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Terms modified by OECD Selected AbstractsAntidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulationDIABETES OBESITY & METABOLISM, Issue 11 2008R. R Ortiz-Andrade Aim:, The present investigation was designed to determine the in vivo antidiabetic effect of naringenin (NG) in normoglycaemic and diabetic rat models through blood glucose (GLU) measurements following acute and subchronic time periods. Possible modes of action of NG were investigated and its acute toxicity determined. Methods:, Normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models were treated for acute and subchronic (5 days) time periods with 50 mg/kg/day of NG. Blood biochemical profiles were determined after 5 days of the treatment in normoglycaemic and NIDDM rats using commercial kits for GLU, triglycerides (TG), total cholesterol (CHOL) and high-density lipoprotein (HDL). In order to elucidate its antidiabetic mode of action, NG was administered intragastrically and an oral glucose tolerance test performed using GLU and sucrose (2 g/kg) as substrates. The inhibitory effect of a single concentration of NG (10 ,M) on 11,-hydroxysteroid dehydrogenase type 1 (11,-HSD1) activity in vitro was determined. Finally, the preclinical safety and tolerability of NG was determined by toxicological evaluation in mice and rats using Organization for Economic Cooperation and Development (OECD) protocols. Results:, Intragastrically administered NG (50 mg/kg) induced a significant decrease in plasma GLU in normoglycaemic and NIDDM rat models (p < 0.05) following acute and subchronic time periods. After 5 days of administration, NG produced significant diminished blood GLU and TG levels in streptozotocin,nicotinamide,induced diabetic rats. The administration of NG to normal rats significantly increased the levels of TG, CHOL and HDL (p < 0.05). NG (5 and 50 mg/kg) induced a total suppression in the increase of plasma GLU levels after administration of substrates (p < 0.01), but NG did not produce inhibition of ,-glucosidase activity in vitro. However, NG (10 ,M) was shown to inhibit 11,-HSD1 activity by 39.49% in a cellular enzyme assay. Finally, NG showed a Medium Lethal Dose LD50 > 5000 mg/kg and ranking at level five based on OECD protocols. Conclusion:, Our findings suggest that NG may exert its antidiabetic effect by extra-pancreatic action and by suppressing carbohydrate absorption from intestine, thereby reducing the postprandial increase in blood GLU levels. [source] REALITIES OF HEALTH POLICY IN NORTH AMERICA: GOVERNMENT IS THE PROBLEM, NOT THE SOLUTIONECONOMIC AFFAIRS, Issue 4 2008Brett J. Skinner Healthcare systems in North America are sometimes criticised as being expensive or socially irresponsible relative to comparable systems in OECD (Organisation for Economic Co-operation and Development) countries or regions. These perceived health system failures are often mistakenly attributed to greater private sector involvement in the delivery of medical care or the provision of medical insurance in Canada and the USA. However, the exact nature and scope of state involvement in the healthcare sector in Canada and the USA is also often misunderstood and underestimated. This paper presents a fact-based context for evaluating health policy in North America. [source] The relative sophistication of Chinese exportsECONOMIC POLICY, Issue 53 2008Peter K. Schott SUMMARY Chinese exports China's exports have grown dramatically over the last three decades in large part due to its rapid penetration of new product markets. To help address the implications of this growth for developed economies, this paper gauges the relative sophistication of Chinese exports along two dimensions. First, I measure China's export overlap with developed countries by comparing the set of products China exports to the United States with the bundle of products exported by the OECD. Second, I compare Chinese and other countries' exports within product markets in terms of the price they receive in the US market. While China's export overlap with the OECD is much greater than one would predict given its low wages, the prices that US consumers are willing to pay for China's exports are substantially lower than the prices they are willing to pay for OECD exports. This fact, as well as the increase in the ,OECD premium' over time, suggests that competition between China and the world's most developed economies may be less direct than their product-mix overlap implies. It may also reflect efforts by developed-country firms to compete with China by dropping their least sophisticated offerings and moving up the quality ladder. , Peter K. Schott [source] Regulation, productivity and growth: OECD evidenceECONOMIC POLICY, Issue 36 2003Giuseppe Nicoletti SUMMARY Liberalization and privatization have made the regulatory environment more market-friendly throughout the OECD. However using a large new dataset on product market regulation, we show that regulatory policies in OECD nations have become more dissimilar in relative terms, even as all nations have liberalized. This seemingly contradictory finding is explained by different starting points and different reform speeds. Our data also show that this divergence in the regulatory settings lines up with the divergent growth performance of OECD nations, in particular the poor performance of large Continental economies relative to that of the US. The data, which tracks various types of product market regulation in manufacturing and service industries for 18 OECD economies over the past two decades, allows us to explore this link in detail. We find that productivity growth is boosted by reforms that promote private corporate governance and competition (where these are viable). Moreover, our detailed findings suggest how product market regulation and productivity growth are linked. In manufacturing, the productivity gains from liberalization are greater the further a given country is from the technology leader. This indicates that entry-limiting regulation may hinder the adoption of existing technologies, possibly by reducing competitive pressures, technology spillovers, or the entry of new high-tech firms. These results offer an interpretation of poor Continental performance. Strict product market regulations , and lack of regulatory reforms , appear to underlie the meagre productivity performance of some European countries, especially in those industries where Europe has accumulated a technology gap (e.g. industries producing or using information and communication technologies). , Giuseppe Nicoletti and Stefano Scarpetta [source] The role of indicators in improving timeliness of international environmental reportsENVIRONMENTAL POLICY AND GOVERNANCE, Issue 1 2006Ulla Rosenström Abstract Environmental indicators were developed mainly to improve information flows from scientists to policy-makers. This article discusses the importance of timely environmental data and investigates the influence of indicator-based reporting on the data timeliness of environmental reports by international organizations. Timeliness of information contributes to the quality and appeal of the reports, and to their role as early warning tools, and increases their usability by decision-makers in short-term decision cycles. The results of an analysis of 11 international reports by the European Environmental Agency (EEA) and the Organization for Economic Co-Operation and Development (OECD) show a considerable time lag of three years on average, with only minor development towards more timely reporting. The results suggest that the introduction of environmental indicators has not improved the timeliness of reporting. In order to overcome these problems, the article recommends some methods for improving timeliness. These include better choice of indicators in smaller sets, use of preliminary data and outlooks, development of new indicators, publishing on the internet and more effective use of internet databases to avoid intermediate levels in data collection. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment. [source] Toxicity of arsenic species to Lemna gibba L. and the influence of phosphate on arsenic bioavailabilityENVIRONMENTAL TOXICOLOGY, Issue 1 2004Martin Mkandawire Abstract The toxicity of arsenic (As) species to Lemna gibba L. and the influence of PO on As bioavailability and uptake were tested in batch culture. L. gibba were exposed to six test concentrations of NaHAsO4 · 7H2O and NaAsO3, with 0, 0.0136, 13.6, and 40 mg L,1 KH2PO4. In batch culture As toxicity to L. gibba did not relate linearly to As concentration. The growth rate, related to frond number as recommended by OECD and ISO/DIN, was significantly inhibited in fronds exposed to 20,50 ,g L,1 As(III) compared with fronds exposed to As(V). The growth rate was stimulated when plants were exposed to 50,250 ,g L,1 of both As(III) and As(V). After exposure to 300,800 ,g L,1 growth inhibition was significantly higher for As(III) than for As(V), whereas above 800 ,g L,1 As(V) was inhibited the most. The bioaccumulation of As(III) and As(V) was significantly higher for P-deficient cultures (0.98 ± 0.08 and 1.02 ± 0.19 g kg,1, respectively for 0.0136 mg L,1 PO) than for P-sufficient cultures (243 and 343 mg kg,1 for 40 mg L,1, respectively). Plants exposed to As(V) had uptake and accumulation values slightly higher than did plants exposed to As(III). No significant differences in bioaccumulation were found between plants exposed to a concentration of As(III) >1 mg L,1 and those exposed to As(V) at the same concentration. This indicates a direct relationship to P content in the culture. Toxicity may result from the uptake of As(V) instead of PO as a result of ion competition during uptake because of close thermodynamic properties, which may change the interaction among components in the media. The toxicity pattern is interpreted as a manifestation of changing speciation in the batch culture and of the oxidation of As(III) to As(V) in an oxygen-rich environment. © 2004 Wiley Periodicals, Inc. Environ Toxicol 19: 26,34, 2004. [source] Toxicity of methyl tert butyl ether to soil invertebrates (springtails: Folsomia candida, Proisotoma minuta, and Onychiurus folsomi) and lettuce (Lactuca sativa)ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 2 2010Matthew Dodd Abstract Experiments were conducted to assess the toxicity of methyl tert butyl ether (MTBE) to three species of Collembola (Proisotoma minuta, Folsomia candida, and Onychiurus folsomi) and lettuce (Lactuca sativa L.) using an artificial Organization for Economic Cooperation and Development (OECD) soil and field-collected sandy loam and silt loam soil samples. Soil invertebrate tests were carried out in airtight vials to prevent volatilization of MTBE out of the test units and to allow for direct head-space sampling and gas chromatography-mass spectrometry (GC-MS) analysis for residual MTBE. The use of the airtight vial protocol proved to be very successful, in that the measured MTBE concentrations at the beginning of the experiments were within 95% of nominal concentrations. The test methods used in this study could be used to test the toxicity of other volatile organic compounds to Collembola. The soil invertebrates tested had inhibitory concentration (ICx) and lethal concentration (LCx) values that ranged from 242 to 844 mg MTBE/kg dry soil. When the three test species of Collembola were tested under identical conditions in the artificial OECD soil, O. folsomi was the most sensitive collembolan, with a median inhibitory concentration (IC50; reproduction) of 296 mg MTBE/kg dry soil. The most sensitive endpoint for lettuce was an IC50 for root length of 81 mg MTBE/kg dry soil after 5 d of germination in OECD soil. Data on the loss of MTBE from the three test soils over time indicated that MTBE was retained in the silt loam soil longer than in either the sandy loam or the artificial OECD soil. Environ. Toxicol. Chem. 2010;29:338,346. © 2009 SETAC [source] Utility of a juvenile fathead minnow screening assay for detecting (anti-)estrogenic substancesENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 2 2002Grace H. Panter Abstract The European Chemical Industry's aquatic research program for endocrine disrupters includes the development of an in vivo juvenile fathead minnow (Pimephales promelas) screening assay.Working within the Organization for Economic Cooperation and Development's (OECD, Paris, France) tiered approach to endocrine disrupter evaluation in fish, the juvenile fish screening protocol was adapted from the OECD test guideline 204. Six chemicals, with different (anti-)estrogenic potencies, were used to develop the in vivo juvenile fish screening protocol: diethylstilbestrol, 17,-ethynylestradiol, genistein, methoxychlor, 4- tert -pentylphenol, and ZM189,154 (a novel pharmaceutical antiestrogen). Mixed-sex juvenile fathead minnows were exposed to individual chemicals (with chemical analyzes) and sampled after 4, 7, 14, and 21 d of exposure. Wet weight, total length, condition factor, and whole-body homogenate concentrations of vitellogenin (VTG) were determined. Estrogens and antiestrogens were detected in this screen by virtue of the VTG response (an elevation or suppression, respectively) after 14 d. The study showed that the use of VTG concentrations in mixed-sex juvenile fish provides a sensitive and robust assay for the detection of both estrogenic and antiestrogenic chemicals, with widely divergent potencies. [source] Soil and plant diet exposure routes and toxicokinetics of lindane in a terrestrial isopodENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 10 2000José Paulo Sousa Abstract In most studies dealing with effects of toxic substances in saprotrophic isopods, animals are exposed to the test substance through contaminated food. Because these animals can be in a close contact with the soil surface, the substrate, as an exposure pathway, should not be neglected. Here the authors analyze the toxicokinetic behavior of lindane (,-hexachlorocyclohexane [,-HCH]) in the isopod species Porcellionides pruinosus, comparing two exposure routes: food and two soil types (artificial Organisation for Economic Cooperation and Development [OECD] soil and a natural agricultural soil). In the feeding experiment, a strong decrease of ,-HCH concentration over time was observed on the food material, with the animals showing a broader range in chemical assimilation efficiency values (averaging 17.7% and ranging from 10 to 40%). The ,-HCH bioaccumulation results indicate that when animals incubated under both soil types reached a steady state, they displayed much higher body burdens (1,359.60 pg/animal on OECD soil and 1,085.30 pg/animal on natural soil) than those exposed to contaminated food (43.75 pg/animal). Kinetic models also revealed much lower assimilation and elimination rates in the food experiment (20.66 pg/d and 0.10 pg/d) than in both soil experiments (238.60 pg/d and 350.54 pg/d for the assimilation rate and 0.19 pg/d and 0.32 pg/d for the elimination rate). Differences in results between exposure routes are discussed according to equilibrium-partitioning theory and the enhanced relevance of the substrate exposure route is analyzed under future prospects on chemical toxicity testing using isopods. [source] The diffusion of regulatory impact analysis , Best practice or lesson-drawing?EUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2004CLAUDIO M. RADAELLI Its main theoretical thrust is to explore the limitations of the conventional analysis of RIA in terms of de-contextualised best practice and provide an alternative framework based on the lesson-drawing literature. After having discussed how demand and supply of best practice emerge in the OECD and the European Union, some analytic (as opposed to normative) lessons are presented. The main lessons revolve around the politics of problem definition, the nesting of RIA into wider reform programmes, the political malleability of RIA, the trade-off between precision and administrative assimilation, the roles of networks and watchdogs, and institutional learning. The conclusions discuss the implications of the findings for future research. [source] Corporatism and income inequality in the global economy: A panel study of 17 OECD countriesEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 1 2003DANIEL J. MINNICH The conventional wisdom of domestic politics in the global economy holds that that the globalization of the market economy has spelled the imminent collapse of corporatist bargaining institutions and the corporatist goal of economic equality. This conventional wisdom, however, highlights an interesting puzzle: it was the process of internationalization and economic openness itself that generated corporatist institutions. This study examines whether corporatist institutions are still effective in ensuring the corporatist goal of equality in the ,global' economy. Income inequality from the early 1980s to the middle 1990s is used as a measure of institutional effectiveness. It is argued that corporatism, as a form of interest mediation, is a path-dependent institution that generates increasing returns in terms of equality in the most internationalized economies. Results of a panel study of 17 Organization for Economic Cooperation and Development (OECD) countries indicate that corporatism reduces income inequality and, contrary to the conventional wisdom, income inequality is lowest in the most ,global' national economies. [source] Developing new measures of welfare state change and reformEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2002Francis G. Castles Since the publication of Gøsta Esping,Andersen's The Three Worlds of Welfare Capitalism (Esping,Andersen 1990), which built its typologies on a rich database of detailed programme characteristics, it has been generally accepted that measures of social expenditure are an inferior, and even a misleading, source of information concerning the character of welfare state development. The problem is, however, that the kinds of detailed programme data Esping,Andersen used are not routinely available, while the quality of social expenditure data has been improving rapidly, culminating in the Organisation for Economic Cooperation and Development's (OECD) now regularly updated and highly disaggregated Social Expenditure Database (SOCX). This article explores the possibility of using SOCX to devise measures of the extent, structure and trajectory of welfare state change and reform in 21 OECD countries over the period 1984 to 1997. On the basis of these measures, it suggests that there has been almost no sign of systematic welfare retrenchment in recent years and only limited evidence of major structural transformation or programmatic reorientation. [source] A Nolan Committee for the German ethics infrastructure?EUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2002Nathalie Behnke An international trend towards establishing and conforming standards of ethical behaviour in the public sector has repeatedly been stated. Germany, however, remains surprisingly reluctant to adopt such recommendations. This article argues that the likelihood of German decision makers implementing new, and especially soft, ethics measures depends on the demand for such measures, on the one hand, and their supply, on the other. The analysis shows that contradictory forces have an impact on Germany. The demand for new ethics measures is relatively low as a high level of hard ethics measures incorporated in the longstanding formal legal system of rules and regulations make the implementation of new measures seem unnecessary. Also, the demand for soft ethics measures is less marked in Germany than in the United Kingdom. This comparatively weak pressure meets the natural inertia caused by cognitive and institutional path,dependency in institutional choices of political decision makers. On the other hand, external bodies (such as the Organisation for Economic Cooperation and Development , OECD) provide blueprints for soft ethics measures and encourage the implementation of uniform standards across countries. Which of these forces will prevail in the long run, however, cannot be deduced from the present situation. [source] Resolving Deadlock: Why International Organisations Introduce Soft LawEUROPEAN LAW JOURNAL, Issue 2 2006Armin Schäfer Instead the EU relies on soft law that does not legally bind governments in the same way as the Community Method used to. The literature assumes that soft law is chosen to achieve common objectives given considerable diversity among the Member States. In contrast, this paper suggests that non-binding coordination is first and foremost a means to foster compromises in the absence of substantial agreements. Three case studies demonstrate that international organisations have repeatedly relied on soft law to overcome disagreements among their members. The IMF, the OECD, and the EU introduced soft coordination at times of institutional crisis to prevent a breakdown of negotiations. [source] Public Sector Decentralisation: Measurement Concepts and Recent International Trends,FISCAL STUDIES, Issue 3 2005Dan Stegarescu Abstract This paper deals with the problems encountered in defining and measuring the degree of fiscal decentralisation. Drawing on a recent analytical framework of the OECD, different measures of tax autonomy and revenue decentralisation are presented which consider the tax-raising powers of sub-central governments. Taking account of changes in the assignment of decision-making competencies over the course of time, new time series of annual data on the degree of fiscal decentralisation are provided for 23 OECD countries over the period between 1965 and 2001. It is shown that common measures usually employed tend to overestimate the extent of fiscal decentralisation considerably. Evidence is also provided of increasing fiscal decentralisation in a majority of OECD countries during the last three decades. [source] Good Government Means Different Things in Different CountriesGOVERNANCE, Issue 1 2010MATT ANDREWS Work on good governance implies a one-best-way model of effective government. This has isomorphic influences on development, whereby governments are influenced to adopt a one-size-fits-all approach to get things done. This article challenges whether such an approach exists, proposing that models actually do not hold even for the so-called effective governments. Governments look different, even if they are similarly called models of good government. This proposition is examined through a study of public financial management practices in a set of Organisation for Economic Co-operation and Development (OECD) and non-OECD countries. The study shows that effective governments are not more likely to exhibit better practice characteristics implied in one-best-way models. Good public financial management means different things in different countries. The article concludes by suggesting that good governance models give way to menus and the development community invest more time in examining why different countries select different menu items. [source] Business Models and the Transfer of Businesslike CentralGovernment AgenciesGOVERNANCE, Issue 2 2001Oliver James At the same time as many researchers in public administration are suggesting the emergence of similar New Public Management (NPM) forms in Organization for Economic Co-operation and Development (OECD) countries, a substantial number of those working in comparative political economy are rediscovering differences between countries. This paper explores a key component of NPM,business-like central government agencies,in four countries: the UK, the U.S., Germany, and Japan. So far, the private sector side of the NPM story has largely been neglected. However, the business-like agency model as developed in the UK was influenced by the Anglo-American system of corporate governance. In comparative political economy, the Anglo-American system is seen as different from that in Germany or Japan. These differences are important for understanding transfer through emulation of the UK agency model by policy-makers in other countries. An apparent inconsistency may be developing, with governments using an NPM form based on an Anglo-American model of business that is far from universal in business itself. [source] Do social inequalities exist in terms of the prevention, diagnosis, treatment, control and monitoring of diabetes?HEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 6 2010A systematic review Abstract The major increase in the prevalence of diabetes mellitus (DM) has led to the study of social inequalities in health-care. The aim of this study is to establish the possible existence of social inequalities in the prevention, diagnosis, treatment, control and monitoring of diabetes in Organisation for Economic Co-operation and Development (OECD) countries which have universal healthcare systems. We searched MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews for all relevant articles published up to 15 December 2007. We included observational studies carried out in OECD countries with universal healthcare systems in place that investigate social inequalities in the provision of health-care to diabetes patients. Two independent reviewers carried out the critical assessment using the STROBE tool items considered most adequate for the evaluation of the methodological quality. We selected 41 articles from which we critically assessed 25 (18 cross-sectional, 6 cohorts, 1 case-control). Consistency among the article results was found regarding the existence of ethnic inequalities in treatment, metabolic control and use of healthcare services. Socioeconomic inequalities were also found in the diagnosis and control of the disease, but no evidence of any gender inequalities was found. In general, the methodological quality of the articles was moderate with insufficient information in the majority of cases to rule out bias. This review shows that even in countries with a significant level of economic development and which have universal healthcare systems in place which endeavour to provide medical care to the entire population, socioeconomic and ethnic inequalities can be identified in the provision of health-care to DM sufferers. However, higher quality and follow-up articles are needed to confirm these results. [source] Examining the Impact of Opportunity Bursaries on the Financial Circumstances and Attitudes of Undergraduate Students in EnglandHIGHER EDUCATION QUARTERLY, Issue 2 2009Anne West Notwithstanding the expansion of higher education across the OECD, there continues to be concern about the levels of participation amongst those from disadvantaged backgrounds. In response to this, a new form of financial support for students from low-income families, the ,opportunity bursary', was introduced for a limited period in England from 2001/02. Surveys of two cohorts of opportunity-bursary applicants were carried out and these suggested possible psychological, behavioural and economic impacts. Fewer opportunity-bursary recipients than non-recipients reported that part-time work had interfered with their studies and more reported that the bursary had made them less worried about meeting the costs of going to university. There was some evidence that the scheme led to increased retention in the first year of university study; it also appeared to lead to lower levels of debt, in particular bank overdrafts or credit card debt. [source] States, Social Policies and Globalisations Arguing on the Right Terrain?IDS BULLETIN, Issue 4 2000Mick Moore Summaries The debate about future social policies in OECD countries is framed in the light of rich country concerns, notably of a ,welfare state at risk'. Because globalisation processes can plausibly be presented as a major source of threat, there is a temptation to generalise the analysis globally, and to assume that social policy issues in poor countries are fundamentally the same as in OECD states. The debate about the future of social policy in poor countries should not be framed in terms of OECD concerns. Three more specific points underpin this general argument: (a) Economic globalisation is not necessarily a threat. There are good historical reasons for believing that it may create political pressures to extend as well as to shrink social provision in poor countries; (b) There is a fundamental problem of state incapacity in much of the poor world that makes many OECD-based arguments about the proper role of the state appear redundant. Greater state capacity will itself lead to more effective social policies; and (c) It makes little sense for poor countries to resist, on grounds of potential adverse impacts on social policy, the trends toward the adoption of either New Public Management practices or the broader shift from ,positive' to regulatory states. Whatever changes occur in the architecture of poor states, more effective regulation will remain an urgent need. [source] Globalization, Financial Crisis, and Industrial Relations: The Case of South KoreaINDUSTRIAL RELATIONS, Issue 3 2003Dong-one Kim The South Korean case shows that the globalization trend in the 1990s and the 1997,1998 financial crisis had two contrasting effects on labor rights. First, these developments resulted in negative labor market outcomes: increased unemployment, greater use of contingent workers, and widened income inequalities. On the other hand, they led international organizations such as the Organization for Economic Co-operation and Development (OECD) and the International Labor Organization (ILO) to play important roles in improving labor standards in Korea. Also, continued restructuring drives prompted unions to merge into industrial unions and wage strikes with increased frequency and intensity. Contrary to the common belief, the Korean case shows that globalization and intensified competition resulted in stronger and strategic responses from labor by stimulating employees' interest in and reliance on trade unionism. [source] Animal use replacement, reduction, and refinement: Development of an integrated testing strategy for bioconcentration of chemicals in fish,INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, Issue 1 2007Watze de Wolf Abstract When addressing the use of fish for the environmental safety of chemicals and effluents, there are many opportunities for applying the principles of the 3Rs: Reduce, Refine, and Replace. The current environmental regulatory testing strategy for bioconcentration and secondary poisoning has been reviewed, and alternative approaches that provide useful information are described. Several approaches can be used to reduce the number of fish used in the Organization for Economic Cooperation and Development (OECD) Test Guideline 305, including alternative in vivo test methods such as the dietary accumulation test and the static exposure approach. The best replacement approach would seem to use read-across, chemical grouping, and quantitative structure-activity relationships with an assessment of the key processes in bioconcentration: Adsorption, distribution, metabolism, and excretion. Biomimetic extraction has particular usefulness in addressing bioavailable chemicals and is in some circumstances capable of predicting uptake. Use of alternative organisms such as invertebrates should also be considered. A single cut-off value for molecular weight and size beyond which no absorption will take place cannot be identified. Recommendations for their use in bioaccumulative (B) categorization schemes are provided. Assessment of biotransformation with in vitro assays and in silico approaches holds significant promise. Further research is needed to identify their variability and confidence limits and the ways to use this as a basis to estimate bioconcentration factors. A tiered bioconcentration testing strategy has been developed taking account of the alternatives discussed. [source] The roles of science and technology in energy and environment research and developmentINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 13 2001Ibrahim Dincer Abstract Countries are becoming increasingly aware of the importance of science and technology in relation to national development and the necessity of formulating a concise science and technology policy. The need to strengthen and orient the scientific and technological infrastructure in line with national development goals, through more effective use of an available qualified work force and the higher education system, is becoming widely recognized. Consequently, appropriate methods of assessing the impact of science and technology on national development are needed so that efforts are concentrated on areas potentially having substantial impacts. Numerous planning studies have been undertaken to this end, particularly by international organizations such as UNESCO, UNIDO, OECD and IEA. This study examines the inter-relationships of the disciplines of science and technology with energy and environment research and development (R&D) activities, particularly for developing countries. The connections between these topics are discussed along with some basic methods that can be used to exploit the relations. Some illustrative examples are presented. It is anticipated that the present study will serve as a preliminary step for more comprehensive work by providing an example of the utilization of formal methods in formulating science and technology policy for energy and environment R&D. Copyright © 2001 John Wiley & Sons, Ltd. [source] Multilateral Trade and Agricultural Policy Reforms in Sugar MarketsJOURNAL OF AGRICULTURAL ECONOMICS, Issue 1 2006Amani Elobeid Q18; F10 Abstract We analyse the impact of trade liberalisation, removal of production subsidies and elimination of consumption distortions in world sugar markets using a partial-equilibrium international sugar model calibrated on 2002 market data and current policies. The removal of trade distortions alone induces a 27% price increase while the removal of all trade and production distortions induces a 48% increase in 2011/2012 relative to the baseline. Aggregate trade expands moderately, but location of production and trade patterns change substantially. Protectionist Organisation for Economic Co-operation and Development (OECD) countries (the EU, Japan, the US) experience an import expansion or export reduction and a significant contraction of production in unfettered markets. Competitive producers in both OECD countries (Australia) and non-OECD countries (Brazil, Cuba), and even some protected producers (Indonesia, Turkey), expand production when all distortions are removed. Consumption distortions have marginal impacts on world markets and the location of production. We discuss the significance of these results in the context of mounting pressures to increase market access in highly protected OECD countries and the impact on non-OECD countries. [source] Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assayJOURNAL OF APPLIED TOXICOLOGY, Issue 1 2006Masahiro Takeyoshi Abstract The murine local lymph node assay (LLNA) is currently recognized as a stand-alone test method for determining the skin sensitizing potential of chemicals. It has been incorporated into the official test guidelines published by some authorities, including the OECD. To avoid the use of radioisotopes, efforts have been made recently to develop non-radioisotopic modifications of the LLNA. A non-radioisotopic modification of the LLNA was developed previously using 5-bromo-2,-deoxyuridine (BrdU) incorporation (non-RI LLNA). However, the non-RI LLNA was found to be somewhat less sensitive than the standard assay. This study reports the advantage of using mice of the CBA/N strain in the non-RI LLNA to improve the sensitivity of this method. The non-RI LLNA was performed using CBA/JN and CBA/N mice exposed to one of four confirmed skin sensitizers, 2,4-dinitrochlorobenzene (DNCB), eugenol (EG), isoeugenol (IEG) or , -hexylcinnamic aldehyde (HCA), and to one non-sensitizer, propylene glycol (PG). The EC3 values for DNCB, IEG, EG, HCA and PG were calculated to be 0.1%, 9.6%, 40.6%, 45.5% and >50% in CBA/JN mice and 0.08%, 1.9%, 10.7%, 20.3% and >50% in CBA/N mice, respectively. The EC3 values for DNCB, IEG, EG, HCA and PG in the standard LLNA using CBA/Ca mice and radioisotopes were reported elsewhere as being 0.08%, 1.3%, 13.0%, 8.0% and >50%, respectively. The EC3 values derived from the CBA/N mice in the non-RI LLNA were nearly equivalent to the EC3 values obtained using the standard radioisotopic LLNA with CBA/Ca mice. These data suggest that the use of CBA/N mice may provide a realistic opportunity to develop a version of the LLNA that does not have a requirement for the use of radioisotopes, but which nevertheless has sensitivity approaching, or comparable to, the standard method. Copyright © 2005 John Wiley & Sons, Ltd. [source] Building Material Flow Accounts in the United StatesJOURNAL OF INDUSTRIAL ECOLOGY, Issue 5-6 2008A Case Study in Public Sector Innovation Summary Building a national system of material flow accounts in the United States could be an important step toward natural resource sustainability. But the task will not be as simple as "If you build it, they will come." The key to understanding the status of and prospects for official material flow accounts in the United States is to see the picture from the point of view of public sector and environmental innovation generally, rather than from the point of view of building the details of the accounts themselves. A simple model of public sector innovation helps explain what is happening and what needs to happen to make further progress. The model used here has four principal elements: methods, organizational capacity, demand, and actual use. The details and sequence of these elements vary in different situations, but all four must be present for successful innovations. Although aspects of culture, innovation, and government bureaucracy differ from country to country, the basic model appears to be similar across borders, at least in countries belonging to the Organisation for Economic Cooperation and Development (OECD). Seen this way, recent events in the United States indicate that (1) there is significant potential for such accounts; (2) the United States is moving toward creating them, although not in a systematic manner, which means that the progression and eventual outcome are uncertain; and (3) there are ways for the research community to participate very positively in the public process. [source] Do Investors Really Value Corporate Governance?JOURNAL OF INTERNATIONAL FINANCIAL MANAGEMENT & ACCOUNTING, Issue 2 2007Evidence from the Hong Kong Market To examine the relation between corporate governance and firm value, we develop an instrument to assess the corporate governance practices of listed companies in Hong Kong. Based on the Revised OECD Principles of Corporate Governance (OECD) and the Code of Best Practices (HKEx), we construct a corporate governance index (CGI) for Hong Kong listed companies. Unlike measures used in other studies, the CGI score reflects the presence of good corporate governance practices as well as variation in the quality of corporate governance practices. Empirical evidence shows that a company's market valuation is positively related to its overall CGI score, a composite measure of a firm's corporate governance practices. We also find that the transparency component of the CGI score drives the relation with market valuation. In summary, this study provides supporting evidence for the notion that, in Hong Kong, good corporate governance practices are consistent with value maximization. [source] Competitive Cities in the Global Economy by Organisation for Economic Co-operation and Development (OECD)JOURNAL OF REGIONAL SCIENCE, Issue 5 2008Eva Kiss No abstract is available for this article. [source] Negotiating Globalization: Global Scripts and Intermediation in the Construction of Asian Insolvency RegimesLAW & SOCIAL INQUIRY, Issue 3 2006Bruce G. Carruthers This article draws from a larger research project on the globalization of bankruptcy law that includes (1) a time-series analysis of all bankruptcy reforms worldwide from 1973 to 1998; (2) participation observation, several hundred interviews and documentary analysis of international financial institutions (IMF, World Bank, Asian Development Bank, European Bank for Reconstruction and Development), international professional associations (International Bar Association, International Federation of Insolvency Practitioners), and world governance organizations (OECD, U.N. Commission on International Trade Law); and (3) case studies of Indonesia, Korea, and China. The globalization of law is a negotiated process. Our research on international organizations and case studies of China, Indonesia, and South Korea indicates that negotiation of the global/local relationship varies by the vulnerability of a country to global forces. Nation-states vary (1) in their balance of power vis-à-vis global actors; and (2) in their social and cultural distance from the global. Yet even where the global/local gap is wide and the asymmetry of power is pronounced, local responses to global pressures are negotiated as much as imposed. Negotiating globalization relies on direct and mediated interactions by several types of intermediaries who translate global scripts into four kinds of outcomes. The impact of intermediaries in this process varies by the phase of the reform in which they participate. Finally, globalizing law proceeds through recursive cycles of lawmaking and law implementation. [source] How Many Brains Does It Take to Build a New Light: Knowledge Management Challenges of a Transdisciplinary ProjectMIND, BRAIN, AND EDUCATION, Issue 1 2009Bruno Della Chiesa ABSTRACT, The Organization for Economic Cooperation and Development's (OECD) Center for Educational Research and Innovation (CERI) carried out the Learning Sciences and Brain Research project (1999,2007) to investigate how neuroscience research can inform education policy and practice. This transdisciplinary project brought many challenges. Within the political community, participation in the project varied, with some countries resisting approval of the project altogether, in the beginning. In the neuroscientific community, participants struggled to represent their knowledge in a way that would be meaningful and relevant to educators. Within the educational community, response to the project varied, with many educational researchers resisting it for fear that neuroscience research might make their work obsolete. Achieving dialogue among these communities was even more challenging. One clear obstacle was that participants had difficulty recognizing tacit knowledge in their own field and making this knowledge explicit for partners in other fields. This article analyzes these challenges through a knowledge management framework. [source] | ||||||||||||||||||||||||||||