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One-pot Reaction (one-pot + reaction)
Selected AbstractsAtom-Transfer Radical Polymerization: A Strategy for the Synthesis of Halogen-Free Amino-Functionalized Poly(methyl methacrylate) in a One-Pot ReactionMACROMOLECULAR CHEMISTRY AND PHYSICS, Issue 17 2004Veera Bhadraiah Sadhu Abstract Summary: An initiator containing an alkyl bromide unit and a protected amine functional group is used with CuBr/N,N,N,,N,,N,-pentamethyldiethylenetriamine (PMDETA), in a 1:2 molar ratio with respect to initiator concentration, in order to obtain amino-group terminated as well as halogen-free poly(methyl methacrylate) (PMMA) in a one-pot atom-transfer radical polymerization (ATRP). The terminal bromines are replaced by hydrogen atoms of the PMDETA ligand, which acts as a transfer agent. However, terminating side reactions like disproportionation or dehydrobromination occur from the beginning of the polymerization. Kinetic studies by in-line Raman spectroscopy and off-line 1H NMR spectroscopy revealed that the controlled character of the ATRP is lost under these conditions. The measured molecular weights were consistently higher than the theoretical ones and the molecular weight distributions are relatively broad. Thermal analysis of the obtained poly(methyl methacrylate) shows two main degradation steps, one starting from unsaturated end groups (depolymerization), and one caused by main-chain scission, a further proof for the occurrence of terminating side reactions. Structural analysis of PMMA by matrix-assisted laser desorption-ionization mass spectrometry. [source] ChemInform Abstract: A Facile C,N Bond Formation: One-Pot Reaction of Phenols and Amines via Smiles Rearrangement.CHEMINFORM, Issue 25 2010Hao Yang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Concise Synthesis of Benzo[h]- and Pyrido[3,2-h]-,-carbolin-2,4-diones from One-Pot Reaction of ,-Lactam Carbenes with Naphthyl and Quinolyl Isonitriles.CHEMINFORM, Issue 4 2009Gao-Feng Shi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: AgOTf-Catalyzed One-Pot Reaction of 2-Alkynylbenzaldehyde, Amine, and Sodium Borohydride.CHEMINFORM, Issue 33 2008Qiuping Ding Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] A Novel Synthesis of Spiro(imidazolidine-2,3,-benzo[b]thiophene) by One-Pot Reaction of Arynes, Aryl Isothiocyanates and N-Heterocyclic Carbenes.CHEMINFORM, Issue 42 2007Jian Xue Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Shaken Not Stirred: A Facile Synthesis of 1,4-Bis(furo[2,3-d]pyrimidine-2,4(1H,3H)-dione-5-yl)benzenes by One-Pot Reaction of Isocyanides, N,N,-Dimethylbarbituric Acid, and Terephthaldialdehyde.CHEMINFORM, Issue 41 2006Mohammad Bagher Teimouri Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] An Efficient and Convenient Approach to the Synthesis of Benzopyrans by a Three-Component Coupling of One-Pot Reaction.CHEMINFORM, Issue 8 2004Tong-Shou Jin Abstract For Abstract see ChemInform Abstract in Full Text. [source] Novel Synthesis of 3-Phenylazo-1,5-benzothiazepines, -1,5-benzoxazepines and -1,5-benzodiazepines via a One-Pot Reaction.CHEMINFORM, Issue 38 2002Fawi M. Abd El Latif Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: Catalytic Asymmetric Synthesis of Cyclopentenones from Propargyl Malonates and Allylic Acetate by Successive Action of Homogeneous Palladium(II) and Cobalt on Charcoal Catalysts in a One-Pot Reaction.CHEMINFORM, Issue 11 2002Seung Uk Son Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Highly Enantio- and Diastereoselective One-Pot Reactions in Aqueous Media: Combined Asymmetric Rh-Catalyzed Conjugate Addition/Metal-Mediated AllylationEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 17 2006Sara Källström Abstract 1,3-Disubstituted, enantiopure cyclohexanols have been prepared in very high diastereoselectivities and good yields by a concise one-pot method combining the enantioselective rhodium-catalyzed conjugate addition of arylboronic acids with indium-mediated allylation into a highly efficient one-pot reaction in aqueous media. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) [source] A simple and efficient synthesis of novel N,N,-bis (1H -pyrrol-1-yl)-1-[2-(2-aryl-5-methyl-3-oxo-2,4-dihydro-3H -1,2,4-triazol-4-yl)ethyl]-1H -1,2,3-triazole-4,5-dicarboxamidesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 6 2007Prashant R. Latthe One-pot reaction of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones 1a-g with ethanolamine yielded the 4-(2-hydroxyethyl)-2-aryl-5-methyl-2,4-dihydro-3H -1,2,4-triazolin-3-ones 2a-g which were converted to the azido compounds 6a-g. These azides on 1,3-dipolar cycloaddition with DMAD afforded the dimethyl-1-[2-(2-aryl-5-methyl-3-oxo-1,2,4-triazol-4-yl)ethyl]-1H -1,2,3-triazol-4,5-dicarboxylates 7a-g which on conversion to bishydrazides 8a-g and further cyclisation with 2,5-hexanedione afforded the title compounds 9a-g. This new short route for the so far unkown bis-(triazolinone-triazole)ethanes involves mild and convergent 1,3-dipolar cycloaddition reaction yielding overall good yields of the products. [source] A CuIINiII Complex with Ethylenediamine: Crystal Structure and Ferromagnetic Behaviour of an Aqua-Bridged Heterometallic Chain Containing Ambidentate Ni(OAc)42, BlocksEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 22 2010Oksana V. Nesterova Abstract A one-pot reaction of copper powder and nickel and ammonium acetates in a CH3OH solution of ethylenediamine (en) yields a unique 1D aqua-bridged polymer [Cu(en)2(,2 -H2O)2Ni(OAc)4]n·4nH2O (1) with an ambidentate Ni(OAc)42, fragment that has not been previously characterized. The basic structural motif of 1 contains a previously unreported heterometallic M(,2 -H2O)M, aqua-bridge chain with alternating metal atoms. A complex system of N/O,H···O hydrogen bonds strengthens the polymeric chains and links them into a supramolecular three-dimensional network. Variable-temperature magnetic susceptibility measurements of 1 revealed a weak ferromagnetic coupling (J = 1.1 cm,1) between the paramagnetic copper(II) and nickel(II) ions, which is transmitted through the oxygen bridges. [source] Single End-to-End Azidocopper(II) Chain Based on an Electroactive Ligand: A Structural, Electrochemical, Magnetic and Ab Initio StudyEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 31 2009Guillaume Pilet Abstract By combining azide and the (Z)-1,1,1-trifluoro-4-(quinolin-8-ylamino)but-3-en-2-one enaminone ligand, HL, an azido-bridged copper(II) one dimensional polymer was synthesized in a one-pot reaction. The solved and refined crystal structure evidenced the unusual single and asymmetric end-to-end coordination mode of the azide ion. The redox properties of this complex were studied by cyclic voltammetry, andoxidation of the azido bridge was evidenced. Magneticmeasurements, combined with magnetostructural-driven analysis revealed a weak ferromagnetic interaction between the copper(II) ions within the N3, -bridged chains, complemented by an antiferromagnetic interaction between the chains mediated by ,,, interactions. A survey of the scarce literature of single end-to-end azido bridges, associated with quantum chemical ab initio calculations, was carried out to tentatively identify the relevant parameters driving the weak intrachain exchange interaction.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] Structural Characterization and a New One-Pot Synthesis of trans -Chloro(phenyl)bis(triphenylphosphane)nickel(II)EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 9 2003Alexander Zeller Abstract trans -[NiCl(Ph)(PPh3)2], the organometallic precursor for a new class of neutral polymerization catalysts, has been synthesized via a new synthetic route. The previously used alkylaluminum compounds are replaced by zinc dust for the reduction of the nickel(II) salt in the presence of triphenylphosphane forming the intermediate Ni(PPh3)4. In a one-pot reaction, chlorobenzene then adds oxidatively to the intermediate to form the title compound, which was structurally characterized, in high yields. Its geometry is compared to known structures of the higher homologues of group 10. All complexes adopt a distorted square-planar geometry, but the parent structure shows significantly shorter metal-ligand bond lengths than its Pd and Pt congeners, as expected. Density functional theory calculations (B3LYP/6,31G*) on the full structure are in very good agreement with the solid-state structure. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003) [source] Highly Enantio- and Diastereoselective One-Pot Reactions in Aqueous Media: Combined Asymmetric Rh-Catalyzed Conjugate Addition/Metal-Mediated AllylationEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 17 2006Sara Källström Abstract 1,3-Disubstituted, enantiopure cyclohexanols have been prepared in very high diastereoselectivities and good yields by a concise one-pot method combining the enantioselective rhodium-catalyzed conjugate addition of arylboronic acids with indium-mediated allylation into a highly efficient one-pot reaction in aqueous media. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) [source] Allylation of Aldehyde and Imine Substrates with In Situ Generated Allylboronates , A Simple Route to Enatioenriched Homoallyl AlcoholsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 12 2005Sara Sebelius Abstract Allylation of aldehyde and imine substrates was achieved using easily available allylacetates and diboronate reagents in the presence of catalytic amounts of palladium. This operationally simple one-pot reaction has a broad synthetic scope, as many functionalities including, acetate, carbethoxy, amido and nitro groups are tolerated. The allylation reactions proceed with excellent regio- and stereoselectivity affording the branched allylic isomer. By employment of commercially available chiral diboronates enantioenriched homoallyl alcohols (up to 53,% ee) could be obtained. The mechanistic studies revealed that the in situ generated allylboronates react directly with the aldehyde substrates, however the allylation of the sulfonylimine substrate requires palladium catalysis. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source] High-Yield Synthesis and Electrochemical and Photovoltaic Properties of Indene-C70 BisadductADVANCED FUNCTIONAL MATERIALS, Issue 19 2010Youjun He Abstract [6, 6]-Phenyl-C61 -butyric acid methyl ester (PC60BM) is the widely used acceptor material in polymer solar cells (PSCs). Nevertheless, the low LUMO energy level and weak absorption in visible region are its two weak points. For enhancing the solar light harvest, the soluble C70 derivative PC70BM has been used as acceptor instead of PC60BM in high efficiency PSCs in recent years. But, the LUMO level of PC70BM is the same as that of PC60BM, which is too low for the PSCs based on the polymer donors with higher HOMO level, such as poly (3-hexylthiophene) (P3HT). Here, a new soluble C70 derivative, indene-C70 bisadduct (IC70BA), is synthesized with high yield of 58% by a one-pot reaction of indene and C70 at 180 °C for 72 h. The electrochemical properties and electronic energy levels of the fullerene derivatives are measured by cyclic voltammetry. The LUMO energy level of IC70BA is 0.19 eV higher than that of PC70BM. The PSC based on P3HT with IC70BA as acceptor shows a higher Voc of 0.84 V and higher power conversion efficiency (PCE) of 5.64%, while the PSC based on P3HT/PC60BM and P3HT/PC70BM displays Voc of 0.59 V and 0.58 V, and PCE of 3.55% and 3.96%, respectively, under the illumination of AM1.5G, 100 mW cm,2. The results indicate that IC70BA is an excellent acceptor for the P3HT-based PSCs and could be a promising new acceptor instead of PC70BM for the high performance PSCs based on narrow bandgap conjugated polymer donor. [source] Convergent Approaches to Saudin IntermediatesHELVETICA CHIMICA ACTA, Issue 8 2003Raquel Different convergent approaches to the highly oxygenated sesquiterpene natural product saudin (1), has been investigated. Our strategy has included a Michael addition and aldol condensation reaction as key steps. During the synthetic development, we have found serious steric hindrance when an , -Me-substituted alkyl vinyl ketone was used. Such steric hindrance has been overcome by synthesizing the vinyl ketone 16 through an anionic fragmentation, which was carefully studied. Finally, the intermediate 18 has been synthesized in a one-pot reaction from the vinyl ketone 16 and has been cyclized to obtain the promising tricyclic intermediate 20. [source] Studies on organophosphorus compounds: Synthesis and reactions of [1,2,4,3]triaza-phospholo[4,5- a]quinoxaline derivativeHETEROATOM CHEMISTRY, Issue 5 2008Hassan M. Moustafa 2,4-Bis-(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent) (1) reacted with 2-hydrazino-3-methyl-quinoxaline (2) to give [1,2,4,3]-triazaphospholo[4,5- a]quinoxaline derivative 3. The Mannich reaction using different amines on compound 3 gave Mannich bases 4a,d. Also, compound 3 reacted with formaldehyde to give the corresponding 2-hydroxymethyl derivative 5, which upon reaction with thionyl chloride gave the corresponding chloromethyl derivative 6. Treatment of compound 6 with some thiols yielded the corresponding sulfides 7a,d. Acylation of compound 3 gave acylated compounds 8a,b. Compound 9, which was prepared through the reaction of compound 3 with ethyl cyanoacetate, was investigated as a starting material for the synthesis of some new heterocyclic systems 10,13. Also, reaction of compound 9 with carbon disulfide and 2 equivalents of methyl iodide in a one-pot reaction yielded the corresponding ketene-S,S-acetal 14, which in turn reacted with bidentates to give some new heterocycles 15,17. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:520,529, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20473 [source] Enders' SAMP-Hydrazone as Traceless Auxiliary in the Asymmetric 1,4-Addition of Cuprates to EnonesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 13 2010Karsten Sammet Abstract Conjugate additions of Gilman cyanocuprates to (S)- N -amino-2-(methoxymethyl)pyrrolidine (SAMP)-hydrazones 4, 5 derived from cyclic and acyclic ,,,-unsaturated ketones were investigated. A protocol utilizing copper(II) sulfate/ammonium chloride was evolved, which allowed cleavage of SAMP (S)- 1 under the hydrolysis and work-up conditions, followed by recovery of the auxiliary with ethylenediaminetetraacetic acid (EDTA). The enantioselectivity of cuprate additions was dominated for cyclic SAMP-hydrazones 4 by the cuprate alkyl substituent and the ring size, in the case of acyclic arylidene SAMP-hydrazones 5, however, by the nature of the aryl substituent. Electron-donating substituents gave poor enantiomeric excesses, whereas electron-withdrawing groups provided excellent ee values of 98,99%. The configuration of the new stereocenter was determined to be (R). Moreover, a reaction sequence was developed which integrates a tandem 1,4-addition/methylation and traceless hydrolytic cleavage of the auxiliary (S)- 1 in a one-pot reaction, resulting in enantiomerically pure methyl ketones 11,13, each of them with>99% ee. [source] One-Pot Palladium-Catalyzed Synthesis of Selectively Substituted Phenanthridines by Sequential Aryl-Aryl and Heck Couplings, Aza-Michael and Retro-Mannich ReactionsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 9 2010Nicola Della Ca' Abstract A catalytic synthesis of selectively substituted phenanthridines is achieved through a reaction sequence involving palladium/norbornene-catalyzed unsymmetrical aryl-aryl and Heck couplings followed by aza-Michael and retro-Mannich reactions. In spite of the many steps involved the method is very simple and allows the formation of selectively substituted phenanthridines under mild conditions in a straightforward one-pot reaction starting from readily available aryl iodides and bromides. [source] A Novel D2 -Symmetrical Chiral Tetraoxazoline Ligand for Highly Enantioselective Hydrosilylation of Aromatic KetonesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 7 2010Wei Jie Li Abstract A novel D2 -symmetrical chiral tetraoxazoline ligand was synthesized from 1,2,4,5-benzenetetracarboxylic acid and L -valinol via a one-pot reaction, and the asymmetric hydrosilylation of aromatic ketones was carried out in dichloromethane in the presence of 1.0,mol% of a bivalent copper ion catalyst with the tetraoxazoline to give optically active secondary alcohols. The chiral catalyst showed excellent activities and enantioselectivities in the hydrosilylation of aryl ketones with up to 99% ee. [source] Trapping of Active Methylene Intermediates with Alkenes, Indoles or Thiols: Towards Highly Selective Multicomponent ReactionsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 18 2009Yanlong Gu Abstract In this paper, a basic method to access new multicomponent reactions (MCRs) is reported. The mechanism of these MCRs is based on the trapping of methylene intermediates, formed in situ by reaction of formaldehyde with electron-rich carbons, with alkene, thiol or indole derivatives. According to our strategy, a wide range of valuable skeletons has been obtained in a one-pot reaction, thus allowing a minimization of waste, cost and labor. The presented methodology exhibits a broad substrate scope and electron-rich carbons in the ,-position of a hydroxy or carbonyl group were found to be particularly efficient. More generally, this work offers new tools for creating molecular complexity and diversity from one of the simplest organic building blocks, formaldehyde. [source] First Transformation of Unsaturated Fatty Esters Involving Enyne Cross-MetathesisADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 7-8 2009Ravalec, Virginie Le Abstract The ruthenium-catalysed enyne cross-metathesis of several alkyne derivatives with terminal olefins was performed. These reactions were efficiently achieved under mild conditions in dimethyl carbonate, an eco-friendly solvent. A unique one-pot reaction based on an ethenolysis step followed by an enyne cross-metathesis allowed the efficient transformation of renewable unsaturated fatty esters into valuable conjugated 1,3-dienes of interest for further transformations. [source] Stereoselective Synthesis of Multifunctionalized 1,2,4-Triazolidines by a Ruthenium Porphyrin-Catalyzed Three-Component Coupling ReactionADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 16-17 2006Ming-Zhong Wang Abstract Multifunctionalized 1,2,4-triazolidines have been synthesized by a ruthenium porphyrin-catalyzed three-component coupling reaction. In a one-pot reaction, ruthenium porphyrins catalyzed the in situ generation of azomethine ylides from ,-diazo esters and imines. Stereoselective 1,3-dipolar cycloaddition reactions of the azomethine ylides with dialkyl azodicarboxylates gave the corresponding 1,2,4-triazolidines in good yields (up to 85,%). Using chiral 8-phenylmenthanol ,-diazo ester as the carbenoid source, chiral 1,2,4-triazolidines have been obtained with good diastereoselectivity (up to 84,% de). Some of the 1,2,4-triazolidines exhibited good cytotoxicity against human nasopharyngeal carcinoma (SUNE1) (IC50=10.4,,M) and human cervical carcinoma (Hela) (IC50=10.7,,M) cell lines. [source] Method for preparing polyaluminocarbosilaneJOURNAL OF APPLIED POLYMER SCIENCE, Issue 6 2009Guomei He Abstract Polyaluminocarbosilane (PACS) was synthesized directly by the one-pot reaction of polydimethylsilane (PDMS) with aluminum acetylacetonate [Al(acac)3] in an autoclave. In this closed system, all the aluminum in Al(acac)3 was converted into PACS. Therefore, the content of aluminum could be readily controlled quantitatively. On the basis of Fourier transform infrared, 1H-NMR, 13C-NMR, 29Si-NMR, and 27Al magic-angle spinning NMR analysis, the reaction mechanism was proposed as follows: PDMS dissociated during pyrolysis to generate silicon free radicals, and then they reacted with Al(acac)3 to yield PACS containing (SiO)nAl groups (n = 4, 5, or 6). Meanwhile, these reactions resulted in the cleavage of OC and/or OC bonds in Al(acac)3. Some of the free-radical fragments generated by this cleavage continued to react with the silicon free radicals and were incorporated into the structural units of PACS; the rest of them may have been converted into small oxygen-containing compounds, which were removed in the subsequent processing after the reactions. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 [source] Ethyl {4-[2-(saccharin-2-yl)acetylsulfamoyl]phenylazo}cyanoacetate in the synthesis of polyfunctionally heteroaromatic derivativesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2009A. A. Aly An efficient and direct one-pot reaction of ethyl saccharinylcyanoacetate derivative 3 with a variety of active methylene reagents and nitrogen nucleophiles afforded novel series of polyfunctionally substituted heteroaromatic derivatives 5,13, respectively. The pyrazole derivative 13 was seemed to be the excellent precursors for the synthesis of pyrazolo[1,5-a]pyrimidine derivatives 14,24. The antimicrobial screening of some synthesized products was evaluated against some selected bacteria and fungi. The structures of the synthesized derivatives were established by elemental and spectral data. J. Heterocyclic Chem., (2009). [source] An efficient and facile synthesis of pyrimidine and quinazoline derivatives via one-pot three-component reaction under solvent-free conditionsJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2009Liangce Rong An efficient and convenient method for the preparation of pyrimidine and quinazoline derivatives by the one-pot reaction of aromatic aldehydes, cyclic ketones and guanidine carbonate, in the presence of sodium hydroxide under solvent-free condition was reported. This method has the advantages of excellent yields, mild reaction conditions, easy work-up, and being environmentally friendly over the existing procedures. J. Heterocyclic Chem., (2009). [source] One-pot three-component synthesis of 2-substituted 4-aminoquinazolinesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 4 2006Kurosh Rad-Moghadam A facile and rapid synthesis of the title compounds via one-pot reaction of 2-aminobenzonitrile, orthoesters and ammonium acetate under solvent-free and microwave condition is described. [source] Enzymatic synthesis of l-tryptophan and 5prime-hydroxy-l-tryptophan labeled with deuterium and tritium at the alpha-carbon positionJOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 8 2003E. Boroda Abstract The enzymatic synthesis of l-tryptophan and its derivative 5,-hydroxy-l-tryptophan labeled with deuterium and tritium at the ,-carbon position is reported. The mixture containing S -methyl-l-cysteine, indole or 5-hydroxyindole dissolved in deuteriated or tritiated water has been converted to [2- 2H]-l-tryptophan, [2- 3H]-l-tryptophan, 5,-hydroxy-[2- 2H]-l-tryptophan, and 5,-hydroxy-[2- 3H]-l-tryptophan, respectively, in a one-pot reaction using the enzyme tryptophanase. The same reaction carried out in heavy water with THO added yielded either doubly labeled [2- 2H/3H]-l-tryptophan or 5,-hydroxy-[2- 2H/3H]-l-tryptophan. Copyright © 2003 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||