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Selected AbstractsNeuronal plasticity: implications in epilepsy progression and managementDRUG DEVELOPMENT RESEARCH, Issue 8 2007Sherifa A. HamedArticle first published online: 12 FEB 200 Abstract Epilepsy is a common neurological disease. A growing number of research studies provide evidence regarding the progressive neuronal damage induced by prolonged seizures or status epilepticus (SE), as well as recurrent brief seizures. Importantly, seizure is only one aspect of epilepsy. However, cognitive and behavioral deficits induced by progressive seizures or antiepileptic treatment can be detrimental to individual function. The neurobiology of epilepsy is poorly understood involving complex cellular and molecular mechanisms. The brain undergoes changes in its basic structure and function, e.g., neural plasticity with an increased susceptibility in neuronal synchronization and network circuit alterations. Some of these changes are transient, while others are permanent with an involvement of both glutamatergic and ,-aminobutyric acid (GABA)ergic systems. Recent data suggest that impaired neuronal plasticity may underlie the cognitive impairment and behavioral changes associated with epilepsy. Many neurologists recognize that the prevention or suppression of seizures by the use of antiepileptic drugs (AEDs) alone is insufficient without clear predictions of disease outcome. Hence, it is important to understand the molecular mechanisms underlying epileptogenesis because this may allow the development of innovative strategies to prevent or cure this condition. In addition, this realization would have significant impact in reducing the long-term adverse consequences of the disease, including neurocognitive and behavioral adverse effects. Drug Dev Res 68:498,511, 2007. © 2008 Wiley-Liss, Inc. [source] An evaluation of a GP out-of-hours service: meeting patient expectations of careJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 3 2004Kate Thompson MSc Abstract Background, The reorganized out-of-hours general practitioner (GP) service, resulting in the creation of out-of-hours cooperatives has been widely welcomed by the medical profession. However, GP satisfaction remains only one aspect of this reorganized service and patients' views and levels of satisfaction must have a contribution to make to the organization and delivery of the service. Aim, To assess patient satisfaction at two out-of-hours cooperatives in Northern Ireland. Method, A sample of 4466 patients contacting the out-of-hours service was surveyed by postal questionnaires using a previously validated patient satisfaction instrument. Results, Patients who initially requested to be seen at the out-of-hours centre were more likely to receive the contact they requested than those who requested telephone advice or a home visit. Only 41.8% of patients requesting a home visit actually received one. Patients were generally satisfied with the service provided and most satisfied with the ,doctor's manner' and the ,explanation and advice' received. Patients who received the contact they initially requested were more satisfied with all aspects of the service than other patients. The type of contact actually received had little effect on the satisfaction levels reported by patients who received the contact they initially requested. Conclusion, The population should be made fully aware of the services provided by out-of-hours cooperatives to enable them to have realistic expectations. With realistic expectations, patients are more likely to receive the medical contact they request and consequently will be more satisfied with the service provided. High satisfaction level is an important outcome measure of any out-of-hours service as it increases patient confidence and compliance and ultimately clinical outcome. [source] Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?JOURNAL OF NEUROCHEMISTRY, Issue 5 2008Elizabeth Scarr Abstract The high affinity of antipsychotic drugs for the dopamine D2 receptor focused attention onto the role of these receptors in the genesis of psychoses and the pathology of schizophrenia. However, psychotic symptoms are only one aspect of the complex symptom profile associated with schizophrenia. Therefore, research continues into other neurochemical systems and their potential roles in key features associated with schizophrenia. Modulating the cholinergic system in attempts to treat schizophrenia predates specific neurochemical hypotheses of the disorder. Cholinergic modulation has progressed from the use of coma therapy, through the use of anti-cholinergic drugs to control side-effects of older (typical) antipsychotic medications, to the development of drugs designed to specifically activate selected muscarinic receptors. This review presents data implicating a decrease in muscarinic receptors, particularly the M1 receptor, in the pathology of schizophrenia and explores the potential physiological consequences of such a change, drawing on data available from muscarinic receptor knockout mice as well as clinical and pre-clinical pharmacology. The body of evidence presented suggests that deficits in muscarinic receptors are associated with some forms of schizophrenia and that targeting these receptors could prove to be of therapeutic benefit to patients with the disorder. [source] Technical Note: Accounting for anatomical symmetry in the first-order optical character of left and right eyesOPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 4 2007W. F. Harris Abstract In quantitative analyses of the optical character of eyes (and related systems) it is sometimes necessary to deal with left and right eyes in the same context. In accounting for anatomical symmetry (mirror symmetry in the mid-sagittal plane) one treats a cylinder axis at 20°, say, in a left eye as equivalent to an axis at 160° in a right eye. But this is only one aspect of the linear optical character of an eye. The purpose of this note is to show how to account for anatomical symmetry in the linear optical character of eyes in general. In particular the note shows how to modify the optical properties of left (or right) eyes so that anatomical symmetry is accounted for in quantitative analyses in contexts in which both left and right eyes are involved. [source] International Mediation and the Question of Failed Peace Agreements: Improving Conflict Management and ImplementationPEACE & CHANGE, Issue 1 2010Jacob Bercovitch This study examines the contribution of international mediation to the successful termination of conflicts. In particular, we look at what exactly can mediation do, and what do we mean by success in mediation? We identify a short-term definition of success that relates only to the signing of an agreement, and a long-term definition of success that relates to the duration of peace following an agreement. We discuss the factors that may contribute to the failure of peace agreements, and use a contingency framework to argue that a settlement is only one aspect of a dynamic conflict, rather than a defining termination point. Within this framework we study how mediation can help with achieving peace agreements and ensuring they remain viable and are adhered to. We examine our ideas in the context of three conflicts, Angola, Sri Lanka, and Sierra Leone. [source] Sensual, material, and technological understanding: exploring prehistoric soundscapes in south IndiaTHE JOURNAL OF THE ROYAL ANTHROPOLOGICAL INSTITUTE, Issue 2 2007Nicole Boivin Recent years have witnessed an increased interest within archaeology in the non-visual senses, and particularly sound. To date, however, most studies have focused on the evidence for musical instruments and the acoustic properties of special structures and spaces, like monuments and caves. This study reports on further evidence for special musical activities at the prehistoric site of Sanganakallu-Kupgal in south India, but then also moves on to a discussion of the acoustic dimension of more mundane Neolithic technological and productive activities, like flint-knapping, axe-grinding, and crop production. It focuses on the evidence for links between such activities at Sanganakallu-Kupgal, based on shared material, gestural, and acoustic properties, and argues that the hammering of ringing rocks to make music was only one aspect of a wider Southern Neolithic cultural propensity to address technological and ritual requirements by applying stone against stone. The article attempts to bring to recent discussions of the senses an awareness of the materiality of sensory experience, which, despite recent interest in the body, remains marginalized in theoretical accounts. [source] Clinical practice guidelines in clinical psychology and psychotherapyCLINICAL PSYCHOLOGY AND PSYCHOTHERAPY (AN INTERNATIONAL JOURNAL OF THEORY & PRACTICE), Issue 6 2003Glenys Parry Evidence-based clinical practice guidelines have proliferated over the past two decades. Few are limited to psychological therapies or are targeted at clinical psychologists and psychotherapists , the UK guideline Treatment Choice in Psychotherapy and Counselling is a major exception. However, psychological therapies will increasingly be considered alongside medical treatments in diagnosis-specific guidelines. There has been interest and debate about the place of guidelines in the psychological therapies, with views ranging from scepticism to enthusiasm. This paper defines clinical practice guidelines, describes major guideline programmes internationally, examines guidelines of specific interest to psychologists and psychotherapists, explores issues in their implementation, reviews evidence for their effectiveness in changing practice and improving therapy outcomes and draws out implications for practice. Guidelines are only one aspect of informing psychologists and psychotherapists about best practice. They need to be supplemented by other clinical support methods and with methods of monitoring what is actually done in practice.,Copyright © 2003 John Wiley & Sons, Ltd. [source] | |||||||||||||