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Selected AbstractsAn Adaptive Sampling Scheme for Out-of-Core SimplificationCOMPUTER GRAPHICS FORUM, Issue 2 2002Guangzheng Fei Current out-of-core simplification algorithms can efficiently simplify large models that are too complex to be loaded in to the main memory at one time. However, these algorithms do not preserve surface details well since adaptive sampling, a typical strategy for detail preservation, remains to be an open issue for out-of-core simplification. In this paper, we present an adaptive sampling scheme, called the balanced retriangulation (BR), for out-of-core simplification. A key idea behind BR is that we can use Garland's quadric error matrix to analyze the global distribution of surface details. Based on this analysis, a local retriangulation achieves adaptive sampling by restoring detailed areas with cell split operations while further simplifying smooth areas with edge collapse operations. For a given triangle budget, BR preserves surface details significantly better than uniform sampling algorithms such as uniform clustering. Like uniform clustering, our algorithm has linear running time and small memory requirement. [source] Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash GrowthDERMATOLOGIC SURGERY, Issue 9 20102Article first published online: 2 APR 2010, JOEL L. COHEN MD BACKGROUND Many women desire prominent eyelashes. In December 2008, bimatoprost ophthalmic solution 0.03% was approved for the treatment of hypotrichosis of the eyelashes in the United States. OBJECTIVE To review eyelash physiology and the proposed mechanisms by which the topical pros-tamide product bimatoprost enhances eyelash growth. METHODS AND MATERIALS Clinical and preclinical studies pertaining to the efficacy, safety, and mechanisms of action of bimatoprost are presented. RESULTS Treatment with bimatoprost increases the percentage of eyelash follicles in anagen at any one time. This probably accounts for its ability to lengthen lashes. Bimatoprost-induced stimulation of melanogenesis appears to result in darker lashes and, at the same time, appears to increase the size of the dermal papilla and hair bulb, affecting lash thickness and fullness. Such effects, largely demonstrated in animal studies, are consistent with the results of a recent Food and Drug Administration phase III clinical trial. The favorable safety profile of bimatoprost in human subjects is probably secondary to the limited exposure of ocular tissues resulting from topical application at the base of the upper lashes. CONCLUSION By influencing the eyelash hair cycle and follicles, bimatoprost ophthalmic solution 0.03% is a safe and effective means of enhancing eyelash growth. Dr. Cohen has served as a consultant and clinical trial participant for Allergan, Inc. [source] Ten-year follow-up study of PTSD diagnosis, symptom severity and psychosocial indices in aging holocaust survivorsACTA PSYCHIATRICA SCANDINAVICA, Issue 1 2009R. Yehuda Objective:, We performed a longitudinal study of holocaust survivors with and without post-traumatic stress disorder (PTSD) by assessing symptoms and other measures at two intervals, approximately 10 years apart. Method:, The original cohort consisted of 63 community-dwelling subjects, of whom 40 were available for follow-up. Results:, There was a general diminution in PTSD symptom severity over time. However, in 10% of the subjects (n = 4), new instances of delayed onset PTSD developed between time 1 and time 2. Self-report ratings at both assessments revealed a worsening of trauma-related symptoms over time in persons without PTSD at time 1, but an improvement in those with PTSD at time 1. Conclusion:, The findings suggest that a nuanced characterization of PTSD trajectory over time is more reflective of PTSD symptomatology than simple diagnostic status at one time. The possibility of delayed onset trajectory complicates any simplistic overall trajectory summarizing the longitudinal course of PTSD. [source] The micro-topography of the wetlands of the Okavango Delta, BotswanaEARTH SURFACE PROCESSES AND LANDFORMS, Issue 1 2005T. Gumbricht Abstract The surface of the 40 000 km2 Okavango alluvial fan is remarkably smooth, and almost everywhere lies within two to three metres of a perfectly smooth theoretical surface. Deviations from this perfect surface give rise to islands in the Okavango wetlands. This micro-topography was mapped by assigning empirical elevations to remotely sensed vegetation community classes, based on the observation that vegetation is very sensitive to small, local differences in elevation. Even though empirical, the method produces fairly accurate results. The technique allows estimation of depths of inundation and therefore will be applicable even when high resolution radar altimetry becomes available. The micro-topography has arisen as a result of clastic sedimentation in distributary channels, which produces local relief of less than two metres, and more importantly as a result of chemical precipitation in island soils, which produces similar local relief. The micro-topography is, therefore, an expression of the non-random sedimentation taking place on the fan. Volume calculations of islands extracted from the micro-topography, combined with estimates of current sediment in,ux, suggest that the land surface of the wetland may only be a few tens of thousands of years old. Constant switching of water distribution, driven by local aggradation, has distributed sediment widely. Mass balance calculations suggest that over a period of c. 150 000 years all of the fan would at one time or other have been inundated, and thus subject to sedimentation. Coalescing of islands over time results in net aggradation of the fan surface. The amount of vertical aggradation on islands and in channels is restricted by the water depth. Restricted vertical relief, in turn, maximizes the distribution of water, limiting its average depth. Aggradation in the permanent swamps occurs predominantly by clastic sedimentation. Rates of aggradation here are very similar to those in the seasonal swamps, maintaining the overall gradient, possibly because of the operation of a feedback loop between the two. The limited amount of local aggradation arising from both clastic and chemical sedimentation, combined with constant changes in water distribution, has resulted in a near-perfect conical surface over the fan. In addition to providing information on sedimentary processes, the micro-topography has several useful hydrological applications. Copyright © 2004 John Wiley & Sons, Ltd. [source] The Kalman filter for the pedologist's tool kitEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 6 2006R. Webster Summary The Kalman filter is a tool designed primarily to estimate the values of the ,state' of a dynamic system in time. There are two main equations. These are the state equation, which describes the behaviour of the state over time, and the measurement equation, which describes at what times and in what manner the state is observed. For the discrete Kalman filter, discussed in this paper, the state equation is a stochastic difference equation that incorporates a random component for noise in the system and that may include external forcing. The measurement equation is defined such that it can handle indirect measurements, gaps in the sequence of measurements and measurement errors. The Kalman filter operates recursively to predict forwards one step at a time the state of the system from the previously predicted state and the next measurement. Its predictions are optimal in the sense that they have minimum variance among all unbiased predictors, and in this respect the filter behaves like kriging. The equations can also be applied in reverse order to estimate the state variable at all time points from a complete series of measurements, including past, present and future measurements. This process is known as smoothing. This paper describes the ,predictor,corrector' algorithm for the Kalman filter and smoother with all the equations in full, and it illustrates the method with examples on the dynamics of groundwater level in the soil. The height of the water table at any one time depends partly on the height at previous times and partly on the precipitation excess. Measurements of the height of water table and their errors are incorporated into the measurement equation to improve prediction. Results show how diminishing the measurement error increases the accuracy of the predictions, and estimates achieved with the Kalman smoother are even more accurate. Le filtre de Kalman comme outil pour le pédologue Résumé Le filtre de Kalman est un outil conçu essentiellement pour estimer les valeurs de l'état d'un système dynamique dans le temps. Il comprend deux équations principales. Celles-ci sont l'équation d'état, qui décrit l'évolution de l'état pendant le temps, et l'équation de mesure qui decrit à quel instants et de quelle façon on observe l'état. Pour le filtre discret de Kalman, décrit dans cet article, l'équation d'état est une équation stochastique différentielle qui comprend une composante aléatoire pour le bruit dans le système et qui peut inclure une force extérieure. On définit l'équation de mesure de façon à ce qu'elle puisse traiter des mesures indirectes, des vides dans des séquences de mesures et des erreurs de mesure. Le filtre de Kalman fonctionne récursivement pour prédire en avance une démarche à temps l'état du système de la démarche prédite antérieure plus l'observation prochaine. Ses prédictions sont optimales dans le sens qu'elles minimisent la variance parmi toutes les prédictions non-biasées, et à cet égard le filtre se comporte comme le krigeage. On peut appliquer, aussi, les équations dans l'ordre inverse pour estimer la variable d'état à toutes pointes à toutes les instants d'une série complète d'observations, y compris les observations du passé, du présent et du futur. Ce processus est connu comme ,smoothing'. Cet article décrit l'algorithme ,predictor,corrector' du filtre de Kalman et le ,smoother' avec toutes les équations entières. Il illustre cette méthode avec des exemples de la dynamique du niveau de la nappe phréatique dans le sol. Le niveau de la nappe à un instant particulier dépend en partie du niveau aux instants précédents et en partie de l'excès de la précipitation. L'équation d'état fournit la relation générale entre les deux variables et les prédictions. On incorpore les mesures du niveau de la nappe et leurs erreurs pour améliorer les prédictions. Les résultats mettent en évidence que lorsqu'on diminue l'erreur de mesure la précision des prédictions augmente, et aussi que les estimations avec le ,smoother' de Kalman sont encore plus précises. [source] Migraine Prevention: What Patients Want From Medication and Their Physicians (A Headache Specialty Clinic Perspective)HEADACHE, Issue 5 2006Todd D. Rozen MD Objective.,To document the results of a migraine patients survey, from a headache specialty clinic, in which patients were asked to rank, in order of importance, certain characteristics of migraine preventive treatment. Methods.,A 10-question survey was completed by 150 patients (114 females and 36 males) with a history of migraine who presented to the Michigan Head Pain & Neurological Institute. The patients were asked to rank, in order of importance, characteristics of migraine preventive treatment. Each characteristic was rated individually on a 1 to 10 scale (1 being of little importance and 10 being extremely important). The mean rating of each characteristic was then calculated and the results analyzed. Results/Discussion.,From this migraine preventive treatment survey, the most important thing to migraineurs, from a headache specialty clinic population, is that the prescribing physician involves them in the decision making of choosing a preventive agent. The physician taking time to explain the possible medication side effects is the second most highly ranked characteristic. Migraine preventives with published efficacy in the medical literature are also deemed very important. Migraineurs do not mind using more than 1 preventive agent at one time if greater efficacy can be achieved. Agents that may affect weight and /or cause sedation may be important factors as to why patients (especially females) may not want to take a preventive medication. Natural therapies and once-daily dosing are ranked lower overall but still are important characteristics of preventive treatment. Some gender differences are noted in the ranking of migraine preventive characteristics. [source] Improvements in early care in Russian orphanages and their relationship to observed behaviorsINFANT MENTAL HEALTH JOURNAL, Issue 2 2005Christina J. Groark This article describes a unique study that attempts to promote positive social-emotional relationships and attachment between caregivers and children in orphanages in St. Petersburg, Russia. The children who reside in these orphanages are typically between birth and 48 months of age; approximately 50% are diagnosed with disabilities, and approximately 60% leave through foreign adoption. Initially, their orphanage caregivers showed a high level of current anxiety and depression and were detached from and communicated little with the children. Likewise, during baseline observations, the children demonstrated poor attachment behaviors such as indiscriminant friendliness, lack of eye contact with adults, aggression, and impulsive behavior. Two interventions were used in a quasiexperimental design: (a) training of caregivers to promote warm, responsive caregiving and (b) staffing and structural alterations to support relationship building, especially increasing the consistency of caregivers. The methodology required that both the training and staffing interventions be provided to one orphanage, only the training to a second, and neither to a third. (At any one time, ns = 80,120 in each condition.) Initial informal observations reveal positive behaviors for both the caregivers and the children, such as increased two-way conversations, animated and enthusiastic emotional responses, and positive social and language interactions. Early data analyses show an increase in the consistency and stability of caregivers and increased scores for caregivers on every subscale of the HOME Scales. Children showed improvements in physical growth, cognition, language, motor, personal-social, and affect, with children having severe disabilities improving the most. The implications of these findings suggest that training staff with modest educational backgrounds and structural changes are effective, can increase socially responsive caregiving behaviors, and improves social interactions of children, at least temporarily. ©2005 Michigan Association for Infant Mental Health. [source] Ethics as process and practiceINTERNAL MEDICINE JOURNAL, Issue 6 2004A. W. Frank Abstract The noun form of ethics suggests something substantive; this substance is located in both offices of institutionalized experts and a body of canonical solutions to recognizable troubles. The present article recommends thinking of ethics not as substance but as a process of lives and decisions affecting each other over time. No single decision stands alone and no single patient can be considered as a stand-alone entity. Examples include how people struggle with choices they should not have to make, how decisions at one time are affected by earlier decisions that are not considered within the purview of ethics, and how to deal with conflicts of legitimate interests. When institutional ethics becomes a prescribed activity, the goal of being ethical is easily forgotten. (Intern Med J 2004; 34: 355,357) [source] Consolidation analysis of a cross-anisotropic homogeneous elastic soil using a finite layer numerical methodINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 2 2004Guo-Xiong Mei Abstract This paper presents a finite layer procedure for Biot's consolidation analysis of layered soils using a cross-anisotropic elastic constitutive model. The program is first verified using published results. Then, using this program, the influences of cross-anisotropy on the immediate settlement, the final settlement, and the consolidation behaviour are investigated by changing one model parameter at one time. The results obtained using the cross-anisotropic elastic model are compared with results using an isotropic elastic model. It is found that the cross-anisotropy has very large influences on the immediate settlement, the final settlement, and the consolidation behaviour. Curves or tables of the immediate settlement coefficients, the final settlement coefficients, and the average degree of consolidation are obtained and presented in the paper. These curves or tables can be easily used to estimate the immediate settlement, the final settlement, and the consolidation settlement of a cross-anisotropic soil. Copyright © 2004 John Wiley & Sons, Ltd. [source] Uncertainties in early Central England temperaturesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 8 2010David E. Parker Abstract Uncertainties in historical climate records constrain our understanding of natural variability of climate, but estimation of these uncertainties enables us to place recent climate events and extremes into a realistic historical perspective. Uncertainties in Central England temperature (CET) since 1878 have already been estimated; here we estimate uncertainties back to the start of the record in 1659, using Manley's publications and more recently developed techniques for estimating spatial sampling errors. Estimated monthly standard errors are of the order of 0.5 °C up to the 1720s, but 0.3 °C subsequently when more observing sites were used. Corresponding annual standard errors are up to nearly 0.4 °C in the earliest years but around 0.15 °C after the 1720s. Daily standard errors from 1772, when the daily series begins, up to 1877 are of the order of 1 °C because only a single site was used at any one time. Inter-diurnal variability in the daily CET record appears greater before 1878 than subsequently, partly because the sites were in the Midlands or southern England where day-to-day temperature variability exceeds that in the Lancashire part of Manley's CET. Copyright © 2009 Royal Meteorological Society [source] An Environmentally Benign, Highly Efficient Catalytic Reduction of p -Nitrophenol using a Nano-Sized Nickel Catalyst Supported on Silica-AluminaADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 7 2010Islam Hamdy Abd El Maksod Abstract A green and effective method is reported for the reduction of p -nitrophenol to p -aminophenol using a nano-sized nickel catalyst supported on silica-alumina in the presence of hydrazine hydrate as an alternative source of hydrogen. It was found that nickel loaded on a silica-alumina support is a very effective catalyst in the hydrogenation of p -nitrophenol to p -aminophenol. Thus it attained 100% conversion in only 69 seconds instead of 260 seconds for commercial Raney nickel. In addition, the possibility to reuse it more than one time with great efficiency gives it another advantage over commercial Rainey nickel which cannot be used more than once. This economical and environmentally friendly method provides a potentially new approach for the synthesis of the intermediate product of paracetamol in industry, which overcomes the drawbacks of the known reduction methods. The prepared catalysts were fully characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and electron spin resonance (ESR) tehniques. [source] Strategy for applying genome-wide selection in dairy cattleJOURNAL OF ANIMAL BREEDING AND GENETICS, Issue 4 2006L.R. Schaeffer Summary Animals can be genotyped for thousands of single nucleotide polymorphisms (SNPs) at one time, where the SNPs are located at roughly 1-cM intervals throughout the genome. For each contiguous pair of SNPs there are four possible haplotypes that could be inherited from the sire. The effects of each interval on a trait can be estimated for all intervals simultaneously in a model where interval effects are random factors. Given the estimated effects of each haplotype for every interval in the genome, and given an animal's genotype, a ,genomic' estimated breeding value is obtained by summing the estimated effects for that genotype. The accuracy of that estimator of breeding values is around 80%. Because the genomic estimated breeding values can be calculated at birth, and because it has a high accuracy, a strategy that utilizes these advantages was compared with a traditional progeny testing strategy under a typical Canadian-like dairy cattle situation. Costs of proving bulls were reduced by 92% and genetic change was increased by a factor of 2. Genome-wide selection may become a popular tool for genetic improvement in livestock. [source] Reproductive status in females of the Brazilian catfish, Pseudoplatystoma fasciatum reared in cagesJOURNAL OF APPLIED ICHTHYOLOGY, Issue 5 2010E. Romagosa Summary The distinctive morphological features of the ovaries the ,cachara', Pseudoplatystoma fasciatum were characterized macroscopically, and by histology, when reared in cages, from March 2005 to February 2006. Forty eight females (mean total weight = 2.7 kg, mean standard length = 65.1 cm) were allocated to four cages of 2.7 m3 (20 fish/cage) which were installed in four 600 m2 ponds, located at the IP, Pariquera-Açu, São Paulo, Brazil. The monthly, samples were fixed in 4%-buffered formalin before preparation for histological examination, ovaries were removed and weighted. The gonadosomatic index (GSI) was calculated as = 100 × weight ovaries/total fish weight. The ovaries are the cystovarian type and macroscopically, were established three stages of ovarian maturation: Resting, developing Maturation (initial, intermediate, final) and Regression (initial, intermediate, final). Based on morphological criteria of those ovaries, the oocyte development has been divided into distinct stages: (i) oocyte growth (vitellogenesis); (ii) oocyte maturation, along which it goes through different phases of development, before (iii) ovulation and, (iv) spawning. When the P. fasciatum were kept in confinement and not induced to breed occurs fail to attain final oocyte maturation, start the process of degeneration. Consequently, the weight started to decline and 45% of the ovaries showed atresia of vitellogenic follicles. This was considered indicative of a recent cessation of the reproductive activity. Such failure could have been caused by stress of the monthly sampling involving a certain degree of disturbance, and perhaps also by the existence of stressors while in captivity. The synchronous ovary contained oocytes in an unique stage of development and had potential to perform total spawning up to one time a year, with the period reproductive beginning in the end of November to the beginning of February, coinciding with the highest water temperatures in the experimental cages (29.0,31.5°C) and the increase of mean values of GSI. During the regression phase, residual oocytes could be observed together with decrease of the mean values of GSI and, the temperatures. [source] Habitat utilisation during staging affects body condition in a long distance migrant, Branta bernicla hrota: potential impacts on fitness?JOURNAL OF AVIAN BIOLOGY, Issue 6 2008R. Inger There is considerable evidence to suggest that an animal's ability to access the appropriate resources at one time of year may profoundly restrict its performance at another. For migrants, wintering and breeding periods are often connected by refuelling or staging periods, critical (particularly for females) in attaining the body reserves required to ensure successful breeding. However in many instances there are differences in the extent to which different individuals gain access to the highest quality resources. Here we demonstrate how body condition in brent geese Branta bernicla hrota, during spring staging is related to differences in marine and terrestrial habitat utilisation (inferred from stable isotope analysis). Female birds with high fat scores feed to a greater extent on marine resources. Body mass and condition are also higher in individuals utilising more marine resources. Given that body mass at spring staging is correlated with reproductive success, the extent of marine habitat maybe critical to this population. Combining this with data from previous studies of dark-bellied brent geese Branta bernicla bernicla, we predict the potential impacts of spring staging resource utilisation on future breeding success. Although staging is of short duration compared to the other components of annual cycles of migratory species, our results suggest that the quality of staging grounds may be vitally important to population processes. [source] Independent evolution of migration on the South American landscape in a long-distance temperate-tropical migratory bird, Swainson's flycatcher (Myiarchus swainsoni)JOURNAL OF BIOGEOGRAPHY, Issue 6 2003Leo Joseph Abstract Aim, To understand the evolution of long-distance temperate,tropical migration in a South American bird, Swainson's flycatcher (Myiarchus swainsoni). Methods, A total of 842 base pairs of the mitochondrial DNA genes ATPase 8 and 6 were sequenced from forty-nine individuals of the M. swainsoni complex from most of its range. Analyses measured the phylogenetic signal in the data, and tools of population genetics, phylogeography and phylogeny were used to interpret the evolution of the bird and its migration on the South American landscape. Results, Migratory populations in the M. swainsoni complex are not each other's closest relatives. The migratory subspecies M. s. swainsoni, which breeds in south-eastern South America, is not closely related to the rest of the complex. The remaining migratory populations of the subspecies M. s. ferocior and two intergrade populations are extremely closely related to non-migratory populations with which they form a well-supported clade despite substantial morphological differentiation from each other. Within this clade of migrants and non-migrants, net divergence across 4000 km of lowland South America is zero and most diversity is distributed among individuals not populations. Mismatch analyses and significant values of Tajima's D and Fu's Fs suggest the clade has undergone a very recent range expansion. Migration and the shifts of breeding distribution that accompanied its evolution evolved twice within what has recently been considered the polytypic species M. swainsoni. Furthermore, these shifts of range probably occurred at very different times as parts of different southward ,pulses' of humid, Amazonian taxa. Main conclusions, Evolution of temperate-tropical migration in the M. swainsoni complex has been spatio-temporally layered on the South American landscape. The analysis cautions that the historical biogeography underlying a single present-day migration system need not have been driven by a single set of environmental factors operating at one time. We suggest directions for further study of ecology and demography in zones of apparent contact between various migratory and non-migratory populations. [source] Zirconocene-catalysed propene polymerisation: kinetics, mechanism, and the role of the anionMACROMOLECULAR SYMPOSIA, Issue 1 2004Fuquan Song Abstract The olefin polymerisation activity of metallocene catalysts strongly depends on the counteranion provided by the activator system. The relative activities of a number of new diborate anions [Z(BAr3)2], have been quantified (Z = CN, NH2, N(CN)2; Ar = C6F5 or o -C6F4C6F5). The kinetic parameters for the initiation, propagation and termination steps of propene polymerisations catalysed by (SBI)ZrCl2 have been determined using quenched-flow kinetic and batch techniques [SBI = rac -Me2Si(1-Ind)2]. Comparison of two activator systems, (i) CPh3[B(C6F5)4] / triisobutylaluminium (TIBA) and (ii) methylaluminoxane (MAO) shows, surprisingly, that the concentration of species actively involved in chain growth at any one time is comparable for both systems, although the MAO-activated catalyst is about 20 times less active than the borate system. It is concluded that the counteranion remains sufficiently strongly bound to the metal centre throughout the chain growth sequence to modulate the energetics of monomer insertion. A model suggesting that the monomer binding follows an associative interchange (Ia) mechanism is proposed. [source] A petrological, mineralogical, and chemical analysis of the lunar mare basalt meteorite LaPaz Icefield 02205, 02224, and 02226METEORITICS & PLANETARY SCIENCE, Issue 7 2006Katherine H. Joy They consist mainly of zoned pyroxene and plagioclase grains, with minor ilmenite, spinel, and mesostasis regions. Large, possibly xenocrystic, forsteritic olivine grains (<3% by mode) contain small trapped multiphase melt inclusions. Accessory mineral and mesostasis composition shows that the samples have experienced residual melt crystallization with silica oversaturation and late-stage liquid immiscibility. Our section of LAP 02224 has a vesicular fusion crust, implying that it was at one time located sufficiently close to the lunar surface environment to have accumulated solar-wind-implanted gases. The stones have a comparable major element composition and petrography to low-Ti, low-Al basalts collected at the Apollos 12 and 15 landing sites. However, the LAP stones also have an enriched REE bulk composition and are more ferroan (Mg numbers in the range of 31 to 35) than similar Apollo samples, suggesting that they represent members of a previously unsampled fractionated mare basalt suite that crystallized from a relatively evolved lunar melt. [source] Cost-effective metal-plate shorted dipole antenna with wide bandwidth for WLAN/WiMAX applicationsMICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 12 2007Jui-Hung Chou Abstract A wideband shorted dipole antenna well suited to applications for WLAN/WiMAX dual-mode operation is presented. The dipole antenna is structured to be of an L shape to fit in corners of possible wireless communications devices. Two radiating arms of the dipole antenna are further short-circuited, which allows the antenna to be cost-effectively fabricated by stamping a single metal plate only one time. In addition, by widening the end portion of each radiating arm, much more improved impedance matching across a wide operating bandwidth can easily be achieved. Details of the proposed dipole antenna are described, and experimental and simulation results of a design prototype are elaborated and discussed. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3044,3046, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22911 [source] Sequencing breakthroughs for genomic ecology and evolutionary biologyMOLECULAR ECOLOGY RESOURCES, Issue 1 2008MATTHEW E. HUDSON Abstract Techniques involving whole-genome sequencing and whole-population sequencing (metagenomics) are beginning to revolutionize the study of ecology and evolution. This revolution is furthest advanced in the Bacteria and Archaea, and more sequence data are required for genomic ecology to be fully applied to the majority of eukaryotes. Recently developed next-generation sequencing technologies provide practical, massively parallel sequencing at lower cost and without the requirement for large, automated facilities, making genome and transcriptome sequencing and resequencing possible for more projects and more species. These sequencing methods include the 454 implementation of pyrosequencing, Solexa/Illumina reversible terminator technologies, polony sequencing and AB SOLiD. All of these methods use nanotechnology to generate hundreds of thousands of small sequence reads at one time. These technologies have the potential to bring the genomics revolution to whole populations, and to organisms such as endangered species or species of ecological and evolutionary interest. A future is now foreseeable where ecologists may resequence entire genomes from wild populations and perform population genetic studies at a genome, rather than gene, level. The new technologies for high throughput sequencing, their limitations and their applicability to evolutionary and environmental studies, are discussed in this review. [source] Long-term efficacy of botulinum toxin A in treatment of various movement disorders over a 10-year periodMOVEMENT DISORDERS, Issue 6 2002G-Y.R. Hsiung MD Abstract Although botulinum toxin A (BTX) has been licensed in Canada for treatment of various movement disorders since 1990, few clinical studies regarding its long-term efficacy and side effects have been reported. We conducted a retrospective analysis of 235 patients who received BTX from our movement disorders clinic over a 10-year period (January 1990 to December 1999). A total of 2,616 treatment cycles (multiple injections) were administered to 235 patients with cervical dystonia (CD), hemifacial spasm (HS), blepharospasm (BP), and other movement disorders. Substantial benefit at 5 years was seen in most patients (90% in BP, 88% in HS, 63% in CD, 100% in jaw closing and lower limb dystonia, and 56% in writer's cramp). Benefit was maintained for up to 10 years in CD, HS, and BP data, with a 75.8% benefit reported. Twenty-eight percent of patients discontinued treatment during the follow-up period due to a variety of reasons. Of these, 9.1% of patients developed primary resistance, and 7.5% of patients secondary resistance. Adverse effects, mostly minor, developed in 27% of patients at any one time, occurring over 4.5% of treatment cycles. These were most frequently reported in blepharospasm (22 of 36 patients in 40 cycles), followed by hemifacial spasm (21 of 70 patients in 46 cycles), and cervical dystonia (17 of 106 in 28 cycles). Only 1.3% of patients discontinued therapy due intolerable adverse effects. The results show that BTX is a safe and effective treatment of various types of movement disorders, and most side effects are well tolerated. Discontinuation for any reason was also low after 5 years. Efficacy was maintained after long periods of treatment with high degree of patient satisfaction. © 2002 Movement Disorder Society [source] Closing Ranks: Fundamentals in History, Politics and AnthropologyTHE AUSTRALIAN JOURNAL OF ANTHROPOLOGY, Issue 2 2006Kirsten Hastrup In this presentation, I discuss fundamentalism from a processual perspective, seeking to tease out some general qualities of the processes involved in a return to fundamentals amidst social change. I start with an analysis of the historical dynamics of Icelandic society in the period 1400,1800, showing how the increasing insistence on old patterns and cultural fundamentals contributed to the gradual destruction of a one time flourishing medieval society. This devolution, I suggest, is closely correlated with a process of amplification (Sahlins) of a particular set of values, leading to a loss of flexibility in the response to environmental and other changes. Next follows a discussion of present day concerns with nationalism and other interests in bounding oneself off from the surrounding world, and demanding recognition in return. One of the processes discussed is a process of transvaluation (Tambiah), assimilating particulars to a larger and less context-bound scheme and thereby gradually deepening the cleavage between selves and others, sometimes to the point of epistemological closure (Ignatieff). Finally, one of the anthropological fundamentals, holism, is discussed with a view to reassessing its potential for present-day anthropology. It is argued that through the process of knowing implied in fieldwork, anthropologists arrive at a dual understanding of perceived wholes and creative agents. A new sense of holism may still grant both consistency and uniqueness to the anthropological discipline. [source] Association between respiratory symptom score and 30-year cause-specific mortality and lung cancer incidenceTHE CLINICAL RESPIRATORY JOURNAL, Issue 2008A. Frostad Abstract Introduction:, Respiratory symptoms are among the main reasons why patients make contact with healthcare professionals and they are associated with several diseases. Objective:, The aim of this study was to investigate the relationship between respiratory symptoms reported at one time and 30 years cause-specific mortality and incidence of lung cancer in an urban Norwegian population. Materials and Methods:, A total of 19 998 men and women, aged 15,70 years, were in 1972 selected from the general population of Oslo. They received a postal respiratory questionnaire (response rate 89%). All were followed for 30 years for end-point mortality and for lung cancer. The association between respiratory symptoms, given as a symptom load, and end point of interest were investigated separately for men and women by multivariable analyses, with adjustment for age, occupational exposure to air pollution and smoking habits. Results:, A total of 6710 individuals died during follow-up. Obstructive lung diseases (OLDs) and pneumonia accounted for 250 and 293 of the total deaths, respectively. Ischaemic heart disease (IHD) accounted for 1572; stroke accounted for 653 of all deaths. Lung cancer developed in 352 persons during follow-up. The adjusted hazard ratio for mortality from OLD and pneumonia, IHD and stroke increased in a dose,response manner with symptom score, more strongly for OLD and IHD than for pneumonia and stroke. Conclusions:, Respiratory symptoms were positively associated with mortality from OLD, pneumonia, IHD and stroke, and incidence of lung cancer. This association was significant for mortality from OLD and IHD. Please cite this paper as: Frostad A. Association between respiratory symptom score and 30-year cause-specific mortality and lung cancer incidence. The Clinical Respiratory Journal 2008; 2: 53,58. [source] Reduced change blindness suggests enhanced attention to detail in individuals with autismTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 3 2009Hayley Smith Background:, The phenomenon of change blindness illustrates that a limited number of items within the visual scene are attended to at any one time. It has been suggested that individuals with autism focus attention on less contextually relevant aspects of the visual scene, show superior perceptual discrimination and notice details which are often ignored by typical observers. Methods:, In this study we investigated change blindness in autism by asking participants to detect continuity errors deliberately introduced into a short film. Whether the continuity errors involved central/marginal or social/non-social aspects of the visual scene was varied. Thirty adolescent participants, 15 with autistic spectrum disorder (ASD) and 15 typically developing (TD) controls participated. Results:, The participants with ASD detected significantly more errors than the TD participants. Both groups identified more errors involving central rather than marginal aspects of the scene, although this effect was larger in the TD participants. There was no difference in the number of social or non-social errors detected by either group of participants. Conclusion:, In line with previous data suggesting an abnormally broad attentional spotlight and enhanced perceptual function in individuals with ASD, the results of this study suggest enhanced awareness of the visual scene in ASD. The results of this study could reflect superior top-down control of visual search in autism, enhanced perceptual function, or inefficient filtering of visual information in ASD. [source] A new practical tool for deriving a functional signature for herbaceous vegetationAPPLIED VEGETATION SCIENCE, Issue 2 2004R. Hunt Abstract Hypothesis: For any one time and place a ,functional signature' can be derived for a sample of herbaceous vegetation in a way that concisely represents the balance between the different clusters of functional attributes that are present among component species. Methods: We developed a spreadsheet-based tool for calculating functional signatures within the context of the C-S-R system of plant functional types. We used the tool to calculate and compare signatures for specimen British vegetation samples which differed in management regime and location in time. Conclusion: The integrative power of the ,C-S-R signature' is useful in comparative studies involving widely differing samples. Movements in the signature can be used to indicate degree of resistance, resilience, eutrophication and dereliction. Systems of plant functional types other than C-S-R might also be approached in this way. Availability: The tool can be downloaded free of charge from the first author's web pages or from the journal's electronic archive. [source] How does alluvial sedimentation at range fronts modify the erosional dynamics of mountain catchments?BASIN RESEARCH, Issue 3 2005S. Carretier At the geological time scale, the way in which the erosion of drainage catchments responds to tectonic uplift and climate changes depends on boundary conditions. In particular, sediment accumulation and erosion occurring at the edge of mountain ranges should influence the base level of mountain catchments, as well as sediment and water discharges. In this paper, we use a landform evolution model (LEM) to investigate how the presence of alluvial sedimentation at range fronts affects catchment responses to climatic or tectonic changes. This approach is applied to a 25 km × 50 km domain, in which the central part is uplifted progressively to simulate the growth of a small mountain range. The LEM includes different slope and river processes that can compete with each other. This competition leads to ,transport-limited', ,detachment-limited' or ,mixed' transport conditions in mountains at dynamic equilibrium. In addition, two end-member algorithms (the channellized-flow and the sheet-flow regimes) have been included for the alluvial fan-flow regime. The three transport conditions and the two flow algorithms represent six different models for which the responses to increase of rock uplift rate and/or cyclic variation of the precipitation rate are investigated. Our results indicate that addition of an alluvial apron increases the long-term mountain denudation. In response to uplift, mountain rivers adapt their profile in two successive stages; first by propagation of an erosion wave and then by slowly increasing their channel gradients. During the second stage, the erosion rate is almost uniform across the catchment area at any one time, which suggests that dynamic equilibrium has been reached, although the balance between erosion and rock uplift rates has not yet been achieved. This second stage is initiated by the uplift of the mountain river outlets because of sedimentation aggradation at the mountain front. The response time depends on the type of water flow imposed on the alluvial fans domains (× by 1.5 for channelized flow regime and by 10 for the sheet flow one). Cyclic variations of precipitation rate generate cyclic incisions in the alluvial apron. These incision pulses create knick-points in the river profile in the case of ,detachment-limited' and ,mixed' river conditions, which could be mistaken for tectonically induced knick-points. ,Transport-limited' conditions do not create such knick-points, but nevertheless trigger erosion in catchments. The feedbacks linked to sedimentation and erosion at range front can therefore control catchment incision or aggradation. In addition, random river captures in the range front trigger auto-cyclic erosion pulses in the catchment, capable of generating incision,aggradation cycles. [source] The quest for the mechanisms of lifeBIOTECHNOLOGY & BIOENGINEERING, Issue 7 2003Maria I. Klapa Abstract The genomic revolution, manifested by the sequencing of the complete genome of many organisms, along with technological advances, such as DNA microarrays and developments in high-throughput analysis of proteins, metabolites, and isotopic tracer distribution patterns, challenged the conventional ways in which questions are approached in the biological sciences: (a) rather than examining a small number of genes and/or reactions at any one time;, we can now analyze gene expression and protein activity in the context of systems of interacting genes and gene products; (b) comprehensive analysis of biological systems requires the integration of all cellular fingerprints: genome sequence, maps of gene expression, protein expression, metabolic output, and in vivo enzymatic activity; and (c) collecting, managing, and analyzing comparable data from various cellular profiles requires expertise from several fields that transcend traditional discipline boundaries. While researchers in systems biology have still to address difficult challenges in both experimental and computational arenas, they possess, for the first time, the opportunity to unravel the mechanisms of life. The enormous impact of these discoveries in diverse areas, such as metabolic engineering, strain selection, drug screening and development, bioprocess development, disease prognosis and diagnosis, gene and other medical therapies, is an obvious motivation for pursuing integrated analyses of cellular systems. © 2003 Wiley Periodicals, Inc. [source] Inquiry-based learning and technology,supporting institutional TEL within one pedagogical contextBRITISH JOURNAL OF EDUCATIONAL TECHNOLOGY, Issue 3 2008Sabine Little Following the establishment of Centres for Excellence in Teaching and Learning in England and Northern Ireland in 2005, several institutions have used these to pursue specific pedagogical approaches at a strategic level, in line with and building on existing institutional strategic thinking. Technology-enhanced learning is often one of the vehicles to implement these pedagogical approaches, leading to institution-wide attempts to identify and support suitable technologies. This paper discusses the role of the educational developer in this process and what impact this particular role might have at strategic level, bearing in mind the numerous simultaneous developments that take place in an institution at any one time. [source] Giant intracavernous internal carotid artery aneurysm with fatal epistaxisCLINICAL ANATOMY, Issue 3 2003M.R. Haffajee Abstract The case history and autopsy findings of a 32-year-old male, who suffered a mild closed-head injury and then had repeated epistaxis beginning 5 months later, is presented. The condition culminated in an episode of fatal epistaxis 1 year after the injury. At one time during the course of his work-up, the etiology of his repeated epistaxis was thought to be a vascular nasopharyngeal neoplasm. The diagnosis of an intracavernous internal carotid artery aneurysm was made only at autopsy. The principles of management of traumatic intracavernous internal carotid artery aneurysm presenting with epistaxis are discussed. Clin. Anat. 16:277,281, 2003. © 2003 Wiley-Liss, Inc. [source] | |||||||||||||||||||||||||