Obstruction

Distribution by Scientific Domains
Distribution within Medical Sciences

Kinds of Obstruction

  • acute airway obstruction
  • acute obstruction
  • airflow obstruction
  • airway obstruction
  • benign prostatic obstruction
  • bile duct obstruction
  • biliary obstruction
  • bladder outlet obstruction
  • bowel obstruction
  • bronchial obstruction
  • caval obstruction
  • colonic obstruction
  • colorectal obstruction
  • complete obstruction
  • duct obstruction
  • esophageal obstruction
  • extrahepatic biliary obstruction
  • gastric outlet obstruction
  • hilar obstruction
  • inflow obstruction
  • infravesical obstruction
  • intestinal obstruction
  • junction obstruction
  • lower airway obstruction
  • lower urinary tract obstruction
  • lymphatic obstruction
  • malignant biliary obstruction
  • mechanical obstruction
  • nasal obstruction
  • nasolacrimal duct obstruction
  • outflow obstruction
  • outflow tract obstruction
  • outlet obstruction
  • partial bladder outlet obstruction
  • partial obstruction
  • prolonged obstruction
  • prostatic obstruction
  • pulmonary venous obstruction
  • recurrent airway obstruction
  • renal obstruction
  • reversible airway obstruction
  • severe upper airway obstruction
  • small bowel obstruction
  • tract obstruction
  • tube obstruction
  • unilateral ureteral obstruction
  • upj obstruction
  • upper airway obstruction
  • ureteral obstruction
  • ureteric obstruction
  • ureteropelvic junction obstruction
  • urethral obstruction
  • urinary obstruction
  • urinary tract obstruction
  • vascular obstruction
  • vein obstruction
  • venous obstruction
  • venous outflow obstruction
  • ventricular inflow obstruction
  • ventricular outflow obstruction
  • ventricular outflow tract obstruction

  • Terms modified by Obstruction

  • obstruction grade
  • obstruction secondary
  • obstruction syndrome

  • Selected Abstracts


    BILIARY STENTING FOR MALIGNANT BILIARY OBSTRUCTION

    DIGESTIVE ENDOSCOPY, Issue 1 2006
    Toshio Tsuyuguchi
    Management of patients with malignant biliary obstruction remains controversial. We reviewed our current status of biliary stenting for malignancy. The initial step in our management is endoscopic nasobiliary drainage, which is used not only for preoperative drainage but also to decide whether or not surgery is appropriate treatment. Although a metal stent has a longer patency time than a plastic stent, it costs up to thirty-fold more than the latter in Japan. Therefore, stent selection, metal or plastic, should be dependent on the expected prognosis of each patient with malignant biliary strictures. In the present paper, we also discuss the efficacy of the covered metal stent and stenting for malignant hilar obstruction. [source]


    A NOVEL WAY TO DIAGNOSE CYSTIC FIBROSIS IN THE NEONATE WITH A BOWEL OBSTRUCTION AND POSSIBLE MECONIUM ILEUS

    JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 9 2003
    V Sung
    No abstract is available for this article. [source]


    REGULATION OF FIBROGENESIS DURING THE EARLY PHASE OF COMMON BILE DUCT OBSTRUCTION

    ANZ JOURNAL OF SURGERY, Issue 7 2006
    Atilla Engin
    Background: Both nitric oxide (NO) and prostaglandins have been proposed as inhibitor substances involved in collagen deposition in the hepatic parenchyma. The possible reciprocal connections between NO and eicosanoids in the development of liver fibrosis were investigated during the initial phase of common bile duct obstructions. Methods: A total of 30 male albino guinea pigs were randomly and equally assigned to three groups. Group 1 underwent sham laparotomy. Group 2 and group 3 were subjected to permanent common bile duct ligature for 24 and 72 h , respectively. Changes in the liver prostaglandin E2 (PGE2), leukotriene C4, malondialdehyde contents and plasma nitrite plus nitrate concentrations were measured. To evaluate the extent of hepatic fibrosis, histological assessment of liver was confirmed with the equivalent hydroxyproline contents of liver. Results: Twenty-four hours after ligature, the amount of malondialdehyde and PGE2 and plasma nitrite plus nitrate concentrations increased significantly, whereas liver hydroxyproline contents did not change. However, 72 h after ligature (Group 3), lipid peroxidation and collagen deposition were significantly higher than that of the group 2 animals. The PGE2 : leukotriene C4 ratio peaked at 24 h and later decreased, whereas PGE2 : NO ratio remained unchanged in both group 2 and group 3 animals. Conclusions: The initiation of collagen synthesis occurred in portal tract as early as within the first 72 h of bile duct obstruction. The optimum function of reactive oxygen species on the stellate cell activation might be determined by the interaction between NO and PGE2. [source]


    CURRENT OPINION AMONGST RADIOLOGISTS AND UROLOGISTS IN THE UK ON PERCUTANEOUS NEPHROSTOMY AND URETERIC STENT INSERTION FOR ACUTE RENAL OBSTRUCTION: RESULTS OF A POSTAL SURVEY

    BJU INTERNATIONAL, Issue 6 2007
    Deen P Sharma
    No abstract is available for this article. [source]


    EXPERIENCES OF SELF-EXPANDABLE METALLIC STENT FOR COLORECTAL OBSTRUCTIONS: 70 CASES

    DIGESTIVE ENDOSCOPY, Issue 2004
    Yoshihisa Saida
    ABSTRACT Clinical utilization of self-expandable metallic stent (EMS) endoprosthesis has come later for colorectal diseases than for other lesions. Recently, EMS has been used for palliative insertions for strictures caused by malignant diseases or as a ,bridge to surgery' for obstructive colorectal cancers, with good clinical results increasingly reported in many western countries. Its application for benign strictures has been reported, but we believe that the surgical indications require more careful analysis because of the absence of data concerning long-term prognosis. The advantage of this technique in the treatment of colorectal strictures is that it limits invasiveness, such as in palliative or temporary stoma creation, thereby improving patient quality-of-life. Therefore, we believe that EMS endoprosthesis will play a key role in this field. We are awaiting the introduction of the metallic stent for the colon and the associated kit, as well as the Japanese government's approval for reimbursement for this procedure. [source]


    Cor Triatriatum Sinister with and without Left Ventricular Inflow Obstruction: Visualization of the Entire Supravalvular Membrane by Real-time Three-dimensional Echocardiography.

    CONGENITAL HEART DISEASE, Issue 6 2006
    Impact on Clinical Management of Individual Patient
    ABSTRACT We present 4 cases of cor triatriatum in whom the diagnosis was correctly made by 2-dimensional transthoracic echocardiography, which showed the supravalvular left atrial membrane that divides the left atrium into 2 chambers. The pulmonary veins were connected normally to the proximal left atrial chamber and the left atrial appendage was connected to the distal left atrial chamber. In 1 patient there was evidence of severe pulmonary venous obstruction to the mitral valve by Doppler examination, while in the other three, there was no venous obstruction. Patients were then examined by real-time 3-dimensional echocardiography (RT3DE, using ×4 matrix array transducer connected to Sonos 7500 echocardiographic system Phillips, Andover, Mass, USA). This showed the exact morphology of the membrane and led to cancellation of planed surgical intervention in 1 case in which the membrane was only a broad band crossing the left atrial cavity. In addition to delineating the exact morphology of the intracavitary anomaly, this novel echocardiographic imaging modality should be an additive tool to better understand the natural history of these nonobstructive left atrial membranes via longitudinal follow-up of these patients. [source]


    Discussant's Comment: Endoscopic Stenting for Malignant Biliary Obstruction

    DIGESTIVE ENDOSCOPY, Issue 2000
    Yoshitsugu Kubota
    No abstract is available for this article. [source]


    An Uncommon Cause of Coronary Artery Ostial Obstruction: Papillary Fibroelastoma

    ECHOCARDIOGRAPHY, Issue 3 2010
    D.E.A.A., Gabor Erdoes M.D.
    Cardiac papillary fibroelastoma is a benign tumor that mainly affects cardiac valves. The tumor has the potential to cause angina and myocardial infarction due to embolization of tumor fragments. We describe a rare case of right coronary artery ostial obstruction by a 12 × 19 mm sized papillary fibroelastoma located in the sinus of Valsalva. The report underlies the importance of echocardiography in diagnosis and intraoperative treatment of this type of cardiac mass. (Echocardiography 2010;27:337-340) [source]


    Severe Right Ventricular Outflow Obstruction by Right Sinus of Valsalva Aneurysm

    ECHOCARDIOGRAPHY, Issue 3 2010
    Anil Avci M.D.
    Aneurysms of the sinus of Valsalva are rarely diagnosed cardiac anomalies, occurring in 0.14%,0.96% of patients who have undergone open heart surgical procedures. The most common congenital anomalies accompanying sinus of Valsalva aneurysm (SVA) are ventricular septal defect, bicuspid aortic valve, atrial septal defect, and coarctation of aorta. We report a patient with an unruptured right SVA presenting with severe right ventricular outflow tract (RVOT) obstruction, and coexisting patent foramen ovale (PFO) with a right to left shunt. It could be assumed that the increase in right atrial pressure due to RVOT obstruction had led to a right to left shunt across the patent foramen ovale. (Echocardiography 2010;27:341-343) [source]


    Baseline Echocardiographic Predictors of Dynamic Intraventricular Obstruction of the Left Ventricle during Dobutamine Stress Echocardiogram

    ECHOCARDIOGRAPHY, Issue 10 2009
    Edmundo Jose Nassri Cāmara M.D., Ph.D.
    Background: Intraventricular obstruction (IVO) during dobutamine stress echocardiogram (DSE) may be associated with or reproduce symptoms. Predictors of IVO are not well established. Methods: 149 patients were studied at rest and during DSE. The normal range of the left ventricular outflow tract (LVOT) velocities was investigated in 68 healthy patients. Results: 19 patients (13%) developed IVO (peak LVOT velocity > 271 cm/sec). A significant linear correlation was observed between peak LVOT velocity during DSE and the following rest parameters: LV end-diastolic dimension (r =,0.20, P = 0.018), LV end-systolic dimension (r =, 0.27, P = 0.001), relative wall thickness (r = 0.23, P = 0.006), shortening fraction (r = 0.24, P = 0.004), LVOT diameter (r =, 0.20, P = 0.023) and LVOT velocity (r = 0.29, P < 0.0001). Only relative wall thickness (P = 0.012) and LVOT diameter (P = 0.027) were independent predictors of IVO. As a dichotomous variable, a relative wall thickness ,0.44 was the only independent predictor of IVO (OR 5.7, 95% CI 1.6,20, P = 0.006), with sensitivity, specificity, negative predictive value, and positive predictive value of 77%, 62%, 95%, and 21%, respectively, and global accuracy of 63% (area under the ROC curve = 0.7). IVO was significantly associated with general cardiovascular symptoms (P = 0.0006) and with chest pain (P = 0.008). Conclusions: Relative wall thickness and LVOT diameter were independent predictors of obstruction. As a dichotomous variable, a relative wall thickness , 0.44 was the only independent predictor of dynamic IVO. [source]


    Left Ventricular Outflow Tract Obstruction Due to Anomalous Attachment of Chordae Tendineae in the Subaortic Region

    ECHOCARDIOGRAPHY, Issue 4 2006
    Sanjay Kumar M.R.C.P.
    No abstract is available for this article. [source]


    Severe Intraventricular Diastolic Gradient Due to Hypertrophic Cardiomyopathy and Systolic Left Ventricular Midcavitary Obstruction

    ECHOCARDIOGRAPHY, Issue 1 2005
    Albert Yuh-Jer Shen M.S.
    No abstract is available for this article. [source]


    Three-Dimensional Transesophageal Echocardiographic Demonstration of Intraatrial Baffle Obstruction

    ECHOCARDIOGRAPHY, Issue 5 2003
    Sujood Ahmed
    We report an adult patient with transposition of the great arteries status post-Mustard procedure in whom three-dimensional transesophageal echocardiography demonstrated intraatrial baffle obstruction. The baffle could be visualized in both long-axis and "en face" short-axis views. (ECHOCARDIOGRAPHY, Volume 20, July 2003) [source]


    Transesophageal Echocardiographic Identification of Thrombus Producing Obstruction of Left Pulmonary Artery Descending Lobar Branches and Bronchial Artery Dilatation

    ECHOCARDIOGRAPHY, Issue 1 2002
    Seung-Wan Kang M.D.
    We report an elderly patient in whom a thrombus in the distal left pulmonary artery was shown by transesophageal echocardiography to extend and produce obstruction of the descending lobar branches as well as dilatation of the left bronchial artery. [source]


    Critical Left Ventricular Outflow Tract Obstruction Due to Accessory Mitral Valve Tissue

    ECHOCARDIOGRAPHY, Issue 2 2000
    RAFFAELE CALABRO M.D.
    Left ventricular outflow tract (LVOT) obstruction due to anomalous tissue tag arising from the mitral valve is a rare congenital cardiac anomaly. It generally becomes symptomatic during the first decade of life as exercise intolerance, chest pain, or syncope at effort. To date, only a few cases of critical systemic obstruction due to isolated mitral valve anomaly in neonates have been reported. We report the case of a neonate who was a few hours old and was referred in severe clinical condition due to critical left ventricular outflow obstruction resulting from an anomalous tissue tag of mitral valve origin. [source]


    Obstruction of cerebral venous sinus secondary to idiopathic intracranial hypertension

    EUROPEAN JOURNAL OF NEUROLOGY, Issue 12 2008
    A. Stienen
    Background:, Whether cerebral venous sinus obstruction is a cause or consequence of idiopathic intracranial hypertension (IIH) is uncertain. Methods and results:, Among the nine children with IIH, five showed stenosis (n = 5) and occlusion (n = 1) of cerebral venous sinus on cranial magnetic resonance imaging (n = 4) or conventional angiography (n = 1), respectively. Follow-up magnetic resonance imaging performed in four children showed complete regression of the venous pathology in one and partial regression in two of them. Conclusions:, Our data demonstrate that cerebral venous sinus obstruction is frequent and frequently transient in pediatric IIH and suggest that stenoses may result from elevated intracranial pressure. [source]


    Left Ventricular Rhabdomyoma With Severe Left Ventricular Outflow Tract Obstruction

    JOURNAL OF CARDIAC SURGERY, Issue 5 2007
    Ali Sarigul M.D.
    Rhabdomyomas are the most common tumors in this group of patients. We herein report a 40-day-old male patient with left ventricular rhabdomyoma. The tumor caused syncope attack and supraventricular tachycardia. An emergency operation was planned and the life-threatening lesion was excised via left ventriculotomy. The patient was extubated on postoperative sixth hour and discharged from hospital on the sixth day of the postoperative period without any problem. This successful operation encourages us not to hesitate to perform an operation in newborns with cardiac neoplasms causing hemodynamic instability. [source]


    Thrombectomy for Prosthetic Heart Valve Obstruction

    JOURNAL OF CARDIAC SURGERY, Issue 3 2007
    P. Ogutu
    No abstract is available for this article. [source]


    Incidence and odds ratio of appendicitis as first manifestation of colon cancer: A retrospective analysis of 1873 patients

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 11 2006
    Hung-Wen Lai
    Abstract Background and Aim:, Obstruction of the lumen of the appendix is the major cause of appendicitis. Tumors could obstruct this lumen and cause appendicitis in the elderly. The association between appendicitis and colon cancer has not been sufficiently investigated, and this study was designed to clarify this association. Methods:, This was a retrospective study. Patients diagnosed with acute appendicitis from January 1998 to December 2003 at the Taipei Veterans General Hospital were surveyed. Patients found to have colon cancers immediately or subsequently after appendectomy were included and analyzed. Results:, A total of 1873 patients were diagnosed as having appendicitis of whom 16 were found to have colon cancer. The incidence of appendicitis associated with colon cancer was 0.85%. The time from appendectomy to the recognition of colonic cancer was at a median delay of 5.8 months. From the Taiwan Cancer Research Annual Report, the incidence of colon cancer was 31.91/100 000 in the year 2000. The odds ratio of colon cancer incidence had a 38.5-fold increase among patients older than 40 with acute appendicitis. Conclusions:, In patients over 40 years who present with symptoms of acute appendicitis the possibility of a coexistent colonic neoplasm should always be kept in mind. These patients should undergo colonoscopy 6 weeks after surgery to exclude the possibility of a coexistent colorectal cancer. [source]


    Role of a Streamer-like Coronary Thrombus in the Genesis of Unstable Angina

    JOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 3 2010
    YASUMI UCHIDA M.D.
    Introduction: It is generally believed that the coronary occlusion occurs at the site of plaque disruption in acute coronary syndromes. An exceptional mechanism of coronary occlusion, namely a streamer-like thrombus (SLT) originating in a nonstenotic lesion extended distally to obstruct a just distal nondisrupted stenotic segment, was found by angioscopy in patients with unstable angina (UA). This study was carried out to examine the incidence of this phenomenon and its relationship to the subtypes of UA. Methods: The culprit coronary artery was investigated by angioscopy in successive 48 patients (mean ± SE age, 61.0 ± 2.3 years; 10 females and 38 males) with UA. Results: SLT originating in a nonstenotic lesion extended distally, and obstructed the just distal most stenotic segment (DMSS) by its tail in 11 patients (eight with class III and three with class II according to Braunwald's classification). Recurrent anginal attacks were observed in all. The nonstenotic lesion in which the SLT originated was a disrupted yellow plaque in most cases. The SLT was frequently red and yellow in a mosaic pattern, indicating a mixture of fresh thrombus and plaque debris. The plaques that constructed the DMSS were not disrupted. Angiographically, the SLT was not detectable and the entry of the DMSS showed a "tapering" configuration. Conclusions: Obstruction of the DMSS by the tail of SLT originating in a nonstenotic lesion is another mechanism of UA. Therefore, treatment of both the nonstenotic lesion and DMSS is needed to prevent recurrent thrombus formation and consequent reattacks. (J Interven Cardiol 2010;23:216,222) [source]


    Acute Myocardial Infarction in a Discrete Coronary Artery Aneurysm Without Obstruction

    JOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 3 2000
    YUJI YOSHITOMI M.D.
    We report an unusual case of acute myocardial infarction attributable to obstruction of a discrete coronary aneurysm in a 54-year-old man. Although coronary angioplasty and thrombolysis were unsuccessful, serial arteriography showed spontaneous recanalization, and no spasm was induced by ergonovine. We discuss its mechanism. [source]


    Systemic to portal shunting following vena cava obstruction: Computed tomography and venographic appearances

    JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, Issue 3 2002
    LG Teh
    SUMMARY Obstruction of the inferior or superior vena cava normally leads to the formation of a well-described and consistent pattern of collateral venous pathways. We present the angiographic and CT features of the unusual development of systemic to portal venous shunting in two cases with central vein obstruction. [source]


    Surgical Stent Fabrication for Unilateral Nasal Obstruction of the Anterior Portion of the Nasal Airway

    JOURNAL OF PROSTHODONTICS, Issue 3 2009
    Fong Wong BSD
    Abstract A description is given of the indication and technical steps for fabricating a unilateral nasal stent to maintain patency of the nasal passage after surgical opening of an obstruction in a pediatric case. The methodology uses a two-step impression of the contralateral unobstructed naris and exterior valve region to generate a two-piece injection mold. The mold is used to fabricate a soft silicone-based anatomical stent. It supports an intranasal skin graft that was placed to reduce the risk of granulation. [source]


    Budd,Chiari-like syndrome in a dog with a chondrosarcoma of the thoracic wall

    JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Issue 2 2007
    Megan F. Whelan DVM
    Abstract Objective: To describe a dog with Budd,Chiari-like syndrome secondary to caudal vena cava compression from a thoracic wall chondrosarcoma. Case summary: A 9-year-old spayed female Shetland Sheepdog cross with a recent history of non-productive cough developed severe abdominal distension and dyspnea. Marked ascites and enlarged hepatic veins were identified with ultrasonography. At surgery, a right thoracic wall mass was found to be compressing the caudal vena cava. Fluid analysis of the ascites revealed a modified transudate with elevated protein concentration, consistent with Budd,Chiari-like syndrome. Clinical signs resolved following thoracotomy and complete resection of the mass. New or unique information provided: Obstruction of venous blood flow can result from compression exerted by a space-occupying thoracic wall mass on the caudal vena cava. Clinical resolution can be achieved with return of adequate venous circulation by removal of the mass and alleviation of the external pressure. [source]


    Increased Parasite Resistance and Recurrent Airway Obstruction in Horses of a High-Prevalence Family

    JOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 2 2010
    S. Neuhaus
    Background: Equine recurrent airway obstruction (RAO) shares many characteristics with human asthma. In humans, an inverse relationship between susceptibility to asthma and resistance to parasites is suspected. Hypothesis/Objectives: Members of a high-incidence RAO half-sibling family (F) shed fewer strongylid eggs compared with RAO-unaffected pasture mates (PM) and that RAO-affected horses shed fewer eggs than RAO-unaffected half-siblings. Animals: Seventy-three F and 73 unrelated, age matched PM. Methods: Cases and controls kept under the same management and deworming regime were examined. Each individual was classified as RAO affected or RAO unaffected and fecal samples were collected before and 1,3 weeks and 3 months after deworming. Samples were analyzed by combined sedimentation-flotation and modified McMaster methods and classified into 3 categories of 0 eggs per gram of feces (EpG), 1,100 EpG, and >100 EpG, respectively. Results: PM compared with RAO-affected F had a 16.7 (95% confidence interval [CI]: 2.0,136.3) times higher risk for shedding > 100 EpG compared with 0 EpG and a 5.3 (95% CI: 1.0,27.4) times higher risk for shedding >100 EpG compared with 0 EpG. There was no significant effect when RAO-unaffected F were compared with their PM. RAO-unaffected compared with RAO-affected offspring had a 5.8 (95% CI: 0.0,1.0) times higher risk for shedding 1,100 EpG. Age, sex, breed, and sharing pastures with other species had no significant confounding effects. Conclusion and Clinical Importance: RAO is associated with resistance against strongylid parasites in a high-prevalence family. [source]


    Airway Mucus in Recurrent Airway Obstruction, Short-Term Response to Environmental Challenge

    JOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 1 2004
    V. Gerber
    Mucus accumulation and neutrophilic inflammation in the airways are hallmarks of heaves. Endoscopically visible mucus accumulations, however, have not been studied during exposure to dusty hay and allergens (ie, environmental challenge). We hypothesized that (1) heaves-affected horses have increased mucus accumulation compared with controls, (2) mucus accumulations increase in heaves-affected horses during environmental challenge, and (3) environmental challenge also induces neutrophilic inflammation and mucus accumulation in control horses. Mucus accumulation was graded endoscopically (mucus grades [MGs] 1,5), and airway inflammation was evaluated by bronchoalveolar lavage fluid (BALF) cytology before (0 hours) and during (6, 24, 48 hours) environmental challenge. Large amounts of mucus (MG 4,5) were specific for heaves-affected horses in this study. Variation among controls was considerable, however, and intermediate grades (MG 2,3) were nonspecific, showing complete overlap between the 2 groups. Median mucus accumulations (25th, 75th percentiles) increased in heaves-affected horses from MG 2.5 (1.5, 3.5) at baseline to MG 3.5 (2.0, 4.0), 4.0 (3.0, 4.0), and 4.0 (4.0, 4.0) at 6, 24, and 48 hours, respectively. MG values did not increase in controls,overall MG 1.0 (1.0, 2.0),even though controls also showed a moderate increase of BALF neutro-phils. Mucus accumulations before and especially after exposure to dust and allergens are increased in heaves-affected horses compared with controls. Healthy controls show considerable variability in mucus accumulation but, despite an influx of neutrophils into the airways, no increase of mucus accumulation after exposure to hay dust. [source]


    Altered expression of thin filament-associated proteins in hypertrophied urinary bladder smooth muscle

    NEUROUROLOGY AND URODYNAMICS, Issue 1 2006
    Anita S. Mannikarottu
    Abstract Aims Obstruction of the urinary bladder outlet induces detrusor smooth muscle (DSM) hypertrophy. The goal of this study was to determine whether the composition of thin filament-associated proteins, known to play important roles in cytoskeletal structure and/or the regulation of contraction, is altered in DSM during hypertrophy. Methods DSM hypertrophy was induced in male rabbits by partial ligation of the urethra. Sham-operated rabbits served as a control. Reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR revealed a significant increase in the expression of mRNAs for basic (h1) calponin (CaP), and ,-isoform of tropomyosin (Tm) in hypertrophied DSM compared to controls. Western blotting and two-dimensional (2-D) gel electrophoresis showed enhanced expression of these proteins and also a significant increase in the expression of ,-non muscle and ,-smooth muscle actin in the DSM from obstructed bladders, while ,-actin remained constant. Results Enhanced expression of these proteins in the DSM from obstructed bladders was confirmed by immunofluorescence microscopy. Double immunostaining with Cap/Tm and ,/,-actin-specific antibodies showed co-localization of these proteins in myocytes. Colocalization of smooth muscle specific myosin and CaP to cytoplasmic filaments in cells dissociated from the hypertrophied DSM indicated that these cells are differentiated smooth muscle cells. Conclusions The change in the isoforms of actin, Cap, and Tm may be part of the molecular mechanism for bladder compensation in increased urethral resistance. Neurourol. Urodynam. © 2005 Wiley-Liss, Inc. [source]


    The effect of tamsulosin on the response of the rabbit bladder to partial outlet obstruction

    NEUROUROLOGY AND URODYNAMICS, Issue 1 2006
    Robert M. Levin
    Abstract Aim To determine if tamsulosin treatment prevents or decreases the incidence and severity of outlet obstruction-induced bladder dysfunction in rabbits. Materials and Methods Male New Zealand White rabbits were treated with tamsulosin or vehicle for 4 weeks with treatments initiated 1 week prior to sham or obstruction surgery. Cystometry was done on anesthetized rabbits 21 days after surgery. The bladders were then removed, weighed, and prepared for in vitro whole bladder studies. Responses to 32 Hz field stimulation (FS), carbachol, phenylephrine, and KCl were measured. Results Obstruction resulted in a significant increase in bladder weight, which was unchanged by tamsulosin treatment and a significant increase in micturition pressure in the vehicle-treated group but not in the tamsulosin-treated group. Compliance was significantly decreased in both obstructed groups. The vehicle-treated obstructed rabbits had a very sharp increase in intravesical pressure as the bladder reached capacity; this was not seen in the tamsulosin-treated obstructed rabbits. Tamsulosin did not change the pattern of modifications in contractile responses induced by bladder outlet obstruction. Conclusions In vitro responses of vehicle and tamsulosin-treated obstructed rabbit groups in this study were similar. A greater micturition pressure was found for the vehicle-treated obstructed group than for the tamsulosin-treated obstructed group, which was probably due to decreased urethral resistance in the latter. On a functional basis, the higher compliance at capacity and decreased micturition pressure in the tamsulosin-treated obstructed group would be considered beneficial for bladder function. Neurourol. Urodynam. © 2005 Wiley-Liss, Inc. [source]


    Severe Venous and Lymphatic Obstruction after Single-Chamber Pacemaker Implantation in a Patient with Chest Radiation Therapy

    PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 4 2010
    JOSHUA M. DIAMOND M.D.
    A 73 - year - old woman with a history of paroxysmal atrial fibrillation, sinus node dysfunction, bilateral breast cancer, and extensive chest radiation developed progressive edema, dyspnea, and recurrent pleural effusions soon after single - chamber pacemaker implantation. Thoracentesis yielded a diagnosis of chylothorax, and progressive refractory anasarca developed. A computed tomography angiogram suggested obstruction of the superior vena cava and left subclavian vein despite outpatient therapeutic anticoagulation. Autopsy confirmed venous thrombosis, along with mediastinal fibrosis. The presumed etiology of the chylothorax and anasarca was obstruction of the atretic central venous structures following pacemaker implantation, critically impairing the already tenuous venous and lymphatic drainage. (PACE 2010; 520,524) [source]


    Right Atrial Pacemaker Lead Thrombosis Causing Tricuspid Inflow Obstruction

    PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 2 2009
    AYLIN TUGCU M.D.
    A 75-year-old man was admitted to our hospital with a complaint of progressive dyspnea with effort. The patient had a permanent pacemaker that was implanted 16 years ago. Transesophageal echocardiography revealed a large, mobile mass in the right atrium attaching to the insertion site of the atrial lead at the tricuspid valve level. Because of the size, mobility, and location of the mass, urgent surgical removal was considered. The mass was successfully removed. Histologic examination of the mass demonstrated a partially organized thrombus. The postoperative course was uneventful and the patient's symptoms improved remarkably after operation. [source]