Home About us Contact
|
Home About us Contact | ||
|
|
||
Occasions
Kinds of Occasions Selected AbstractsOn the Occasion of the 65th Birthday of Dr. Ferdinand NäfHELVETICA CHIMICA ACTA, Issue 12 2005Roger Snowden The following six publications in this issue of Helvetica Chimica Acta are dedicated to Dr. Ferdinand Näf who was Corporate Vice President of R & D at Firmenich (1989,2005). [source] On the Occasion of the Inauguration of PSYCHOGERIATRICS, the Journal of the Japanese Psychogeriatric SocietyPSYCHOGERIATRICS, Issue 1 2001Edmond Chiu No abstract is available for this article. [source] On the Occasion of the 50th Canadian Chemical Engineering Conference in Montreal, QCTHE CANADIAN JOURNAL OF CHEMICAL ENGINEERING, Issue 4 2001Christophe Guy P.Eng. No abstract is available for this article. [source] On the Occasion of the 9th Vienna International Workshop on Functional Electrical StimulationARTIFICIAL ORGANS, Issue 8 2007Winfried Mayr PhD No abstract is available for this article. [source] On the Occasion of the 8th Vienna International Workshop on Functional Electrical StimulationARTIFICIAL ORGANS, Issue 8 2004Winfried Mayr PhD Guest Editors No abstract is available for this article. [source] On the Occasion of the Presentation of the SSAI Festschrift to Daryl John DaleyAUSTRALIAN & NEW ZEALAND JOURNAL OF STATISTICS, Issue 1 2004Joe Gani First page of article [source] Meetings Organised on the Occasion of Excellence in PaediatricsCHILD: CARE, HEALTH AND DEVELOPMENT, Issue 2010Article first published online: 2 DEC 200 First page of article [source] John Donne, godly inscription, and permanency of self in Devotions upon Emergent OccasionsRENAISSANCE STUDIES, Issue 3 2010Matthew Horn I argue that throughout his career but especially during his sickness of 1623, Donne fears self annihilation in death. Examining critical views on Donne's concept of death and the self, I identify this as a fear of a temporal blackout of the self between the body's death and the final Resurrection. Donne believes that the self is the result of the combination of the body and the soul, and although the soul can survive the body's dissolution, the self cannot. In order to counter this fear of the self's temporal disappearance, Donne seeks to inscribe himself in his Devotions upon Emergent Occasions, assuming the posture of an anatomist to distance himself from his physical body to capture the observations of his body in a text using a corporeal register. Donne preserves this textual encoding of himself by addressing God as the main audience for the Devotions: when God reads the text, the content of the text (Donne's self) becomes archived in the eternally stable mind of God. Ultimately, Donne's authorship of the Devotions is his imitation of God's own activity. Donne sees God's nature, his ,core self', as a system of eternally preserved propositions, and God's activity in creation is an act of copious literary expression using an alphabet of physical things that are used not for their own endurance qua physical entities but for their ability to figurative reveal God's self, which stands beyond and above them. Donne imitates this nature and activity in his act of writing the Devotions. [source] Maternal Alcohol Use During Pregnancy Causes Systemic Oxidation of the Glutathione Redox SystemALCOHOLISM, Issue 1 2010Theresa W. Gauthier Background:, Increased systemic oxidant stress contributes to a variety of maternal complications of pregnancy. Although the antioxidant glutathione (GSH) and its oxidized component glutathione disulfide (GSSG) have been demonstrated to be significantly altered in the adult alcoholic, the effects of maternal alcohol use during pregnancy on oxidant stress in the postpartum female remain under investigation. We hypothesized that maternal alcohol use would increase systemic oxidant stress in the pregnant female, evidenced by an oxidized systemic GSH redox potential. Methods:, As a subset analysis of a larger maternal language study, we evaluated the effects of alcohol consumption during pregnancy on the systemic GSH redox status of the postpartum female. Using an extensive maternal questionnaire, postpartum women where queried regarding their alcohol consumption during pregnancy. Any drinking, the occurrence of drinking >3 drinks/occasion, and heavy drinking of >5 drinks/occasion during pregnancy were noted. Using HPLC, maternal plasma samples were analyzed for GSH, oxidized GSSG and the redox potential of the GSH/GSSG antioxidant pair calculated. Results:, Maternal alcohol use occurred in 25% (83/321) of our study sample. Two in ten women reported consuming >3 drinks/occasion during pregnancy, while 1 in 10 women reported consuming alcohol at >5 drinks/occasion. Any alcohol use during pregnancy significantly decreased plasma GSH (p < 0.05), while alcohol at >3 drinks/occasion or >5 drinks/occasion significantly decreased plasma GSH concentration (p < 0.05), increased the percent of oxidized GSSG (p < 0.05), and substantially oxidized the plasma GSH redox potential (p < 0.05). Conclusions:, Alcohol use during pregnancy, particularly at levels >3 drinks/occasion, caused significant oxidation of the systemic GSH system in the postpartum women. The clinical ramifications of the observed alcohol-induced oxidation of the GSH redox system on high risk pregnancies or on the exposed offspring require more accurate identification and further investigation. [source] Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction propertiesACTA PHYSIOLOGICA, Issue 1 2010P. Hakim Abstract Aim:, In contrast to extensive reports on the roles of Nav1.5 , -subunits, there have been few studies associating the , -subunits with cardiac arrhythmogenesis. We investigated the sino-atrial and conduction properties in the hearts of Scn3b,/, mice. Methods:, The following properties were compared in the hearts of wild-type (WT) and Scn3b,/, mice: (1) mRNA expression levels of Scn3b, Scn1b and Scn5a in atrial tissue. (2) Expression of the ,3 protein in isolated cardiac myocytes. (3) Electrocardiographic recordings in intact anaesthetized preparations. (4) Bipolar electrogram recordings from the atria of spontaneously beating and electrically stimulated Langendorff-perfused hearts. Results:,Scn3b mRNA was expressed in the atria of WT but not Scn3b,/, hearts. This was in contrast to similar expression levels of Scn1b and Scn5a mRNA. Immunofluorescence experiments confirmed that the ,3 protein was expressed in WT and absent in Scn3b,/, cardiac myocytes. Lead I electrocardiograms from Scn3b,/, mice showed slower heart rates, longer P wave durations and prolonged PR intervals than WT hearts. Spontaneously beating Langendorff-perfused Scn3b,/, hearts demonstrated both abnormal atrial electrophysiological properties and evidence of partial or complete dissociation of atrial and ventricular activity. Atrial burst pacing protocols induced atrial tachycardia and fibrillation in all Scn3b,/, but hardly any WT hearts. Scn3b,/, hearts also demonstrated significantly longer sinus node recovery times than WT hearts. Conclusion:, These findings demonstrate, for the first time, that a deficiency in Scn3b results in significant atrial electrophysiological and intracardiac conduction abnormalities, complementing the changes in ventricular electrophysiology reported on an earlier occasion. [source] Mental health outcomes of adjudicated males and females: the aftermath of juvenile delinquency and problem behaviourCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 4 2004Mélanie Corneau Background Empirical evidence indicates that the rates of mental health problems and disorders are relatively high among adjudicated youths, especially females, yet few longitudinal studies have focused on gender differences regarding their mental health outcomes as adults. Aims The present study was designed to assess the prevalence rates of self-reported suicide attempts and psychological help-seeking in young adults adjudicated for antisocial behaviours in adolescence. This study also assessed gender differences in the prevalence rates of mental health problems and disorders reported by participants. Methods Structured interviews assessing personal and social adaptation were conducted on three occasions with 292 adjudicated male and 113 female youths (mean age 15 years on the first occasion). Data from the third testing wave (mean age 23.51 at T3) provide information on their mental health outcomes in adulthood. Results Results indicate that in individuals with a history of juvenile delinquency and/or problem behaviour over 10% of the males and 20% of the females reported suicide attempts, and one-fifth and one-third respectively reported psychological consultation. Similar and lower proportions reported psychiatric hospitalization and/or drug addiction programme/therapy at the beginning of adulthood. Implications for practice The present study suggests that these youths may need more mental health directed interventions in their assessment rehabilitation programmes. Copyright © 2004 Whurr Publishers Ltd. [source] Prof Dr Klaus-Werner Benz on the occasion of his 70th birthdayCRYSTAL RESEARCH AND TECHNOLOGY, Issue 1 2008Editor-in-Chief Wolfgang Neumann No abstract is available for this article. [source] T-cell subset counting and the fight against AIDS: Reflections over a 20-year struggleCYTOMETRY, Issue 2 2002Francis Mandy Abstract The story of T-lymphocyte subset immunophenotyping technology is reviewed on the occasion of the 20th anniversary of CD4 T-cell enumeration. Over time, immunophenotyping has evolved into precise, reliable, but complicated and expensive technology requiring fresh blood samples. The gating technologies that were universally adapted for clinical flow cytometry for the past decade relied on rapidly deteriorating morphological scatter characteristics of leukocytes. This special issue dedicated to CD4 T-cell enumeration features most of the available new options that will have a significant impact on how this technology will be implemented within the first decade of the 21st century. In a series of original publications, including the new NIH guideline for T-cell subset enumeration, contemporary gating protocols that use immunologically logical parameters are presented as part of the more reliable and affordable immunophenotyping alternative. Some of the improvements addressed here include the costs of the assays and the capacity to monitor interlaboratory and intralaboratory performances. It is clear that an effective attack on the human immunodeficiency virus (HIV) epidemic has to embrace resource-poor regions. Reducing the cost of the assay while improving reliability and durability is a move in the right direction. Cytometry (Clin. Cytometry) 50:39,45, 2002. © 2002 Wiley-Liss, Inc. [source] Women's Movements and Challenges to Neopatrimonial Rule: Preliminary Observations from AfricaDEVELOPMENT AND CHANGE, Issue 1 2001Aili Tripp Women's movements in Africa represent one of the key societal forces challenging state clientelistic practices, the politicization of communal differences, and personalized rule. In the 1980s and 1990s we have witnessed not only the demise of patronage-based women's wings that were tied to ruling parties, but also the concurrent growth of independent women's organizations with more far-reaching agendas. The emergence of such autonomous organizations has been a consequence of the loss of state legitimacy, the opening-up of political space, economic crisis, and the shrinking of state resources. Drawing on examples from Africa, this article shows why independent women's organizations and movements have often been well situated to challenge clientelistic practices tied to the state. Gendered divisions of labour, gendered organizational modes and the general exclusion of women from both formal and informal political arenas have defined women's relationship to the state, to power, and to patronage. These characteristics have, on occasion, put women's movements in a position to challenge various state-linked patronage practices. The article explores some of the implications of these challenges. [source] Laudatio in honour of Professor em Dr med Dr med h.c. Jules Angst on the occasion of the Burghölzli AwardACTA PSYCHIATRICA SCANDINAVICA, Issue 2003H. Häfner First page of article [source] SPLENIC RUPTURE FOLLOWING ROUTINE COLONOSCOPYDIGESTIVE ENDOSCOPY, Issue 4 2010Tabraze Rasul Splenic rupture is a life-threatening condition characterized by internal hemorrhage, often difficult to diagnose. Colonoscopy is a gold standard routine diagnostic test to investigate patients with gastrointestinal symptoms as well as to those on the screening program for colorectal cancer. Splenic injury is seldomly discussed during consent for colonoscopy, as opposed to colonic perforation, as its prevalence accounts for less than 0.1%. A 66-year-old Caucasian woman with no history of collagen disorder was electively admitted for routine colonoscopy for surveillance of adenoma. She was admitted following the procedure for re-dosing of warfarin, which was stopped prior to the colonoscopy. The patient was found collapsed on the ward the following day with clinical shock and anemia. Computed tomography demonstrated grade 4 splenic rupture. Immediate blood transfusion and splenectomy was required. Splenic rupture following routine colonoscopy is extremely rare. Awareness of it on this occasion saved the patient's life. Despite it being a rare association, the seriousness warrants inclusion in all information leaflets concerning colonoscopy and during its consent. [source] Challenges to antagonist blockade during sustained-release naltrexone treatmentADDICTION, Issue 9 2010Nikolaj Kunøe ABSTRACT Aims Naltrexone is a competitive opioid antagonist that effectively blocks the action of heroin and other opioid agonists. Sustained-release naltrexone formulations are now available that provide long-acting opioid blockade. This study investigates the use of heroin and other opioids among opioid-dependent patients receiving treatment with long-acting naltrexone implants, their subjective experience of drug ,high' after opioid use, and factors associated with opioid use. Methods Participants (n = 60) were opioid-dependent patients receiving treatment with naltrexone implants. Outcome data on substance use, drug ,high', depression and criminal activity were collected over a 6-month period. Blood samples were taken to monitor naltrexone plasma levels, and hair samples to verify self-reported opioid use. Findings More than half [n = 34 or 56%; 95% confidence interval (CI) 44,68%)] the patients challenged the blockade with illicit opioids during the 6-month treatment period; 44% (n = 26; 95% CI 32,56%) were abstinent from opioids. Mean opioid use was reduced from 18 [standard deviation (SD)13] days during the month preceding treatment to 6 days (SD 11) after 6 months. Of the respondents questioned on opioid ,high' (n = 31), nine patients (30%; 95% CI 16,47%) reported partial drug ,high' following illicit opioid use, and three (12%; 95% CI 3,26%) reported full ,high'. Opioid use was associated with use of non-opioid drugs and criminal behaviour. Conclusions Challenging naltrexone blockade with heroin on at least one occasion is common among sustained-release naltrexone patients, but only a minority of patients use opioids regularly. Challenges represent a warning sign for poor outcomes and often occur in the context of polydrug use and social adjustment problems. [source] The epidemiology of cannabis use and cannabis-related harm in Australia 1993,2007ADDICTION, Issue 6 2010Amanda Roxburgh ABSTRACT Aims To examine trends in patterns of cannabis use and related harm in the Australian population between 1993 and 2007. Design Analysis of prospectively collected data from: (1) the National Drug Strategy Household Survey (NDSHS) and Australian Secondary Student Alcohol and Drug Survey (ASSADS); (2) the National Hospital Morbidity Database (NHMD); and (3) the Alcohol and Other Drug Treatment Services National Minimum Dataset (AODTS-NMDS). Participants Australians aged 14 years and over from the general population; students aged 12,17 years; public and private hospital in-patients; public and private in-patients and out-patients attending for drug treatment. Measurement Prevalence of 12-month cannabis use among the general population and secondary students. Proportions in the general population by age group reporting: daily cannabis use; difficulties in controlling cannabis use; and heavy cannabis use on each occasion. Number of hospital and treatment presentations for cannabis-related problems. Findings Prevalence of past-year cannabis use has declined in the Australian population since the late 1990s. Among those reporting past-year use, daily use is prevalent among 40,49-year-olds, while heavy patterns of use are prevalent among 14,19-year-olds. Hospital presentations for cannabis-related problems reflect similar trends. Past-year cannabis use has decreased among the 10,19-year age group, but those who are daily users in this age group report using large quantities of cannabis. Conclusions Despite declines in the prevalence of cannabis use, continued public health campaigns warning of the harms associated with cannabis use are essential, aimed particularly at users who are already experiencing problems. The increasing demand for treatment for cannabis problems in Australia suggests the need for more accessible and more effective interventions for cannabis use disorders. [source] Evidence of a complex association between dose, pattern and timing of prenatal alcohol exposure and child behaviour problemsADDICTION, Issue 1 2010Colleen M. O'Leary ABSTRACT Background There is a lack of evidence regarding the effect of dose, pattern and timing of prenatal alcohol exposure and behaviour problems in children aged 2 years and older. Methods A 10% random sample of women delivering a live infant in Western Australia (1995,96) were invited to participate in an 8-year longitudinal survey (78% response rate n = 2224); 85% were followed-up at 2 years, 73% at 5 years and 61% at 8 years. Alcohol consumption was classified by combining the overall dose, dose per occasion and frequency to reflect realistic drinking patterns. Longitudinal analysis was conducted using generalized estimating equations (GEE) to investigate the association between child behaviour as measured by the Child Behaviour Checklist at 2, 5 and 8 years of age and prenatal alcohol exposure collected 3 months postpartum for each trimester separately, adjusting for a wide range of confounding factors. Results Low levels of prenatal alcohol were not associated with child behaviour problems. There were increased odds of internalizing behaviour problems following heavy alcohol exposure in the first trimester; anxiety/depression [adjusted odds ratio (aOR) 2.82; 95% confidence interval (CI) 1.07,7.43] and somatic complaints (aOR 2.74; 95% CI 1.47,5.12) and moderate levels of alcohol exposure increased the odds of anxiety/depression (aOR 2.24; 95% CI 1.16,4.34). Conclusions Prenatal alcohol exposure at moderate and higher levels increased the odds of child behaviour problems with the dose, pattern and timing of exposure affecting the type of behaviour problems expressed. Larger studies with more power are needed to confirm these findings. [source] Cover Picture: Electrophoresis 8/2008ELECTROPHORESIS, Issue 8 2008Article first published online: 17 APR 200 Regular issues provide a wide range of research and review articles covering all aspects of electrophoresis. Here you will find cutting-edge articles on methods and theory, instrumentation, nucleic acids, CE and CEC, miniaturization and microfluidics, proteomics and two-dimensional electrophoresis. On April 2 Professor Hjertén celebrated his 80th birthday, and it is an honor to take this opportunity to congratulate him on this special occasion and at the same time on his fruitful work. Stellan Hjertén's distinguished personality in research and life makes this celebration very special. It is therefore appropriate to devote a separate laudation in ELECTROPHORESIS to his achievements through which he has attained renown within the separation science community: indeed, he is considered undoubtedly to be the "Father of Capillary Electrophoresis". Professor Hjertén's preliminary work with Arne Tiselius motivated him to commit his career to electrophoresis: the development of free zone electrophoresis certainly revolutionized separation science, and since the construction of the first "capillary electrophoresis" equipment, one of the most cited works in this field carries his name. His friends were very keen to contribute manuscripts to this Issue, covering almost all areas in which Professor Hjertén has worked in his distinguished career. [source] The importance of drinking frequency in evaluating individuals' drinking patterns: implications for the development of national drinking guidelinesADDICTION, Issue 7 2009Catherine Paradis ABSTRACT Aims This paper examines the relationship between frequency of drinking, usual daily consumption and frequency of binge drinking, taking into consideration possible age and gender differences. Participants and design Subjects were 10 466 current drinkers (5743 women and 4723 men) aged between 18 and 76 years, who participated in the GENACIS Canada (GENder Alcohol and Culture: an International Study) study. Setting Canada. Measurements The independent variable was the annual drinking frequency. The dependent variables were the usual daily quantity consumed, annual, monthly and weekly frequency of binge drinking (five drinks or more on one occasion). Findings Logistic regressions show (i) that those who drink less than once a week are less likely than weekly drinkers to take more than two drinks when they do drink; (ii) that the usual daily quantity consumed by weekly drinkers is not related to their frequency of drinking; but that (iii) the risk and frequency of binge drinking increase with the frequency of drinking. Conclusions Given that risk and frequency of binge drinking among Canadians increases with their frequency of drinking, any public recommendation to drink moderately should be made with great caution. [source] Dedication to Professor Bertold J. Radola on the occasion of his retirementELECTROPHORESIS, Issue 23-24 2004Ziad El Rassi No abstracts. [source] Do the Transtheoretical Model processes of change, decisional balance and temptation predict stage movement?ADDICTION, Issue 5 2009Evidence from smoking cessation in adolescents ABSTRACT Aims To examine the effects of processes of change (POC) on forward stage movement directly, indirectly through decisional balance and temptation, and total effects as a test of the key hypothesis of the Transtheoretical Model (TTM). Design Prospective cohort study. Setting United Kingdom. Participants A total of 1160 adolescents aged 13,14 years who were current or former smokers at baseline. Measurements Stage was assessed with the standard algorithm three times, once every 3 months. On each occasion the POC, decisional balance and temptation were measured with the standard questionnaires. Path analysis was used to examine the direct, indirectly mediated and total contribution of POC and the other constructs to stage movement 3 months later. Findings Four of the 24 analyses showed evidence that the theoretically appropriate POC predicted stage transition, with statistically significant total effects. Effect sizes were small. When the POC were summarized to experiential and behavioural process means, one transition from pre-contemplation was predicted by experiential processes and, contrary to the TTM, one transition predicted by behavioural processes. There was slightly more evidence that decisional balance (attitudes towards smoking) and temptation (ability to resist the urge to smoke) was associated with stage transition. Conclusions POC use was not associated generally with stage transition and evidence that effects, if missed, must be modest, giving no support to the central tenet of the TTM. [source] Policy implications of the widespread practice of ,pre-drinking' or ,pre-gaming' before going to public drinking establishments,are current prevention strategies backfiring?ADDICTION, Issue 1 2009Samantha Wells ABSTRACT Aim To describe the research, policy and prevention implications of pre-drinking or pre-gaming; that is, planned heavy drinking prior to going to a public drinking establishment. Methods The authors describe the phenomenon of pre-drinking, motivations for pre-drinking and its associated risks using available research literature, media and popular internet vehicles. Results Heavy drinking prior to going out has emerged as a common and celebrated practice among young adults around the world. Apparent motivations are: (i) to avoid paying for high priced drinks at commercial drinking establishments; (ii) to achieve drunkenness and enhance and extend the night out; and (iii) to socialize with friends, reduce social anxiety or enhance male group bonding before going out. Limited existing research on pre-drinking suggests that it is associated with heavy drinking and harmful consequences. We argue that policies focused upon reducing drinking in licensed premises may have the unintended consequence of displacing drinking to pre-drinking environments, possibly resulting in greater harms. Conclusions Effective policy and prevention for drinking in licensed premises requires a comprehensive approach that takes into account the entire drinking occasion (not just drinking that occurs in the licensed environment), as well as the ,determined drunkenness' goal of some young people. [source] The relative efficacy of two levels of a primary care intervention for family members affected by the addiction problem of a close relative: a randomized trialADDICTION, Issue 1 2009Alex Copello ABSTRACT Objectives A randomized trial to compare two levels of an intervention (full versus brief) for use by primary health-care professionals with family members affected by the problematic drug or alcohol use of a close relative. Design A prospective cluster randomized comparative trial of the two interventions. Setting A total of 136 primary care practices in two study areas within the West Midlands and the South West regions of England. Participants A total of 143 family members affected by the alcohol or drug problem of a relative were recruited into the study by primary health-care professionals. All recruited family members were seen on at least one occasion by the professional delivering the intervention and 129 (90 %) were followed-up at 12 weeks. Main outcome measures Two validated and standardized self-completion questionnaires measuring physical and psychological symptoms of stress (Symptom Rating Test) and behavioural coping (Coping Questionnaire) experienced by the family members. It was predicted that the full intervention would show increased reduction in both symptoms and coping when compared to the brief intervention. Results The primary analysis adjusted for clustering, baseline symptoms and stratifying variables (location and professional group) showed that there were no significant differences between the two trial arms. The symptom score at follow-up was 0.23 [95% confidence interval (CI): ,3.65, +4.06] higher in the full intervention arm than in the brief intervention arm, and the coping score at follow-up was 0.12 (95% CI: ,5.12, +5.36) higher in the full intervention arm than in the brief intervention arm. Conclusions A well-constructed self-help manual delivered by a primary care professional may be as effective for family members as several face-to-face sessions with the professional. [source] Hostility, drinking pattern and mortalityADDICTION, Issue 1 2008Stephen H. Boyle ABSTRACT Aims This study examined the association of hostility to drinking pattern and whether this association mediated the relation of hostility to mortality. Participants and design Subjects were 3326 current drinkers from the Vietnam Experience Study cohort who were followed for vital status. Setting United States. Measurements Hostility was measured by an abbreviated version of the Cook,Medley Hostility Scale (ACM). The alcohol variables were total monthly intake of alcohol, drinking frequency, drinks per drinking day and drinking , 5 drinks on at least one occasion in the past month (i.e. heavy episodic drinking). Findings Regression analyses showed associations between the ACM and total monthly intake of alcohol (P < 0.0001), drinks per drinking day (P < 0.0001) and heavy episodic drinking (P < 0.0001), but not with frequency of drinking days. Hostility, drinks per drinking day, heavy episodic drinking and total monthly alcohol intake were also associated with all-cause mortality (all Ps < 0.0001). Further analyses showed that drinking pattern, particularly drinks per drinking day, may account partially for the relation of hostility to mortality. Conclusions High hostility is associated with elevated mortality and a deleterious drinking pattern characterized by relatively high intake per drinking occasion. Drinking pattern could help explain the relationships between hostility and health. [source] Effects of home access and availability of alcohol on young adolescents' alcohol useADDICTION, Issue 10 2007Kelli A. Komro ABSTRACT Aims The purpose of the present study was to examine the effects of parental provision of alcohol and home alcohol accessibility on the trajectories of young adolescent alcohol use and intentions. Design Data were part of a longitudinal study of alcohol use among multi-ethnic urban young adolescents who were assigned randomly to the control group of a prevention trial. Setting Data were collected from a cohort of youth, and their parents, who attended public schools in Chicago, Illinois (2002,2005). Participants The sample comprised the 1388 students, and their parents, who had been assigned randomly to the control group and were present and completed surveys at baseline, in the beginning of 6th grade (age 12). The sample was primarily low-income, and African American and Hispanic. Measurements Students completed self-report questionnaires when in the 6th, 7th and 8th grades (age 12,14 years; response rates 91,96%). Parents of the 6th grade students also completed questionnaires (70% response rate). Findings Student report, at age 12, of parental provision of alcohol and home alcohol availability, and parental report of providing alcohol to their child and the accessibility of alcohol in the home, were associated with significant increases in the trajectories of young adolescent alcohol use and intentions from ages 12,14 years. Student report of receiving alcohol from their parent or taking it from home during their last drinking occasion were the most robust predictors of increases in alcohol use and intentions over time. Conclusions Results indicate that it is risky for parents to allow children to drink during early adolescence. When these findings are considered together with the risks associated with early onset of alcohol use, it is clear that parents can play an important role in prevention. [source] Tests of causal linkages between cannabis use and psychotic symptomsADDICTION, Issue 3 2005David M. Fergusson ABSTRACT Aim To examine possible causal linkages between cannabis use and psychosis using data gathered over the course of a 25-year longitudinal study. Design A 25-year longitudinal study of the health, development and adjustment of a birth cohort of 1265 New Zealand children (635 males, 630 females). Setting The Christchurch Health and Development Study, a general community sample. Participants A total of 1055 participants from the Christchurch Health and Development Study (CHDS) cohort for whom data on cannabis use and psychotic symptoms were available on at least one occasion from 18, 21 and 25 years. Measurements As part of this study, data were gathered on frequency of cannabis use and psychotic symptoms at ages 18, 21 and 25 years. Findings Regression models adjusting for observed and non-observed confounding suggested that daily users of cannabis had rates of psychotic symptoms that were between 1.6 and 1.8 times higher (P < 0.001) than non-users of cannabis. Structural equation modelling suggested that these associations reflected the effects of cannabis use on symptom levels rather than the effects of symptom levels on cannabis use. Conclusions The results of the present study add to a growing body of evidence suggesting that regular cannabis use may increase risks of psychosis. The present study suggests that: (a) the association between cannabis use and psychotic symptoms is unlikely to be due to confounding factors; and (b) the direction of causality is from cannabis use to psychotic symptoms. [source] Drinking patterns in mid-adolescence and psychosocial outcomes in late adolescence and early adulthoodADDICTION, Issue 12 2004J. Elisabeth Wells ABSTRACT Aims To describe the pattern of drinking at age 16 and to relate this to outcomes at 16,21 years and 21,25 years across a number of psychosocial domains. Design A prospective birth cohort study with annual follow-up until age 16 then at 18, 21 and 25 years. Setting Christchurch, New Zealand. Participants Of 1265 subjects, 953 were interviewed at age 16. Measurements Multiple measures of family background were collected from birth to 16 years. Alcohol consumption was measured in terms of frequency, usual or last quantity drunk and most drunk per occasion. Problems were also recorded. Questions about psychiatric symptoms enabled Diagnostic and Statistical Manual (DSM) criteria to be applied. Detailed reports on educational outcomes, employment, sexual behaviours and offending were collected. Findings Four latent classes were required to describe drinking at age 16, but these appeared to lie along a single dimension which strongly predicted outcomes at ages 16,21 and 21,25 across all domains (alcohol-related, substance dependence, mental health, education, sexual relationships and offending). After controlling for background and correlates only a small number of outcomes were still related consistently to drinking at age 16 over both periods: most alcohol-related outcomes, the number of sexual partners and the extent of violent offending. Conclusions Drinking at age 16 is a clear indicator of future life-course over most domains in late adolescence and early adulthood. Many of these associations are due to other covariates. Outcomes specific to drinking at age 16 are alcohol outcomes, number of sexual partners and violence. [source] Pharmacokinetics of detomidine administered to horses at rest and after maximal exerciseEQUINE VETERINARY JOURNAL, Issue 5 2009J. A. E. HUBBELL Summary Reason for performing study: Increased doses of detomidine are required to produce sedation in horses after maximal exercise compared to calm or resting horses. Objectives: To determine if the pharmacokinetics of detomidine in Thoroughbred horses are different when the drug is given during recuperation from a brief period of maximal exercise compared to administration at rest. Methods: Six Thoroughbred horses were preconditioned by exercising them on a treadmill. Each horse ran a simulated race at a treadmill speed that caused it to exercise at 120% of its maximal oxygen consumption. One minute after the end of exercise, horses were treated with detomidine. Each horse was treated with the same dose of detomidine on a second occasion a minimum of 14 days later while standing in a stocks. Samples of heparinised blood were obtained at various time points on both occasions. Plasma detomidine concentrations were determined by liquid chromatographymass spectrometry. The plasma concentration vs. time data were analysed by nonlinear regression analysis. Results: Median back-extrapolated time zero plasma concentration was significantly lower and median plasma half-life and median mean residence time were significantly longer when detomidine was administered after exercise compared to administration at rest. Median volume of distribution was significantly higher after exercise but median plasma clearance was not different between the 2 administrations. Conclusions and potential relevance: Detomidine i.v. is more widely distributed when administered to horses immediately after exercise compared to administration at rest resulting in lower peak plasma concentrations and a slower rate of elimination. The dose requirement to produce an equivalent effect may be higher in horses after exercise than in resting horses and less frequent subsequent doses may be required to produce a sustained effect. [source] | |||||||||||||||||||||||||||||||||||||||||||