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Organizer
Kinds of Organizer Terms modified by Organizer Selected AbstractsCPA assessment , the regional assessors' experienceCYTOPATHOLOGY, Issue 2007E. Welsh Many individuals within Laboratory Medicine will be unaware that CPA conducts assessments to two different sets of CPA Standards. There are the Standards for the Medical Laboratory and the Standards for EQA Schemes in Laboratory Medicine. The style and format of both sets of standards is very similar with each being presented in eight sections A , H. The EQA standards are almost identical to the laboratory standards with the exception of the E.F and G standards which are specific to EQA schemes. There are approximately 40 EQA Schemes registered with CPA compared with almost 2 500 laboratories. These EQA schemes vary from very large national/international schemes with numerous analytes to small interpretive schemes run by one individual with a personal interest in that specific subject. The large schemes usually come under the UKNEQAS consortia banner and due to their size and configuration do not present undue problems in the assessment process. Smaller interpretive EQA schemes present a challenge both for the scheme and CPA in gaining accreditation. These schemes are usually within the discipline of Histopathology and are regarded as educational rather than proficiency testing schemes. Very frequently, the scheme is organized by a single individual with a collection of microscope slides, storage facilities for the slides and a computer. This presents the Scheme Organizer with great difficulty in complying with the Quality Management System requirements of the CPA Standards. There are a number of models which can be applied in order to satisfy the requirement of the Quality Management System, but ultimately it must be recognized that in some circumstances it is not possible to accredit these small schemes. The NHSCSP Gynae Cytology EQA Scheme is probably the largest EQA scheme within the UK, in respect of the number of participants and the number of staff supporting the scheme. Scheme Management decided that all nine regions of England would apply for accreditation under one CPA Reference Number. This process meant that the scheme would be assessed as a Managed Pathology Network. This is unique in terms of EQA schemes and presented a number of problems not previously encountered in EQA scheme accreditation. This decision meant that all nine regions must comply with a single Quality Management System and other CPA standards whilst allowing flexibility within the system for each region to facilitate the assessment process specific to their user's requirements. The process worked in a satisfactory manner and the overall outcome was not dissimilar to that of other large EQA schemes. The assessment to the current EQA Standards only commenced in April 2006 whilst the Standards for Medical Laboratories commenced in 2003, and it is perhaps not surprising to find that the principal non-conformities are related to the Quality Management System. This parallels the findings encountered in laboratory accreditation. There is an ongoing educational process for Scheme Management and the Facilitators in each region in how to comply fully with the standards and a commitment to quality improvement which ultimately is beneficial to the participant's of the scheme and to patient safety. [source] Organizing and personalizing intelligence gathering from the webINTELLIGENT SYSTEMS IN ACCOUNTING, FINANCE & MANAGEMENT, Issue 1 2002Hwee-Leng Ong In this paper, we describe how an integrated web-based application, code-named FOCI (Flexible Organizer for Competitive Intelligence), can help the knowledge worker in the gathering, organizing, tracking and dissemination of competitive intelligence (CI). It combines the use of a novel user-configurable clustering, trend analysis and visualization techniques to manage information gathered from the web. FOCI allows its users to define and personalize the organization of the information clusters according to their needs and preferences into portfolios. These personalized portfolios created are saved and can be subsequently tracked and shared with other users. The paper runs through an example to show how the use of a predefined domain template coupled with personalization can greatly enhance an organization and tracking of CI gathered from the web. Copyright © 2002 John Wiley & Sons, Ltd. [source] Isthmus organizer for mesencephalon and metencephalonDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 2008Harukazu Nakamura The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon,metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed. [source] How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?DEVELOPMENT GROWTH & DIFFERENTIATION, Issue 6 2004Tatsuya Sato The mesencephalic/rhombomere 1 border (isthmus) is an organizing center for early development of midbrain and cerebellum. In this review, we summarize recent progress in studies of Fgf signaling in the isthmus and discuss how the isthmus instructs the differentiation of the midbrain versus cerebellum. Fgf8 is shown to play a pivotal role in isthmic organizer activity. Only a strong Fgf signal mediated by Fgf8b activates the Ras-extracellular signal-regulated kinase (ERK) pathway, and this is sufficient to induce cerebellar development. A lower level of signaling transduced by Fgf8a, Fgf17 and Fgf18 induce midbrain development. Numerous feedback loops then maintain appropriate mesencephalon/rhombomere1 and organizer gene expression. [source] Cloning a novel developmental regulating gene, Xotx5: Its potential role in anterior formation in Xenopus laevisDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 2 2000Hiroki Kuroda The vertebrate Otx gene family is related to otd, a gene contributing to head development in Drosophila. In Xenopus, Xotx1, Xotx2, and Xotx4 have already been isolated and analyzed. Here the cloning, developmental expression and functions of the additional Otx Xenopus gene, Xotx5 are reported. This latter gene shows a greater degree of homology to Xotx2 than Xotx1 and Xotx4. Xotx5 was initially expressed in Spemann's organizer and later in the anterior region. Ectopic expression of Xotx5 had similar effects to other Xotx genes in impairing trunk and tail development, and especially similar effects to Xotx2 in causing secondary cement glands. Taken together, these findings suggest that Xotx5 stimulates the formation of the anterior regions and represses the formation of posterior structures similar to Xotx2. [source] Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryoDEVELOPMENTAL DYNAMICS, Issue 12 2006Kerstin Feistel Abstract Motile monocilia play a pivotal role in left-right axis determination in mouse and zebrafish embryos. Cilia with 9+0 axonemes localize to the distal indentation of the mouse egg cylinder ("node"), while Kupffer's vesicle cilia in zebrafish show 9+2 arrangements. Here we studied cilia in a prototype mammalian embryo, the rabbit, which develops via a flat blastodisc. Transcription of ciliary marker genes Foxj1, Rfx3, lrd, polaris, and Kif3a initiated in Hensen's node and persisted in the nascent notochord. Cilia emerged on cells leaving Hensen's node anteriorly to form the notochordal plate. Cilia lengthened to about 5 ,m and polarized from an initially central position to the posterior pole of cells. Electron-microscopic analysis revealed 9+0 and 9+2 cilia and a novel 9+4 axoneme intermingled in a salt-and-pepper-like fashion. Our data suggest that despite a highly conserved ciliogenic program, which initiates in the organizer, axonemal structures may vary widely within the vertebrates. Developmental Dynamics 235:3348,3358, 2006. © 2006 Wiley-Liss, Inc. [source] Groucho corepressor proteins regulate otic vesicle outgrowthDEVELOPMENTAL DYNAMICS, Issue 3 2005Baubak Bajoghli Abstract The Groucho/Tle family of corepressor proteins is known to regulate multiple developmental pathways. Applying the dominant-negative effect of the short member Aes, we demonstrate here a critical role of this gene family also for ear development. Misexpression of Aes in medaka embryos resulted in reduced size or loss of otic vesicles, whereas overexpression of the full-length Groucho protein Tle4 gave the opposite phenotype. These results are in close agreement with phenotypes observed for eye formation, suggesting a similar role for Groucho/Tle proteins in the developmental pathways of both sensory organs. Furthermore, by using the heat-inducible HSE promoter, we observed reversible branching of the embryonic axis upon Aes misexpression, indicating a transient duplication of the organizer. Groucho proteins, therefore, are critical for organizer maintenance. Developmental Dynamics 233:760,771, 2005 © 2005 Wiley-Liss, Inc. [source] Plants, gall midges, and fungi: a three-component systemENTOMOLOGIA EXPERIMENTALIS ET APPLICATA, Issue 1 2008Odette Rohfritsch Abstract Larvae of gall midges (Diptera: Cecidomyiidae) induce the activation of plant cells, partial cell lysis, and differentiation of nutritive tissue. Specialized nutritive tissue is essential for larval development and plays a key role in gall organization. Midges of the tribes Lasiopterini and Asphondyliini, however, do not induce nutritive tissues as part of the formation of their galls. Instead, these ,ambrosia galls' contain fungal mycelia that line the interior surface of the chambers. The fungi not only provide Lasiopterini with nutrition, they also penetrate the stems, induce the lysis of the middle lamella of host cells, and open a channel to the vascular bundles. Larvae of Lasioptera arundinis (Schiner) (Lasiopterini) follow the fungus and feed on its mycelium along with adjoining stem cells of Phragmites australis (Cav.) Trin. (Poaceae). Eggs together with fungal conidia are deposited by the imago on the host. Asphondyliini use a needle-like ovipositor to introduce fungal conidia and eggs into the organs they attack. Larvae of Schizomyia galiorum Kieffer (Asphondyliini) are unable to initiate the gall or to develop in the flowers of Galium mollugo L. (Rubiaceae) without their fungal associate. In this article, I provide an overview of oviposition behaviour in the Asphondyliini, as well as descriptions of the ovipositor and the female post-abdominal segments. Gall formation by Lasiopterini and Asphondyliini and the role of associated fungi are discussed, as is the role of the fungus as an inquiline or an organizer of gall tissues and a nutritive device. [source] Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogenEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2003P. J. McCaffery Abstract Retinoic acid (RA) is essential for both embryonic and adult growth, activating gene transcription via specific nuclear receptors. It is generated, via a retinaldehyde intermediate, from retinol (vitamin A). RA levels require precise regulation by controlled synthesis and catabolism, and when RA concentrations deviate from normal, in either direction, abnormal growth and development occurs. This review describes: (i) how the pattern of RA metabolic enzymes controls the actions of RA; and (ii) the type of abnormalities that result when this pattern breaks down. Examples are given of RA control of the anterior/posterior axis of the hindbrain, the dorsal/ventral axis of the spinal cord, as well as certain sex-specific segments of the spinal cord, using varied animal models including mouse, quail and mosquitofish. These functions are highly sensitive to abnormal changes in RA concentration. In rodents, the control of neural patterning and differentiation are disrupted when RA concentrations are lowered, whereas inappropriately high concentrations of RA result in abnormal development of cerebellum and hindbrain nuclei. The latter parallels the malformations seen in the human embryo exposed to RA due to treatment of the mother with the acne drug Accutane (13- cis RA) and, in cases where the child survives beyond birth, a particular set of behavioural anomalies can be described. Even the adult brain may be susceptible to an imbalance of RA, particularly the hippocampus. This report shows how the properties of RA as a neural induction agent and organizer of segmentation can explain the consequences of RA depletion and overexpression. [source] Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroidesFEBS JOURNAL, Issue 7 2002Francesco Francia The core complex of Rhodobacter sphaeroides is formed by the association of the light-harvesting antenna 1 (LH1) and the reaction center (RC). The PufX protein is essential for photosynthetic growth; it is located within the core in a 1 : 1 stoichiometry with the RC. PufX is required for a fast ubiquinol exchange between the QB site of the RC and the Qo site of the cytochrome bc1 complex. In vivo the LH1,PufX,RC complex is assembled in a dimeric form, where PufX is involved as a structural organizer. We have modified the PufX protein at the N and the C-terminus with progressive deletions. The nine mutants obtained have been characterized for their ability for photosynthetic growth, the insertion of PufX in the core LH1,RC complex, the stability of the dimers and the kinetics of flash-induced reduction of cytochrome b561 of the cytochrome bc1 complex. Deletion of 18 residues at the N-terminus destabilizes the dimer in vitro without preventing photosynthetic growth. The dimer (or a stable dimer) does not seem to be a necessary requisite for the photosynthetic phenotype. Partial C-terminal deletions impede the insertion of PufX, while the complete absence of the C-terminus leads to the insertion of a PufX protein composed of only its first 53 residues and does not affect the photosynthetic growth of the bacterium. Overall, the results point to a complex role of the N and C domains in the structural organization of the core complex; the N-terminus is suggested to be responsible mainly for dimerization, while the C-terminus is thought to be involved mainly in PufX assembly. [source] Effect of Using Photos from Authentic Video as Advance Organizers on Listening Comprehension in an FLES Chinese ClassFOREIGN LANGUAGE ANNALS, Issue 4 2004Lee Wilberschied The first type of advance organizer consisted of written words and sentences in Chinese, which summarized major scenes in the video the students were to watch. The second advance organizer involved the same written words and sentences as the first, with accompanying pictures taken from the video itself. Statistical significance of the listening comprehension scores from the exercises could not be established. However, the exercises seemed to be helpful, particularly for younger and less language-proficient students. Interview results indicated that students perceived the pictures as more helpful than text alone. [source] Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord,GENESIS: THE JOURNAL OF GENETICS AND DEVELOPMENT, Issue 12 2007Amit Kumar Abstract During development, the organizer provides instructive signals to surrounding cells as well as contributing cells to axial structures. To dissect organizer function at different developmental stages, conditional approaches such as the Cre/loxP system for conditional mutagenesis are particularly useful. Here we describe two new Cre transgenic mouse lines, Foxa2 NFP-Cre and Nodal PNC-Cre, with activity in two organizer domains, the posterior notochord (PNC) and notochord. These lines were made using defined regulatory elements from the Foxa2 and Nodal genes that direct Cre expression in overlapping domains of the PNC and notochord. Our detailed analysis of the timing and location of Foxa2 NFP-Cre and Nodal PNC-Cre activity indicates that these lines are appropriate for conditional mutagenesis of genes expressed from early somite stages onward. genesis 45:729,736, 2007. Published 2007 Wiley-Liss, Inc. [source] Identification of evolutionarily conserved regulatory elements in the mouse Fgf8 locusGENESIS: THE JOURNAL OF GENETICS AND DEVELOPMENT, Issue 1 2006Friedrich Beermann Abstract The secreted signaling molecule fibroblast growth factor 8 (Fgf8) is an essential component of certain embryonic signaling centers including the mid-hindbrain (isthmic) organizer, the first branchial arch (BA1), and the apical ectodermal ridge (AER). In these signaling centers Fgf8 transcripts are expressed in a dynamic and transient fashion, but the mechanism by which this highly specific expression pattern is established remains largely unknown. We used DNA sequence comparisons coupled to transgenic approaches to obtain insight into the structure and function of regulatory elements in the Fgf8 locus. First, a bacterial artificial chromosome (BAC) containing the mouse Fgf8 gene partially rescues the embryonic lethality of Fgf8- deficient mice and controls Fgf8 -specific gene expression of a coinjected lacZ reporter transgene. Second, sequence comparison of vertebrate Fgf8 loci revealed evolutionarily highly conserved noncoding sequences that were unexpectedly located mainly 3, of the Fgf8 coding region. Third, in transgenic mice some of these elements were sufficient to target expression to the AER, tail bud, and brain, including the isthmic organizer, indicating that they may represent Fgf8 cis-acting elements. Collectively, these data identify novel regulatory elements of the Fgf8 gene sufficient to drive expression to regions of known Fgf8 activity. genesis 44:1,6, 2006. © 2006 Wiley-Liss, Inc. [source] Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell,cell-attachment characteristic for transformed mesenchymal cellsINTERNATIONAL JOURNAL OF CANCER, Issue 9 2009Steffen Rickelt Abstract In contrast to the desmosome-containing epithelial and carcinoma cells, normal and malignantly transformed cells derived from mesenchymal tissues and tumors are connected only by adherens junctions (AJs) containing N-cadherins and/or cadherin-11, anchored in a cytoplasmic plaque assembled by ,- and ,-catenin, plakoglobin, proteins p120 and p0071. Here, we report that the AJs of many malignantly transformed cell lines are characterized by the additional presence of plakophilin-2 (Pkp2), a protein hitherto known only as a major component of desmosomal plaques, i.e., AJs of epithelia and carcinomatous cells. This massive acquisition of Pkp2 and its integration into AJ plaques of a large number of transformed cell lines is demonstrated with biochemical and immunolocalization techniques. Upregulation of Pkp2 and its integration into AJs has also been noted in some soft tissue tumors insitu and some highly proliferative colonies of cultured mesenchymal stem cells. As Pkp2 has recently been identified as a functionally important major regulatory organizer in AJs and related junctions in epithelial cells and cardiomyocytes, we hypothesize that the integration of Pkp2 into AJs of "soft tissue tumor" cells also can serve functions in the upregulation of proliferation, the promotion of malignant growth in general as well as the close-packing of diverse kinds of cells and the metastatic behavior of such tumors. We propose to examine its presence in transformed mesenchymal cells and related tumors and to use it as an additional diagnostic criterion. © 2009 UICC [source] Expectations of the child health nurse in Sweden: two perspectivesINTERNATIONAL NURSING REVIEW, Issue 2 2003A. Fägerskiöld MScN Abstract Background: the child health service exists to support and stimulate parents in order to reduce stress and to encourage an advantageous development of the preschool child. Aim: To explore and describe similarities and differences in expectations of the child health nurse, from the perspective of the recently delivered first-time mother, as compared to an expression of what the child health nurse believed mothers of infants expected of them. The data consisted of 15 interviews with child health nurses and 20 interviews with first-time mothers. Thematic content analysis resulted in seven categories of expectations. The child health nurse was expected to be someone to approach, who could assess the child's development and give immunizations and to be a supporter, counsellor, safety provider and a parent group organizer with knowledge. Similarities between the mothers' and the nurses' statements occurred more frequently than differences, which is suggested to depend on the Swedish tradition among new mothers of visiting the child health clinic. The mothers expected participation in parent groups to a higher degree than the nurses thought they did. Child health nurses who fulfil the mothers' expectations appear to require a good relationship with the mother in order to find out what she desires, which the allocation of sufficient time for regular meetings, will facilitate. Moreover, the nurse requires knowledge about children's requirements and the transition to motherhood as well as the father's important role. [source] Layout modeling and construction procedure for the arrangement of exhibition spaces in a fairINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 4 2003P. Schneuwly Abstract This paper tackles a subset of layout problems that is not a subject of the scientific research to date: the arrangement of the exhibition spaces in a fair. A fair is a large-scale exhibition for goods and services; for example a trade fair or a regional fair. The layout problem of fairs consists in finding an acceptable layout for both the exhibitors, the visitors, and the organizer of the fair. A model for representing the layout of fairs is presented: the adjacency model. Based on the adjacency model, a construction procedure is developed that leads to the generation of alternative layout solutions. Numerical results for the layout of a real fair are reported. [source] Laudatio to Professor D. Luc Massart (1941,2005), educator, organizer, and scientist,JOURNAL OF CHEMOMETRICS, Issue 7-9 2007Paul J. Lewi Abstract The intention of this laudatio is to portray how the educational, organizational, and scientific achievements of Professor D. Luc Massart affected the life and work of his contemporaries and will influence that of the next generations of scientists and professionals. Our perspective, therefore, is more toward the future than the past. Copyright © 2007 John Wiley & Sons, Ltd. [source] Early steps in neural developmentJOURNAL OF MORPHOLOGY, Issue 7 2006Marc Callebaut Abstract We studied early neurulation events in vitro by transplanting quail Hensen's node, central prenodal regions (before the nodus as such develops), or upper layer parts of it on the not yet definitively committed upper layer of chicken anti-sickle regions (of unincubated blastoderms), eventually associated with central blastoderm fragments. We could demonstrate by this quail-chicken chimera technique that after the appearance of a pronounced thickening of the chicken upper layer by the early inductive effect of neighboring endophyll, a floor plate forms by insertion of Hensen's node-derived quail cells into the median part of the groove. This favors, at an early stage, the floor plate "allocation" model that postulates a common origin for notochord and median floor plate cells from the vertebrate's secondary major organizer (Hensen's node in this case). A comparison is made with results obtained after transplantation of similar Hensen's nodes in isolated chicken endophyll walls or with previously obtained results after the use of the grafting procedure in the endophyll walls of whole chicken blastoderms. J. Morphol. © 2006 Wiley-Liss, Inc. [source] Fuzzy Legality in Regulation: The Legislative Mandate RevisitedLAW & POLICY, Issue 4 2001Margit Cohn How does law interact with regulatory reality, and why does legislative mandate, which presumably stands at the apex of a regulatory package, often deviate from its ideal-type as exclusive organizer of action? These questions are treated in this article through the concept of "fuzzy legality," which serves as a common title for six different legal arrangements that stray from the ideal-type legislative mandate, while enabling "perfectly legal" industry behavior. Against the background of potential dangers involved in such practices, the article traces the politics of preference for fuzziness both by regulators and regulatees. It reassesses calls for responsive and reflexive law as a cure for the regulatory malaise: these may have been voiced due to existing overly rigid regulatory frameworks, rather than the intrinsic flaw of legal constructs. [source] Graphic Organizers Applied to Secondary Algebra Instruction for Students with Learning DisordersLEARNING DISABILITIES RESEARCH & PRACTICE, Issue 2 2007Bob Ives Students who have particular difficulty in mathematics are a growing concern for educators. Graphic organizers have been shown to improve reading comprehension and may be applied to upper level secondary mathematics content. In two systematic replications, one randomly assigned group was taught to solve systems of linear equations through direct instruction and strategy instruction. The other group was taught with the same methods with the addition of a graphic organizer. Students who received instruction with the graphic organizers outperformed those who received instruction without the organizers. They also better understood the related concepts as measured by immediate posttests in both replications. The difference in understanding concepts was maintained on a 2,3 week posttest. [source] A Classroom Investigation: Can Video Improve Intermediate-Level French Language Students' Ability to Learn about a Foreign Culture?MODERN LANGUAGE JOURNAL, Issue 1 2002Carol Herron This study examines the effects of video on cultural knowledge at the intermediate level. Fifty-one intermediate-level French students viewed 8 videos. A pretest/posttest design assessed long-term gains in cultural knowledge and in the learning of cultural practices and cultural products from exposure to a curriculum with a video component. Eight postvideo tests measured the students' ability to retain information and to make inferences. A questionnaire assessed perceptions of cultural learning. Results indicated a significant gain in cultural knowledge with posttest scores significantly higher than pretest scores. On the short-answer and free-recall portions of the 8 postvideo tests, the students' ability to make inferences or retain information did not improve significantly in either an advance organizer (AO) or a non-AO condition. For free recall, scores were significantly higher for mentions of cultural practices than for products. The students believed that they learned more cultural practices than products. The results support using video to enhance cultural knowledge. [source] The Obama Victory, Asset-Based Development and the Re-Politicization of Community OrganizingNORTH AMERICAN DIALOGUE (ELECTRONIC), Issue 2 2008Susan B. Hyatt Abstract: In this commentary, I argue that Obama's victory in the recent Democratic primary was largely a consequence of his early experiences as an Alinsky-style community organizer in Chicago. I compare the nature of the broad-based organizing that Obama was trained in to a newer model of "community building" called Asset-Based Community Development (ABCD). ABCD promotes the belief that communities suffering the effects of economic restructuring, such as abandoned housing, crime, and deindustrialization among others, can "heal themselves" by looking within for resources,or "assets",rather than by making demands on the state, a stance its proponents stigmatize as evidence of a "client" mentality. I argue that however chimerical its promises of redemption are, ABCD illustrates an important shift in contemporary understandings of citizenship, away from the possibilities for collective action that characterize Alinsky-style organizing and toward a view that is both radically neoliberal and potentially totalitarian in its homogenizing notions of its two key concepts,"community" and "assets." I suggest that the grassroots nature of the Obama campaign may have the potential to reanimate an interest in broad-based organizing toward the end of creating a more just distribution of resources. [source] Effects of advance organizers, mental models and abilities on task and recall performance using a mobile phone networkAPPLIED COGNITIVE PSYCHOLOGY, Issue 9 2006Janice Langan-Fox Mobile phone usage is now at saturation point in most Western countries. The current research investigated the usability of services provided by a mobile phone network, specifically whether two different forms (text, graphic) of an advance organizer (AO) assisted novice users in applying information supplied in a manual. It was hypothesized that a graphic AO would facilitate the development of coherent mental models of the network to enhance task performance, and that lower ability groups in particular would benefit from AOs. Contrary to prediction, the text AO group outperformed both the graphic AO and control groups. Lower ability groups also benefited more from a text AO than a graphic AO. Copyright © 2006 John Wiley & Sons, Ltd. [source] Organizing chordates with an organizerBIOESSAYS, Issue 7 2007Jordi Garcia-Fernàndez Understanding how the chordate body plan originated and evolved is still controversial. The discovery by Spemann and Mangold in 1924 of the vertebrate organizer and its inductive properties in patterning the AP and DV axis was followed by a long gap until the 1960s when scientists started characterizing the molecular events responsible for such inductions. However, the evolutionary origin of the organizer itself remained obscure until very recently; did it appear together with the origin and radiation of vertebrates, or was it a chordate affair? A recent study by Yu and collaborators,1 which analyses the expression of several organizer-specific genes in amphioxus together with recent phylogenetic data that reversed the position of invertebrate extant chordates (e.g. urochordates and cephalochordates), indicates that the organizer probably appeared in early chordates. It likely had separate signalling centres generating BMP and Wnt signalling gradients along the DV and AP axis. The organizer was then lost in the urochordate lineage, most probably as an adaptation to a rapid and determinate development. BioEssays 29:619,624, 2007. © 2007 Wiley Periodicals, Inc. [source] Protein Design and Evolution for BiocatalysisBIOTECHNOLOGY JOURNAL, Issue 4 2009Article first published online: 15 APR 200 Cover illustration: Protein Design and Evolution for Biocatalysis. This special issue of Biotechnology Journal contains selected contributions from scientists participating to the ESF-EMBO Symposium which took place in October 2008 in San Feliu, Spain. Guest Editor is the chair and organizer of the meeting, Jiri Damborsky from Brno (Czech Republic). He highlights a variety of topics brought up in the meeting, ranging from new methods of rational design, directed evolution, metagenomics and single-molecule techniques, to construction of useful enzymes for industrial applications. Uwe Bornscheuer (Greifswald, Germany) authored a meeting report. Image colored pencils, © PhotoDisc, Inc.; Protein logo © ESF. [source] Hans Spemann (1869,1941): Discoverer of the neuronal organizerACTA PAEDIATRICA, Issue 4 2006Hugo Lagercrantz No abstract is available for this article. [source] The role of stakeholders in Sydney's green gamesCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 3 2002Kate Kearins This paper focuses on the various roles played by stakeholders in the construction of Sydney Olympics as the Green Games. It draws material from the official website of the Sydney 2000 Olympic Games, the websites and other material made public by major stakeholders, and the considerable commentary generated by the greening efforts of the games' organizers and their many partners and critics. Sydney's ,Green Games' is shown to involve a wide variety of stakeholders in both its construction and deconstruction. Environmental groups both assisted in defining the agenda and, in retaining their independence, reserved the right to evaluate and publicly critique performance. It is argued that through the engagement of stakeholders, organizations can be expected to understand and elucidate the different dimensions of the environmental challenge they face,even though at times, as the Sydney ,Green Games' example shows, they may not fully meet these more exacting expectations, and the environmental groups themselves thus risk becoming compromised. Copyright © 2002 John Wiley & Sons, Ltd. and ERP Environment. [source] Selling archaeology and anthropology: early medieval artefacts at the Expositions universelles and the Wiener Weltausstellung, 1867,1900EARLY MEDIEVAL EUROPE, Issue 1 2008Bonnie Effros The archaeological and anthropological exhibits included in the four Expositions universelles held in Paris between 1867 and 1900 and the Wiener Weltausstellung in the Austro-Hungarian capital in 1873, contributed to the commercialization of antiquarianism and granted international attention to the amateur practitioners of these emerging disciplines. Displays of archaeological artefacts and human remains from the migration period and the early Middle Ages, juxtaposed with more exotic ,primitive' art, permitted organizers to broaden the aesthetic sensibilities of fairgoers and promote the acquisition of native antiquities. Exhibiting private collections of early medieval objects likewise justified nineteenth-century concepts of French and ,pan-Germanic' identity by linking them to iconic artefacts and romanticizing the barbarity of this distant epoch. [source] Scaffolding proteins organize multimolecular protein complexes for sensory signal transductionEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 5 2001Armin Huber Abstract Scaffolding proteins composed of protein,protein interaction domains have emerged as organizers of multiprotein complexes in diverse cellular compartments, including neuronal synapses, cell,cell junctions of epithelial cells, and the stimulus perceiving structures of sensory neurons. This review focuses on the INAD-assembled signalling complex of Drosophila photoreceptors, which organizes key components of the phototransduction cascade into a multiprotein signal transduction unit. The structure, the physiological consequences, and the assembly and targeting of the members of the INAD signalling complex will be described. In addition, the existence of signalling complexes in vertebrate photoreceptors, olfactory neurons and mechanosensitive hair cells will be discussed. [source] Management of hepatitis C; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009)HEPATOLOGY RESEARCH, Issue 4 2010Izumi Namiki The consensus meeting for the diagnosis, management and treatment for hepatitis C was held in 45th annual meeting for the Japan Society of Hepatology (JSH) in June 2009 where the recommendations and informative statements were discussed including organizers and presenters. The Several important informative statements and recommendations have been shown. This was the fourth JSH consensus meeting of hepatitis C, however, the recommendations have not been published in English previously. Thus, this is the first report of JSH consensus of hepatitis C. The rate of development of hepatocellular carcinoma (HCC) in HCV-infected patients in Japan is higher than in the USA, because the average age of the HCV-infected patients is greater and there are more patients with severe fibrosis of the liver than in the USA. In Japan, more than 60% of HCV-infected patients are genotype 1b infection, and they show lower response to perinterferon and ribavirin combination treatment. To improve the response rate is also an important issue in our country. To establish the original recommendations and informative statements to prevent the development of HCC is a very important issue in Japan. [source] | ||||||||||||||||||||||||||||||||||||||||