Novel Manner (novel + manner)

Distribution by Scientific Domains

Selected Abstracts

Model population analysis for variable selection

Hong-Dong Li
Abstract To build a credible model for given chemical or biological or clinical data, it may be helpful to first get somewhat better insight into the data itself before modeling and then to present the statistically stable results derived from a large number of sub-models established only on one dataset with the aid of Monte Carlo Sampling (MCS). In the present work, a concept model population analysis (MPA) is developed. Briefly, MPA could be considered as a general framework for developing new methods by statistically analyzing some interesting parameters (regression coefficients, prediction errors, etc.) of a number of sub-models. New methods are expected to be developed by making full use of the interesting parameter in a novel manner. In this work, the elements of MPA are first considered and described. Then, the applications for variable selection and model assessment are emphasized with the help of MPA. Copyright © 2010 John Wiley & Sons, Ltd. [source]


Abstract: In a series of influential articles, George Bealer argues for the autonomy of philosophical knowledge on the basis that philosophically known truths must be necessary truths. The main point of his argument is that the truths investigated by the sciences are contingent truths to be discovered a posteriori by observation, while the truths of philosophy are necessary truths to be discovered a priori by intuition. The project of assimilating philosophy to the sciences is supposed to be rendered illegitimate by the more or less sharp distinction in these characteristic methods and its modal basis. In this article Bealer's particular way of drawing the distinction between philosophy and science is challenged in a novel manner, and thereby philosophical naturalism is further defended. [source]

Ground penetrating radar survey and stratigraphic interpretation of the Plan du Lac rock glaciers, Vanoise Massif, northern French Alps

Sébastien Monnier
Abstract Internal boundaries of the Plan du Lac rock glaciers in the northern French Alps were investigated using ground-penetrating radar (GPR) and were correlated with the surface morphology. Data collected using 50,MHz antennae along three profiles were processed in a novel manner by applying modulated automatic gain control to discriminate reflection events according to coherence and continuity patterns. Based on the GPR and morphological analyses, the stratigraphy appears complex, with prominent internal boundaries dividing the features into several depositional units, interpreted as sequential creeping or thrusting events. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Topical treatment with aqueous solutions of rofleponide palmitate and budesonide in a pollen-season model of allergic rhinitis

C. Ahlström-Emanuelsson
Summary Background Rofleponide palmitate is an esterified glucocorticosteroid pro-drug with a promising pre-clinical profile designed to deliver topical airway treatment for allergic rhinitis and asthma in a novel manner. Thus, the rofleponide palmitate pro-drug is designed to provide topical exposure of the mucosa to the inactive lipophilic drug, which would be locally metabolized to the more hydrophilic and readily cleared drug rofleponide. Objective To examine whether rofleponide palmitate affects nasal symptoms and peak inspiratory flow (PIF) in a pollen-season model of allergic rhinitis and to compare any such effects with those of another glucocorticosteroid (i.e., budesonide). Methods During the pollen-free season, 40 patients with strictly seasonal allergic rhinitis received topical nasal spray treatment with an aqueous solution of rofleponide palmitate 400 ,g and an aqueous solution of budesonide 128 ,g once daily for 10 days in a double-blind, placebo-controlled, and crossover study. After 3 days of drug treatment, individualized allergen challenges were given once daily for 7 days while the treatment continued. The washout periods between each of the challenge series were 2 weeks. Nasal symptoms and PIF were recorded in the morning and evening, as well as 10 and 20 min after each allergen challenge. The mean recordings obtained during the last 3 days of the allergen-challenge series, when symptoms were established and when the treatment had lasted for 8,10 days, were used in the analysis. Results Both active treatments reduced nasal symptoms and improved nasal PIF compared with placebo (P<0.01,0.001). There was no overall difference in efficacy between rofleponide palmitate 400 ,g and budesonide 128 ,g. Conclusions Topical treatment with aqueous solutions of rofleponide palmitate attenuates nasal symptoms and improves nasal PIF in allergic rhinitis. The overall efficacy of 400 ,g of rofleponide palmitate is similar to that of 128 ,g of budesonide in the pollen-season model used in this study. [source]