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Architecture
Kinds of Architecture Terms modified by Architecture Selected AbstractsENDOSCOPIC MICROVASCULAR ARCHITECTURE OF THE PORTAL HYPERTENSIVE GASTRIC MUCOSA ON NARROW BAND IMAGINGDIGESTIVE ENDOSCOPY, Issue 3 2007Seishu Hayashi Background:, We evaluated the endoscopic microvascular architecture of the gastric mucosa in portal hypertension patients using the prototype of narrow band imaging (NBI). Material and Methods:, The study included 103 Helicobacter pylori -negative patients with chronic liver disease (22 without portal hypertension (group 1), 81 with portal hypertension (group 2)). Results:, (i) Abnormality of collecting venules, reddening mucosa, red spots, a mosaic-like pattern, and gastric antral vascular ectasia (GAVE) were observed on the gastric mucosa, and an obscure change in collecting venules (73% vs 14%; P < 0.001), reddening mucosa (49% vs 5%; P < 0.001), red spots (36% vs 5%; P < 0.01) and a mosaic-like pattern (40% vs 5%; P < 0.01) were more frequently observed in group 2 than in group 1. (ii) On magnifying endoscopy with NBI, the mucosa with an obscure change in collecting venules was demonstrated as dilation of the capillaries surrounding the gastric pits in various degrees, and reddening mucosa was observed as extended and swollen gastric pits and various degrees of dilated and convoluted capillaries surrounding the gastric pits. Red spots were demonstrated as extended and swollen gastric pits, dilated and convoluted capillaries surrounding the gastric pits, and intramucosal hemorrhage around these capillaries. GAVE was recognized as partial and marked dilatation of the capillaries surrounding the gastric pits. Conclusion:, Abnormality of collecting venules, swelling of gastric pits, dilatation of capillaries surrounding the gastric pits, intramucosal hemorrhage around capillaries, and partial and marked dilatation of the capillaries were observed on the gastric mucosa in portal hypertension patients. [source] WATER STRESS ALTERS THE GENETIC ARCHITECTURE OF FUNCTIONAL TRAITS ASSOCIATED WITH DROUGHT ADAPTATION IN AVENA BARBATAEVOLUTION, Issue 3 2009Mark E. Sherrard Environmental stress can alter genetic variation and covariation underlying functional traits, and thus affect adaptive evolution in response to natural selection. However, the genetic basis of functional traits is rarely examined in contrasting resource environments, and consequently, there is no consensus regarding whether environmental stress constrains or facilitates adaptive evolution. We tested whether resource availability affects genetic variation for and covariation among seven physiological traits and seven morphological/performance traits by growing the annual grass Avena barbata in dry and well-watered treatments. We found that differences in the overall genetic variance,covariance (G) matrix between environments were driven by physiological traits rather than morphology and performance traits. More physiological traits were heritable in the dry treatment than the well-watered treatment and many of the genetic correlations among physiological traits were environment dependent. In contrast, genetic variation and covariation among the morphological and performance traits did not differ across treatments. Furthermore, genetic correlations between physiology and performance were stronger in the dry treatment, which contributed to differences in the overall G -matrix. Our results therefore suggest that physiological adaptation would be constrained by low heritable variation in resource-rich environments, but facilitated by higher heritable variation and stronger genetic correlations with performance traits in resource-poor environments. [source] EVOLUTION OF GENETIC ARCHITECTURE UNDER DIRECTIONAL SELECTIONEVOLUTION, Issue 8 2006Thomas F. Hansen Abstract We investigate the multilinear epistatic model under mutation-limited directional selection. We confirm previous results that only directional epistasis, in which genes on average reinforce or diminish each other's effects, contribute to the initial evolution of mutational effects. Thus, either canalization or decanalization can occur under directional selection, depending on whether positive or negative epistasis is prevalent. We then focus on the evolution of the epistatic coefficients themselves. In the absence of higher-order epistasis, positive pairwise epistasis will tend to weaken relative to additive effects, while negative pairwise epistasis will tend to become strengthened. Positive third-order epistasis will counteract these effects, while negative third-order epistasis will reinforce them. More generally, gene interactions of all orders have an inherent tendency for negative changes under directional selection, which can only be modified by higher-order directional epistasis. We identify three types of nonadditive quasi-equilibrium architectures that, although not strictly stable, can be maintained for an extended time: (1) nondirectional epistatic architectures; (2) canalized architectures with strong epistasis; and (3) near-additive architectures in which additive effects keep increasing relative to epistasis. [source] THE EVOLUTION OF GENETIC ARCHITECTURE UNDER FREQUENCY-DEPENDENT DISRUPTIVE SELECTIONEVOLUTION, Issue 8 2006Michael Kopp Abstract We propose a model to analyze a quantitative trait under frequency-dependent disruptive selection. Selection on the trait is a combination of stabilizing selection and intraspecific competition, where competition is maximal between individuals with equal phenotypes. In addition, there is a density-dependent component induced by population regulation. The trait is determined additively by a number of biallelic loci, which can have different effects on the trait value. In contrast to most previous models, we assume that the allelic effects at the loci can evolve due to epistatic interactions with the genetic background. Using a modifier approach, we derive analytical results under the assumption of weak selection and constant population size, and we investigate the full model by numerical simulations. We find that frequency-dependent disruptive selection favors the evolution of a highly asymmetric genetic architecture, where most of the genetic variation is concentrated on a small number of loci. We show that the evolution of genetic architecture can be understood in terms of the ecological niches created by competition. The phenotypic distribution of a population with an adapted genetic architecture closely matches this niche structure. Thus, evolution of the genetic architecture seems to be a plausible way for populations to adapt to regimes of frequency-dependent disruptive selection. As such, it should be seen as a potential evolutionary pathway to discrete polymorphisms and as a potential alternative to other evolutionary responses, such as the evolution of sexual dimorphism or assortative mating. [source] SEXUAL SELECTION, GENETIC ARCHITECTURE, AND THE CONDITION DEPENDENCE OF BODY SHAPE IN THE SEXUALLY DIMORPHIC FLY PROCHYLIZA XANTHOSTOMA (PIOPHILIDAE)EVOLUTION, Issue 1 2005Russell Bonduriansky Abstract The hypothesis that sexual selection drives the evolution of condition dependence is not firmly supported by empirical evidence, and the process remains poorly understood. First, even though sexual competition typically involves multiple traits, studies usually compare a single sexual trait with a single "control" trait, ignoring variation among sexual traits and raising the possibility of sampling bias. Second, few studies have addressed the genetic basis of condition dependence. Third, even though condition dependence is thought to result from a form of sex-specific epistasis, the evolution of condition dependence has never been considered in relation to intralocus sexual conflict. We argue that condition dependence may weaken intersexual genetic correlations and facilitate the evolution of sexual dimorphism. To address these questions, we manipulated an environmental factor affecting condition (larval diet) and examined its effects on four sexual and four nonsexual traits in Prochyliza xanthostoma adults. As predicted by theory, the strength of condition dependence increased with degree of exaggeration among male traits. Body shape was more condition dependent in males than in females and, perhaps as a result, genetic and environmental effects on body shape were congruent in males, but not in females. However, of the four male sexual traits, only head length was significantly larger in high-condition males after controlling for body size. Strong condition dependence was associated with reduced intersexual genetic correlation. However, homologous male and female traits exhibited correlated responses to condition, suggesting an intersexual genetic correlation for condition dependence itself. Our findings support the role of sexual selection in the evolution of condition dependence, but reveal considerable variation in condition dependence among sexual traits. It is not clear whether the evolution of condition dependence has mitigated or exacerbated intralocus sexual conflict in this species. [source] ARCHITECTURE, INCULTURATION AND CHRISTIAN MISSIONINTERNATIONAL REVIEW OF MISSION, Issue 353 2000AND THEIR MEANING FOR THE CHURCH TODAY, THE BUILDINGS OF THE CAMBRIDGE MISSION TO DELHI First page of article [source] CORPORATE GOVERNANCE, ETHICS, AND ORGANIZATIONAL ARCHITECTUREJOURNAL OF APPLIED CORPORATE FINANCE, Issue 3 2003James A. Brickley Effective corporate leadership involves more than developing a good strategic plan and setting high ethical standards. It also means coming up with an organizational design that encourages the company's managers and employees to carry out its business plan and maintain its ethical standards. In this article, the authors use the term organizational architecture to refer to three key elements of a company's design: ,the assignment of decision-making authority,who gets to make what decisions; ,performance evaluation,the key measures of performance for evaluating business units and individual employees; and ,compensation structure,how employees are rewarded for meeting performance goals. In well-designed companies, each of these elements is mutually reinforcing and supportive of the company's overall business strategy. Decision-making authority is assigned to managers and employees who have the knowledge and experience needed to make the best investment and operating decisions. And to ensure that those decision makers have the incentive as well as the knowledge to make the best decisions, the corporate systems used to evaluate and reward their performance are based on measures that are linked as directly as possible to the corporate goal of creating value. Some of the most popular management techniques of the past two decades, such as reengineering, TQM, and the Balanced Scorecard, have often had disappointing results because they address only one or two elements of organizational architecture, leaving the overall structure out of balance. What's more, a flawed organizational design can lead to far worse than missed opportunities to create value. As the authors note, the recent corporate scandals involved not just improper behavior by senior executives, but corporate structures that, far from safeguarding against such behavior, in some ways encouraged it. In the case of Enron, for example, top management's near-total focus on boosting reported earnings (a questionable corporate goal to begin with) combined with decentralized decision making and loose oversight at all levels of the company to produce an enormously risky high-leverage strategy that ended up bringing down the firm. [source] "THE SPACE OF COMMUNICATIVITY": LÉVINAS AND ARCHITECTUREJOURNAL OF CHINESE PHILOSOPHY, Issue 2008Dorian Wiszniewski [source] RELATIONSHIPS BETWEEN PRIMARY PLANT CELL WALL ARCHITECTURE AND MECHANICAL PROPERTIES FOR ONION BULB SCALE EPIDERMAL CELLSJOURNAL OF TEXTURE STUDIES, Issue 6 2004DAVID G. HEPWORTH ABSTRACT This article investigates onion epidermal tissue (Allium cepa) using a combination of mechanical testing, microscopy and modeling and relates tissue mechanical properties to the known structure of the cell walls. Onion epidermal tissue has a simple, regular structure of elongated cells, which have been used to enable the contributions to mechanical properties of cell walls and of higher order structures to be separated and analyzed. Two models of wall behavior were used to explore how Poisson's ratio of cell walls parallel to the plane of the epidermal surface may vary with applied strain. In the first model, cellulose microfibrils can be reorientated in an unrestricted way with the result that the cell wall volume decreases. In the second model the volume of the cell wall remains constant, which controls the reorientation of microfibrils, hence the Poisson's ratio. Measurements made from uniaxially stretched cells show that the data most closely fits model I, therefore, it is concluded that the bulk of the matrix has little influence on the observed mechanical properties (at a test rate of 1 mm/min), allowing cellulose microfibrils to reorient through the matrix in an unrestricted way during uniaxial tests. In its mechanical attributes the primary cell wall resembles more a knitted cloth than a semisolid composite material. When biaxial stretching is applied to tissue, so that there is no re-orientation of microfibrils, the cell wall material is still able to reach surprisingly large elastic strains of up to 12.5% and no plastic deformation was recorded. Current theory suggests that cellulose microfibrils can stretch elastically by a maximum of 7%, therefore further work is required to identify mechanisms that could account for the extra elastic strain. [source] THE REDISCOVERY OF AMERICAN SACRED SPACESRELIGIOUS STUDIES REVIEW, Issue 4 2004Louis P. Nelson Book reviewed in this article: THE HERMENEUTICS OF SACRED ARCHITECTURE: EXPERIENCE, INTERPRETATION, COMPARISON (2 volumes) By Lindsay Jones TEMPLES OF GRACE: THE MATERIAL TRANSFORMATION OF CONNECTICUT'S CHURCHES, 1790,1840 By Gretchen Buggeln WHEN CHURCH BECAME THEATRE: THE TRANSFORMATION OF EVANGELICAL ARCHITECTURE AND WORSHIP IN THE NINETEENTH-CENTURY AMERICA By Jeanne Kilde PRAYERS IN STONE: CHRISTIAN SCIENCE ARCHITECTURE IN THE UNITED STATES, 1894,1930 By Paul Eli Ivey SHUL WITH A POOL: THE "SYNAGOGUE-CENTER" IN AMERICAN JEWISH HISTORY By David Kaufman MYTHS IN STONE: RELIGIOUS DIMENSIONS OF WASHINGTON, D.C. By Jeffrey F. Meyer UGLY AS SIN: WHY THEY CHANGED OUR CHURCHES FROM SACRED PLACES TO MEETING SPACES AND HOW WE CAN CHANGE THEM BACK AGAIN By Michael S. Rose BUILDING FROM BELIEF: ADVANCE, RETREAT, AND COMPROMISE IN THE REMAKING OF CATHOLIC CHURCH ARCHITECTURE By Michael E. DeSanctis ARCHITECTURE IN COMMUNION: IMPLEMENTING THE SECOND VATICAN COUNCIL THROUGH LITURGY AND ARCHITECTURE By Steven J. Schloeder [source] THE HARMONIC MIND: FROM NEURAL COMPUTATION TO OPTIMALITY-THEORETIC GRAMMAR,VOLUME 1: COGNITIVE ARCHITECTURE AND VOLUME 2: LINGUISTIC AND PHILOSOPHICAL IMPLICATIONSANALYTIC PHILOSOPHY, Issue 3 2009WILLIAM RAMSEY First page of article [source] Front and Back Covers, Volume 21, Number 3.ANTHROPOLOGY TODAY, Issue 3 2005June 200 Front and back cover caption, volume 21 issue 3 ENERGY AND VERNACULAR ARCHITECTURE The photo on the front and back cover illustrates the article by Annette Henning in this issue. A solar collector is hoisted onto the roof of a Swedish house. In Sweden, the most common solar heating systems are those that supply hot water for both heating and general domestic hot water purposes. Contrary to popular belief, solar collectors are not dependent on a high air temperature, but produce heat throughout the year, whenever there is a clear sky. In her article, Annette Henning examines the actual and potential role of anthropology in energy studies. She reflects on her own experience of the trials of working as an anthropologist in the energy sector, where economists and technical expertise reign, and where production- and distribution-oriented approaches prevail. There is a great deal of resistance to anthropological contributions, in part because anthropologists have made so little effort to be heard in the public domain on this issue. In his editorial, Hal Wilhite makes the case for "energy anthropology". He argues that anthropologists have paid insufficient attention to one of the most urgent problems facing the world, namely our patterns of energy consumption and their economic and environmental consequences. Increasing consumerism in developing countries makes anthropological approaches indispensable, particularly in finding ways to moderate energy consumption and to help implement small-scale renewable energy initiatives. In his review of three of the latest books on vernacular architecture, Marcel Vellinga identifies architecture as a prominent cultural category and a major consumer of energy and resources, and thus a significant contributor to current environmental problems. Vellinga argues that anthropology should pay more attention to vernacular architecture as a locus of indigenous knowledge, to help the global community address the challenges of creating a sustainable built environment for all. ANTHROPOLOGY TODAY brings these contributions to your attention in the hope of stimulating discussion and promoting wider ethnographic research in areas of public concern. [source] ARCHITECTURE, GENDER AND POLITICS: THE VILLA IMPERIALE AT PESAROART HISTORY, Issue 5 2006CATHERINE KING Factors addressed by art historians in interpreting and explaining the unconventional design of the new Villa Imperiale at Pesaro by Girolamo Genga (c1529-38) have included functional questions of topography and aspect, the court year, court ceremonies and theatre, and its relation to the older villa beside it, as well as stylistic explanations associated with ,Mannerism.' However the new villa was inscribed on its façade as having been built by Leonora Gonzaga Duchess of Urbino for her husband Duke Francesco Maria I. This essay discusses gender decorum to understand more about the interplay of factors underlying the choice of its peculiar design. The evidence of contemporary texts addressing the proper feminine appearance and behaviour of the Duchess and other noblewomen is considered in relation to the unusually enclosed and private themes characterising the plan and elevation of this villa. [source] SIMDE: An educational simulator of ILP architectures with dynamic and static schedulingCOMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 3 2007I. Castilla Abstract This article presents SIMDE, a cycle-by-cycle simulator to support teaching of Instruction-Level Parallelism (ILP) architectures. The simulator covers dynamic and static instruction scheduling by using a shared structure for both approaches. Dynamic scheduling is illustrated by means of a simple superscalar processor based on Tomasulo's algorithm. A basic Very Long Instruction Word (VLIW) processor has been designed for static scheduling. The simulator is intended as an aid-tool for teaching theoretical contents in Computer Architecture and Organization courses. The students are provided with an easy-to-use common environment to perform different simulations and comparisons between superscalar and VLIW processors. Furthermore, the simulator has been tested by students in a Computer Architecture course in order to assess its real usefulness. © 2007 Wiley Periodicals, Inc. Comput Appl Eng Educ 14: 226,239, 2007; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20154 [source] On-Line Control Architecture for Enabling Real-Time Traffic System OperationsCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 5 2004Srinivas Peeta Critical to their effectiveness are the control architectures that provide a blueprint for the efficient transmission and processing of large amounts of real-time data, and consistency-checking and fault tolerance mechanisms to ensure seamless automated functioning. However, the lack of low-cost, high-performance, and easy-to-build computing environments are key impediments to the widespread deployment of such architectures in the real-time traffic operations domain. This article proposes an Internet-based on-line control architecture that uses a Beowulf cluster as its computational backbone and provides an automated mechanism for real-time route guidance to drivers. To investigate this concept, the computationally intensive optimization modules are implemented on a low-cost 16-processor Beowulf cluster and a commercially available supercomputer, and the performance of these systems on representative computations is measured. The results highlight the effectiveness of the cluster in generating substantial computational performance scalability, and suggest that its performance is comparable to that of the more expensive supercomputer. [source] A Distributed Object-Oriented Finite-Element Analysis Program ArchitectureCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 5 2001Hung-Ming Chen This article presents a distributed object-oriented design for a nonlinear finite-element analysis using the message-passing paradigm and a single-program, multiple-data scheme. The architecture is an extension of an existing sequential object-oriented architecture. The design recognizes the costly communication startup time penalty by attempting to minimize the frequency of communications. This is facilitated by distributing not only the elements in the model but also their associated nodes and mapping between the degrees of freedom and the analytical equations of equilibrium. The proposed object design was implemented and tested on a nonlinear static pushover analysis of three moment-resisting frames. [source] High-performance hybrid information service architectureCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 15 2010Mehmet S. Aktas Abstract We introduce a distributed high-performance Information Service Architecture, which forms a metadata replica hosting system to manage both highly dynamic small-scale metadata and relatively large static metadata associated with Grid/Web Services. We present an empirical evaluation of the proposed architecture and investigate its practical usefulness. The results demonstrate that the proposed system achieves high performance and fault tolerance with negligible processing overheads. The results also indicate that efficient decentralized hybrid Information Service Architectures can be built by utilizing publish-subscribe-based messaging schemes. Copyright © 2010 John Wiley & Sons, Ltd. [source] HLA real-time extensionCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 15 2004Hui Zhao Abstract The IEEE 1516 Standard ,High Level Architecture (HLA)' and its implementation ,Run-Time Infra-structure (RTI)' defines a general-purpose network communication mechanism for Distributed Interactive Simulation (DIS). However, it does not address real-time requirements of DIS. Current operating system technologies can provide real-time processing through some real-time operating systems (RTOSs) and the Internet is also moving to an age of Quality of Service (QoS), providing delay and jitter bounded services. With the availability of RTOSs and IP QoS, it is possible for HLA to be extended to take advantage of these technologies in order to construct an architecture for Real-Time DIS (RT-DIS). This extension will be a critical aspect of applications in virtual medicine, distributed virtual environments, weapon simulation, aerospace simulation and others. This paper outlines the current real-time technology with respect to operating systems and at the network infrastructure level. After summarizing the requirements and our experiences with RT-DIS, we present a proposal for HLA real-time extension and architecture for real-time RTI. Similar to the growth of real-time CORBA (Common Object Request Broker) after the mature based CORBA standard suite, Real-Time HLA is a natural extension following the standardization of HLA into IEEE 1516 in September 2000. Copyright © 2004 John Wiley & Sons, Ltd. [source] Simulation of resource synchronization in a dynamic real-time distributed computing environmentCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 14 2004Chen Zhang Abstract Today, more and more distributed computer applications are being modeled and constructed using real-time principles and concepts. In 1989, the Object Management Group (OMG) formed a Real-Time Special Interest Group (RT SIG) with the goal of extending the Common Object Request Broker Architecture (CORBA) standard to include real-time specifications. This group's most recent efforts have focused on the requirements of dynamic distributed real-time systems. One open problem in this area is resource access synchronization for tasks employing dynamic priority scheduling. This paper presents two resource synchronization protocols that the authors have developed which meet the requirements of dynamic distributed real-time systems as specified by Dynamic Scheduling Real-Time CORBA (DSRT CORBA). The proposed protocols can be applied to both Earliest Deadline First (EDF) and Least Laxity First (LLF) dynamic scheduling algorithms, allow distributed nested critical sections, and avoid unnecessary runtime overhead. In order to evaluate the performance of the proposed protocols, we analyzed each protocol's schedulability. Since the schedulability of the system is affected by numerous system configuration parameters, we have designed simulation experiments to isolate and illustrate the impact of each individual system parameter. Simulation experiments show the proposed protocols have better performance than one would realize by applying a schema that utilizes dynamic priority ceiling update. Copyright © 2004 John Wiley & Sons, Ltd. [source] A CORBA Commodity Grid KitCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 13-15 2002Manish Parashar Abstract This paper reports on an ongoing research project aimed at designing and deploying a Common Object Resource Broker Architecture (CORBA) (ww.omg.org) Commodity Grid (CoG) Kit. The overall goal of this project is to enable the development of advanced Grid applications while adhering to state-of-the-art software engineering practices and reusing the existing Grid infrastructure. As part of this activity, we are investigating how CORBA can be used to support the development of Grid applications. In this paper, we outline the design of a CORBA CoG Kit that will provide a software development framework for building a CORBA ,Grid domain'. We also present our experiences in developing a prototype CORBA CoG Kit that supports the development and deployment of CORBA applications on the Grid by providing them access to the Grid services provided by the Globus Toolkit. Copyright © 2002 John Wiley & Sons, Ltd. [source] The CCA core specification in a distributed memory SPMD frameworkCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 5 2002Benjamin A. Allan Abstract We present an overview of the Common Component Architecture (CCA) core specification and CCAFFEINE, a Sandia National Laboratories framework implementation compliant with the draft specification. CCAFFEINE stands for CCA Fast Framework Example In Need of Everything; that is, CCAFFEINE is fast, lightweight, and it aims to provide every framework service by using external, portable components instead of integrating all services into a single, heavy framework core. By fast, we mean that the CCAFFEINE glue does not get between components in a way that slows down their interactions. We present the CCAFFEINE solutions to several fundamental problems in the application of component software approaches to the construction of single program multiple data (SPMD) applications. We demonstrate the integration of components from three organizations, two within Sandia and one at Oak Ridge National Laboratory. We outline some requirements for key enabling facilities needed for a successful component approach to SPMD application building. Copyright © 2002 John Wiley & Sons, Ltd. [source] Towards a More Rational IMF Quota Structure: Suggestions for the Creation of a New International Financial ArchitectureDEVELOPMENT AND CHANGE, Issue 3 2000Raghbendra Jha The authors of this article argue that, in the absence of a well-founded quota formula, the very basis of the creation of the IMF as an institution at the centre of international financial arrangements was flawed; that there is no clear rationale for the determinants of quota structures and their weighting scheme; and that the quota allocation as an instrument seeks to target too many objectives. As a result, large and arbitrary cross-country variations exist in the relative impact of different determinants on the quota shares of different countries. The quota formulas therefore need to be reviewed and an alternative approach evolved, in which emphasis is placed on the size of the economy rather than its openness, along with efficiency parameters. The authors suggest some principles which might underpin redefined quota structures in support of a new financial architecture. They provide illustrative calculations using India as a case study, and trace the impact of the redefined quota structures against the backdrop of the impact of the Eleventh General Review on India's quota position. [source] Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporterENVIRONMENTAL MICROBIOLOGY, Issue 7 2009e Váchová Summary Yeasts, when growing on solid surfaces, form organized multicellular structures, colonies, in which cells differentiate and thus possess different functions and undergo dissimilar fate. Understanding the principles involved in the formation of these structures requires new approaches that allow the study of individual cells directly in situ without needing to remove them from the microbial community. Here we introduced a new approach to the analysis of whole yeast microcolonies either containing specific proteins labelled by fluorescent proteins or stained with specific dyes, by two-photon excitation confocal microscopy. It revealed that the colonies are covered with a thin protective skin-like surface cell layer which blocks penetration of harmful compounds. The cells forming the layer are tightly connected via cell walls, the presence of which is essential for keeping of protective layer function. Viewing the colonies from different angles allowed us to reconstruct a three-dimensional profile of the cells producing ammonium exporter Ato1p within developing microcolonies growing either as individuals or within a group of microcolonies. We show that neighbouring microcolonies coordinate production of Ato1p-GFP. Ato1p itself appears synchronously in cells, which do not originate from the same ancestor, but occupy specific position within the colony. [source] Genetic Architecture of Idiopathic Generalized Epilepsy: Clinical Genetic Analysis of 55 Multiplex FamiliesEPILEPSIA, Issue 5 2004Carla Marini Summary: Purpose: In families with idiopathic generalized epilepsy (IGE), multiple IGE subsyndromes may occur. We performed a genetic study of IGE families to clarify the genetic relation of the IGE subsyndromes and to improve understanding of the mode(s) of inheritance. Methods: Clinical and genealogic data were obtained on probands with IGE and family members with a history of seizures. Families were grouped according to the probands' IGE subsyndrome: childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and IGE with tonic,clonic seizures only (IGE-TCS). The subsyndromes in the relatives were analyzed. Mutations in genes encoding ,1 and ,2 ,-aminobutyric acid (GABA)-receptor subunits, ,1 and ,1 sodium channel subunits, and the chloride channel CLC-2 were sought. Results: Fifty-five families were studied. 122 (13%) of 937 first- and second-degree relatives had seizures. Phenotypic concordance within families of CAE and JME probands was 28 and 27%, respectively. JAE and IGE-TCS families had a much lower concordance (10 and 13%), and in the JAE group, 31% of relatives had CAE. JME was rare among affected relatives of CAE and JAE probands and vice versa. Mothers were more frequently affected than fathers. No GABA-receptor or sodium or chloride channel gene mutations were identified. Conclusions: The clinical genetic analysis of this set of families suggests that CAE and JAE share a close genetic relation, whereas JME is a more distinct entity. Febrile seizures and epilepsy with unclassified tonic,clonic seizures were frequent in affected relatives of all IGE individuals, perhaps representing a nonspecific susceptibility to seizures. A maternal effect also was seen. Our findings are consistent with an oligogenic model of inheritance. [source] 3D Architecture and Load Partition in Eutectic Al-Si Alloys,ADVANCED ENGINEERING MATERIALS, Issue 12 2009Guillermo Requena Abstract The changes of the three dimensional architecture of a eutectic AlSi12 alloy during heat treatment are revealed by means of synchrotron holotomography. The non-destructive nature of the holotomography technique allows to analyze the same volumes in different thermal conditions. The results show a disintegration of the interconnected eutectic Si-lamellae into isolated elongated particles. The load carrying capacity of both types of Si morphologies is studied by in situ neutron diffraction during compression tests. The experimental results are compared to those obtained using a micromechanical model developed for metal matrix composites based on a homogenization approach. The correlation between experiments and calculations shows that the interconnectivity of Si must be considered to account for the strength exhibited by the eutectic alloy. The present study bridges the gap between the already available two-dimensional studies of architecture and properties of the binary AlSi12 alloy and new three-dimensional studies of more complex systems based on this alloy. [source] IntServ6: an approach to support QoS over IPv6 wired and wireless networksEUROPEAN TRANSACTIONS ON TELECOMMUNICATIONS, Issue 6 2008Jhon J. Padilla In this paper we propose a new approach for Quality of Service (QoS) support on Internet. This approach, named IntServ6, is based on the Integrated Services Architecture (ISA). It takes advantage of the IPv6 header flow label field to improve a set of the standard ISA properties such as reservations within tunnels, flows aggregation and interconnection with MPLS transport networks. IntServ6 can be used for QoS support in IPv6 wired and wireless networks. This paper describes the IntServ6 operation and performance evaluation over both environments. Evaluation results show that this approach has a better router performance with respect to the standard IntServ. Thus, IntServ6 reduces the mean packet delay and reduces the packet delay dependence with the mobility. Copyright © 2007 John Wiley & Sons, Ltd. [source] Experiences from the Implementation and Use of Multimedia Synchronization MechanismsEUROPEAN TRANSACTIONS ON TELECOMMUNICATIONS, Issue 3 2000Theodoros H. Bozios This paper presents experiences from the implementation of Multimedia Synchronization Mechanisms related to the support of the many-to-one inter-media synchronization and describes the proposed Synchronization Architecture and its Design Objectives. The main goal of the communication system in the proposed architecture is to maintain the asynchrony levels between the media streams belonging in a Synchronization Group between the levels specitied by the Multimcdia Application. This is achieved through appropriate Synchronization Primitives related to the management and monitoring of the synchronization. The pilper emphasizes on the implementation issues and problems, and the solutions adopted. concluding to the lirst experiences from the use of the synchronization. [source] Architecture of Supramolecular Soft Functional Materials: From Understanding to Micro-/Nanoscale EngineeringADVANCED FUNCTIONAL MATERIALS, Issue 19 2010Jing-Liang Li Abstract This article gives an overview of the current progress of a class of supramolecular soft materials consisting of fiber networks and the trapped liquid. After discussing the up-to-date knowledge on the types of fiber networks and the correlation to the rheological properties, the gelation mechanism turns out to be one of the key subjects for this review. In this concern, the following two aspects will be focused upon: the single fiber network formation and the multi-domain fiber network formation of this type of material. Concerning the fiber network formation, taking place via nucleation, and the nucleation-mediated growth and branching mechanism, the theoretical basis of crystallographic mismatch nucleation that governs fiber branching and formation of three-dimensional fiber networks is presented. In connection to the multi-domain fiber network formation, which is governed by the primary nucleation and the subsequent formation of single fiber networks from nucleation centers, the control of the primary nucleation rate will be considered. Based on the understanding on the the gelation mechanism, the engineering strategies of soft functional materials of this type will be systematically discussed. These include the control of the nucleation and branching-controlled fiber network formation in terms of tuning the thermodynamic driving force of the gelling system and introducing suitable additives, as well as introducing ultrasound. Finally, a summary and the outlook of future research on the basis of the nucleation-growth-controlled fiber network formation are given. [source] Architecture of Supramolecular Soft Functional Materials: From Understanding to Micro-/Nanoscale EngineeringADVANCED FUNCTIONAL MATERIALS, Issue 19 2010Jing-Liang Li Abstract This article gives an overview of the current progress of a class of supramolecular soft materials consisting of fiber networks and the trapped liquid. After discussing the up-to-date knowledge on the types of fiber networks and the correlation to the rheological properties, the gelation mechanism turns out to be one of the key subjects for this review. In this concern, the following two aspects will be focused upon: the single fiber network formation and the multi-domain fiber network formation of this type of material. Concerning the fiber network formation, taking place via nucleation, and the nucleation-mediated growth and branching mechanism, the theoretical basis of crystallographic mismatch nucleation that governs fiber branching and formation of three-dimensional fiber networks is presented. In connection to the multi-domain fiber network formation, which is governed by the primary nucleation and the subsequent formation of single fiber networks from nucleation centers, the control of the primary nucleation rate will be considered. Based on the understanding on the the gelation mechanism, the engineering strategies of soft functional materials of this type will be systematically discussed. These include the control of the nucleation and branching-controlled fiber network formation in terms of tuning the thermodynamic driving force of the gelling system and introducing suitable additives, as well as introducing ultrasound. Finally, a summary and the outlook of future research on the basis of the nucleation-growth-controlled fiber network formation are given. [source] A CdSe Nanowire/Quantum Dot Hybrid Architecture for Improving Solar Cell PerformanceADVANCED FUNCTIONAL MATERIALS, Issue 9 2010Yanghai Yu Abstract Incorporating colloidal CdSe quantum dots (QDs) into CdSe nanowire (NW)-based photoelectrochemical solar cells increases their incident-photon-to-carrier conversion efficiencies (IPCE) from 13% to 25% at 500,nm. While the effect could, in principle, stem from direct absorption and subsequent carrier generation by QDs, the overall IPCE increase occurs across the entire visible spectrum, even at wavelengths where the dots do not absorb light. This beneficial effect originates from an interplay between NWs and QDs where the latter fill voids between interconnected NWs, providing electrically accessible conduits, in turn, enabling better carrier transport to electrodes. The presence of QDs furthermore reduces the residual polarization anisotropy of random NW networks. Introducing QDs therefore addresses an important limiting constraint of NW photoelectrochemical solar cells. The effect appears to be general and may aid the future design and implementation of other NW-based photovoltaics. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||