontal supportive therapy and his immunosuppressive medication was switched from CyA to tacrolimus. Results: Twenty months after therapy, neither new cyst formation nor recurrence of gingival overgrowth was registered. Conclusion: Formation of an eruption cyst may be an adverse effect of CyA in children with erupting teeth. Zusammenfassung Hintergrund: Cyclosporin A (CyA) ist potentes immunmodulierendes Pharmakon mit einer breiten Applikationsmöglichkeit. Unabhängig von seinem therapeutischen Wert sind multiple Nebeneffekte von CyA beschrieben worden. Dieser Fallbericht beschreibt die Bildung einer Zyste beim Zahndurchbruch als eine mögliche Nebenwirkung von CyA Medikation bei einem Jungen, der mit CyA wegen einer Herztransplantation behandelt wurde. Die klinische Diagnose der Zystenbildung wurde histopathologisch bestätigt. Behandlung: Die parodontale Behandlung bestand in supragingivaler und subgingivaler Zahnreinigung gefolgt von der chirurgischen Entfernung des die Zahnkronen überdeckenden Gewebes, was mit der Zystenbildung verbunden war, und der Lappenchirurgie in der Region der gingivalen Wucherung. Der Patient wurde dann in das vierteljährliche parodontale Recall übernommen, und seine immunsuppressive Medikation wurde von CyA zu Tacrolimus verändert. Ergebnisse: 20 Monate nach der Therapie wurde weder eine neue Zystenbildung noch eine Wiederkehr der gingivalen Wucherung registriert. Schlussfolgerung: Die Bildung einer Durchbruchszyste kann eine Nebenwirkung bei der CyA Medikation bei Kindern während des Zahndurchbruchs sein. Résumé La cyclosporine A (CyA) est un agent immuno-modulateur puissant avec un large éventail d'applications. Malgré sa valeur thérapeutique, de multiples effets secondaires CyA ont été identifiés. Ce rapport de cas décrit une formation de kystes d'éruption qui pourrait être un effet secondaire possible de l'administration de CyA durant l'éruption dentaire chez un garçon traité par CyA à la suite d'une transplantation cardiaque. Le diagnostic clinique du kyste d'éruption a été confirmé par l'histopathologie. Le traitement parodontal a consisté en détartrage et surfaçage suivis par l'enlèvement chirurgical des tissus recouvrant les couronnes des dents associés aux kystes d'éruptions, et une chirurgie par lambeaux dans la région d'accroissement gingivale. L'enfant a bénéficié d'un suivi parodontal trimestriel et sa médication immunosuppressive est passée du CyA au tacrolimus. Vingt mois après le traitement, ni la formation de kystes ni la réapparition d'hypertrophie gingivale n'a été enregistrée. La formation de kystes d'éruption pourrait donc être un effet secondaire de l'utilisation de la CyA chez les enfants au moment de l'éruption des dents. [source] Persistent post-sclerotherapy pigmentation due to minocycline.JOURNAL OF COSMETIC DERMATOLOGY, Issue 4 2002Three cases, a review of post-sclerotherapy pigmentation Summary, Background, Post-sclerotherapy pigmentation, usually overlying the treated veins and independent of any drug ingestion, is common. This pigmentation is brown and represents haemosiderin and sometimes melanin as well. It usually slowly fades over a period of months, only uncommonly persisting for years. Cutaneous pigmentation due to minocycline ingestion is a known but rare adverse effect. It usually appears as a round or irregular shaped patch that is dark blue to black, representing minocycline moieties and iron complexes. Its persistence for years is common. Clinically and histopathologically, these two causes of pigmentation are quite distinct. In the absence of ulceration, minocycline pigmentation koebnerised by sclerotherapy has not previously been reported. Aims, To determine the nature of the pigmentation appearing in three patients who had been taking minocycline at the time, or shortly after, they had received sclerotherapy. Clinically, although this pigmentation had the usual distribution observed after sclerotherapy, it was persistent and appeared dark blue to black. Results, The persistent post-sclerotherapy linear pigmentation observed in all three patients had the characteistics of minocycline pigmentation. Conclusions, This is the first report of such minocycline-aggravated post-sclerotherapy pigmentation. Persistent post-sclerotherapy pigmentation caused by minocycline is a risk associated with ingestion of this drug. Patients need to be warned of this risk because, unlike post-sclerotherapy pigmentation that develops in the absence of drug ingestion, minocycline-aggravated post-sclerotherapy pigmentation may persist for years. [source] Peritoneal mesothelioma presenting as a skin noduleJOURNAL OF CUTANEOUS PATHOLOGY, Issue 6 2009Cynthia Abban Mesothelioma is a malignancy of the pleura, pericardium and peritoneum that is rarely seen in cutaneous biopsies. We present a case of a 75-year-old man with significant occupational exposure to asbestos who developed peritoneal mesothelioma that presented as a skin nodule in an old appendectomy scar. The patient presented with a complaint of increased hardness along his appendectomy scar. Physical examination revealed an anterior abdominal wall mass overlying the appendectomy scar, which was subsequently biopsied. Histologic examination of the abdominal wall mass revealed an infiltrating epithelioid and papillary neoplasm within the dermis and subcutaneous tissue. Immunohistochemical stains showed immunoreactivity for cytokeratin (CK) 7, CK 5/6, calretinin and vimentin. CK 20, monoclonal carcinoembryonic antigen, prostate-specific antigen and prostate-specific acid phosphatase were negative. The profile supported the diagnosis of mesothelioma. Cutaneous presentation of mesothelioma is rare but should be considered in the differential diagnosis of patients with significant asbestos exposure. [source] Pacinian corpuscle in the juxtaoral organ of ChievitzJOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 7 2004Fumio Ide The juxtaoral organ of Chievitz (JOOC) is a normal permanent anatomical structure located within the soft tissue overlying the angle of the mandible in the buccotemporal space. Although the sensory organ nature of JOOC, repeatedly mentioned in German publications, has been neglected in the last decade by the American anatomists and pathologists, we incidentally found JOOC-type squamous epithelium accompanied by Pacinian corpuscles. This fortuitous finding appears to be the first report of the authentic Paciniform nerve endings within JOOC, supporting its mechanosensory function. [source] | ||||||||||||||||||||||||||||||||||