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Archival Material (archival + material)
Selected AbstractsMembranous expression of glucose transporter-1 protein (GLUT-1) in embryonal neoplasms of the central nervous systemNEUROPATHOLOGY & APPLIED NEUROBIOLOGY, Issue 1 2000M. Loda The human erythrocyte GLUT-1 is a transmembrane protein which facilitates transport of glucose in the cell in an energy-independent fashion. Neuroectodermal stem cells show strong membrane immunoreactivitry with this marker at early developmental stages in rodents. Membranous expression by undifferentiated neuroectodermal cells gradually decreases while GLUT-1 becomes confined to the endothelial cells, when these acquire blood,brain barrier function. We thus sought to determine whether GLUT-1 expression was limited to embryonal neoplasms of the central nervous system (CNS) which are presumably derived from developmentally arrested neuroectodermal stem cells. Archival material of 40 primary CNS neoplasms were examined for immunoreactivity with anti-GLUT-1. This included both non-embryonal neoplasms (18 astrocytic tumours, one ependymoma and three oligodendroglioma) and embryonal neoplasms (12 cerebellar medulloblastomas, four supratentorial PNETs and two atypical teratoid/rhabdoid tumours (AT/RhT)). In addition, cell lines and nude mice xenografts derived from both undifferentiated and differentiated tumours were assessed for GLUT-1 immunoreactivity by both immunohistochemistry and Western blotting. All embryonal tumours, MBs and PNET xenografts consistently showed GLUT-1 membrane staining. Non-embryonal neoplasms were negative except for vascular staining. Membrane protein fraction of embryonal tumours cell lines immunoreacted by immunoblot with GLUT-1, whereas the glioblastoma cell line was negative. Expression of GLUT-1 supports the stem cell nature of the cells of origin of MBs, supratentorial PNET and AT/RhTs. As a result, GLUT-1 is a useful marker to define the embryonal nature of CNS neoplasms. [source] Public Opinion and the Contradictions of Jimmy Carter's Foreign PolicyPRESIDENTIAL STUDIES QUARTERLY, Issue 4 2000ANDREW Z. KATZ President Jimmy Carter's failure to achieve popular support for his foreign policy is commonly attributed to his disregard of public opinion. The author evaluates this perception by examining the Carter administration's use of polls in the areas of human rights and U.S.-Soviet relations. Archival material confirms that Carter did not ignore public opinion; rather, his polling operation did not provide the White House with a complete and objective portrait of public attitudes. Carter's team assumed that public opinion on foreign policy was malleable and lacked structure. Thus, no effort was made to determine whether the contradictions pollsters found on the surface were actually held together by an underlying structure. Therefore, the Carter White House had neither an accurate gauge of public attitudes nor an understanding of those attitudes sufficient to build support for its policies. [source] Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40APMIS, Issue 7 2009SŘREN DAUGAARD Chondroid tumors comprise a heterogenous group of benign to overt malignant neoplasms, which may be difficult to differentiate from one another by histological examination. A group of 43 such tumors was stained with nine relevant antibodies in an attempt to find consistent marker profile(s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. All 25 chondrosarcomas showed a positive staining reaction for D2-40, none for actin and CD117, and a partial reactivity for bcl-2 (36%). Chondroblastomas (5/5) and chondromyxoid fibromas (2/5) were the only tumors with a positive reaction for actin, and all chondroblastomas (n=5) and extraskeletal myxoid chondrosarcomas (n=3) were positive for bcl-2. In contrast to all other tumors, two of three extraskeletal myxoid chondrosarcomas were also positive for CD17 and negative for osteonectin, cox-2, mdm-2 and actin. All five chordomas were negative for D2-40 and positive for mdm-2 and YKL-40. The diagnosis of chondrosarcoma may be aided by its positivity for D2-40 and YKL-40 and its lack of reactivity for actin and CD117. This should be seen in the light of no reaction for D2-40 in chordomas and a corresponding lack of reaction for osteonectin, cox-2, mdm-2 and actin in extraskeletal myxoid chondrosarcomas. A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas. [source] The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomasCELL PROLIFERATION, Issue 1 2005L. Maes However, a number of these tumours recur even after total resection. The aim of this study is to evaluate the prognostic significance for recurrence of the human telomerase catalytic subunit (hTERT) in the cells of meningiomas. The expression of hTERT-protein can be evaluated by immunohistochemical staining using a monoclonal antibody against hTERT (clone 44F42, NCL-L-hTERT). The interdependence between tumour recurrence and cell proliferation in this study is analysed by Ki-67 immunoreactivity (clone MIB-1). Archival material from 29 non-recurrent and 32 recurrent tumours has been evaluated, including specimens from World Health Organization (WHO) stages I (n = 73), II (n = 2) and III (n = 12). Although the tumours were categorized as benign meningiomas following the WHO classification, recurrence in 22 of 50 cases did not correlate with the tumour stage. For hTERT staining, the following results were found for nucleolar and total nuclear staining, respectively: non-recurrent meningiomas, 2.9% (± 7.7) and 3.0% (± 8.0); recurrent meningiomas at first resection, 16.8% (± 19.7) and 31.6% (± 30.2). Concerning the Ki-67 labelling index (LI): for the group of non-recurrent meningiomas, results were 2.1% (± 1.7) and for the recurrent group at first resection, 1.7% (± 2.0). A significant difference was seen for the hTERT staining (P < 0.001) between the non-recurrent and recurrent meningiomas, whereas no statistical significance was found for Ki-67. In conclusion hTERT-positive meningiomas had a high incidence for recurrence. Ki-67 was a good marker of cell proliferation status of the tumours, but did not correlate with recurrence; thus, hTERT alone seemed to be a potential predictor for recurrence. [source] The natural endocast of Taung (Australopithecus africanus): Insights from the unpublished papers of Raymond Arthur DartAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue S49 2009Dean Falk Abstract Dart's 1925 announcement of Australopithecus africanus (Dart: Nature 115 [1925] 195,199) was highly controversial, partly because of an interpretation of the Taung natural endocast that rested on an erroneous identification of the lambdoid suture as the lunate sulcus. Unpublished materials from the University of Witwatersrand Archives (Dart, unpublished material) reveal that Dart reacted to the controversy by: 1) describing and illustrating the entire sulcal pattern on the Taung endocast, in contrast to just two sulcal identifications in 1925, 2) identifying a hypothetical part of the lambdoid suture and revising his description of the lunate sulcus, and 3) bolstering his argument that Taung's brain was advanced by detailing expansions in three significant cortical association areas. Four unpublished illustrations of Dart's identifications for sulci and sutures on the Taung endocast are compared here with those published by Keith (Keith: New discoveries relating to the antiquity of man (1931)), Schepers (Schepers: The endocranial casts of the South African ape-men. In: Broom R, Schepers GWH, editors. The South African fossil ape-men; the Australopithecinae [1946] p 155,272), and Falk (Falk: Am J Phys Anthropol 53 [1980] 525,539), and the thorny issue of the location of the lunate sulcus is revisited in light of new information. Archival materials reveal that Dart believed that Taung's brain was reorganized globally rather than in a mosaic manner, and that the shapes of certain cortical association areas showed that Australopithecus was closer to Pithecanthropus than to the living apes. Although a few of Dart's hitherto-unpublished sulcal identifications, including his revision for the lunate sulcus, were questionable, his claim that the Taung endocast reproduced a shape that was advanced toward a human condition in its prefrontal cortex and caudally protruded occipital lobe was correct. Yrbk Phys Anthropol 52:49,65, 2009. © 2009 Wiley-Liss, Inc. [source] How the 1977 World Health Organization report on alcohol-related disabilities came to be written: a provisional analysisADDICTION, Issue 11 2007Griffith Edwards ABSTRACT Background In 1977 the World Health Organization (WHO) published a report entitled ,Alcohol-Related Disabilities'. The crucial contribution of this report was to differentiate between alcohol dependence, on one hand, and alcohol-related disabilities (or problems) on the other hand. Essentially, it offered a bi-axial mapping of the field of concern. Aims This paper seeks to identify the multiple influences which shaped the evolution of this report. Methods Use is made of unpublished archival material and recall of personal involvement, together with relevant published material. Results Three major influences made it possible to move beyond the confines of previous WHO thinking on alcohol: the multi-disciplinary nature of the input; the internationality of the enterprise; and the expectations set that the concepts developed should speak to the practical world. Conclusions The arena of drug and alcohol policy has, for more than a century, been rich in its reports. This case study, although limited in its immediate content, points to the need for further analysis of the history of such reports. [source] Notes on the origins of Epilepsia and the International League Against EpilepsyEPILEPSIA, Issue 3 2009Simon D. Shorvon Summary The recent discovery of archival material has shed interesting light on the origins of Epilepsia and also the International League Against Epilepsy (ILAE). The idea of an international journal devoted to epilepsy seems first to have arisen from talks between Dr. L. J. J. Muskens and Dr. W. Aldren Turner in 1905. A protracted series of subsequent letters between Muskens and a Haarlem publisher show how the idea slowly took shape. The committee of patronage, editorial board, and editorial assistants was probably first approached at the First International Congress of Psychiatry, Neurology, Psychology, and Nursing of the Insane, held in Amsterdam in 1907. At this meeting, the concept of an international organization to fight epilepsy (to become the ILAE) was also first proposed in public, again by Muskens. The concept of the ILAE was clearly modeled on another international organization,the International Commission for the Study of the Causes of Mental Diseases and Their Prophylaxis. This Commission had been first publicly proposed in 1906 by Ludwig Frank, at the Second International Congress for the Care and Treatment of the Insane. The proposed Commission and ILAE shared many features, aims, and personnel. Despite an auspicious start, the International Commission was prevented by personal and political differences from ever actually coming into being. However, the first issue of Epilepsia appeared in March 1909 and the ILAE was inaugurated in August 1909; and both have flourished and celebrate their centenaries this year. [source] Things Still To Be Done on the Still-Face EffectINFANCY, Issue 4 2003E. Z. Tronick Adamson and Frick (2003/this issue) have written a fine and challenging review of the research on the still-face. Of special value is their placement of the face-to-face still-face (FFSF) paradigm in a historical framework, which permits us to see how much about the still-face effect and infant functioning we have learned in the past 30 years. Their review led me to think about several issues. First was the issue of whether or not to standardize the FFSF paradigm. Second, Adamson and Frick argue the still-face put the "infant's reaction in a new interpretive frame," but it is a reaction that still challenges our "understanding of young infants' social, emotional, and cognitive capacities." Thus, I would like to discuss explanations of the still-face effect. Last, I discuss some suggestions for further research. For an elaborated version of this article, additional archival material is located at http:www.infancyarchives.com. [source] Australia and the DPRK: A Sixty-Year RelationshipPACIFIC FOCUS, Issue 3 2008Leonid A. Petrov The record of relations between Australia and the Democratic People's Republic of Korea (DPRK) is one of the oddest and most checkered in diplomatic history. A short period of recognition and cultural cooperation was followed by the resurgent nuclear crisis and the drug-smuggling ship incident, which proved to be hard tests for this shaky relationship. The closure of the DPRK embassy to Australia in January 2008 once again left the public confused and the pundits guessing about the true reasons behind this quiet démarche. This paper examines the major ups and downs in the history of Australia,DPRK bilateral relations and offers some clues as to what might have been wrong in Australian policy and attitudes toward the isolated communist nation. Australian involvement in the US-led Proliferation Security Initiative and the ban on the supply of "luxury goods" to North Korea will be discussed. Interviews with serving and veteran diplomats, declassified Department of Foreign Affairs and Trade archival material and international media reports provided the basis for this research. [source] Functional allelic loss detected at the protein level in archival human tumours using allele-specific E-cadherin monoclonal antibodiesTHE JOURNAL OF PATHOLOGY, Issue 5 2002Karl-Friedrich Becker Abstract Immunohistochemical analysis has been used to show that expression of the homophilic cell-to-cell adhesion molecule, E-cadherin, is frequently altered in human cancers, including gastric and breast carcinoma. Besides genetic down-regulation, structural mutations such as in-frame deletions of exon 8 and exon 9 were frequently found; these may affect the binding of monoclonal antibodies used for immunohistochemical analysis. In this study it was found that antibodies HECD-1 and E9, two monoclonal antibodies often used in E-cadherin immunoanalysis, react with epitopes present at least in part in exon 8 and exon 9, respectively. This study generated and characterized a mutation-specific monoclonal antibody, E-cad delta 8-1, reacting with the mutant protein lacking exon 8 but not with the wild-type molecule. By using E-cad delta 8-1 and HECD-1, it was possible separately to analyse the immunoreactivity of mutant and normal E-cadherin proteins, respectively, in an allele-specific manner in archival material. A similar analysis was performed using E9 and the previously characterized mutation-specific antibody E-cad delta 9-1. Typically, in gastric and breast cancer harbouring E-cadherin splice site gene mutations, the mutant proteins were expressed but the wild-type protein was not detected in malignant tissues. These results indicate that variant-specific monoclonal antibodies can be used to identify differentially expressed E-cadherin proteins. For immunohistochemical analysis of E-cadherin, at least two different monoclonal antibodies should be used to exclude alterations of the epitopes resulting in failure to detect a mutant protein. Copyright © 2002 John Wiley & Sons, Ltd. [source] Immunohistochemical profile of ephrin A4 expression in human osteosarcomaAPMIS, Issue 4 2009ASMAA GABER ABDOU Ephrin receptors and ephrin ligands constitute one of the largest groups of tyrosine kinases. The division of ephrin receptors into type A or type B is determined by their ligand-binding specificities. Ephrin A4 as a ligand has a broad capacity to bind and stimulate different subtypes of ephrin A receptors. Little is known about the role of ephrins generally and ephrin A4 particularly in osteosarcoma. Ephrin A4 was immunohistochemically assessed on archival material from 46 primary osteosarcoma cases, 10 metastatic pulmonary lesions and 20 normal control bone specimens. Ephrin A4 was expressed in 100% of normal bone specimens, in 84.4% of primary osteosarcoma cases and in all metastatic pulmonary lesions. Cytoplasmic and nucleocytoplasmic patterns of ephrin A4 immunoreactivity were observed, with the predominance of the latter pattern in normal bone (100%), and in 43.5% of primary osteosarcoma cases, which showed a higher intensity of expression compared with normal bone (p<0.05). The cytoplasmic pattern is the only staining pattern seen in metastatic cases, which may suggest its role in enhancement of invasion and metastasis. The differences in the distribution of the two patterns of ephrin A4 may indicate a different biological activity of this molecule depending on its localization. The nuclear localization of ephrin A4 requires further investigation to clarify the mechanism and the significance of the nuclear trafficking of ephrin A4. [source] Raman Spectroscopic Analysis of Ancient Egyptian PigmentsARCHAEOMETRY, Issue 4 2001A. Rosalie David The application of FT-Raman spectroscopy and visible Raman microscopy to the non-destructive analysis of pigment specimens excavated from Tell el Amarna by Flinders Petrie in the 1890s has provided information about the chemical composition of the materials used by XVIIIth Dynasty artists in the New Kingdom at the time of King Akhenaten, c. 1340 bc. Comparison of the Raman spectra of the samples labelled ,red and yellow ochre' with documented, archival material from geological collections provided a clear indication of the materials used in the iron(III) oxide/hydroxide system, including ,-hematite, goethite, maghemite, magnetite and lepidocrocite. The yellow,orange specimen labelled ,realgar' proved to be a mixture of realgar and pararealgar; since the specimen had been sheltered from light since its excavation, this could indicate that the ancient Egyptian artists recognized the colour variation and may have used this to effect in their decorations. A specimen of yellow ochre contained goethite, ,-FeO.OH, with particles of crystalline, highly ordered graphite; in contrast, the red ochre specimens contained amorphous carbon particles. [source] FRAMING ROBERT AGGAS: THE PAINTER,STAINERS' COMPANY AND THE ,ENGLISH SCHOOL OF PAINTERS'ART HISTORY, Issue 3 2008RICHARD JOHNS Drawing on unpublished archival material, this essay offers a new understanding of London's Painter,Stainers' Company during the second half of the seventeenth century. Beginning and ending with a discussion of the English painter Robert Aggas, whose Landscape at Sunset became the centrepiece of an ambitious display of paintings within the Painter,Stainers' Hall, the essay identifies the Company as a vital presence within the cultural economy of the early modern capital. A reassessment of the Company's attitude towards overseas painters during the later 1600s points to the cosmopolitan make-up of the self-styled ,English school' of painting, first chronicled in Bainbrigg Buckeridge's influential An Essay towards an English School of Painters (1706). [source] A Mace to Swat Two Blow-Flies: Interpreting the Fitzpatrick and Browne Privilege CaseAUSTRALIAN JOURNAL OF POLITICS AND HISTORY, Issue 1 2009Andrew Moore It is not widely remembered that on 10 June 1955 two men, Raymond Edward Fitzpatrick and Frank Courtenay Browne, were sentenced to gaol for three months on a vote of the Commonwealth House of Representatives for contempt of parliament. Two parliamentary officials, Frank Green and Harry Evans, have dominated scholarly attempts to explain this unusual event. To the former, the privilege case largely reflected the animus of Prime Minister Menzies towards Browne and his desire for revenge. To the latter the matter was a genuine case of contempt. This article revisits the 1955 Bankstown Observer privilege case with the benefit of recently released archival material. It seeks to understand why two citizens were deprived of their liberty without legal representation or redress and to find some compromise between the divergent interpretations proffered by Green and Evans. [source] The Reappraisal of the White Australia Policy against the Background of a Changing Asia, 1945,67,AUSTRALIAN JOURNAL OF POLITICS AND HISTORY, Issue 2 2006Matthew Jordan This paper is concerned with the way in which Australian policy-makers approached the problem of "White Australia" in the years 1945,67. It makes extensive use of original archival material to show how Australia's increasing engagement with Asia in the 1950s and 1960s exercised a direct influence on officials within the Department of Immigration. In response to Australia's changing geopolitical circumstances and the international community's increasing hostility towards racism during this period, Immigration Department officials persuaded the government to introduce a series of piecemeal adjustments which were specifically designed to placate Asian and world opinion. Although cautious, these changes nevertheless involved a corresponding reassessment of the policy's racial assumptions. By accepting in the late 1960s that certain Asians were capable of being integrated into the Australian community, policymakers had discarded the previously inviolable belief that all non-Europeans were unassimilable by virtue of their race. The White Australia Policy, though not entirely defunct by the end of the decade, was nevertheless crumbling under the weight of Australia's new circumstances. [source] Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma,CANCER, Issue 4 2005Dafydd G. Thomas M.D., Ph.D. Abstract BACKGROUND Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of one of several duplicated SSX genes (most notably SSX1 and SSX2) at chromosome Xp11. SYT/SSX1 translocations are seen in nearly three times as many synovial sarcomas as SYT/SSX2 translocations. Although the SYT/SSX2 fusion is usually associated with the monophasic disease pattern, the SYT/SSX1 fusion is present in tumors with biphasic or monophasic patterns. The SYT/SSX1 fusion gene is associated with more aggressive tumor growth and poor outcome. Despite advances in the therapy of local disease, distant metastasis remains the predominant cause of death. Accordingly, there is a need for alternate therapies, such as those recently developed against the receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and HER-2/neu. METHODS Archival specimens of synovial sarcoma (n = 38) representing 30 patients were assessed for EGFR and HER-2/neu protein expression by standard immunohistochemical techniques. To validate the immunohistochemistry results, quantitative real-time polymerase chain reaction (Q-PCR) assays using either fresh and/or archival material was performed. The presence of gene amplification was determined by chromogenic in-situ hybridization. RESULTS EGFR and HER-2/neu protein were detected by immunohistochemistry in 21 of 38 (55.3%) and 20 of 38 (52.6%) synovial specimens, respectively. EGFR immunoreactivity showed a granular and membranous pattern, whereas HER-2/neu immunoreactivity demonstrated only a membrane pattern. Coexpression was observed in 13 of 38 specimens (34.2%). HER-2/neu expression by immunohistochemistry in synovial sarcomas was restricted to tumors with the SYT/SSX1 translocations. Of 6 specimens with SSX2 translocation, none (0%) showed HER-2/neu immunoreactivity and 1 (17%) demonstrated EGFR expression. Q-PCR demonstrated the presence of mRNA for EGFR and HER-2/neu in 19 of 30 specimens (63.3%) and 22 of 30 specimens (73.3%), respectively. EGFR and HER-2/neu were expressed at low concentrations compared with the expression of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). No evidence of gene amplification was observed. CONCLUSIONS EGFR and HER-2/neu are expressed in the majority of patients with SYT/SSX1 synovial sarcomas, albeit at low levels. Treatment with tyrosine kinase inhibitors may represent appropriate alternate therapy for these patients. Cancer 2005. © 2005 American Cancer Society. [source] Androgen receptors frequently are expressed in breast carcinomasCANCER, Issue 4 2003Potential relevance to new therapeutic strategies Abstract BACKGROUND Several studies have demonstrated the biologic and therapeutic significance of estrogen and progesterone receptors (ER and PR) in breast carcinomas. The aim of the current study was to examine the presence of androgen receptors (AR) in breast carcinomas. METHODS Two hundred cases of breast carcinoma, consisting of 145 invasive and 55 noninvasive (ductal carcinoma in situ [DCIS]) lesions, were examined using a monoclonal antibody against AR on formalin-fixed, paraffin-embedded archival material. The results were analyzed for correlations with immunohistochemically determined ER, PR, and HER-2/neu expression. RESULTS Eighty-seven of the 145 cases (60%) of invasive carcinoma and 45 of the 55 cases (82%) of DCIS were AR-positive according to internationally standardized guidelines. The vast majority of Grade 1 carcinomas were positive for AR (90% of invasive Grade 1 carcinomas and 95% of Grade 1 DCIS), whereas in Grade 3 invasive carcinomas and DCIS, positive immunoreactions for AR were observed in 46% and 76% of cases, respectively. Among the cases of Grade 3 carcinoma, 33 invasive carcinomas (39%) and 17 DCIS lesions (68%) were ER-negative but AR-positive. Among Grade 1 carcinomas (invasive and DCIS), not a single case was positive for HER-2/neu, but most cases were intensely positive for AR. In contrast, many invasive Grade 3 carcinomas exhibited agreement between AR status and HER-2/neu status (AR-positive and HER-2/neu-positive, 30.5%; AR-negative and HER-2/neu-negative, 42.5%). CONCLUSIONS Androgen receptors are commonly expressed in DCIS and in invasive breast carcinoma. A significant number of poorly differentiated carcinomas are ER-negative and PR-negative but AR-positive. Immunohistochemical examination of AR would be desirable because it would provide additional information about steroid receptors in breast carcinomas. Cancer 2003;98:703,11. © 2003 American Cancer Society. DOI 10.1002/cncr.11532 [source] Chromosomal anomalies in oligodendroglial tumors are correlated with clinical featuresCANCER, Issue 5 2003M.D., Martin J. van den Bent Ph.D. Abstract BACKGROUND Patients who have oligodendrogliomas (OD) that demonstrate loss of both 1p and 19q appear to have a better prognosis after they receive chemotherapy and radiotherapy compared with patients who have OD without these characteristics. It is unclear whether this improvement in outcome is due only to a better response to treatment. The authors investigated the correlation between genetic and clinical characteristics of OD in 33 patients who received chemotherapy with procarbazine, lomustine, and vincristine for recurrent disease after receiving radiotherapy. METHODS The initial presentation, prior treatments, overall survival, and response to chemotherapy were assessed. The 1p and 19q status in OD lesions was determined with fluorescence in situ hybridization on paraffin embedded, archival material using locus specific probes. P53 mutations were assessed by polymerase chain reaction,single-strand conformation polymorphism analysis and immunohistochemistry for P53; the proliferation index was assessed with the MIB-1 antibody. RESULTS Patients who had OD lesions with a combined loss of 1p and 19q typically presented with low-grade tumors that manifested with seizures of long-standing duration. In contrast, patients who had OD lesions without a combined loss of 1p and 19q usually presented with focal deficits that required immediate treatment. Both the response rate to chemotherapy and the time to disease progression after chemotherapy were significantly better in patients who had a combined loss of 1p and 19. Tumors with classic OD morphology more often had a combined loss of 1p and 19q, although the genotype was better at identifying patients with chemoresponsive tumors. P53 mutations were observed in three tumors, none of which had a combined loss of 1p and 19q. CONCLUSIONS OD lesions with combined a loss of 1p and 19q have a more indolent nature compared with OD lesions that do not have these losses. Virtually all patients with these tumors present with low-grade tumors accompanied by seizures and remain stable for prolonged periods. Future trials must keep these tumor types apart. Cancer 2003;97:1276,84. © 2003 American Cancer Society. DOI 10.1002/cncr.11187 [source] A Serpent without Teeth.CENTAURUS, Issue 2 20071875), The Conservative Transformism of Jean-Baptiste d'Omalius d'Halloy (178 This essay, however, wants to indicate that in the same time period, a more moderate (even conservative) transformism was developed in the well-respected centres of scientific debate. It does so by concentrating on the intellectual trajectory of the Belgian Jean-Baptiste d'Omalius d'Halloy, not only a geologist of European reputation but also a noted conservative and catholic aristocrat. On the basis of previously unused archival material, this essay researches how d'Omalius developed his evolutionist ideas, starting from the lessons he took with Lamarck in the beginning of the 19th century and ending with the last transformist publications he published as a 90-year-old in the 1870s. Furthermore, the essay analyses how d'Omalius adapted Lamarck's transformist ideas to his personal worldview and looks at the tactics he used to open a space for the evolution debate. In this way, it shows a largely unknown aspect of the transforming of transformism in mid-19th-century science. [source] Fashioning victims: Dr. Henry Jones and the plight of Irish Protestants, 1642HISTORICAL RESEARCH, Issue 186 2001Joseph Cope This article explores Dr. Henry Jones's work in conveying first-hand testimony on the Irish rising to English audiences in 1642. It compares Jones's Remonstrance of Diverse Remarkable Passages Concerning the Church and Kingdom of Ireland with the archival materials from which he drew his information. In order to persuade the English parliament and the English people to support charitable projects for Ireland's poor, Jones needed to portray the victims of the rising in a positive light. The resulting image of deserving war victims was broadly sympathetic but in fact reflected a distorted view of the experiences of those despoiled in the rebellion. [source] Controversies of US-USSR Cultural Contacts During the Cold War: The Perspective of Latvian Refugees1JOURNAL OF HISTORICAL SOCIOLOGY, Issue 1 2008IEVA ZAKE While most of the American political and cultural elites saw cultural exchanges with the Soviets as beneficial, the reactions of the émigrés were much more controversial and polarizing. This study reveals the unrecognized side of the Cold War politics as experienced by the refugee groups. The study employs American, Latvian and Soviet publications, memoirs, interviews and archival materials. [source] The Church of England and the Origins of Homosexual Law ReformJOURNAL OF RELIGIOUS HISTORY, Issue 4 2009GRAHAM WILLETT That the Church of England was an active and public supporter of homosexual law reform during the long debate on the issue in England between 1957 and 1967 is reasonably well known. It released reports and documents justifying and arguing for decriminalisation, and its bishops in the House of Lords were among those voting in favour in 1965. In this article, relying upon archival materials that have been only rarely used, I demonstrate that the Church's support went much deeper than is often assumed. Beginning in 1952, a process of theological reconsideration and behind the scenes lobbying lead by a relatively small group of thinkers made the Church an initiator in the reform process. Relying upon Rochon's notion of a "critical community," I offer a description and explanation for the Church's role. [source] Separation and divergence: The untold story of James Robertson's and John Bowlby's theoretical dispute on mother,child separationJOURNAL OF THE HISTORY OF THE BEHAVIORAL SCIENCES, Issue 3 2009Frank C. P. van der Horst The work of Robertson and Bowlby is generally seen as complementary, Robertson being the practically oriented observer and Bowlby focusing on theoretical explanations for Robertson's observations. The authors add to this picture an "untold story" of the collaboration between Robertson and Bowlby: the dispute between the two men that arose in the 1960s about the corollaries of separation and the ensuing personal animosity. On the basis of unique archival materials, this until now little known aspect of the history of attachment theory is extensively documented. The deteriorating relationship between Robertson and Bowlby is described against the background of different currents in psychoanalysis in Britain in the interbellum. © 2009 Wiley Periodicals, Inc. [source] Gleaning signals about the past from cemetery dataAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 1 2010Lisa Sattenspiel Abstract Cemetery headstones provide an easily accessible source of demographic data in human populations. In common with other sources of demographic data, such as skeletal samples, cemetery data may not be representative of the populations from which they were derived. In some circumstances they can be reasonably representative, however, and in such cases they may provide signals about demographic changes in the population that contributed to the cemetery. We present here analyses of burials occurring between 1900 and 1990 at the Columbia Cemetery in Columbia, Missouri. Our analyses, in combination with archival materials relating to infrastructure improvements in Columbia and data on infectious disease mortality in the state of Missouri, show that patterns of death observed in the cemetery data provide evidence for the timing of changes in the health of Columbia's residents. At the time that major improvements in sanitation and hygiene were implemented, burials of individuals dying under age 45 decreased significantly while burials of individuals older than 45 remained relatively high. Furthermore, data on infectious disease mortality indicate significant declines in deaths from water- and milk-borne infections, but no change in mortality from respiratory illnesses. These data also indicate that observed changes occurred about a decade later in Columbia than in large cities and more densely populated states elsewhere in the United States. Thus, this study illustrates the value of cemetery data in helping to fill gaps about how and when different events known to affect patterns of birth and death may have played out across time and space. Am J Phys Anthropol, 2010. © 2009 Wiley-Liss, Inc. [source] | ||||||||||||||||