Old Man (old + man)

Distribution by Scientific Domains
Distribution within Medical Sciences

Selected Abstracts

Prosthetic Valve Dysfunction Presenting as Intermittent Acute Aortic Regurgitation

Dali Fan M.D., Ph.D.
We describe the case of a 43 year old man with a history of aortic stenosis, for which he had undergone aortic valve replacement in 1991 with a 25-mm Medtronic Hall prosthesis. He presented with several acute episodes of dyspnea and flash pulmonary edema. Transthoracic and transesophageal echocardiography performed to evaluate prosthetic valve function revealed evidence of "intermittent" episodes of AI, documented on color M-mode flow mapping to have a variable duration of diastolic flow (early vs. pandiastolic) across the left ventricular outflow tract and the pulse wave Doppler in the descending thoracic aorta showed similar variability in the duration of diastolic flow reversal. [source]

An old man for certain

Robert Cocks
No abstract is available for this article. [source]

Effect of supplementation with grain, hay or straw on the performance of weaner Merino sheep grazing old man (Atriplex nummularia) or river (Atriplex amnicola) saltbush

H. C. Norman
Abstract Old man saltbush (Atriplex nummularia) and river saltbush (A. amnicola) are widely used in commercial grazing systems on saline land in south-western Australia. Three hypotheses were tested during a 3-year study aimed at understanding the performance of weaner Merino sheep grazing saltbush-based pastures. The first hypothesis, that young Merino sheep grazing river saltbush would be better able to maintain live weight, body condition and would grow more wool than sheep grazing old man saltbush, was not supported by the data. Across the 3 years of the study, sheep grazing old man saltbush lost significantly less live weight and grew more wool (proportionately 006) than sheep grazing river saltbush. Differences in animal performance were considered to be associated with differences between the plant species in in vitro digestibility, concentrations of fibre, sulphur and crude protein in the herbage and the architecture of the Atriplex plants. The second and third hypotheses concerned supplementation strategies for sheep grazing saltbush. Three supplements were offered, namely barley grain, cereal straw or cereal hay, at a rate that approximated to one-third of the daily metabolizable energy requirements for maintenance of live weight. The performance of the sheep was higher when the grain supplement was offered but there was no effect of feeding roughage supplements compared to no supplementation. The findings suggested that the practice of feeding saltbush with adjacent crop stubbles is unlikely to be beneficial once any fallen grain has been consumed. [source]

Ultrasonographic detection of spontaneous rupture in the Biceps tendon of a patient with rheumatoid arthritis

Hyun-Sook KIM
Abstract Ultrasonography is a useful imaging modality for the diagnosis of pathologic conditions in the biceps tendon. We describe a 64-year old man with rheumatoid arthritis (RA) who suddenly developed a painless lump in the antecubital region of the right arm. The bulging was prominent when he flexed his forearm. Proximal loss of the long head in biceps tendon could be demonstrated by ultrasonography. The ultrasonographic features of spontaneous isolated biceps tendon rupture occurring in a patient with RA are described. [source]

Paratesticular mucinous cystadenocarcinoma: Metastasis from pancreatic cancer

Abstract, We experienced a case of a paratesticular mucinous adenocarcinoma from primary pancreatic cancer. A 67-year old man presented with a scrotal mass. Scrotal ultrasound showed a cystic mass on the testis. Radical orchiectomy was performed and the tumor was revealed as a mucinous cystadenocarcinoma separated from epididymis and testis. Metastatic cancer was suspected and abdominal computed tomography showed pancreatic cancer. We report this rare case of metastatic paratesticular cystoadenocarcinoma. [source]

Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo

C Bonifati
Abstract Localized scleroderma and vitiligo only rarely have been reported to occur simultaneously. Here we report a case of a 21 year old man affected with both linear scleroderma of the left upper limb and homolateral segmental vitiligo of the trunk. Since the two diseases appeared during the same period, involved the same side of the body and their progression paralleled, a possible non-coincidental association between these two diseases is discussed. [source]

A Coroner's Request for Closure: The Value of the Stored Electrogram

Pacemaker diagnostics can be useful to troubleshoot both during life and after death. A 58-year old man with a single chamber ventricular pacemaker and a previous His bundle ablation died suddenly. Interrogation of his pacemaker revealed the cause of death not as pacemaker malfunction, but a fatal ventricular arrhythmia. [source]

Recurrent pneumothoraces associated with nocturnal noninvasive ventilation in a patient with muscular dystrophy

Lee R. Choo-Kang MD
Abstract Although a common complication of mechanical ventilation in acute respiratory failure, spontaneous pneumothorax has been rarely reported among patients on chronic, intermittent, noninvasive positive pressure support. We report the first case of recurrent pneumothoraces associated with nocturnal bilevel positive airway pressure ventilation via a nasal mask. A 26-year old man with chronic respiratory failure secondary to an unclassified neuromuscular condition suffered four separate episodes of spontaneous pneumothorax over a 12-month period. Two episodes occurred while he was asleep on bilevel positive airway pressure support. He was found to have numerous subpleural blebs, and we propose a mechanism for their development. Following open pleurodesis and blebectomy, the patient has not had another pneumothorax. Given the increasing utilization of chronic nocturnal bilevel positive airway pressure ventilation, we suggest that healthcare providers and patients be made aware of this potentially life-threatening complication. Pediatr Pulmonol. 2002; 34:73,78. 2002 Wiley-Liss, Inc. [source]

Thrombotic thrombocytopenic purpura following transurethral resection of the prostate

ANAESTHESIA, Issue 9 2009
S. R. Benington
Summary A 65-year old man developed anaemia, profound thrombocytopenia and acute renal failure 2 days after transurethral resection of the prostate. Based on the clinical picture and blood film evidence of microangiopathic haemolysis, thrombotic thrombocytopenic purpura was diagnosed. The patient was treated with a course of plasma exchange, renal replacement therapy and methylprednisolone and made a good recovery. Thrombotic thrombocytopenic purpura is an uncommon cause of haematological and renal abnormalities in the postoperative period. It has a high mortality if untreated, and should be considered in the differential diagnosis of any postoperative patient with a low platelet count and anaemia, since prompt investigation and treatment is life-saving. [source]

On the Run: The Narrative of an Asylum Seeker

Solrun Williksen
The object of the article is to try and understand how a young woman managed to live through the experience of losing everything that was dear to her, first of all of her sister being "sold" to an old man, then of being threatened with death, then having to leave the picture of her mother behind, and then traveling into the unknown to a new existence in a country that she had never heard of,until she was told the name by the immigration police. It is the story of how to create an experience out of chaos, and how to come to terms with it through looking back and groping for words to give shape and sense to what has happened. In a wider theoretical perspective the article explores the problem of the interplay between the lived experience and the story in the making. This might indicate a dichotomy between experience and narrative, and that acting in the world, in this case being on the run, is lived experience, whereas the telling is just that ,telling, thus removed from the drama of getting on with the living of it. That is not how I see it. When I was in the middle of unraveling Ada's life story I read an article by Sarah Lamb, "Being a Widow" (2001), where she shows that the widow's story is part of her lived life. However, I find the distinctions in approaches very subtle and have, in fact, never quite seen how anything concerned with human experience, let alone one's own life story, can be seen as outside of lived life, outside of reality, like a text. It is true that to the person in this account, a young asylum seeker in Norway, it may seem at times as if the story she is telling is about somebody else. "Sometimes I don't know who I am. How can all this have happened and yet I am still alive?" she asks. Nevertheless I was inspired by Lamb's insistence on the creative practice, and indeed experience, of the narrative presentation itself. Although I have encouraged Ada,as she will be called here,to tell her story, I have done so with a small feeling of doubt. Is it really the case that a forgotten period needs to be recaptured in order for people to feel they own their own lives? She herself has said, "If I told people everything that happened, nobody would believe me and I wouldn't know what words to use either, or how to start." [source]

A couple with gastrointestinal stromal tumor (GIST)

We present a 70-year old woman with metastatic gastrointestinal stromal tumor (GIST) and her partner, a 79-year old man with multiple gastric GIST tumors. This tumor is considered a rare malignancy with a reported incidence of 6,13 new cases per million. Our patients were found to have different genetic mutations in the C-KIT gene as the cause of their disease but, given the rarity of this tumor, it raises a question about their possible exposure to carcinogens or another shared mechanism that might have been involved in the pathogenesis of this cancer. [source]

Systolic Total Narrowing of Left Anterior Descending Coronary Artery and Flow Interruption Secondary to Myocardial Bridge: A Rare Case Report and Review of Literature

Fehmi Kacmaz MD
Abstract A 33-y-old man was admitted to the emergency department with sudden onset of severe substernal chest pain radiating to the left arm and neck. No pathological signs were recorded upon physical examination. The admission electrocardiogram (ECG) recorded during chest pain showed a large anterior wall myocardial infarction. Intravenous (IV) infusion of 1.5 million units of streptokinase over 1 h was initiated. Coronary angiography revealed total narrowing and flow interruption in the midsegment of the left anterior descending (LAD) coronary artery secondary to a myocardial bridge during systole and disappearance with diastole. He was discharged on aspirin (300 mg/d), metoprolol (100 mg/d), enalapril (10 mg twice daily), and atorvastatin (40 mg/d) treatment at the follow-up period. Copyright 2008 Wiley Periodicals, Inc. [source]

,What should I do with a 60-year old man with a slightly low serum total testosterone concentration and normal levels of serum gonadotrophins'?

T. Hugh Jones
Summary The fundamental question in assessing an older man with a slightly low total testosterone and normal gonadotrophin levels is to determine whether or not he has clinical hypogonadism. Hypogonadism is defined as a clinical syndrome complex, which comprises both symptoms as well as biochemical testosterone deficiency. As symptoms are nonspecific and there are no clear cut-off values for testosterone levels this invariably leads to a clinical dilemma. International guidelines have been published which provide recommendations to aid the clinician in making a diagnosis. Late-onset hypogonadism, the preferred terminology for age-related hypogonadism, can only be made once other causes have been excluded. Evidence shows that low testosterone levels are associated with several common male conditions including erectile dysfunction, osteoporosis and diabetes. Short-term studies have shown benefits of testosterone replacement therapy (TRT) on body composition, bone metabolism, insulin resistance, sexual function and quality of life. Recommendations give clear advice on safety monitoring, specifically in relation to prostate health. If a diagnosis of hypogonadism is made with borderline testosterone levels then a 3-month trial of TRT can be considered. The diagnosis of hypogonadism associated with borderline testosterone levels and the decision to treat should only be made by an experienced clinician. [source]

Cardiovascular Response to Graded Lower Body Negative Pressure in Young and Elderly Man

R. van Hoeyweghen
Lower body negative pressure (LBNP) reduces central venous pressure (CVP) and cardiac output. The elderly are reported to have a limited capacity to increase cardiac output by increasing heart rate (HR), are especially dependent on end diastolic volume to maintain stroke volume and therefore should be especially vulnerable to LBNP. The present study compared the effects of LBNP in the young and old. Stroke volume was assessed non-invasively as stroke distance (SD) by aortovelography. Two groups of healthy male volunteers were studied: eight young (29.7 2.0 years, mean S.E.M.) and nine old (70.1 0.9 years). LBNP was applied progressively at 17.5, 35 and 50 mmHg in 20 min steps, with measurements taken during each steady state. There were similar, significant, falls in CVP in both groups. SD fell significantly in both groups from respective control values of 24.8 1.6 and 16.6 0.9 cm to 12.5 1.3 and 8.9 0.4 cm at a LBNP of 50 mmHg. Although SD in the elderly was significantly lower than in the young, the LBNP-induced changes were not different between groups. Both groups produced similar significant increases in vascular resistance, HR, plasma vasopressin (AVP) and noradrenaline. Mean arterial blood pressure (MBP) and plasma adrenaline did not change significantly. Therefore healthy old men respond to LBNP in a similar manner to the young, although MBP and SD are regulated around different baselines in the two groups. [source]

Effects of aging and gender on the spatial organization of nuclei in single human skeletal muscle cells

AGING CELL, Issue 5 2010
Alexander Cristea
Summary The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of the cytoplasm, i.e., the myonuclear domain (MND). We analysed aging- and gender-related effects on myonuclei organization and the MND size in single muscle fibres from six young (21,31 years) and nine old men (72,96 years), and from six young (24,32 years) and nine old women (65,96 years), using a novel image analysis algorithm applied to confocal images. Muscle fibres were classified according to myosin heavy chain (MyHC) isoform expression. Our image analysis algorithm was effective in determining the spatial organization of myonuclei and the distribution of individual MNDs along the single fibre segments. Significant linear relations were observed between MND size and fibre size, irrespective age, gender and MyHC isoform expression. The spatial organization of individual myonuclei, calculated as the distribution of nearest neighbour distances in 3D, and MND size were affected in old age, but changes were dependent on MyHC isoform expression. In type I muscle fibres, average NN-values were lower and showed an increased variability in old age, reflecting an aggregation of myonuclei in old age. Average MND size did not change in old age, but there was an increased MND size variability. In type IIa fibres, average NN-values and MND sizes were lower in old age, reflecting the smaller size of these muscle fibres in old age. It is suggested that these changes have a significant impact on protein synthesis and degradation during the aging process. [source]

Circadian variation in salivary testosterone across age classes in Ache Amerindian males of Paraguay

Richard G. Bribiescas
Testosterone levels exhibit a circadian rhythm in healthy men, with morning levels tending to be higher compared to evening titers. However, circadian rhythms wane with age. Although this has been described in males living within industrialized settings, age-related changes have not received similar attention in populations outside these contexts. Because many nonindustrialized populations, such as Ache Amerindians of Paraguay, exhibit testosterone levels that are lower than what is commonly reported in the clinical literature and lack age-associated variation in testosterone, it was hypothesized that Ache men would not show age-related variation in testosterone circadian rhythms. Diurnal rhythmicity in testosterone within and between Ache men in association with age (n = 52; age range, 18,64) was therefore examined. A significant negative association was evident between the ratio of morning and evening salivary testosterone and age (r = ,0.28, P = 0.04). Men in their third decade of life exhibited significant diurnal variation (P = 0.0003), whereas older and younger age classes did not. Men between the ages of 30 and 39 also exhibited a higher AM:PM testosterone ratio compared to 40,49 and 50< year old men (P = 0.002, 0.006). Overall, declines in testosterone with aging may not be universal among human males, however, within-individual analyses of diurnal variation capture age-related contrasts in daily testosterone fluctuations. Circadian rhythmicity differs with age among the Ache and may be a common aspect of reproductive senescence among men regardless of ecological context. Am. J. Hum. Biol., 2010. 2009 Wiley-Liss, Inc. [source]

CASE REPORTS: Xanthogranulomatous Inflammation of Corpus Cavernosum

Young Seo III MD
ABSTRACT Introduction., Xanthogranulomatous inflammation is a rare, chronic destructive inflammatory lesion. The pathological finding is typically lymphocyte and plasma cell infiltration, surrounded by accumulating lipid-laden macrophages. Methods., A 65-year-old healthy man presented with a 3-week history of a painless palpable mass in the penis. Results., The patient underwent an excision of the mass with a tunica albuginea, and a graft from the tunica vaginaglis. Histopathological findings showed the diffuse xanthogranulomatous inflammation. Conclusions., Xanthogranulomatous inflammation of corpus cavernosum in old men is a rare condition. The inflammatory mass should be treated by complete excision and graft. Seo IY, Jo HJ, and Rim JS. Xanthogranulomatous inflammation of corpus cavernosum. J Sex Med 2007;4:1763,1765. [source]

Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging

Martin Laimer
Abstract:, Studies of skin aging are usually performed at the genomic level by investigating differentially regulated genes identified through subtractive hybridization or microarray analyses. In contrast, relatively few studies have investigated changes in protein expression of aged skin using proteomic profiling by two-dimensional (2-D) gel electrophoresis and mass spectrometry, although this approach at the protein level is suggested to reflect more accurately the aging phenotype. We undertook such a proteomic analysis of intrinsic human skin aging by quantifying proteins extracted and fluorescently labeled from sun-protected human foreskin samples pooled from ,young' and ,old' men. In addition, we analyzed these candidate gene products by 1-D and 2-D western blotting to obtain corroborative protein expression data, and by both real-time PCR (RT-PCR) and microarray analyses to confirm expression at the mRNA level. We discovered 30 putative proteins for skin aging, including previously unrecognized, post-translationally regulated candidates such as phosphatidyl-ethanolamine binding protein (PEBP) and carbonic anhydrase 1 (CA1). [source]