One-pot Process (one-pot + process)

Distribution by Scientific Domains


Selected Abstracts


ChemInform Abstract: Dual Electrophilic Trapping,Negishi Coupling with Dilithiothiophenes in a Three-Component, One-Pot Process.

CHEMINFORM, Issue 24 2010
Christian Muschelknautz
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


ChemInform Abstract: A One-Pot Process for the Regioselective Synthesis of 1,3,4-Trisubstituted-1H-pyrazoles.

CHEMINFORM, Issue 21 2009
Steven A. Raw
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


ChemInform Abstract: Synthesis of Novel Pyrrolo[1,,5,-a]-1,8-naphthyridine Derivatives Through a Facile One-Pot Process.

CHEMINFORM, Issue 1 2008
Xi-Juan Zhao
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


Sulfilimines and Sulfoximines by Reaction of Nitriles with Perfluoroalkyl Sulfoxides

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 19 2009
Yohan Macé
Abstract The species obtained by activation of perfluoroalkylated sulfoxides with trifluoromethanesulfonic anhydride behaves as highly electrophilic entities. Their reaction with nitriles allows a Ritter-like process leading to the new fluorinated acylsulfilimines 1,21 after hydrolysis. This flexible methodology allows some variation of both the sulfoxide and nitrile components. Derived acylsulfoximines 22,25 or free sulfoximines 26,28 could be selectively obtained, as needed, by further controlled oxidation with the cheap and nontoxic potassium permanganate. This oxidation may be performed either after isolation of the intermediate sulfilimine, or more conveniently in a one-pot process directly from fluorinated sulfoxides. This versatile, solvent and metal free, reaction is thus an opening way through the synthesis of new ligands or electrophilic trifluoromethylating reagents.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source]


Direct conversion of secondary phosphine oxides and H -phosphinates with [Di(acyloxy)iodo]benzenes to phosphinic and phosphonic amides

HETEROATOM CHEMISTRY, Issue 2 2009
Anna Hubacz
The reaction of [di(acyloxy)iodo]benzene with secondary phosphine oxides or H -phosphinates in the presence of primary or secondary amines allows one to obtain phosphinic or phosphonic acids amides in the one-pot process. We take advantage of the strong acylating system DAIB/R2P(O)H to phosphinylation of amines. However, the reaction mechanism is multipathway and causes yields of phosphinic or phosphonic acids amides to be moderate. When the concentration of amines is low, the intermolecular process plays a main role leading to the formation of carboxylic amides through mixed phosphoric,carboxylic anhydride, and also in the low concentration of amines, tetrahydrofuran effectively competes with the amines in the nucleophilic attack on the acylating intermediates. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:81,86, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20514 [source]


Organocatalyzed Conjugate Addition of Carbonyl Compounds to Nitrodienes/Nitroenynes and Synthetic Applications

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 4 2010
Sébastien Belot
Abstract The purpose of this study is to point out the synthetic utility of a new class of Michael acceptors (nitrodienes and nitroenynes). The highly enantioselective organocatalytic Michael addition of carbonyl compounds to these functionalized nitroolefins has been carried out in the presence of (S)-diphenylprolinol silyl ether to achieve some interesting building blocks in high selectivities. The adducts thus obtained can be easily converted by taking advantage of the corresponding unsaturated carbon-carbon bond. In presence of the double bond, metathesis or electrophilic activation could be carried out whereas in the presence of the triple bond electrophilic activation could be conducted. We thus focused on a gold-catalyzed cyclization of the bis-homopropargylic alcohol to afford the corresponding substituted tetrahydrofuran. Then, we also demonstrated that organic and gold catalysts were compatible in a one-pot process. Indeed, we developed a one-pot enantioselective organocatalytic Michael addition to a nitroenyne followed by a gold-catalyzed acetalization/cyclization to achieve tetrahydrofuranyl ethers in high diastereo- and enantioselectivities with excellent yields. [source]


Copper-Catalyzed One-Pot Synthesis of 2-Alkylidene-1,2,3,4- tetrahydropyrimidines

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2009
Wei Lu
Abstract A one-pot synthesis of N -sulfonyl-2-alkylidene-1,2,3,4-tetrahydropyrimidines via a highly selective and copper-catalyzed multicomponent reaction of sulfonyl azides, terminal alkynes and ,,,-unsaturated imines has been developed. The ,,,-unsaturated imine substrates could be generated from amines and ,,,-unsaturated aldehydes in a one-pot process. The procedure is concise, general and efficient. [source]


Efficient and Practical Cross-Coupling of Arenediazonium Tetrafluoroborate Salts with Boronic Acids Catalyzed by Palladium(0)/Barium Carbonate

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2008
François-Xavier Felpin
Abstract The cross-coupling reaction of arenediazonium tetrafluoroborate salts with boronic acids catalyzed by the unusual palladium(0)/barium carbonate catalyst is described as an extremely practical and highly efficient alternative to classical homogeneous conditions. Reactions are conducted under mild conditions at room temperature without any base and ligand. The opportunity of preparing unsymmetrical terphenyls in a one-pot process is also demonstrated. Finally, the power of this methodology is highlighted by the synthesis of Bifenazate. [source]


Substitution-reduction: an alternative process for the [18F]N -(2-fluoroethylation) of anilines

JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 4 2004
Emmanuelle Briard
Abstract Substitution of a halo atom (chloro or bromo) in easily prepared N -haloacetyl-anilines with no-carrier added (NCA) cyclotron-produced [18F]fluoride ion (18F, t1/2= 109.8 min; ,+=96.9%), followed by reduction with borane,tetrahydrofuran (BH3,THF), provides an alternative route to NCA [18F]N -(2-fluoroethyl)-anilines. This two-step and one-pot process is rapid (,50 min) and moderately high yielding (,40% decay-corrected radiochemical yield (RCY) overall). In the nucleophilic substitution reaction, 18-crown-6 is preferred to Kryptofix® 222 as complexing agent for the solubilization of the counter-ion (K+), derived from an added metal salt, in acetonitrile. Weakly basic potassium bicarbonate is preferred as the added metal salt. Inclusion of a small amount of water, equating to 4,5 molar equivalents relative to 18-crown-6, base or precursor (held in equimolar ratio), is beneficial in preventing the adsorption of radioactivity onto the wall of the glass reaction vessel and for achieving high RCY in the nucleophilic substitution reaction. BH3,THF is effective for the rapid reduction of the generated [18F]N -fluoroacetyl-aniline to the [18F]N -(2-fluoroethyl)-aniline. Copyright © 2004 John Wiley & Sons, Ltd. [source]


Dispersion polymerization of vinyl monomers in supercritical carbon dioxide in the presence of drug molecules: A one-pot route for the preparation of controlled delivery systems

JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 22 2008
Alessandro Galia
Abstract The polymerization of 1-vinyl-2-pyrrolidone in supercritical carbon dioxide in the presence of ibuprofen as a model drug was investigated as a new one-pot process for the preparation of polymer-based drug delivery systems (DDSs). The composites were prepared at 65 °C and P = 31,42 MPa by changing the initial concentration of the drug and the concentration of a crosslinking agent and that of a hydrophobic comonomer. The effects of these parameters on the performances of the polymerization and on the in vitro release kinetics of ibuprofen were studied. In all the experiments, part of the drug was entrapped inside the polymer particles and dissolved more slowly with respect to the pure compound. Copolymerization with methyl methacrylate was the most effective route to obtain a DDS with sustained temporal release of the drug molecule. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7429,7446, 2008 [source]