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Occupational Agents (occupational + agent)

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Medical Sciences	100%

Selected Abstracts

Sputum eosinophilia: an early marker of bronchial response to occupational agents

ALLERGY, Issue 5 2009
O. Vandenplas
Background:, False-negative responses to specific inhalation challenge (SIC) with occupational agents may occur. We explored whether assessing changes in sputum cell counts would help improve the identification of bronchial reactivity to occupational agents during SICs. Methods:, The predictive value of the changes in sputum cell counts after a negative FEV1 response to a first challenge exposure to an occupational agent was determined using the changes in airway calibre observed during repeated challenges as the ,gold standard'. The study included 68 subjects investigated for work-related asthma in a tertiary centre. After a control day, the subjects were challenged with the suspected occupational agent(s) for up to 2 h. All subjects who did not show an asthmatic reaction were re-challenged on the following day. Additional challenges were proposed to those who demonstrated a , 2% increase in sputum eosinophils or an increase in nonspecific bronchial hyperresponsiveness to histamine after the second challenge day. Results:, Six of the 35 subjects without changes in FEV1 on the first challenge developed an asthmatic reaction on subsequent challenges. ROC analysis revealed that a >3% increase in sputum eosinophils at the end of the first challenge day was the most accurate parameter for predicting the development of an asthmatic response on subsequent challenges with a sensitivity of 67% and a specificity of 97%. Conclusions:, An increase in sputum eosinophils is an early marker of specific bronchial reactivity to occupational agents, which may help to identify subjects who will develop an asthmatic reaction only after repeated exposure. [source]

Reliability of demographic, smoking and occupational data provided by mothers vs. fathers in a childhood cancer study

PAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 3 2000
R. McKean-Cowdin
A large case,control study of children was used to test mothers' reporting of information on fathers' background, lifestyle and occupational factors. For a subset (104) of 1341 enrolled families, both parents were interviewed about fathers' characteristics. Reliability of reporting was determined for fathers' race, education, smoking status, non-recent job history and use of occupational agents. The ability of mothers to report fathers' race, education and smoking status was high (kappa > 0.70). Mothers were generally able to report jobs held by the fathers in the 5 years preceding the birth of the child, but reliability was higher for jobs held for longer (kappa typically above 0.70), rather than shorter periods (kappa above 0.40). The finding that mothers' reporting on fathers' background, lifestyle and non-recent job history was reliable is encouraging, because many studies on childhood health rely exclusively on information from interviews with mothers. However, mothers were not reliably able to describe exposure to specific occupational agents. [source]

Occupational risk factors for non-Hodgkin's lymphoma: A population-based case,control study in Northern Germany

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 4 2008
David B. Richardson
Abstract Objectives To identify occupational factors associated with non-Hodgkin's lymphoma (NHL). Methods A population-based case,control study was conducted in which incident cases of high-malignancy NHL (NHLhigh), low-malignancy NHL (NHLlow), and chronic lymphocytic leukemia (CLL) were ascertained during the period 1986,1998 among men and women aged 15,75 years residing in six German counties; controls were drawn from population registries. Occupational histories were collected and agent-specific exposures were estimated via a job-exposure-matrix. Odds ratios were estimated by conditional logistic regression. Results A total of 858 cases were included in these analyses. Agricultural workers [odds ratio (OR),=,2.67, 95% confidence interval (CI): 0.99, 7.21) and farmers (OR,=,1.98, 95% CI: 0.98, 3.98] had elevated risk of NHLhigh. Risk of NHLlow was elevated among agricultural workers (OR,=,2.46, 95% CI: 1.17, 5.16), and among blacksmiths, toolmakers, and machine tool operators (OR,=,3.12, 95% CI: 1.31, 7.47). Workers in sales and construction had elevated risks of NHLhigh and NHLlow. Exposure to arsenic compounds, chlorophenols, diesel fuel, herbicides, nitrites/nitrates/nitrosamines, and organic dusts were associated with NHLhigh and NHLlow, while exhibiting little association with CLL. A positive monotonic trend in NHLlow risk across tertiles of cumulative diesel fuel exposure was observed [P -value for test of linear trend (P),=,0.03]. Conclusions These findings provide insights into several potential occupational risk factors for NHL and suggest some specific occupational agents for further investigation. Am. J. Ind. Med. 51:258,268, 2008. © 2008 Wiley-Liss, Inc. [source]

Skin symptoms and work-related skin symptoms among grape farmers in Crete, Greece

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 2 2006
Leda Chatzi MD
Abstract Background Grape farmers are exposed to a variety of agents capable of inducing occupational skin disease. We conducted a study to measure the prevalence of skin symptoms and work-related skin symptoms among grape farmers in the Malevisi region of Crete and to provide data on associated risk factors. Methods One hundred twenty grape farmers and 100 controls participated in the study. The protocol consisted of a questionnaire, skin prick tests for 16 common allergens, and measurement of specific IgE antibodies against 8 allergens. Results Self-reported itchy rash (OR, 2.31; 95%CI, 1.10,4.84, P,<,0.05) within the last 12 months, and work-related itchy rash (OR, 4.08; 95%CI, 1.01,20.33, P,<,0.05) were significantly higher in grape farmers than in controls, after adjusting for age and sex. Sensitization to pollens (OR, 4.20; 95% CI, 1.41,12.82, P,<,0.01) and allergic rhinitis (OR, 3.06; 95% CI, 1.21,8.28, P,<,0.05) were found to be significantly associated with self-reported itchy rash in the grape farmers group. Conclusions Grape farmers reported skin symptoms more frequently than non-exposed controls, and IgE-mediated sensitization to pollens was found to be significantly associated with the reported symptoms. Further studies are needed to evaluate the impact of specific occupational agents on skin diseases among grape farmers. Am. J. Ind. Med., 2006. © 2005 Wiley-Liss, Inc. [source]