Novel Single (novel + single)

Distribution by Scientific Domains

Terms modified by Novel Single

  • novel single nucleotide polymorphism

  • Selected Abstracts

    Promiscuous Zinc-Dependent Acylase-Mediated One-Pot Synthesis of Monosaccharide-Containing Pyrimidine Derivatives in Organic Medium

    Qi Wu
    Abstract A facile one-pot synthesis route to monosaccharide-containing pyrimidine derivatives was developed by combining the two types of catalytic activities of one enzyme in an organic medium, i.e., the Michael addition/acylation activities of zinc-dependent D -aminoacylase (DA) from Escherichia coli. First, the stepwise approach was investigated. DA showed higher activity towards the Michael addition than acylation in this reaction system. The enzymatic Michael additions of pyrimidines to vinyl acrylate proceeded very rapidly and the initial reaction rates for the Michael addition of pyrimidines to vinyl acrylate were 7.2,16.5,mM,min,1. The catalytic specificity of aminoacylases toward Michael addition was demonstrated by the combination of different control experiments. Then, the two steps could be performed in one pot and a single aminoacylase catalyzed one-pot biotransformation was constructed. Using this strategy, a series of saccharide-pyrimidine complexes with potentially biological and pharmacological applications was prepared efficiently. This high Michael addition activity of zinc-dependent aminoacylases and the novel single aminoacylase-catalyzed one-pot synthesis combining two catalytic activities in vitro is of practical significance in expanding the application of enzymes and in the evolution of new biocatalysts. [source]

    First Experiences for Pulmonary Vein Isolation with the High-Density Mesh Ablator (HDMA): A Novel Mesh Electrode Catheter for Both Mapping and Radiofrequency Delivery in a Single Unit

    Background: Interventional therapy of atrial fibrillation (AF) is often associated with long examination and fluoroscopy times. The use of mapping catheters in addition to the ablation catheter requires multiple transseptal sheaths for left atrial access. Objectives: The purpose of this prospective study was to evaluate feasibility and safety of pulmonary vein (PV) isolation using the high-density mesh ablator (HDMA), a novel single, expandable electrode catheter for both mapping and radiofrequency (RF) delivery at the left atrium/PV junctions. Methods: Twenty-six patients with highly symptomatic paroxysmal AF (14, 53.8%) and persistent AF (12, 46.2%) were studied. Segmental PV isolation via the HDMA was performed using a customized pulsed RF energy delivery program (target temperature 55,60C, power 70,100 W, 600,900 seconds RF application time/PV). Results: All 104 PVs in 26 patients could be ablated by the HDMA. Segmental PV isolation was achieved with a mean of 3.25 1.4 RF applications for a mean of 603 185 seconds. Entrance conduction block was obtained in 94.2% of all PV. The mean total procedure and fluoroscopy time was 159.0 32 minutes and 33.5 8.6 minutes, respectively. None of the patients experienced severe acute complications. After 3 months no PV stenosis was observed, and 85.6% and 41.6% of the patients with PAF and persistent AF, respectively, did not report symptomatic AF. Conclusions: In this first study of PV isolation using the HDMA, our findings suggest that this method is safe and yields good primary success rates. The HDMA simplifies AF ablation, favorably impacting procedure and fluoroscopy times. [source]

    Single linearly polarized, widely tunable Yb3+ -doped fiber laser with alternative polarization and wavelength

    D.-F. Liu
    Abstract A novel single linearly polarized, widely tunable Yb3+ -doped fiber laser with alternative two orthogonal polarization (wavelength) laser beams was proposed and demonstrated experimentally. Using a polarization beam splitting (PBS) as the separating of the two tunable laser beams in a linear Yb3+ -doped fiber cavity, the laser generates two alternatively tunable wavelength laser. Beam 1 is from 1001.9 nm to 1083.4 nm with single linear polarization and 368 mW (at 1030.1 nm) output power. Beam 2 is from 1000.0 nm to 1082.5 nm with 395 mW (at 1018.4 nm) output power and orthogonally polarized with beam 1. In addition, the laser can also work in widely tunable two wavelengths oscillating simultaneously. ( 2010 by Astro Ltd., Published exclusively by WILEY-VCH Verlag GmbH & Co. KGaA) [source]

    Spectroscopic phase modulated ellipsometry in application to some novel single and polycrystalline ternary compounds

    N. Mamedov
    Abstract The results of the application of the spectroscopic phase modulated ellipsometry (SPME) to a series of novel ternary compounds from anisotropic to polycrystalline are presented to show the high effectiveness of this optical technique with regard to the dielectric function of the new materials. Besides, SPME in specular reflection mode to study the polarization degree of the light reflected at specular angle is shown to be very informative in determination of the best conditions for optical measurements on rough surfaces such as, for example, surfaces of the polycrystalline ternary thiogallate compounds studied in this work. An incoherent approach relating the measured depolarization with the surface variance and optical constants of a material or thin film is proposed. ( 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]